Research Topics
| R G BlasbergSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expressionJuri Gelovani Tjuvajev
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Nucl Med 43:1072-83. 2002....- Multimodality registration without a dedicated multimodality scannerBradley J Beattie
Momorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Imaging 6:108-20. 2007.... 
Imaging: strategies, controversies, and opportunitiesRonald Blasberg
Department of Neurology, Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 18:631-7. 2012....- In vivo molecular-genetic imagingRonald G Blasberg
Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
J Cell Biochem Suppl 39:172-83. 2002.... - PET imaging of gene expressionRonald Blasberg
Departments of Neurology and Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Eur J Cancer 38:2137-46. 2002..Issues related to the translation of non-invasive molecular imaging technology into the clinic are discussed... - Imaging gene expression and endogenous molecular processes: molecular imagingRonald Blasberg
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Cereb Blood Flow Metab 22:1157-64. 2002..Issues related to the translation of noninvasive molecular imaging technology into the clinic are also discussed... 
MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomasRuimin Huang
Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
FASEB J 25:4138-49. 2011....- Molecular-genetic imaging: a nuclear medicine-based perspectiveRonald G Blasberg
Departments of Neurology and Radiology, Memorial Sloan Kettering Cancer Center, Box 52, 1275 York Avenue, New York, NY 10021, USA
Mol Imaging 1:280-300. 2002.... - Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenogT Oku
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 58:4185-92. 1998..VEGF-targeted antiangiogenic gene therapy could be an effective component of a combined strategy to treat VEGF-producing brain tumors... - Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivoA Jacobs
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 61:2983-95. 2001.... - Tumor-specific transcriptional targeting of suicide gene therapyJ Qiao
Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Gene Ther 9:168-75. 2002.... - Molecular imaging of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 signal transduction activity in tumors in living miceInna Serganova
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
Cancer Res 64:6101-8. 2004.... - Midazolam changes cerebral blood flow in discrete brain regions: an H2(15)O positron emission tomography studyR A Veselis
Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center and Cornell University Medical College, New York, New York 10021, USA
Anesthesiology 87:1106-17. 1997..Changes in regional cerebral blood flow (rCBF) determined with H2(15)O positron emission tomographic imaging can identify neural circuits affected by centrally acting drugs... - Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TKSurren A Soghomonyan
Departments of Neurology and Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Cancer Gene Ther 12:101-8. 2005.... - Assessment of treatment response by autoradiography with (14)C-aminocyclopentane carboxylic acid, (67)Ga-DTPA, and (18)F-FDG in a herpes simplex virus thymidine kinase/ganciclovir brain tumor modelTadashi Miyagawa
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Nucl Med 44:1845-54. 2003..Amino acid transport imaging may be a good surrogate paradigm to monitor treatment response of brain tumors... - Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imagingVladimir Ponomarev
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Neoplasia 5:245-54. 2003.... - Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I]FIAU and PETTrevor Hackman
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Mol Imaging 1:36-42. 2002..Imaging with [124I]FIAU and PET could provide pre- and posttreatment assessments of CD/TK-based double prodrug activation in clinical gene therapy trials... - Apparent diffusion coefficient of glial neoplasms: correlation with fluorodeoxyglucose-positron-emission tomography and gadolinium-enhanced MR imagingA I Holodny
Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
AJNR Am J Neuroradiol 31:1042-8. 2010.... - A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imagingVladimir Ponomarev
Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Eur J Nucl Med Mol Imaging 31:740-51. 2004..It provides for the seamless transition from fluorescence microscopy and FACS to whole-body bioluminescence imaging, to nuclear (PET, SPET, gamma camera) imaging, and back to in situ fluorescence image analysis... - Reporter gene imaging: potential impact on therapyInna Serganova
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Nucl Med Biol 32:763-80. 2005..quot;.. - Human reporter genes: potential use in clinical studiesInna Serganova
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Nucl Med Biol 34:791-807. 2007.... - hNIS-IRES-eGFP dual reporter gene imagingJiantu Che
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Mol Imaging 4:128-36. 2005..These studies indicate the potential for a wider application of hNIS reporter imaging and translation into patient studies using radioisotopes that are currently available for human use for both SPECT and PET imaging... - Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expressionPhilipp Mayer-Kuckuk
Molecular Pharmacology and Therapeutics Program, Department of Surgery, Nuclear Medicine Service, Radiochemistry/ Cyclotron, and Preparative Synthesis Chemistry Core Facilities, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Proc Natl Acad Sci U S A 99:3400-5. 2002..Drug-mediated elevation of cellular DHFR-fused proteins is a very useful method to modulate gene expression in vivo for imaging as well as therapeutic purposes... - Imaging of hypoxia-driven gene expression in an orthotopic liver tumor modelPeter Brader
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Cancer Ther 6:2900-8. 2007..However, the severity of tumor ischemia after permanent ligation of the hepatic artery limits our ability to image severe hypoxia in this animal model... - Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imagingPeter Brader
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Clin Cancer Res 14:2295-302. 2008..Imaging bacteria specifically targeting and replicating within tumors using radiotracer techniques and optical imaging can provide confirmation of successful colonization of malignant tissue... - Tumor hypoxia imagingInna Serganova
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 12:5260-4. 2006 - Multimodality imaging of TGFbeta signaling in breast cancer metastasesInna Serganova
Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
FASEB J 23:2662-72. 2009.... - HSP70-inducible hNIS-IRES-eGFP reporter imaging: response to heat shockJiantu Che
