M F Brennan

..With accurate nodal staging, pN0 was associated with excellent prognosis. With pN+, prognosis was similar to that for gastric antral adenocarcinoma...

..Identification of targeted therapy utilising direct specific molecular targets raises hope that future progress in control, if not cure, is realistic...

..Advances in management are confined to more accurate preoperative diagnosis and staging, and decreased operative mortality. Long-term survival in the absence of resection remains poor...

..More current studies now relate long term cancer survival to other issues of specialization, volume, payor and institution. The challenge is to determine what volume thresholds are sufficient for acceptable outcomes...

..A brief description is given of three problems, which are how to bring the derived information into broad applicability, when are the results of a trial significant enough to make it a standard for care and the issue of quality control...

..At the current time, given the relative failure of standard adjuvant approaches, it is reasonable to suggest that all patients should have tissue harvested for molecular markers and enter into investigative regimens...

..Predictive nomograms are becoming increasingly used to define and predict outcome. They can be developed at presentation or following treatment and include variables not conventionally used in standard staging systems...

..The objective of this study was to evaluate outcome of initially unresectable patients who respond to multimodality therapy and undergo resection...

..Complete surgical resection is the recommended treatment approach to achieve local control. Stratification by prognostic factors will facilitate selection of patients with STS for adjuvant systemic therapies...

..The overexpression of p53 and mdm2 proteins in the nuclei of tumor cells did not always correlate well with gene amplification at the mdm2 locus or mutation at the p53 gene. The possible reasons for these discrepancies are discussed...

..pRB and Ki-67 status may be useful to predict recurrence in certain subsets of patients...

..The objective of this study was to define whether survival of patients with extremity soft tissue sarcoma (STS), stratified for known risk factors, has improved over the last 20 years...

..This study correlates reresection with local recurrence-free survival, metastasis-free survival, and disease-free survival...

..The objective of this study was to determine independent prognostic factors of primary synovial sarcoma localized to the extremity...

..Concordance of triplicate cores is high (96 to 98%) for two category distinction and decreases with the complexity of the phenotypes being analyzed (91%)...

..All histologic subtypes of RMS are aggressive malignancies with poor disease specific survival despite aggressive multimodality management...

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..Routine use of drains after pancreaticoduodenectomy may not be necessary and should be subjected to a randomized trial...

..The aim of the present study is to determine whether preoperative chemotherapy is associated with any difference in the number of LNs obtained from specimens of patients who underwent curative surgery for gastric adenocarcinoma...

..In patients who require total pancreatectomy for ductal adenocarcinoma, the survival is so poor as to bring into question the value of the operation...

..The current study was performed to determine if liver resection for colorectal metastases is safe and effective and to evaluate predictors of outcome...

..The majority of survival studies in patients with extremity soft tissue sarcoma have focused on early recurrence and mortality. There are few data addressing long-term follow-up and survival...

..After publication of the MAGIC trial results, preoperative chemotherapy is increasingly used to treat advanced gastric cancer before resection. Tools for measuring response must be assessed...

..Our goal was to investigate the spectrum of pathologic response and molecular alterations in a group of GIST patients, clinically defined as having imatinib-stable/imatinib-responsive lesions, who underwent surgical resection...

..Treatment with IF should be considered in patients with high-risk primary extremity liposarcoma...

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..This study is a retrospective analysis of the long-term outcomes of patients who had operations for sarcomas of the spine using modern surgical approaches, intralesional resections, and spinal instrumentation...

..CONCLUSIONS: Aggressive therapy and follow-up beginning with wide excision can be associated with long-term survival in adults with primary perineal sarcoma...

..The survival of these patients depends on complete surgical resection and is independent of individual histologic characteristics of the tumor...

..However, the risk of recurrence for pancreatoblastoma is high. The roles of chemotherapy and radiation remain undefined...

..CONCLUSIONS: Surgical resection remains the only potentially curative therapy for adenocarcinoma of the pancreas. There is no clear indication as to a single preferable resection approach...

..We tested the utility of a nomogram created for determining disease-specific survival (DSS) after R0 resection of gastric cancer in estimating DSS for patients with resected duodenal cancer...

..DSS nomograms aid in more accurate counseling of patients, identification of patients appropriate for adjuvant therapy, and stratification of patients for clinical trials and molecular analysis...

..Prior studies have shown a high rate of local recurrence and a dismal overall prognosis in malignant peripheral nerve sheath tumors (MPNSTs)...

..The purpose of this study was to determine if adjuvant RT improves local control in patients with high-grade STS who had positive margins of resection...

..p. FUdR/LV can be safely delivered to patients undergoing radical gastrectomy and D2 lymphadenectomy. The R0 resection and the survival rates are encouraging. An association between pathologic response and patient outcome was suggested...

..It is postulated that RB alterations are primary events in human sarcomas and may be involved in tumorigenesis or early phases of tumour progression in these neoplasias...

..To characterise recurrence patterns and survival following pathologic complete response (pCR) in patients who received preoperative therapy for localised gastric or gastrooesophageal junction (GEJ) adenocarcinoma...

..Based on these results, closed suction drainage should not be considered mandatory or standard after pancreatic resection...

..The biology of these tumors is similar to other extremity STS, and similar principles of management apply. Even with neurovascular involvement, most patients with primary groin STS do not require amputation...

..The pattern of distant spread follows the known patterns of hematogenous dissemination. Complete surgical resection is the cornerstone of treatment for primary GIST and LMS and in selected patients with local and distant recurrence...

..Amputation improves local disease control but not survival under these circumstances...

..We attempted to define the effect of tumor histotype on local recurrence, distant metastasis, and disease-specific survival in patients with surgically treated primary extremity sarcoma...

