C P Blobel

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding
    C P Blobel
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Inflamm Res 51:83-4. 2002
  2. pmc Potential role for ADAM15 in pathological neovascularization in mice
    Keisuke Horiuchi
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 23:5614-24. 2003
  3. pmc Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
    Umut Sahin
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA
    J Cell Biol 164:769-79. 2004
  4. ncbi Remarkable roles of proteolysis on and beyond the cell surface
    C P Blobel
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, New York 10021, USA
    Curr Opin Cell Biol 12:606-12. 2000
  5. ncbi Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1
    L Howard
    Cellular Biochemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 274:31693-9. 1999
  6. pmc Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta
    K K Nelson
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Biochem J 343:673-80. 1999
  7. ncbi Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival
    L Lum
    Tri Institutional Cornell Rockefeller University Memorial Sloan Kettering Cancer Center, Training Program, New York, New York 10021, USA
    J Biol Chem 274:13613-8. 1999
  8. pmc Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28
    L Howard
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Avenue, New York, NY 10021, USA
    Biochem J 348:21-7. 2000
  9. ncbi Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity
    M Roghani
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 274:3531-40. 1999
  10. ncbi Evidence for distinct serine protease activities with a potential role in processing the sperm protein fertilin
    L Lum
    Program in Cellular Biochemistry and Biophysics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Biol 191:131-45. 1997

Collaborators

  • G Murphy
  • Shigeki Higashiyama
  • H Cai
  • M L Moss
  • R Josien
  • V E Reuter
  • W Zhou
  • D Alfandari
  • Paul Saftig
  • Peter J Gough
  • Daniel D Carson
  • Roy A Black
  • Andreas Ludwig
  • Keisuke Horiuchi
  • Gisela Weskamp
  • J David Becherer
  • Dieter Hartmann
  • Umut Sahin
  • Katia Manova
  • L Lum
  • Kristine Kelly
  • J Schlondorff
  • Hong Ming Zhou
  • Steven Swendeman
  • Atsuko Sehara-Fujisawa
  • T Maretzky
  • Valerie Chesneau
  • Thomas A Brodie
  • L Howard
  • Yufang Zheng
  • Beate Schulz
  • Asheesh Harsha
  • Karina Reiss
  • Yoshiaki Toyama
  • Nianyu Li
  • Emilia Dyczynska
  • L Peduto
  • Beate B Böhm
  • Peter J Dempsey
  • Peter W Janes
  • Lucie Peduto
  • G Weskamp
  • Andrew J P Docherty
  • Roland Baron
  • Riccardo Chiusaroli
  • Lawrence Lum
  • K K Nelson
  • Amantha Thathiah
  • Aldo Borroto
  • Johannes Schlondorff
  • Kyle J Garton
  • Thomas Ludwig
  • Augustin Amour
  • X Y Huang
  • R A Maciewicz
  • Ulla Wewer
  • Karen Mendelson
  • Shahin Rafii
  • H Erdjument-Bromage
  • Peggy Scherle
  • J Krätzschmar
  • J D Becherer
  • Harold Brem
  • P Tempst
  • Marjana Tomic-Canic
  • Thorsten Maretzky
  • Cynthia A Loomis
  • Andrea Hooper
  • Jessica Pruessmeyer
  • M Roghani
  • Olivera Stojadinovic
  • Urban Deutsch
  • Naoto Kosaki
  • Mitsuru Furukawa
  • Anna Zolkiewska
  • John J Rossi
  • Bret S Heale
  • Yoshiteru Miyauchi
  • Karen Forbes
  • Marc Schulte
  • Hironari Takaishi
  • Yao Wang
  • Creg J Workman
  • Akihiro Hakozaki
  • Takafumi Yamaguchi
  • Hironori Kaneko
  • Kenichiro Matsuzaki
  • Danqiong Sun
  • Sylvain Le Gall
  • Kate M Vignali

