Brett S Carver

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Improved clinical outcome in recent years for men with metastatic nonseminomatous germ cell tumors
    Brett S Carver
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, 353 E 68th St, New York, NY 10021, USA
    J Clin Oncol 25:5603-8. 2007
  2. pmc Feasibility study of a clinically-integrated randomized trial of modifications to radical prostatectomy
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 11215, USA
    Trials 13:23. 2012
  3. pmc The total number of retroperitoneal lymph nodes resected impacts clinical outcome after chemotherapy for metastatic testicular cancer
    Brett S Carver
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 75:1431-5. 2010
  4. doi request reprint Management of post-chemotherapy extra-retroperitoneal residual masses
    Brett S Carver
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    World J Urol 27:489-92. 2009
  5. ncbi request reprint Incidence of metastatic nonseminomatous germ cell tumor outside the boundaries of a modified postchemotherapy retroperitoneal lymph node dissection
    Brett S Carver
    Department of Urology and Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 25:4365-9. 2007
  6. ncbi request reprint Long-term clinical outcome after postchemotherapy retroperitoneal lymph node dissection in men with residual teratoma
    Brett S Carver
    Department of Urology and Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 25:1033-7. 2007
  7. pmc Gleason grade remains an important prognostic predictor in men diagnosed with prostate cancer while on finasteride therapy
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 95:509-12. 2005
  8. ncbi request reprint Race is not a predictor of prostate cancer detection on repeat prostate biopsy
    Brett S Carver
    Department of Urology, Louisiana State University Health Sciences Center and Overton Brooks Veterans Administration Medical Center, Shreveport, Louisiana, USA
    J Urol 172:1853-5. 2004
  9. ncbi request reprint Predicting teratoma in the retroperitoneum in men undergoing post-chemotherapy retroperitoneal lymph node dissection
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Urol 176:100-3; discussion 103-4. 2006
  10. doi request reprint Clinical impact of residual extraretroperitoneal masses in patients with advanced nonseminomatous germ cell testicular cancer
    Timothy A Masterson
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Urology 79:156-9. 2012

Detail Information

Publications50

  1. ncbi request reprint Improved clinical outcome in recent years for men with metastatic nonseminomatous germ cell tumors
    Brett S Carver
    Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, 353 E 68th St, New York, NY 10021, USA
    J Clin Oncol 25:5603-8. 2007
    ..We evaluated men undergoing postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for NSGCT to determine associations between year of treatment and clinical outcome...
  2. pmc Feasibility study of a clinically-integrated randomized trial of modifications to radical prostatectomy
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 11215, USA
    Trials 13:23. 2012
    ..We aimed to determine the feasibility of implementing such a trial for radical prostatectomy...
  3. pmc The total number of retroperitoneal lymph nodes resected impacts clinical outcome after chemotherapy for metastatic testicular cancer
    Brett S Carver
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 75:1431-5. 2010
    ..After the multidisciplinary management of metastatic germ cell tumor, approximately 10%-15% of patients with the histologic finding of fibrosis or teratoma will suffer disease recurrence...
  4. doi request reprint Management of post-chemotherapy extra-retroperitoneal residual masses
    Brett S Carver
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    World J Urol 27:489-92. 2009
    ..While the retroperitoneum is often the first and only site of metastatic disease, approximately 40% of patients presenting with metastatic disease will have disease involving extra-retroperitoneal sites...
  5. ncbi request reprint Incidence of metastatic nonseminomatous germ cell tumor outside the boundaries of a modified postchemotherapy retroperitoneal lymph node dissection
    Brett S Carver
    Department of Urology and Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 25:4365-9. 2007
    ..We evaluated our experience with PC-RPLND to determine the incidence of disease extending outside the boundaries of a modified PC-RPLND...
  6. ncbi request reprint Long-term clinical outcome after postchemotherapy retroperitoneal lymph node dissection in men with residual teratoma
    Brett S Carver
    Department of Urology and Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Clin Oncol 25:1033-7. 2007
    ..We evaluated patients at our institution undergoing initial PC-RPLND for teratoma to determine their clinical outcome...
  7. pmc Gleason grade remains an important prognostic predictor in men diagnosed with prostate cancer while on finasteride therapy
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    BJU Int 95:509-12. 2005
    ....
  8. ncbi request reprint Race is not a predictor of prostate cancer detection on repeat prostate biopsy
    Brett S Carver
    Department of Urology, Louisiana State University Health Sciences Center and Overton Brooks Veterans Administration Medical Center, Shreveport, Louisiana, USA
    J Urol 172:1853-5. 2004
    ..We evaluated men undergoing repeat prostate biopsies for persistently increased serum prostate specific antigen (PSA) levels to determine if race was a predictor of cancer detection...
