Research Topics
Genomes and Genes
| C P BlobelSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Detail Information
Publications
Potential role for ADAM15 in pathological neovascularization in miceKeisuke Horiuchi
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell Biol 23:5614-24. 2003..Since ADAM15 does not appear to be required for developmental angiogenesis or for adult homeostasis, it may represent a novel target for the design of inhibitors of pathological neovascularization...
Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain sheddingC P Blobel
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Inflamm Res 51:83-4. 2002..The main focus of my lab is to understand the role of different ADAMs in protein ectodomain shedding, and to learn about the functional consequences of protein ectodomain shedding for individual substrates...- Remarkable roles of proteolysis on and beyond the cell surfaceC P Blobel
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, New York 10021, USA
Curr Opin Cell Biol 12:606-12. 2000..Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis... - Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1L Howard
Cellular Biochemistry Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 274:31693-9. 1999.... - Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2betaK K Nelson
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Biochem J 343:673-80. 1999.... - Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28L Howard
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Avenue, New York, NY 10021, USA
Biochem J 348:21-7. 2000..This is in contrast with several other ADAMs, for which furin-like proprotein convertases are involved in pro-domain removal, and in which a glutamate-to-alanine mutation in the catalytic site does not alter pro-domain removal... - Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survivalL Lum
Tri Institutional Cornell Rockefeller University Memorial Sloan Kettering Cancer Center, Training Program, New York, New York 10021, USA
J Biol Chem 274:13613-8. 1999..We propose that the TRANCE ectodomain is released from cells by TACE or a related metalloprotease-disintegrin, and that this release is an important component of the function of TRANCE in bone and immune homeostasis... - Evidence for distinct serine protease activities with a potential role in processing the sperm protein fertilinL Lum
Program in Cellular Biochemistry and Biophysics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Dev Biol 191:131-45. 1997.... - MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domainsG Weskamp
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Cell Biol 132:717-26. 1996..We propose that MDC9 might function as a membrane-anchored integrin ligand or metalloprotease, or that MDC9 may combine both activities in one protein... - Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activityM Roghani
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 274:3531-40. 1999.... - Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertaseJ Schlondorff
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 276:14665-74. 2001..This study provides insights into the properties of different activities involved in protein ectodomain shedding and has implications for the functional regulation of TRANCE by potentially more than one protease... - Intracellular maturation of the mouse metalloprotease disintegrin MDC15L Lum
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 273:26236-47. 1998..These results further suggest possible intracellular functions for mMDC15, such as in protein maturation, in addition to a potential role in cell-surface proteolysis or cell adhesion... - Neural crest-specific and general expression of distinct metalloprotease-disintegrins in early Xenopus laevis developmentH Cai
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, 10021, USA
Dev Biol 204:508-24. 1998..The noteworthy features of these four xmdc genes and the implications of their distinct spatial and temporal expression patterns are discussed... - Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequenceJ Krätzschmar
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 271:4593-6. 1996..These features are consistent with a model in which metargidin is an integrin ligand which, as a transmembrane protein, might function in cell-cell adhesion and/or signaling... - Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain sheddingJ Schlondorff
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, Box 368, Tri Institutional Cornell Rockefeller University Sloan Kettering Institute MD PhD Program, New York, NY 10021, USA
J Cell Sci 112:3603-17. 1999.... - A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17T Maretzky
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, USA
Oncogene 30:611-8. 2011.... - Functional processing of fertilin: evidence for a critical role of proteolysis in sperm maturation and activationC P Blobel
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Rev Reprod 5:75-83. 2000..The identification of the responsible proteases could provide novel targets for contraceptive drugs... - ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progressionL Peduto
Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Oncogene 25:5462-6. 2006.... - A family of cellular proteins related to snake venom disintegrinsG Weskamp
Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021
Proc Natl Acad Sci U S A 91:2748-51. 1994..Evidently, cellular proteins containing a disintegrin domain define a superfamily of potential integrin ligands that are likely to function in important cell-cell and cell-matrix interactions... - The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPsAugustin Amour
School of Biological Sciences, University of East Anglia, Norwich, UK
FEBS Lett 524:154-8. 2002.... - Catalytic properties of ADAM19Valerie Chesneau
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 278:22331-40. 2003..The identification of potential in vitro substrates offers the basis for further functional studies of ADAM19 in cells and in mice... - ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherinBeate Schulz
Biochemical Institute, Christian Albrecht University Kiel, Olshausenstr 40, D 24098 Kiel, Germany
Circ Res 102:1192-201. 2008.... - Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in transPeter W Janes
Department of Biochemistry and Molecular Biology, PO Box 13D, Monash University, Victoria 3800, Australia
Cell 123:291-304. 2005..Our data suggest a simple mechanism for regulating ADAM10-mediated ephrin proteolysis, which ensures that only Eph bound ephrins are recognized and cleaved... - VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signalingSteven Swendeman
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