..44%). pN2 or pN3 were mainly limited to SS tumors and these patients had poor survival (26% and 0%). CONCLUSION: For pT2 gastric adenocarcinoma, the depth of mural invasion was not an independently significant prognostic factor...

..Patients considered for treatment protocols for locally unresectable pancreatic cancer should be staged laparoscopically before initiation of therapy...

..DSS in patients with primary RAS is significantly worse compared with sporadic STS independent of sarcoma histologic type...

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..Surgical resection remains the primary therapy, but 5-year survival remains approximately 40%...

..An alternative system based on mitotic rate and necrosis correlates strongly with survival without specifically designating any group as benign...

..The international gastric cancer community can help define the important issues that need to be answered in the coming decades...

..The patterns of failure and mechanisms of sarcoma-specific death are poorly characterized among the minority of patients with low-grade soft tissue sarcoma (STS) who succumb to disease...

..Intervention-related mortality was minimal. The burden of metastatic disease and functional performance status were important prognostic factors...

..Hepatectomy should be considered when complete gross resection is possible, especially when the time to the development of liver metastasis exceeds 2 years...

..Conclusion: We recommend induction chemotherapy (P6) followed by aggressive surgical debulking and external beam radiotherapy for the treatment of DSRCT. Further progress will require new forms of treatment...

..These data suggest that preoperative biliary drainage should be avoided in candidates for pancreaticoduodenectomy...

..Unlike differentiated thyroid cancer, nodal metastases predict a worse outcome in widely invasive Hürthle cell carcinoma, as does extrathyroidal extension...

..To evaluate the neoadjuvant use of a herpes simplex viral (HSV) amplicon vector expressing the murine interleukin-12 (IL-12) gene...

..Extended distal pancreatectomy is justified in this group of patients...

..The ability of the nomogram to evaluate the effects of preop CRT on survival is limited by the potential effects of preop CRT on factors within the nomogram...

..This tool should be useful for patient counseling, follow-up scheduling, and clinical trial eligibility determination...

..Treatment of metastatic GIST with imatinib mesylate results in a 2-year survival of approximately 72%. The outcome of patients with metastatic GIST not treated with tyrosine kinase inhibitors is not well defined...

..To compare disease-specific survival (DSS) between the US and Korea following R0 resection for gastric carcinoma (GC)...

..Additional organ resection can be performed with minimal morbidity and can improve the chance of overall survival in patients with advanced T-stage disease...

..To identify the prognostic variables that predict disease-specific survival and second local recurrence-free survival in patients with recurrent retroperitoneal liposarcoma so as to guide clinical management...

..23% negative; P=0.006). In this study, patients who underwent resection in the presence of positive peritoneal cytology and absence of other identifiable metastatic disease had a similar survival as other patients with stage IV disease...

..Factors associated with the likelihood of subradiographic unresectable disease have not been clearly defined...

..Intraoperative FS added very little to surgical management. The majority of thyroid operations at this institution are planned and performed based on known prognostic factors and intraoperative findings...

..Despite metastatic disease, prolonged survival is often achieved with or without open surgical treatment. Laparoscopy can be used in diagnosis and accurately identifies metastases not seen on CT, thus sparing laparotomy in some patients...

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..Data that document academic status after surgical oncology fellowship are sparse. This study was done to report the academic status and clinical practice of graduates of a major surgical oncology program...

..Many patients treated for breast cancer with radiotherapy will survive their disease and be at risk for treatment-related sarcoma for many years...

..The purpose of this study was to evaluate the toxicity associated with adjuvant BRT in terms of wound complications, bone fracture, and peripheral nerve damage...

..Time to first recurrence and optimal surgical resection were predictors of improved outcome in this study...

..The authors sought to determine whether differences existed in patterns of outcome and morbidity between the 3 thigh compartments after limb-sparing surgery and postoperative radiation therapy (RT)...

..Patients who are determined to have high-risk disease postoperatively should be offered adjuvant therapy that will address the site of recurrence most likely to affect survival...

..To the authors' knowledge, few studies to date have examined the effect of chemotherapy in patients undergoing pulmonary resection for metastatic STS of the extremity...

..Future research is needed to better identify patients for metastasectomy, to determine the role of minimally invasive procedures, and to develop better adjuvant therapy...

..Conversion to PD should be considered when intraoperative or final pathology identifies invasive adenocarcinoma. Refinement of clinicopathologic factors may reduce the occasional PD for benign disease and AMP for malignancy...

..The aim of this study was to determine whether adequate staging revealed different prognostic factors or improved survival compared with patients with <15 nodes examined after R0 resection for GEJ cancer...

..The purpose of this study was to compare preoperative EUS staging with postoperative pathologic staging and to assess the ability of EUS to predict survival after resection for GEJ adenocarcinoma...

..Given the potential for increased morbidity and mortality from multiple organ resection we asked the question as to whether extended (multiple organ) resection was justified for advanced gastric cancer...

..We believe that laparoscopy should be used in a selective manner for preoperative staging of patients suspected of having nonpancreatic periampullary tumors...

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..CONCLUSIONS: We demonstrated that aggressive surgical strategies, including reoperative wide resection, significantly decrease local recurrence and may improve disease free-survival in select patients with spermatic cord sarcoma...

..Novel multimodality approaches are required...

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..This study analyzes factors associated with differences in long-term outcomes after hepatic resection for metastatic colorectal cancer over time...

..To examine the importance of adequate lymph node sampling in staging of extrahepatic bile duct cancer (EHBDCA)...

..Emerging areas in predicting outcome of patients with soft tissue sarcoma include response to neoadjuvant chemotherapy and molecular markers...

..We also analyzed P53 status, because this parameter has been found to have a significant prognostic impact in other sarcomas with chromosomal translocations...