R G Blasberg

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression
    Juri Gelovani Tjuvajev
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 43:1072-83. 2002
  2. ncbi request reprint Multimodality registration without a dedicated multimodality scanner
    Bradley J Beattie
    Momorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Imaging 6:108-20. 2007
  3. pmc Real-time imaging of HIF-1alpha stabilization and degradation
    Ekaterina Moroz
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS ONE 4:e5077. 2009
  4. doi request reprint Imaging: strategies, controversies, and opportunities
    Ronald Blasberg
    Department of Neurology, Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 18:631-7. 2012
  5. ncbi request reprint In vivo molecular-genetic imaging
    Ronald G Blasberg
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    J Cell Biochem Suppl 39:172-83. 2002
  6. ncbi request reprint PET imaging of gene expression
    Ronald Blasberg
    Departments of Neurology and Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Eur J Cancer 38:2137-46. 2002
  7. ncbi request reprint Imaging gene expression and endogenous molecular processes: molecular imaging
    Ronald Blasberg
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cereb Blood Flow Metab 22:1157-64. 2002
  8. ncbi request reprint Molecular-genetic imaging: a nuclear medicine-based perspective
    Ronald G Blasberg
    Departments of Neurology and Radiology, Memorial Sloan Kettering Cancer Center, Box 52, 1275 York Avenue, New York, NY 10021, USA
    Mol Imaging 1:280-300. 2002
  9. pmc MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas
    Ruimin Huang
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    FASEB J 25:4138-49. 2011
  10. ncbi request reprint Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenog
    T Oku
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 58:4185-92. 1998

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression
    Juri Gelovani Tjuvajev
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 43:1072-83. 2002
    ....
  2. ncbi request reprint Multimodality registration without a dedicated multimodality scanner
    Bradley J Beattie
    Momorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Imaging 6:108-20. 2007
    ....
  3. pmc Real-time imaging of HIF-1alpha stabilization and degradation
    Ekaterina Moroz
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS ONE 4:e5077. 2009
    ..Overall, the continuous bioluminescence readout of HIF-1alpha/FLuc stabilization in vitro and in vivo will facilitate the development and validation of therapeutics that affect the stability and accumulation of HIF-1alpha...
  4. doi request reprint Imaging: strategies, controversies, and opportunities
    Ronald Blasberg
    Department of Neurology, Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 18:631-7. 2012
    ....
  5. ncbi request reprint In vivo molecular-genetic imaging
    Ronald G Blasberg
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    J Cell Biochem Suppl 39:172-83. 2002
    ....
  6. ncbi request reprint PET imaging of gene expression
    Ronald Blasberg
    Departments of Neurology and Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Eur J Cancer 38:2137-46. 2002
    ..Issues related to the translation of non-invasive molecular imaging technology into the clinic are discussed...
  7. ncbi request reprint Imaging gene expression and endogenous molecular processes: molecular imaging
    Ronald Blasberg
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cereb Blood Flow Metab 22:1157-64. 2002
    ..Issues related to the translation of noninvasive molecular imaging technology into the clinic are also discussed...
  8. ncbi request reprint Molecular-genetic imaging: a nuclear medicine-based perspective
    Ronald G Blasberg
    Departments of Neurology and Radiology, Memorial Sloan Kettering Cancer Center, Box 52, 1275 York Avenue, New York, NY 10021, USA
    Mol Imaging 1:280-300. 2002
    ....
  9. pmc MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas
    Ruimin Huang
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    FASEB J 25:4138-49. 2011
    ....
  10. ncbi request reprint Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenog
    T Oku
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 58:4185-92. 1998
    ..VEGF-targeted antiangiogenic gene therapy could be an effective component of a combined strategy to treat VEGF-producing brain tumors...
  11. ncbi request reprint Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo
    A Jacobs
    Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 61:2983-95. 2001
    ....
  12. ncbi request reprint Tumor-specific transcriptional targeting of suicide gene therapy
    J Qiao
    Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Gene Ther 9:168-75. 2002
    ....
  13. ncbi request reprint Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living mice
    Inna Serganova
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 64:6101-8. 2004
    ....
  14. ncbi request reprint Midazolam changes cerebral blood flow in discrete brain regions: an H2(15)O positron emission tomography study
    R A Veselis
    Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center and Cornell University Medical College, New York, New York 10021, USA
    Anesthesiology 87:1106-17. 1997
    ..Changes in regional cerebral blood flow (rCBF) determined with H2(15)O positron emission tomographic imaging can identify neural circuits affected by centrally acting drugs...
  15. ncbi request reprint Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I]FIAU and PET
    Trevor Hackman
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mol Imaging 1:36-42. 2002
    ..Imaging with [124I]FIAU and PET could provide pre- and posttreatment assessments of CD/TK-based double prodrug activation in clinical gene therapy trials...
  16. pmc Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging
    Vladimir Ponomarev
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Neoplasia 5:245-54. 2003
    ....