Circ Res 103:916-8. 2008..Targeting the sheddases of VEGFR2 or NRP-1 might offer new opportunities to modulate VEGF-A signaling, an already-established target for treatment of pathological neovascularization... - ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23Gisela Weskamp
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery and Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Nat Immunol 7:1293-8. 2006..Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies... - Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influxKeisuke Horiuchi
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
Mol Biol Cell 18:176-88. 2007.... - Proteolytic processing of delta-like 1 by ADAM proteasesEmilia Dyczynska
Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
J Biol Chem 282:436-44. 2007..Our findings expand the role of ADAM proteins in the regulation of Notch signaling... - Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17Umut Sahin
Arthritis and Tissue Degeneration Program, Caspary Research Building, Room 426, Hospital for Special Surgery, New York, NY 10021, USA
FEBS Lett 581:41-4. 2007..These results suggest that ADAM17 might be a good target to block the release of bioactive epigen, a highly mitogenic ligand of the EGFR which has been implicated in wound healing and cancer... - ADAM12: a potential target for the treatment of chronic woundsAsheesh Harsha
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, USA
J Mol Med (Berl) 86:961-9. 2008.... - Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain sheddingAldo Borroto
Laboratori de Recerca Oncològica, Servei d Oncologia Medica, Hospital Universitari Vall d Hebron, Psg Vall d Hebron 119 129, Barcelona 08035, Spain
J Biol Chem 278:25933-9. 2003..In summary, the characterization of shedding-defective somatic cell mutants unveils the existence of a specific mechanism that directs the proteolytic activation of TACE through the control of its exit from the ER... - Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent mannerKeisuke Horiuchi
Department of Anti aging Orthopedic Research, Keio University, School of Medicine, Tokyo, Japan
J Immunol 179:6715-24. 2007..These results indicate that the local availability of mCSF-1 is actively regulated by ectodomain shedding and endocytosis. This mechanism may have important implications for the development and survival of monocyte lineage cells... - Critical function for ADAM9 in mouse prostate cancerLucie Peduto
Department of Pathology, Memorial Sloan Kettering Cancer Center, NY 10021, USA
Cancer Res 65:9312-9. 2005..Taken together, these results suggest that ADAM9 contributes to the pathogenesis of prostate cancer and potentially also other carcinomas, raising the possibility that ADAM9 might be a good target for antitumor drugs... - Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2Keisuke Horiuchi
Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
Dev Biol 283:459-71. 2005..These results raise the possibility that ADAMs 9, 17, and 19 contribute to heart development in humans and have implications for understanding the mechanisms underlying congenital heart disease... - Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1Yufang Zheng
Graduate Program in Physiology, Biophysics and Molecular Medicine, Weill Graduate School of Medical Science of Cornell University, New York, New York 10021, USA
J Biol Chem 277:42463-70. 2002..Taken together, these results suggest that PTPH1 may be a negative regulator of TACE levels and function, and thus provide the first evidence for the regulation of TACE through a cytoplasmic protein... - Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 sheddingAmantha Thathiah
Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
J Biol Chem 278:3386-94. 2003..These studies establish a proteolytic mechanism for MUC1 clearance from a human uterine epithelial cell line and identify TACE as a MUC1 sheddase... - Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs)J David Becherer
Department of Biochemical and Analytical Pharmacology, GlaxoSmithKline Research Inc, Research Triangle Park, North Carolina 27709, USA
Curr Top Dev Biol 54:101-23. 2003 - Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult lifeGisela Weskamp
Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell Biol 22:1537-44. 2002.... - Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17)Kyle J Garton
Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104 2499, USA
J Biol Chem 278:37459-64. 2003..Therefore, TACE-mediated shedding of VCAM-1 may be important for the regulation of VCAM-1 function at the cell surface... - Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR)Gisela Weskamp
Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Biol Chem 279:4241-9. 2004..Because ectodomain shedding of p75NTR releases a soluble ectodomain and could also be a prerequisite for its regulated intramembrane proteolysis, these findings may have important implications for the functional regulation of p75NTR... - Essential role for ADAM19 in cardiovascular morphogenesisHong Ming Zhou
Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell Biol 24:96-104. 2004..Most adam19(-/-) animals die perinatally, likely as a result of their cardiac defects. These findings raise the possibility that mutations in ADAM19 may contribute to human congenital heart valve and septal defects... - Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligandsUmut Sahin
Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA
J Cell Biol 164:769-79. 2004..Identification of EGFR ligand sheddases is a crucial step toward understanding the mechanism underlying ectodomain release, and has implications for designing novel inhibitors of EGFR-dependent tumors... - Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in miceKristine Kelly
Cell Biology Program, Sloan Kettering Institute, New York, New York, USA
Dev Dyn 232:221-31. 2005..Examination of Adam8-/- mice, however, revealed no major defects in these or other structures during development or in adult tissues and no evident pathological phenotypes... - ADAMs: key components in EGFR signalling and developmentCarl P Blobel
Arthritis and Tissue Degeneration Program and Cell Biology Program, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, New York 10021, USA
Nat Rev Mol Cell Biol 6:32-43. 2005..Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins... - Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodelingBeate B Böhm
Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
Arthritis Rheum 52:1100-9. 2005..In addition, a human chondrocyte cell line overexpressing ADAM15 was used to investigate the role of ADAM15 in an in vitro model of chondrocyte-matrix interactions... - Metalloproteases regulate T-cell proliferation and effector function via LAG-3Nianyu Li
Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
EMBO J 26:494-504. 2007....