Stuart M Chambers

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors
    Stuart M Chambers
    Center for Stem Cell Biology, Sloan Kettering Institute, New York, New York, USA
    Nat Biotechnol 30:715-20. 2012
  2. pmc Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
    Stuart M Chambers
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, New York 10065, USA
    Nat Biotechnol 27:275-80. 2009
  3. doi request reprint Cell fate plug and play: direct reprogramming and induced pluripotency
    Stuart M Chambers
    Center for Stem Cell Biology, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Cell 145:827-30. 2011
  4. pmc Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, USA
    Nature 461:402-6. 2009
  5. pmc Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs
    Yvonne Mica
    The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
    Cell Rep 3:1140-52. 2013
  6. doi request reprint Derivation of neural crest cells from human pluripotent stem cells
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Nat Protoc 5:688-701. 2010
  7. doi request reprint Efficient derivation of functional floor plate tissue from human embryonic stem cells
    Christopher A Fasano
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, NY 10065, USA
    Cell Stem Cell 6:336-47. 2010
  8. pmc ZFX controls the self-renewal of human embryonic stem cells
    Sivan Harel
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e42302. 2012
  9. pmc Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation
    Eirini P Papapetrou
    Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:12759-64. 2009
  10. doi request reprint Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration
    Stuart M Chambers
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Methods Mol Biol 793:87-97. 2011

Collaborators

Detail Information

Publications11

  1. pmc Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors
    Stuart M Chambers
    Center for Stem Cell Biology, Sloan Kettering Institute, New York, New York, USA
    Nat Biotechnol 30:715-20. 2012
    ..The quick and high-efficiency derivation of nociceptors offers unprecedented access to this medically relevant cell type for studies of human pain...
  2. pmc Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
    Stuart M Chambers
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, New York 10065, USA
    Nat Biotechnol 27:275-80. 2009
    ..Noggin/SB431542-based neural induction should facilitate the use of hES and hiPS cells in regenerative medicine and disease modeling and obviate the need for protocols based on stromal feeders or embryoid bodies...
  3. doi request reprint Cell fate plug and play: direct reprogramming and induced pluripotency
    Stuart M Chambers
    Center for Stem Cell Biology, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Cell 145:827-30. 2011
    ..Here we discuss the advantages and challenges of harnessing this direct reprogramming method for regenerative medicine...
  4. pmc Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, USA
    Nature 461:402-6. 2009
    ..Our study illustrates the promise of iPSC technology for gaining new insights into human disease pathogenesis and treatment...
  5. pmc Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs
    Yvonne Mica
    The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA
    Cell Rep 3:1140-52. 2013
    ..Our data define a highly specific requirement for WNT signaling during NC induction and enable the generation of pure populations of human iPSC-derived melanocytes for faithful modeling of pigmentation disorders...
  6. doi request reprint Derivation of neural crest cells from human pluripotent stem cells
    Gabsang Lee
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Nat Protoc 5:688-701. 2010
    ..Our protocol has been validated in multiple independent hESC and hiPSC lines. The average time required for generating purified hPSC-NC precursors using this protocol is 2-5 weeks...
  7. doi request reprint Efficient derivation of functional floor plate tissue from human embryonic stem cells
    Christopher A Fasano
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Ave, New York, NY 10065, USA
    Cell Stem Cell 6:336-47. 2010
    ..These data define the early signals that drive human FP versus AN specification and determine regional identity in hESC-derived FP...
  8. pmc ZFX controls the self-renewal of human embryonic stem cells
    Sivan Harel
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e42302. 2012
    ..Thus, ZFX acts as a molecular rheostat regulating the balance between self-renewal and differentiation in hESCs, revealing the close evolutionary conservation of the self-renewal mechanisms in murine and human ESCs...
  9. pmc Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation
    Eirini P Papapetrou
    Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:12759-64. 2009
    ..The vector system described here presents a powerful tool for mechanistic studies of reprogramming and the optimization of hiPSC generation...
  10. doi request reprint Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration
    Stuart M Chambers
    Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA
    Methods Mol Biol 793:87-97. 2011
    ..In this chapter, we detail methods to direct hESCs or hiPSCs into early neural cells and subsequently postmitotic neurons...
  11. doi request reprint Build-a-brain
    Stuart M Chambers
    Center for Stem Cell Biology, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Cell Stem Cell 13:377-8. 2013
    ..2013) established a protocol for culturing pluripotent stem cell (PSC)-derived "cerebral organoids" that mimics the developing human brain's cellular organization, segregates into distinct brain regions, and models microcephaly. ..