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Imaging 6:404-16. 2007..The pQHNIG70 reporter system can be used to study stress and drug responses in transduced cells and tissues... - Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brainNicholas D Schiff
Department of Neurology and Neuroscience, Medicine and Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
Brain 125:1210-34. 2002..The variations in cerebral metabolism in chronic PVS patients indicate that some cerebral regions can retain partial function in catastrophically injured brains... - Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living ratsPhilipp Mayer-Kuckuk
Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Eur J Nucl Med Mol Imaging 30:1281-91. 2003..It is concluded that the two examined nucleotide imaging methods are feasible techniques for monitoring of DHFR-HSV TK fusion protein expression in hepatic colorectal tumor tissue in living animals... - A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxiaBixiu Wen
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, NY, New York 10021, USA
Eur J Nucl Med Mol Imaging 31:1530-8. 2004.... - PET-based reporter gene imaging. Assessment of endogenous molecular-genetic eventsMichael Doubrovin
Cotzias Neuro-Oncology Lab, Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
IEEE Eng Med Biol Mag 23:38-50. 2004 - Imaging update: new windows, new viewsRonald G Blasberg
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021-6094, USA
Clin Cancer Res 13:3444-8. 2007 - Development of a new reporter gene system--dsRed/xanthine phosphoribosyltransferase-xanthine for molecular imaging of processes behind the intact blood-brain barrierMikhail Doubrovin
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 513, New York, NY 10021, USA
Mol Imaging 2:93-112. 2003..quot; Therefore, the novel dsRed/XPRT fusion gene can be used as a multimodality reporter system in the biological applications requiring two independent reporter genes, including the cells located behind the BBB... - Molecular-genetic imaging: current and future perspectivesRonald G Blasberg
Departments of Neurology and Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
J Clin Invest 111:1620-9. 2003 - In vivo imaging of molecular-genetic targets for cancer therapyJuri Gelovani Tjuvajev
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Cancer Cell 3:327-32. 2003 - Imaging of HSV-tk Reporter gene expression: comparison between [18F]FEAU, [18F]FFEAU, and other imaging probesTadashi Miyagawa
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Nucl Med 49:637-48. 2008.... - Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytesGuenther Koehne
Allogeneic Bone Marrow Transplantation Service, Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Nat Biotechnol 21:405-13. 2003..This technique for imaging the migration of ex vivo-transduced antigen-specific T cells in vivo is informative, nontoxic, and potentially applicable to humans... - Imaging hNET reporter gene expression with 124I-MIBGMaxim A Moroz
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
J Nucl Med 48:827-36. 2007..We have extended this effort by constructing an internal ribosomal entry site (IRES)-linked hNET-green fluorescent protein (GFP) hybrid reporter gene for both nuclear and optical imaging... - In vivo molecular-genetic imaging: multi-modality nuclear and optical combinationsRonald G Blasberg
Memorial Sloan Kettering Cancer Center, Nueurology and Radiology, 1275 York Ave, Box 52, New York, NY 10021, USA
Nucl Med Biol 30:879-88. 2003..Many of the shortcomings of each modality alone can be overcome by the use of dual- or triple-modality reporter constructs that incorporate the opportunity for PET, fluorescence and bioluminescence imaging... - Multimodality in vivo molecular-genetic imagingMichael Doubrovin
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Bioconjug Chem 15:1376-88. 2004.... - High-resolution imaging of bone precursor cells within the intact bone marrow cavity of living micePhilipp Mayer-Kuckuk
In Vivo Cellular Molecular Imaging Center, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Ther 12:33-41. 2005..In summary, we describe a versatile platform suitable for studying the biology of many bone marrow cell types in living bone... - Imaging herpes viral thymidine kinase-1 reporter gene expression with a new 18F-labeled probe: 2'-fluoro-2'-deoxy-5-[18F]fluoroethyl-1-beta-d-arabinofuranosyl uracilJulius A Balatoni
Radiochemistry/Cyclotron Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Nucl Med Biol 32:811-9. 2005..The animal imaging experiment showed low levels of radioactivity in the lungs, with little or no radioactivity seen in the heart, liver, spleen and intestines... - [131I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicityPat Zanzonico
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
Eur J Nucl Med Mol Imaging 33:988-97. 2006.... - Molecular imaging reveals skeletal engraftment sites of transplanted bone marrow cellsPhilipp Mayer-Kuckuk
In Vivo Cellular Molecular Imaging Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Cell Transplant 15:75-82. 2006..Multiple, discrete BM cell engraftment sites were observed. Taken together, this multimodality approach may be useful for further in vivo characterization of various therapeutic cell types... - Role of reporter gene imaging in molecular and cellular biologyPhilipp Mayer-Kuckuk
Department of Pharmacology, The Cancer Institute of New Jersey, UMDNJ, New Brunswick, NJ 08903, USA
Biol Chem 385:353-61. 2004..The review indicates that molecular imaging is likely to be useful in the translation of molecular biology to medicine and biotechnological applications... - Multi-modality molecular imaging of tumorsInna Serganova
Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Hematol Oncol Clin North Am 20:1215-48. 2006..Molecular imaging studies being performed in experimental animals will be translated to animals in the near future... - Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expressionNagavarakishore Pillarsetty
Radiochemistry and Cyclotron Core Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
J Med Chem 49:5377-81. 2006..The results indicate that [18F]FBrVAU and [18F]FTMAU have better uptake profiles in comparison to [18F]FPAU and have potential as PET probes for imaging HSV1-tk gene expression... - Imaging transgene activity in vivoTerence P F Gade
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Res 68:2878-84. 2008..This study presents a translational imaging paradigm for precise, in vivo measurements of transgene activity with potential applications in both preclinical and clinical settings... - Molecular imaging and cancerRonald G Blasberg
Department of Neurology and Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Mol Cancer Ther 2:335-43. 2003..Issues related to the translation of noninvasive molecular imaging technology into the clinic are discussed...