Detail Information

Publications45

  1. ncbi Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding
    C P Blobel
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Inflamm Res 51:83-4. 2002
    ..The main focus of my lab is to understand the role of different ADAMs in protein ectodomain shedding, and to learn about the functional consequences of protein ectodomain shedding for individual substrates...
  2. pmc Potential role for ADAM15 in pathological neovascularization in mice
    Keisuke Horiuchi
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 23:5614-24. 2003
    ..Since ADAM15 does not appear to be required for developmental angiogenesis or for adult homeostasis, it may represent a novel target for the design of inhibitors of pathological neovascularization...
  3. pmc Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
    Umut Sahin
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA
    J Cell Biol 164:769-79. 2004
    ..Identification of EGFR ligand sheddases is a crucial step toward understanding the mechanism underlying ectodomain release, and has implications for designing novel inhibitors of EGFR-dependent tumors...
  4. ncbi Remarkable roles of proteolysis on and beyond the cell surface
    C P Blobel
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, New York 10021, USA
    Curr Opin Cell Biol 12:606-12. 2000
    ..Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis...
  5. ncbi Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1
    L Howard
    Cellular Biochemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 274:31693-9. 1999
    ....
  6. pmc Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta
    K K Nelson
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Biochem J 343:673-80. 1999
    ....
  7. ncbi Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival
    L Lum
    Tri Institutional Cornell Rockefeller University Memorial Sloan Kettering Cancer Center, Training Program, New York, New York 10021, USA
    J Biol Chem 274:13613-8. 1999
    ..We propose that the TRANCE ectodomain is released from cells by TACE or a related metalloprotease-disintegrin, and that this release is an important component of the function of TRANCE in bone and immune homeostasis...
  8. pmc Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28
    L Howard
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Avenue, New York, NY 10021, USA
    Biochem J 348:21-7. 2000
    ..This is in contrast with several other ADAMs, for which furin-like proprotein convertases are involved in pro-domain removal, and in which a glutamate-to-alanine mutation in the catalytic site does not alter pro-domain removal...
  9. ncbi Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity
    M Roghani
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 274:3531-40. 1999
    ....
  10. ncbi Evidence for distinct serine protease activities with a potential role in processing the sperm protein fertilin
    L Lum
    Program in Cellular Biochemistry and Biophysics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Biol 191:131-45. 1997
    ....
  11. pmc MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains
    G Weskamp
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Cell Biol 132:717-26. 1996
    ..We propose that MDC9 might function as a membrane-anchored integrin ligand or metalloprotease, or that MDC9 may combine both activities in one protein...
  12. ncbi Intracellular maturation of the mouse metalloprotease disintegrin MDC15
    L Lum
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 273:26236-47. 1998
    ..These results further suggest possible intracellular functions for mMDC15, such as in protein maturation, in addition to a potential role in cell-surface proteolysis or cell adhesion...
  13. ncbi Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase
    J Schlondorff
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 276:14665-74. 2001
    ..This study provides insights into the properties of different activities involved in protein ectodomain shedding and has implications for the functional regulation of TRANCE by potentially more than one protease...
  14. ncbi Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence
    J Krätzschmar
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 271:4593-6. 1996
    ..These features are consistent with a model in which metargidin is an integrin ligand which, as a transmembrane protein, might function in cell-cell adhesion and/or signaling...
  15. ncbi Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding
    J Schlondorff
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, Box 368, Tri Institutional Cornell Rockefeller University Sloan Kettering Institute MD PhD Program, New York, NY 10021, USA
    J Cell Sci 112:3603-17. 1999
    ....
  16. pmc A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17
    T Maretzky
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, USA
    Oncogene 30:611-8. 2011
    ....
  17. ncbi Neural crest-specific and general expression of distinct metalloprotease-disintegrins in early Xenopus laevis development
    H Cai
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, 10021, USA
    Dev Biol 204:508-24. 1998
    ..The noteworthy features of these four xmdc genes and the implications of their distinct spatial and temporal expression patterns are discussed...
  18. pmc A family of cellular proteins related to snake venom disintegrins
    G Weskamp
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 91:2748-51. 1994
    ..Evidently, cellular proteins containing a disintegrin domain define a superfamily of potential integrin ligands that are likely to function in important cell-cell and cell-matrix interactions...
  19. ncbi Functional processing of fertilin: evidence for a critical role of proteolysis in sperm maturation and activation
    C P Blobel
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Rev Reprod 5:75-83. 2000
    ..The identification of the responsible proteases could provide novel targets for contraceptive drugs...
  20. ncbi ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression
    L Peduto
    Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Oncogene 25:5462-6. 2006
    ....
  21. ncbi The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs
    Augustin Amour
    School of Biological Sciences, University of East Anglia, Norwich, UK
    FEBS Lett 524:154-8. 2002
    ....
  22. ncbi Catalytic properties of ADAM19
    Valerie Chesneau
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 278:22331-40. 2003
    ..The identification of potential in vitro substrates offers the basis for further functional studies of ADAM19 in cells and in mice...
  23. pmc Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life
    Gisela Weskamp
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 22:1537-44. 2002
    ....
  24. ncbi ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23
    Gisela Weskamp
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery and Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Immunol 7:1293-8. 2006
    ..Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies...
