JONINE LISA BERNSTEIN

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report
    Jonine L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Eur J Cancer 49:2979-85. 2013
  2. pmc Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
    Sharon N Teraoka
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 0717, USA
    Breast Cancer Res 13:R114. 2011
  3. ncbi request reprint Population-based estimates of breast cancer risks associated with ATM gene variants c.7271T>G and c.1066-6T>G (IVS10-6T>G) from the Breast Cancer Family Registry
    J L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Mutat 27:1122-8. 2006
  4. ncbi request reprint The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry
    Jonine L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 3rd Floor, 307 East 63rd Street, New York, New York 10021, USA
    Cancer Epidemiol Biomarkers Prev 15:348-52. 2006
  5. ncbi request reprint Identification of mammaglobin as a novel serum marker for breast cancer
    Jonine L Bernstein
    Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Clin Cancer Res 11:6528-35. 2005
  6. pmc Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res 6:R199-214. 2004
  7. pmc Variation of breast cancer risk among BRCA1/2 carriers
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    JAMA 299:194-201. 2008
  8. ncbi request reprint Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2
    Deborah Goldfrank
    Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Epidemiol Biomarkers Prev 15:2311-3. 2006
  9. ncbi request reprint Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Hum Mutat 21:542-50. 2003
  10. pmc Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002
    Jonine L Bernstein
    Department of Community Medicine, Mount Sinai School of Medicine, New York, USA
    Breast Cancer Res 4:249-52. 2002

Research Grants

Detail Information

Publications16

  1. pmc Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report
    Jonine L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Eur J Cancer 49:2979-85. 2013
    ..BRCA1/BRCA2 genes help maintain genome stability and assist in DNA repair. We examined whether the risk of CBC associated with radiation treatment was higher among women with germline BRCA1/BRCA2 mutations than among non-carriers...
  2. pmc Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study
    Sharon N Teraoka
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908 0717, USA
    Breast Cancer Res 13:R114. 2011
    ..A subset of these SNPs, selected upon their main effects on contralateral breast cancer risk was further evaluated for interaction with treatment modalities and estrogen receptor (ER) status...
  3. ncbi request reprint Population-based estimates of breast cancer risks associated with ATM gene variants c.7271T>G and c.1066-6T>G (IVS10-6T>G) from the Breast Cancer Family Registry
    J L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Mutat 27:1122-8. 2006
    ....
  4. ncbi request reprint The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry
    Jonine L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 3rd Floor, 307 East 63rd Street, New York, New York 10021, USA
    Cancer Epidemiol Biomarkers Prev 15:348-52. 2006
    ..63; 95% CI, 1.25-10.52). These data supporting the biological relevance of CHEK2 in breast carcinogenesis suggest that further studies examining the joint roles of CHEK2*1100delC carrier status and radiation exposure may be warranted...
  5. ncbi request reprint Identification of mammaglobin as a novel serum marker for breast cancer
    Jonine L Bernstein
    Departments of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Clin Cancer Res 11:6528-35. 2005
    ..The present studies were undertaken to develop the mammaglobin protein as a serum biomarker for detection of breast cancer...
  6. pmc Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res 6:R199-214. 2004
    ..Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated...
  7. pmc Variation of breast cancer risk among BRCA1/2 carriers
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    JAMA 299:194-201. 2008
    ..The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers...
  8. ncbi request reprint Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2
    Deborah Goldfrank
    Clinical Genetics Service, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Epidemiol Biomarkers Prev 15:2311-3. 2006
    ..08; P = 0.03). These findings indicate that screening mammography is unlikely to be associated with a large increase in breast cancer risk in this population...
  9. ncbi request reprint Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Hum Mutat 21:542-50. 2003
    ..Finally, we report novel mutations in the ATM gene identified both in patients with ataxia-telangiectasia and in patients with unilateral or bilateral breast cancer...
  10. pmc Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002
    Jonine L Bernstein
    Department of Community Medicine, Mount Sinai School of Medicine, New York, USA
    Breast Cancer Res 4:249-52. 2002
    ..In the present meeting report, the aims of each project are described...
  11. pmc Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study
    Jonine L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd St Fl 3, New York, NY 10065, USA
    J Natl Cancer Inst 102:475-83. 2010
    ..We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women...
  12. ncbi request reprint The descriptive epidemiology of second primary breast cancer
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Epidemiology 14:552-8. 2003
    ..This study describes the epidemiology of second primary breast cancer among a population-based cohort of 305,533 U.S. women diagnosed with breast cancer between 1973 and 1998...
  13. ncbi request reprint Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy
    Alice Y Ho
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 69:677-84. 2007
    ..The ATM gene product is a central component of cell cycle regulation and genomic surveillance. We hypothesized that DNA sequence alterations in ATM predict for adverse effects after external beam radiotherapy for early breast cancer...
  14. ncbi request reprint Factors influencing mortality among young women with second primary breast carcinoma
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer 95:2051-8. 2002
    ....
  15. ncbi request reprint Comparison of techniques for the successful detection of BRCA1 mutations in fixed paraffin-embedded tissue
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Epidemiol Biomarkers Prev 11:809-14. 2002
    ..We concluded that DNA derived from PET that archived for less than 18 years can be used successfully for detecting BRCA1 gene mutations if quality control is strictly maintained...
  16. ncbi request reprint ATM sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancer
    Jamie A Cesaretti
    Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Int J Radiat Oncol Biol Phys 61:196-202. 2005
    ....

Research Grants12

  1. Breast Cancer, Radiation and the ATM-CHEK2 Pathway
    Jonine Bernstein; Fiscal Year: 2007
    ..Conduct a population-based case-control association study of 6 genes involved in the ATM-CHEK2 pathway to determine whether they are associated with an increased risk of radiation-induced contralateral breast cancer. ..
  2. BREAST CANCER, RADIATION EXPOSURE, AND THE ATM GENE
    Jonine Bernstein; Fiscal Year: 2003
    ..Further, the rising incidence of breast cancer coupled with improved survival, has placed an increased number of women at risk for second primary breast cancer making it an issue of public health importance. ..
  3. Interaction of Radiation, BRCA1/2, and Breast Cancer
    Jonine Bernstein; Fiscal Year: 2006
    ..Once our study has been completed, we will have established an outstanding resource for future studies of other putative breast cancer genes and environmental exposures, with a particular focus on radiation exposure. ..
  4. Genome-Wide Association Study of Radiation Exposure and Bilateral Breast Cancer
    JONINE LISA BERNSTEIN; Fiscal Year: 2010
    ..Results from this study will have important implications for the long-term management of women with breast cancer and for targeting therapeutic and prevention efforts. ..