  9. ncbi request reprint Predicting teratoma in the retroperitoneum in men undergoing post-chemotherapy retroperitoneal lymph node dissection
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Urol 176:100-3; discussion 103-4. 2006
    ..We evaluated patients undergoing post-chemotherapy retroperitoneal lymph node dissection for nonseminomatous germ cell tumors to determine predictors of teratomatous elements in the retroperitoneum...
  10. doi request reprint Clinical impact of residual extraretroperitoneal masses in patients with advanced nonseminomatous germ cell testicular cancer
    Timothy A Masterson
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Urology 79:156-9. 2012
    ..We reviewed our institutional experience in patients undergoing resection of extraretroperitoneal (ERP) residual masses after chemotherapy to assess its impact on cancer progression and survival...
  11. ncbi request reprint Clinical outcome following post-chemotherapy retroperitoneal lymph node dissection in men with intermediate- and poor-risk nonseminomatous germ cell tumour
    Bobby Shayegan
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BJU Int 99:993-7. 2007
    ....
  12. doi request reprint Outcomes in patients with clinical stage III NSGCT who achieve complete clinical response to chemotherapy at extraretroperitoneal disease site
    Timothy A Masterson
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 79:1079-84. 2012
    ..To compare the survival outcomes of patients with advanced nonseminoma and extraretroperitoneal (ERP) disease observed for a clinical complete response (CCR) with those demonstrating a pathologic complete response (PCR)...
  13. ncbi request reprint Radical prostatectomy for clinically localized, high risk prostate cancer: critical analysis of risk assessment methods
    Ofer Yossepowitch
    Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 178:493-9; discussion 499. 2007
    ..Of patients undergoing radical prostatectomy we identified those at high risk based on 8 previously described definitions. We examined pathological characteristics and prostate specific antigen outcomes...
  14. pmc Clinical outcome and predictors of survival in late relapse of germ cell tumor
    David S Sharp
    Department of Urology, Memorial Sloan Kettering Cancer Center, 353 E 68th St, New York, NY 10021, USA
    J Clin Oncol 26:5524-9. 2008
    ..Late relapse (LR) of germ cell tumor (GCT) is a well recognized entity associated with poor survival. We report on our experience with LR and determine predictors of survival...
  15. doi request reprint Body mass index is associated with higher lymph node counts during retroperitoneal lymph node dissection
    R Houston Thompson
    Department of Surgery Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Urology 79:361-4. 2012
    ..Lymph node counts are a proposed measure of quality assurance for numerous malignancies. Investigation of patient factors associated with lymph node counts are lacking...
  16. doi request reprint The indication for postchemotherapy lymph node dissection in clinical stage IS nonseminomatous germ cell tumor
    Atreya Dash
    Department of Urology and Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 112:800-5. 2008
    ..The objectives of the current study were to determine the clinical outcome, patterns of relapse, and incidence of teratoma in the retroperitoneum for men with cIS NSGCT...
  17. pmc ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss
    Yu Chen
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Med 19:1023-9. 2013
    ..We propose that ETS factors cause prostate-specific transformation by altering the AR cistrome, priming the prostate epithelium to respond to aberrant upstream signals such as PTEN loss. ..
  18. pmc Secondary therapy, metastatic progression, and cancer-specific mortality in men with clinically high-risk prostate cancer treated with radical prostatectomy
    Ofer Yossepowitch
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Eur Urol 53:950-9. 2008
    ..We assessed how accurately these definitions identify patients likely to receive secondary cancer therapy, experience metastatic progression, or die of prostate cancer...
  19. pmc MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors
    Nicola J Clegg
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e17449. 2011
    ..Since increased MYC expression is an early feature of many human prostate cancers, these data have implications for treatment of human prostate cancers with PI3K-pathway alterations using mTOR inhibitors...
  20. ncbi request reprint African-American race is a predictor of prostate cancer detection: incorporation into a pre-biopsy nomogram
    Brent V Yanke
    State University of New York Downstate Medical Center, New York, NY, USA
    BJU Int 98:783-7. 2006
    ....
  21. ncbi request reprint Incidence of disease outside modified retroperitoneal lymph node dissection templates in clinical stage I or IIA nonseminomatous germ cell testicular cancer
    Scott E Eggener
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 177:937-42; discussion 942-3. 2007
    ..We evaluated the incidence, sites and histology of disease outside 5 modified retroperitoneal lymph node dissection templates for patients with low stage nonseminomatous germ cell tumors of the testis...
