Cameron Brennan

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. doi request reprint The somatic genomic landscape of glioblastoma
    Cameron W Brennan
    Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, Department of Neurological Surgery, Weill Cornell Medical Center, New York, NY 10065, USA Electronic address
    Cell 155:462-77. 2013
  2. pmc Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development
    Ruprecht Wiedemeyer
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 13:355-64. 2008
  3. doi request reprint Genomic profiles of glioma
    Cameron Brennan
    Human Oncology and Pathogenesis Program, Department of Neurosurgery and The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Curr Neurol Neurosci Rep 11:291-7. 2011
  4. pmc Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    Cameron Brennan
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    PLoS ONE 4:e7752. 2009
  5. pmc Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression
    Elena I Fomchenko
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e20605. 2011
  6. pmc Emerging insights into the molecular and cellular basis of glioblastoma
    Gavin P Dunn
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Genes Dev 26:756-84. 2012
  7. doi request reprint A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastases
    Cameron Brennan
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York
    Int J Radiat Oncol Biol Phys 88:130-6. 2014
  8. pmc Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia
    Christoph P Hofstetter
    Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
    PLoS ONE 7:e30059. 2012
  9. ncbi request reprint Magnetic resonance spectroscopy imaging in radiotherapy planning for recurrent glioma
    Ase M Ballangrud
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Phys 38:2724-30. 2011
  10. pmc Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine
    Sevin Turcan
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Oncotarget 4:1729-36. 2013

Collaborators

Detail Information

Publications19

  1. doi request reprint The somatic genomic landscape of glioblastoma
    Cameron W Brennan
    Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, Department of Neurological Surgery, Weill Cornell Medical Center, New York, NY 10065, USA Electronic address
    Cell 155:462-77. 2013
    ....
  2. pmc Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development
    Ruprecht Wiedemeyer
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 13:355-64. 2008
    ....
  3. doi request reprint Genomic profiles of glioma
    Cameron Brennan
    Human Oncology and Pathogenesis Program, Department of Neurosurgery and The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Curr Neurol Neurosci Rep 11:291-7. 2011
    ..The analysis of this data is still in the early stage. Nonetheless, several preliminary findings merit consideration in the development and interpretation of current clinical trials...
  4. pmc Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    Cameron Brennan
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    PLoS ONE 4:e7752. 2009
    ..From a practical and therapeutic standpoint, classifying GBMs by signal transduction pathway activation and by mutation in pathway member genes may be particularly valuable for the development of targeted therapies...
  5. pmc Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression
    Elena I Fomchenko
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e20605. 2011
    ..Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. Yet, gliomas are cellularly heterogeneous; they recruit and trap normal cells during infiltration...
  6. pmc Emerging insights into the molecular and cellular basis of glioblastoma
    Gavin P Dunn
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Genes Dev 26:756-84. 2012
    ..These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions...
  7. doi request reprint A phase 2 trial of stereotactic radiosurgery boost after surgical resection for brain metastases
    Cameron Brennan
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York
    Int J Radiat Oncol Biol Phys 88:130-6. 2014
    ..To evaluate local control after surgical resection and postoperative stereotactic radiosurgery (SRS) for brain metastases...
  8. pmc Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia
    Christoph P Hofstetter
    Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
    PLoS ONE 7:e30059. 2012
    ..Recent evidence suggests that hypoxia induces protein phosphatase 2A (PP2A), a regulator of cell cycle and cell death. The effects of PP2A on GBM tumor cell proliferation and survival during hypoxic conditions have not been studied...
  9. ncbi request reprint Magnetic resonance spectroscopy imaging in radiotherapy planning for recurrent glioma
    Ase M Ballangrud
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Phys 38:2724-30. 2011
    ..The purpose of this study was to investigate how incorporation of magnetic resonance spectroscopy imaging (MRSI) into radiotherapy planning would increase the target volume for patients with recurrent glioma...
  10. pmc Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine
    Sevin Turcan
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Oncotarget 4:1729-36. 2013
    ..These findings have substantial impact for exploring new treatment strategies for patients with IDH mutant gliomas. ..
  11. ncbi request reprint A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma
    Fenghua Liu
    Department of Neurological Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Res 66:10815-23. 2006
    ..This novel genome-wide approach greatly expanded the list of target genes in glioblastoma and represents a powerful new strategy to identify the upstream determinants of tumor phenotype in a range of human cancers...
  12. doi request reprint Glioblastoma stem-like cells give rise to tumour endothelium
    Rong Wang
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 468:829-33. 2010
    ....
  13. pmc The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
    Igor Vivanco
    Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 107:6459-64. 2010
    ..Our study identifies a critical role for PTEN in EGFR signal termination and suggests that more potent EGFR inhibition should overcome resistance caused by PI3K pathway activation...
  14. pmc The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
    Jason T Huse
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 23:1327-37. 2009
    ..Our results document a new epigenetic mechanism for PTEN regulation in glioma and further highlight dysregulation of Akt signaling as crucial to the development of these tumors...
  15. doi request reprint Advanced imaging in brain tumor surgery
    Robert J Young
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Neuroimaging Clin N Am 20:311-35. 2010
    ....
  16. pmc The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers
    Selvaraju Veeriah
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:9435-40. 2009
    ..PTPRD was found to dephosphorylate the oncoprotein STAT3. These results implicate PTPRD as a tumor suppressor on chromosome 9p that is involved in the development of GBMs and multiple human cancers...
  17. doi request reprint Presurgical evaluation of language using functional magnetic resonance imaging in brain tumor patients with previous surgery
    Kyung K Peck
    Department of Radiology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Neurosurgery 64:644-52; discussion 652-3. 2009
    ....
  18. pmc MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    James Bean
    Human Oncology and Pathogenesis Program, Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:20932-7. 2007
    ..Taken together, these data suggest that MET amplification occurs independently of EGFR(T790M) mutations and that MET may be a clinically relevant therapeutic target for some patients with acquired resistance to gefitinib or erlotinib...
  19. ncbi request reprint Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastases
    Ashwatha Narayana
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA
    Stereotact Funct Neurosurg 85:82-7. 2007
    ....