  17. ncbi request reprint Assessment of treatment response by autoradiography with (14)C-aminocyclopentane carboxylic acid, (67)Ga-DTPA, and (18)F-FDG in a herpes simplex virus thymidine kinase/ganciclovir brain tumor model
    Tadashi Miyagawa
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 44:1845-54. 2003
    ..This study addresses whether imaging amino acid transport, glucose utilization, and passive vascular permeability provides an early indication of treatment response and can predict long-term outcome...
  18. ncbi request reprint Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK
    Surren A Soghomonyan
    Departments of Neurology and Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Gene Ther 12:101-8. 2005
    ....
  19. ncbi request reprint Apparent diffusion coefficient of glial neoplasms: correlation with fluorodeoxyglucose-positron-emission tomography and gadolinium-enhanced MR imaging
    A I Holodny
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    AJNR Am J Neuroradiol 31:1042-8. 2010
    ....
  20. ncbi request reprint A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging
    Vladimir Ponomarev
    Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Eur J Nucl Med Mol Imaging 31:740-51. 2004
    ..It provides for the seamless transition from fluorescence microscopy and FACS to whole-body bioluminescence imaging, to nuclear (PET, SPET, gamma camera) imaging, and back to in situ fluorescence image analysis...
  21. ncbi request reprint Reporter gene imaging: potential impact on therapy
    Inna Serganova
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucl Med Biol 32:763-80. 2005
    ..quot;..
  22. ncbi request reprint Human reporter genes: potential use in clinical studies
    Inna Serganova
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucl Med Biol 34:791-807. 2007
    ....
  23. ncbi request reprint hNIS-IRES-eGFP dual reporter gene imaging
    Jiantu Che
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Imaging 4:128-36. 2005
    ..These studies indicate the potential for a wider application of hNIS reporter imaging and translation into patient studies using radioisotopes that are currently available for human use for both SPECT and PET imaging...
  24. pmc Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression
    Philipp Mayer-Kuckuk
    Molecular Pharmacology and Therapeutics Program, Department of Surgery, Nuclear Medicine Service, Radiochemistry Cyclotron, and Preparative Synthesis Chemistry Core Facilities, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:3400-5. 2002
    ..Drug-mediated elevation of cellular DHFR-fused proteins is a very useful method to modulate gene expression in vivo for imaging as well as therapeutic purposes...
  25. ncbi request reprint Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model
    Peter Brader
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cancer Ther 6:2900-8. 2007
    ..However, the severity of tumor ischemia after permanent ligation of the hepatic artery limits our ability to image severe hypoxia in this animal model...
  26. ncbi request reprint HSP70-inducible hNIS-IRES-eGFP reporter imaging: response to heat shock
    Jiantu Che
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Imaging 6:404-16. 2007
    ..The pQHNIG70 reporter system can be used to study stress and drug responses in transduced cells and tissues...
  27. pmc Multimodality imaging of TGFbeta signaling in breast cancer metastases
    Inna Serganova
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    FASEB J 23:2662-72. 2009
    ....
  28. ncbi request reprint Tumor hypoxia imaging
    Inna Serganova
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 12:5260-4. 2006
  29. doi request reprint Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging
    Peter Brader
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 14:2295-302. 2008
    ..Imaging bacteria specifically targeting and replicating within tumors using radiotracer techniques and optical imaging can provide confirmation of successful colonization of malignant tissue...
  30. ncbi request reprint Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain
    Nicholas D Schiff
    Department of Neurology and Neuroscience, Medicine and Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Brain 125:1210-34. 2002
    ..The variations in cerebral metabolism in chronic PVS patients indicate that some cerebral regions can retain partial function in catastrophically injured brains...
  31. ncbi request reprint Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats
    Philipp Mayer-Kuckuk
    Molecular Pharmacology and Therapeutics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Eur J Nucl Med Mol Imaging 30:1281-91. 2003
    ..It is concluded that the two examined nucleotide imaging methods are feasible techniques for monitoring of DHFR-HSV TK fusion protein expression in hepatic colorectal tumor tissue in living animals...
  32. ncbi request reprint A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxia
    Bixiu Wen
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, NY, New York 10021, USA
    Eur J Nucl Med Mol Imaging 31:1530-8. 2004
    ..The purpose of this study was to develop and characterize a rodent tumor model with a reporter gene construct that would be transactivated by the hypoxia-inducible molecular switch, i.e., the upregulation of HIF-1...
  33. ncbi request reprint Multimodality in vivo molecular-genetic imaging
    Michael Doubrovin
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Bioconjug Chem 15:1376-88. 2004
    ....
  34. ncbi request reprint In vivo molecular-genetic imaging: multi-modality nuclear and optical combinations
    Ronald G Blasberg
    Memorial Sloan Kettering Cancer Center, Nueurology and Radiology, 1275 York Ave, Box 52, New York, NY 10021, USA
    Nucl Med Biol 30:879-88. 2003
    ..Many of the shortcomings of each modality alone can be overcome by the use of dual- or triple-modality reporter constructs that incorporate the opportunity for PET, fluorescence and bioluminescence imaging...
