Genomes and Genes
Affiliation: Memorial Sloan-Kettering Cancer Center
- Feedback circuit among INK4 tumor suppressors constrains human glioblastoma developmentRuprecht Wiedemeyer
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 13:355-64. 2008....
- Genomic profiles of gliomaCameron Brennan
Human Oncology and Pathogenesis Program, Department of Neurosurgery and The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Curr Neurol Neurosci Rep 11:291-7. 2011..The analysis of this data is still in the early stage. Nonetheless, several preliminary findings merit consideration in the development and interpretation of current clinical trials...
- Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterationsCameron Brennan
Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
PLoS ONE 4:e7752. 2009..From a practical and therapeutic standpoint, classifying GBMs by signal transduction pathway activation and by mutation in pathway member genes may be particularly valuable for the development of targeted therapies...
- Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progressionElena I Fomchenko
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
PLoS ONE 6:e20605. 2011..Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. Yet, gliomas are cellularly heterogeneous; they recruit and trap normal cells during infiltration...
- Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxiaChristoph P Hofstetter
Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
PLoS ONE 7:e30059. 2012..Recent evidence suggests that hypoxia induces protein phosphatase 2A (PP2A), a regulator of cell cycle and cell death. The effects of PP2A on GBM tumor cell proliferation and survival during hypoxic conditions have not been studied...
- Emerging insights into the molecular and cellular basis of glioblastomaGavin P Dunn
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Genes Dev 26:756-84. 2012..These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions...
- Magnetic resonance spectroscopy imaging in radiotherapy planning for recurrent gliomaAse M Ballangrud
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Med Phys 38:2724-30. 2011..The purpose of this study was to investigate how incorporation of magnetic resonance spectroscopy imaging (MRSI) into radiotherapy planning would increase the target volume for patients with recurrent glioma...
- Glioblastoma stem-like cells give rise to tumour endotheliumRong Wang
Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Nature 468:829-33. 2010....
- Advanced imaging in brain tumor surgeryRobert J Young
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Neuroimaging Clin N Am 20:311-35. 2010....
- The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradationIgor Vivanco
Memorial Sloan Kettering Cancer Center, New York, NY 10021
Proc Natl Acad Sci U S A 107:6459-64. 2010..Our study identifies a critical role for PTEN in EGFR signal termination and suggests that more potent EGFR inhibition should overcome resistance caused by PI3K pathway activation...
- The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoJason T Huse
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Genes Dev 23:1327-37. 2009..Our results document a new epigenetic mechanism for PTEN regulation in glioma and further highlight dysregulation of Akt signaling as crucial to the development of these tumors...
- The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancersSelvaraju Veeriah
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Proc Natl Acad Sci U S A 106:9435-40. 2009..PTPRD was found to dephosphorylate the oncoprotein STAT3. These results implicate PTPRD as a tumor suppressor on chromosome 9p that is involved in the development of GBMs and multiple human cancers...
- Presurgical evaluation of language using functional magnetic resonance imaging in brain tumor patients with previous surgeryKyung K Peck
Department of Radiology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Neurosurgery 64:644-52; discussion 652-3. 2009....
- MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinibJames Bean
Human Oncology and Pathogenesis Program, Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:20932-7. 2007..Taken together, these data suggest that MET amplification occurs independently of EGFR(T790M) mutations and that MET may be a clinically relevant therapeutic target for some patients with acquired resistance to gefitinib or erlotinib...
- Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastasesAshwatha Narayana
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA
Stereotact Funct Neurosurg 85:82-7. 2007....