  25. pmc Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx
    Keisuke Horiuchi
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    Mol Biol Cell 18:176-88. 2007
    ....
  26. pmc Proteolytic processing of delta-like 1 by ADAM proteases
    Emilia Dyczynska
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 282:436-44. 2007
    ..Our findings expand the role of ADAM proteins in the regulation of Notch signaling...
  27. ncbi Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17
    Umut Sahin
    Arthritis and Tissue Degeneration Program, Caspary Research Building, Room 426, Hospital for Special Surgery, New York, NY 10021, USA
    FEBS Lett 581:41-4. 2007
    ..These results suggest that ADAM17 might be a good target to block the release of bioactive epigen, a highly mitogenic ligand of the EGFR which has been implicated in wound healing and cancer...
  28. ncbi Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding
    Amantha Thathiah
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    J Biol Chem 278:3386-94. 2003
    ..These studies establish a proteolytic mechanism for MUC1 clearance from a human uterine epithelial cell line and identify TACE as a MUC1 sheddase...
  29. ncbi Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner
    Keisuke Horiuchi
    Department of Anti aging Orthopedic Research, Keio University, School of Medicine, Tokyo, Japan
    J Immunol 179:6715-24. 2007
    ..These results indicate that the local availability of mCSF-1 is actively regulated by ectodomain shedding and endocytosis. This mechanism may have important implications for the development and survival of monocyte lineage cells...
  30. pmc ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin
    Beate Schulz
    Biochemical Institute, Christian Albrecht University Kiel, Olshausenstr 40, D 24098 Kiel, Germany
    Circ Res 102:1192-201. 2008
    ....
  31. pmc ADAM12: a potential target for the treatment of chronic wounds
    Asheesh Harsha
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, USA
    J Mol Med (Berl) 86:961-9. 2008
    ....
  32. pmc VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling
    Steven Swendeman
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Circ Res 103:916-8. 2008
    ..Targeting the sheddases of VEGFR2 or NRP-1 might offer new opportunities to modulate VEGF-A signaling, an already-established target for treatment of pathological neovascularization...
  33. ncbi Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
    Peter W Janes
    Department of Biochemistry and Molecular Biology, PO Box 13D, Monash University, Victoria 3800, Australia
    Cell 123:291-304. 2005
    ..Our data suggest a simple mechanism for regulating ADAM10-mediated ephrin proteolysis, which ensures that only Eph bound ephrins are recognized and cleaved...
  34. ncbi Critical function for ADAM9 in mouse prostate cancer
    Lucie Peduto
    Department of Pathology, Memorial Sloan Kettering Cancer Center, NY 10021, USA
    Cancer Res 65:9312-9. 2005
    ..Taken together, these results suggest that ADAM9 contributes to the pathogenesis of prostate cancer and potentially also other carcinomas, raising the possibility that ADAM9 might be a good target for antitumor drugs...
  35. ncbi Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs)
    J David Becherer
    Department of Biochemical and Analytical Pharmacology, GlaxoSmithKline Research Inc, Research Triangle Park, North Carolina 27709, USA
    Curr Top Dev Biol 54:101-23. 2003
  36. ncbi Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1
    Yufang Zheng
    Graduate Program in Physiology, Biophysics and Molecular Medicine, Weill Graduate School of Medical Science of Cornell University, New York, New York 10021, USA
    J Biol Chem 277:42463-70. 2002
    ..Taken together, these results suggest that PTPH1 may be a negative regulator of TACE levels and function, and thus provide the first evidence for the regulation of TACE through a cytoplasmic protein...
  37. ncbi Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17)
    Kyle J Garton
    Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104 2499, USA
    J Biol Chem 278:37459-64. 2003
    ..Therefore, TACE-mediated shedding of VCAM-1 may be important for the regulation of VCAM-1 function at the cell surface...
  38. ncbi Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR)
    Gisela Weskamp
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 279:4241-9. 2004
    ..Because ectodomain shedding of p75NTR releases a soluble ectodomain and could also be a prerequisite for its regulated intramembrane proteolysis, these findings may have important implications for the functional regulation of p75NTR...
  39. pmc Essential role for ADAM19 in cardiovascular morphogenesis
    Hong Ming Zhou
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 24:96-104. 2004
    ..Most adam19(-/-) animals die perinatally, likely as a result of their cardiac defects. These findings raise the possibility that mutations in ADAM19 may contribute to human congenital heart valve and septal defects...
  40. ncbi Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding
    Aldo Borroto
    Laboratori de Recerca Oncològica, Servei d Oncologia Medica, Hospital Universitari Vall d Hebron, Psg Vall d Hebron 119 129, Barcelona 08035, Spain
    J Biol Chem 278:25933-9. 2003
    ..In summary, the characterization of shedding-defective somatic cell mutants unveils the existence of a specific mechanism that directs the proteolytic activation of TACE through the control of its exit from the ER...
  41. ncbi Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice
    Kristine Kelly
    Cell Biology Program, Sloan Kettering Institute, New York, New York, USA
    Dev Dyn 232:221-31. 2005
    ..Examination of Adam8-/- mice, however, revealed no major defects in these or other structures during development or in adult tissues and no evident pathological phenotypes...
  42. ncbi ADAMs: key components in EGFR signalling and development
    Carl P Blobel
    Arthritis and Tissue Degeneration Program and Cell Biology Program, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, New York 10021, USA
    Nat Rev Mol Cell Biol 6:32-43. 2005
    ..Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins...
  43. ncbi Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling
    Beate B Böhm
    Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 52:1100-9. 2005
    ..In addition, a human chondrocyte cell line overexpressing ADAM15 was used to investigate the role of ADAM15 in an in vitro model of chondrocyte-matrix interactions...
  44. ncbi Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2
    Keisuke Horiuchi
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Dev Biol 283:459-71. 2005
    ..These results raise the possibility that ADAMs 9, 17, and 19 contribute to heart development in humans and have implications for understanding the mechanisms underlying congenital heart disease...
  45. pmc Metalloproteases regulate T-cell proliferation and effector function via LAG-3
    Nianyu Li
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 26:494-504. 2007
    ....