  35. ncbi request reprint Development of a new reporter gene system--dsRed/xanthine phosphoribosyltransferase-xanthine for molecular imaging of processes behind the intact blood-brain barrier
    Mikhail Doubrovin
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 513, New York, NY 10021, USA
    Mol Imaging 2:93-112. 2003
    ..quot; Therefore, the novel dsRed/XPRT fusion gene can be used as a multimodality reporter system in the biological applications requiring two independent reporter genes, including the cells located behind the BBB...
  36. pmc Molecular-genetic imaging: current and future perspectives
    Ronald G Blasberg
    Departments of Neurology and Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Clin Invest 111:1620-9. 2003
  37. doi request reprint Imaging of HSV-tk Reporter gene expression: comparison between [18F]FEAU, [18F]FFEAU, and other imaging probes
    Tadashi Miyagawa
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Nucl Med 49:637-48. 2008
    ....
  38. ncbi request reprint In vivo imaging of molecular-genetic targets for cancer therapy
    Juri Gelovani Tjuvajev
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Cell 3:327-32. 2003
  39. ncbi request reprint Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes
    Guenther Koehne
    Allogeneic Bone Marrow Transplantation Service, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Nat Biotechnol 21:405-13. 2003
    ..This technique for imaging the migration of ex vivo-transduced antigen-specific T cells in vivo is informative, nontoxic, and potentially applicable to humans...
  40. ncbi request reprint Imaging update: new windows, new views
    Ronald G Blasberg
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 6094, USA
    Clin Cancer Res 13:3444-8. 2007
  41. ncbi request reprint Role of reporter gene imaging in molecular and cellular biology
    Philipp Mayer-Kuckuk
    Department of Pharmacology, The Cancer Institute of New Jersey, UMDNJ, New Brunswick, NJ 08903, USA
    Biol Chem 385:353-61. 2004
    ..The review indicates that molecular imaging is likely to be useful in the translation of molecular biology to medicine and biotechnological applications...
  42. ncbi request reprint High-resolution imaging of bone precursor cells within the intact bone marrow cavity of living mice
    Philipp Mayer-Kuckuk
    In Vivo Cellular Molecular Imaging Center, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Ther 12:33-41. 2005
    ..In summary, we describe a versatile platform suitable for studying the biology of many bone marrow cell types in living bone...
  43. ncbi request reprint PET-based reporter gene imaging. Assessment of endogenous molecular-genetic events
    Michael Doubrovin
    Cotzias Neuro Oncology Lab, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    IEEE Eng Med Biol Mag 23:38-50. 2004
  44. ncbi request reprint Imaging herpes viral thymidine kinase-1 reporter gene expression with a new 18F-labeled probe: 2'-fluoro-2'-deoxy-5-[18F]fluoroethyl-1-beta-d-arabinofuranosyl uracil
    Julius A Balatoni
    Radiochemistry Cyclotron Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nucl Med Biol 32:811-9. 2005
    ..The animal imaging experiment showed low levels of radioactivity in the lungs, with little or no radioactivity seen in the heart, liver, spleen and intestines...
  45. ncbi request reprint Imaging hNET reporter gene expression with 124I-MIBG
    Maxim A Moroz
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Nucl Med 48:827-36. 2007
    ..We have extended this effort by constructing an internal ribosomal entry site (IRES)-linked hNET-green fluorescent protein (GFP) hybrid reporter gene for both nuclear and optical imaging...
  46. ncbi request reprint [131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicity
    Pat Zanzonico
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Eur J Nucl Med Mol Imaging 33:988-97. 2006
    ....
  47. ncbi request reprint Molecular imaging reveals skeletal engraftment sites of transplanted bone marrow cells
    Philipp Mayer-Kuckuk
    In Vivo Cellular Molecular Imaging Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cell Transplant 15:75-82. 2006
    ..Multiple, discrete BM cell engraftment sites were observed. Taken together, this multimodality approach may be useful for further in vivo characterization of various therapeutic cell types...
  48. ncbi request reprint Multi-modality molecular imaging of tumors
    Inna Serganova
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Hematol Oncol Clin North Am 20:1215-48. 2006
    ..Molecular imaging studies being performed in experimental animals will be translated to animals in the near future...
  49. ncbi request reprint Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expression
    Nagavarakishore Pillarsetty
    Radiochemistry and Cyclotron Core Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    J Med Chem 49:5377-81. 2006
    ..The results indicate that [18F]FBrVAU and [18F]FTMAU have better uptake profiles in comparison to [18F]FPAU and have potential as PET probes for imaging HSV1-tk gene expression...
  50. ncbi request reprint Molecular imaging and cancer
    Ronald G Blasberg
    Department of Neurology and Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cancer Ther 2:335-43. 2003
    ..Issues related to the translation of noninvasive molecular imaging technology into the clinic are discussed...
  51. pmc Imaging transgene activity in vivo
    Terence P F Gade
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Res 68:2878-84. 2008
    ..This study presents a translational imaging paradigm for precise, in vivo measurements of transgene activity with potential applications in both preclinical and clinical settings...