Cameron Brennan

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development
    Ruprecht Wiedemeyer
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 13:355-64. 2008
  2. ncbi Genomic profiles of glioma
    Cameron Brennan
    Human Oncology and Pathogenesis Program, Department of Neurosurgery and The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Curr Neurol Neurosci Rep 11:291-7. 2011
  3. ncbi Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    Cameron Brennan
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    PLoS ONE 4:e7752. 2009
  4. ncbi Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression
    Elena I Fomchenko
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e20605. 2011
  5. ncbi Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia
    Christoph P Hofstetter
    Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
    PLoS ONE 7:e30059. 2012
  6. ncbi Emerging insights into the molecular and cellular basis of glioblastoma
    Gavin P Dunn
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Genes Dev 26:756-84. 2012
  7. ncbi Magnetic resonance spectroscopy imaging in radiotherapy planning for recurrent glioma
    Ase M Ballangrud
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Phys 38:2724-30. 2011
  8. ncbi Glioblastoma stem-like cells give rise to tumour endothelium
    Rong Wang
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 468:829-33. 2010
  9. ncbi Advanced imaging in brain tumor surgery
    Robert J Young
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Neuroimaging Clin N Am 20:311-35. 2010
  10. ncbi The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
    Igor Vivanco
    Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 107:6459-64. 2010

Collaborators

Detail Information

Publications15

  1. ncbi Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development
    Ruprecht Wiedemeyer
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 13:355-64. 2008
    ....
  2. ncbi Genomic profiles of glioma
    Cameron Brennan
    Human Oncology and Pathogenesis Program, Department of Neurosurgery and The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Curr Neurol Neurosci Rep 11:291-7. 2011
    ..The analysis of this data is still in the early stage. Nonetheless, several preliminary findings merit consideration in the development and interpretation of current clinical trials...
  3. ncbi Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    Cameron Brennan
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    PLoS ONE 4:e7752. 2009
    ..From a practical and therapeutic standpoint, classifying GBMs by signal transduction pathway activation and by mutation in pathway member genes may be particularly valuable for the development of targeted therapies...
  4. ncbi Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression
    Elena I Fomchenko
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e20605. 2011
    ..Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. Yet, gliomas are cellularly heterogeneous; they recruit and trap normal cells during infiltration...
  5. ncbi Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia
    Christoph P Hofstetter
    Department of Neurological Surgery, Weill Cornell Brain Tumor Center, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York, United States of America
    PLoS ONE 7:e30059. 2012
    ..Recent evidence suggests that hypoxia induces protein phosphatase 2A (PP2A), a regulator of cell cycle and cell death. The effects of PP2A on GBM tumor cell proliferation and survival during hypoxic conditions have not been studied...
  6. ncbi Emerging insights into the molecular and cellular basis of glioblastoma
    Gavin P Dunn
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Genes Dev 26:756-84. 2012
    ..These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions...
  7. ncbi Magnetic resonance spectroscopy imaging in radiotherapy planning for recurrent glioma
    Ase M Ballangrud
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Phys 38:2724-30. 2011
    ..The purpose of this study was to investigate how incorporation of magnetic resonance spectroscopy imaging (MRSI) into radiotherapy planning would increase the target volume for patients with recurrent glioma...
  8. ncbi Glioblastoma stem-like cells give rise to tumour endothelium
    Rong Wang
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 468:829-33. 2010
    ....
  9. ncbi Advanced imaging in brain tumor surgery
    Robert J Young
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Neuroimaging Clin N Am 20:311-35. 2010
    ....
  10. ncbi The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation
    Igor Vivanco
    Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 107:6459-64. 2010
    ..Our study identifies a critical role for PTEN in EGFR signal termination and suggests that more potent EGFR inhibition should overcome resistance caused by PI3K pathway activation...
  11. ncbi The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
    Jason T Huse
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 23:1327-37. 2009
    ..Our results document a new epigenetic mechanism for PTEN regulation in glioma and further highlight dysregulation of Akt signaling as crucial to the development of these tumors...
  12. ncbi The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers
    Selvaraju Veeriah
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:9435-40. 2009
    ..PTPRD was found to dephosphorylate the oncoprotein STAT3. These results implicate PTPRD as a tumor suppressor on chromosome 9p that is involved in the development of GBMs and multiple human cancers...
  13. ncbi Presurgical evaluation of language using functional magnetic resonance imaging in brain tumor patients with previous surgery
    Kyung K Peck
    Department of Radiology and Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Neurosurgery 64:644-52; discussion 652-3. 2009
    ....
  14. ncbi MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    James Bean
    Human Oncology and Pathogenesis Program, Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:20932-7. 2007
    ..Taken together, these data suggest that MET amplification occurs independently of EGFR(T790M) mutations and that MET may be a clinically relevant therapeutic target for some patients with acquired resistance to gefitinib or erlotinib...
  15. ncbi Hypofractionated stereotactic radiotherapy using intensity-modulated radiotherapy in patients with one or two brain metastases
    Ashwatha Narayana
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA
    Stereotact Funct Neurosurg 85:82-7. 2007
    ....