  22. doi request reprint Contemporary lymph node counts during primary retroperitoneal lymph node dissection
    R Houston Thompson
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Urology 77:368-72. 2011
    ..We report our contemporary single-surgeon experience with lymph node counts during primary RPLND for nonseminomatous germ cell tumors...
  23. ncbi request reprint Pathologic findings and clinical outcome of patients undergoing retroperitoneal lymph node dissection after multiple chemotherapy regimens for metastatic testicular germ cell tumors
    Scott E Eggener
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer 109:528-35. 2007
    ..The authors assessed their institutional experience of retroperitoneal lymph node dissection (RPLND) after multiple chemotherapy regimens for advanced GCT...
  24. pmc ETS rearrangements and prostate cancer initiation
    Brett S Carver
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 457:E1; discussion E2-3. 2009
    ..To this end, we demonstrate that the prostate-specific overexpression of ERG does not initiate prostate tumorigenesis...
  25. pmc Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
    Brett S Carver
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer Cell 19:575-86. 2011
    ....
  26. doi request reprint Primary retroperitoneal lymph node dissection in low-stage testicular germ cell tumors: a detailed pathologic study with clinical outcome analysis with special emphasis on patients who did not receive adjuvant therapy
    Hikmat A Al-Ahmadie
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
    Urology 82:1341-6. 2013
    ....
  27. ncbi request reprint Long-term outcome following radical prostatectomy in men with clinical stage T3 prostate cancer
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 176:564-8. 2006
    ..We evaluated patients at our institution who underwent radical prostatectomy for clinical stage T3 prostate cancer to determine their long-term clinical outcomes...
  28. doi request reprint Evaluation of lymph node counts in primary retroperitoneal lymph node dissection
    R Houston Thompson
    Department of Surgery Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer 116:5243-50. 2010
    ..Lymph node counts are a measure of quality assurance and are associated with prognosis for numerous malignancies. To date, investigations of lymph node counts in testis cancer are lacking...
  29. doi request reprint Retroperitoneal histologic findings of patients with elevated serum alpha-fetoprotein and pure seminoma at orchiectomy
    Shilajit D Kundu
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Urology 78:844-7. 2011
    ..These patients underwent treatment on the assumption that the lesion was nonseminomatous germ cell tumor (NSGCT)...
  30. doi request reprint Impact of age on clinicopathological outcomes and recurrence-free survival after the surgical management of nonseminomatous germ cell tumour
    Timothy A Masterson
    Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BJU Int 110:950-5. 2012
    ..Our results showed similar clinical and pathological characteristics, and survival outcomes that compare favourably with those of men aged <50 years...
  31. pmc Integrative genomic profiling of human prostate cancer
    Barry S Taylor
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Cancer Cell 18:11-22. 2010
    ..The genomic and clinical outcome data from these patients are now made available as a public resource...
  32. ncbi request reprint Prostate cancer in patients with an abnormal digital rectal examination and serum prostate-specific antigen less than 4.0 ng/mL
    Caleb B Bozeman
    Department of Urology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana 71130, USA
    Urology 66:803-7. 2005
    ..To evaluate men with abnormal digital rectal examination (DRE) findings and a serum prostate-specific antigen (PSA) level less than 4.0 ng/mL who underwent prostate biopsy...
  33. pmc Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    Brett S Carver
    Cancer Biology and Genetics Program, Sloan Kettering Institute, New York, New York, USA
    Nat Genet 41:619-24. 2009
    ..Thus, ERG has a distinct role in prostate cancer progression and cooperates with PTEN haploinsufficiency to promote progression of HGPIN to invasive adenocarcinoma...
  34. ncbi request reprint The current status of laparoscopic retroperitoneal lymph node dissection for non-seminomatous germ-cell tumors
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, USA
    Nat Clin Pract Urol 2:330-5. 2005
    ..Future prospective internal review board-approved trials need to be developed to evaluate the therapeutic efficacy of laparoscopic RPLND, with careful observation of patients with pathologic low-volume nodal disease...
  35. ncbi request reprint Impact of positive surgical margins in patients undergoing partial nephrectomy for renal cortical tumours
    Eric O Kwon
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BJU Int 99:286-9. 2007
    ....
  36. pmc Preservation of ejaculation in patients undergoing nerve-sparing postchemotherapy retroperitoneal lymph node dissection for metastatic testicular cancer
    Joseph A Pettus
    Department of Surgery, Division of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 73:328-31; discussion 331-2. 2009
    ..To evaluate the clinical parameters associated with the recovery of ejaculation after nerve-sparing postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) for nonseminomatous germ cell tumor...
  37. ncbi request reprint Late relapse of testicular germ cell tumors
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Urol Oncol 23:441-5. 2005
    ..In this review, we present the recent data regarding the clinical presentation, patterns of relapse, histologic findings, appropriate treatment options, and outcomes for men with late relapse of germ cell tumors...
  38. ncbi request reprint Squamous cell carcinoma of the penis: a retrospective review of forty-five patients in northwest Louisiana
    Brett S Carver
    Department of Urology, Louisiana State University Health Science Center, Shreveport 71130, USA
    South Med J 95:822-5. 2002
    ..Squamous cell carcinoma of the penis is a rare malignancy in the United States, accounting for only 0.4% of all cancers in men...
  39. ncbi request reprint Do concerns about more advanced pathological features increase the likelihood of neurovascular bundle resection in black men undergoing radical prostatectomy?
    Brett S Carver
    Department of Urology, Louisiana State University Health Sciences Center and Overton Brooks Veterans Administration Medical Center, Shreveport, USA
    J Urol 171:700-2. 2004
    ....
  40. pmc Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
    Jennifer C King
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Genet 41:524-6. 2009
    ..TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis...
  41. ncbi request reprint Adult and pediatric testicular teratoma
    Brett S Carver
    Department of Urology and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Urol Clin North Am 34:245-51; abstract x. 2007
    ....
  42. ncbi request reprint Germ cell tumors of the testis
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, 353 East 68th Street, New York 10021, USA
    Ann Surg Oncol 12:871-80. 2005
    ..This review summarizes the principal management of germ cell tumors of the testis, highlighting the indications for surgery, controversies surrounding the integration of surgery, and alternative management strategies...
  43. ncbi request reprint The prevalence of men with National Institutes of Health category IV prostatitis and association with serum prostate specific antigen
    Brett S Carver
    Department of Urology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    J Urol 169:589-91. 2003
    ..We evaluated the prevalence and relationship of serum prostate specific antigen (PSA) levels in a screening population of men diagnosed with National Institutes of Health (NIH) category IV prostatitis...
  44. doi request reprint Postchemotherapy surgery for germ cell tumors of the testis
    Brett S Carver
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Curr Opin Oncol 23:271-4. 2011
    ..To summarize the surgical management of metastatic germ cell tumors of the testis, highlighting the indications for surgery and controversies surrounding the integration of surgery...
  45. ncbi request reprint Large granular cell tumor of the penis in a 53-year-old man with coexisting prostate cancer
    Brett S Carver
    Department of Urology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Urology 59:602. 2002
    ..Thus far, only 7 cases of granular cell tumor of the penis have been reported. We report a case of granular cell tumor of the penis in a man undergoing radical retropubic prostatectomy for organ-confined adenocarcinoma of the prostate...
  46. ncbi request reprint Treatment of chronic prostatitis lowers serum prostate specific antigen
    Caleb B Bozeman
    Department of Urology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
    J Urol 167:1723-6. 2002
    ..We evaluated men with documented chronic prostatitis and elevated serum prostate specific antigen (PSA) to determine whether treatment with antibiotics and anti-inflammatory drugs lowers serum PSA...
  47. ncbi request reprint Ureteral injury due to penetrating trauma
    Brett S Carver
    Department of Urology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    South Med J 97:462-4. 2004
    ..We sought to evaluate the diagnosis and management of penetrating ureteral injuries at our trauma center...
  48. pmc Surgery for retroperitoneal relapse in the setting of a prior retroperitoneal lymph node dissection for germ cell tumor
    Geoffrey T Gotto
    Department of Urology, Memorial Sloan Kettering Cancer Center, Weill College of Medicine, New York, USA
    Indian J Urol 26:102-7. 2010
    ..Patients with retroperitoneal relapse following initial RPLND should be treated with reoperative RPLND and chemotherapy and can expect long term survival rates nearing 70% when treated in tertiary centers by experienced surgeons...
  49. ncbi request reprint Mouse modeling in oncologic preclinical and translational research
    Brett S Carver
    Cancer Biology and Genetics Program and Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 12:5305-11. 2006
    ..Ultimately this will translate from preclinical mouse model trials to the development of clinical trials and protocols for cancer patients. Here we review the usefulness of mouse modeling in oncologic translational research...
  50. pmc Ubiquitination regulates PTEN nuclear import and tumor suppression
    Lloyd C Trotman
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell 128:141-56. 2007
    ....