ROBERT I BENEZRA

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
    Rocio Sotillo
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 464:436-40. 2010
  2. ncbi request reprint Role of Id proteins in embryonic and tumor angiogenesis
    R Benezra
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Trends Cardiovasc Med 11:237-41. 2001
  3. ncbi request reprint Endostatin's endpoints-Deciphering the endostatin antiangiogenic pathway
    Robert Benezra
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USA
    Cancer Cell 5:205-6. 2004
  4. ncbi request reprint The Id proteins and angiogenesis
    R Benezra
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Oncogene 20:8334-41. 2001
  5. pmc Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells
    Diego Fraidenraich
    Cancer Biology and Genetics Program, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 306:247-52. 2004
  6. ncbi request reprint Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
    Shahin Rafii
    Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, Room D601, New York, New York 10021, USA
    Nat Rev Cancer 2:826-35. 2002
  7. ncbi request reprint Embryonic stem cells prevent developmental cardiac defects in mice
    Diego Fraidenraich
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nat Clin Pract Cardiovasc Med 3:S14-7. 2006
  8. ncbi request reprint Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors
    Marianna B Ruzinova
    Program of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Cell 4:277-89. 2003
  9. pmc Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression
    Dingcheng Gao
    Department of Cardiothoracic Surgery, Lehman Brothers Lung Cancer Research Center, Cornell University Medical Center, New York, NY 10065, USA
    Biochim Biophys Acta 1796:33-40. 2009
  10. pmc Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors
    Paola de Candia
    Program in Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:12337-42. 2003

Research Grants

Collaborators

  • Diego Fraidenraich
  • S Rafii
  • Robert Kerbel
  • Yuval Shaked
  • Marco Seandel
  • Neal Rosen
  • Sina Y Rabbany
  • N Altorki
  • Adam B Olshen
  • Dilip Giri
  • Vivek Mittal
  • Jonathan Perk
  • Hyung Song Nam
  • Daniel Nolan
  • Marianna B Ruzinova
  • Paola de Candia
  • Daylon James
  • Rocio Sotillo
  • Dingcheng Gao
  • Alessia Ciarrocchi
  • Jaspreet Singh Jaggi
  • William L Gerald
  • Edi Brogi
  • Haiqing Li
  • Katja Wassmann
  • Gabsang Lee
  • Mark Tomishima
  • David Lyden
  • Nikica Zaninovic
  • Lorenz Studer
  • Juan Manuel Schvartzman
  • Tyler Janovitz
  • Nicholas D Socci
  • Zev Rosenwaks
  • Kevin McDonnell
  • Linda Vahdat
  • Debjit Chattopadhyay
  • Daniel J Nolan
  • Michael R McDevitt
  • Barry J Kappel
  • Stephen D Nimer
  • David A Scheinberg
  • Vladimir Jankovic
  • Chad May
  • Surya V Seshan
  • Erik Henke
  • Shirley Chao
  • John J S Chen
  • Yaohuang Ke
  • Wai Cheong
  • Yvette Chin
  • Hikmat Al-Ahmadie
  • Yuntao Zhao
  • Ignacio Gil-Bazo
  • Antonio Iavarone
  • William Gerald
  • David B Solit
  • Pier Paolo Pandolfi
  • Vasco Liberal
  • James E Egan
  • Peter M Siegel
  • Rebecca A Schoer
  • Katia Manova
  • William J Muller

Detail Information

Publications19

  1. pmc Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
    Rocio Sotillo
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 464:436-40. 2010
    ..The recurrent tumours are highly aneuploid and have varied activation of pro-proliferative pathways. Thus, early chromosomal instability may be responsible for tumour relapse after seemingly effective anticancer treatments...
  2. ncbi request reprint Role of Id proteins in embryonic and tumor angiogenesis
    R Benezra
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Trends Cardiovasc Med 11:237-41. 2001
    ....
  3. ncbi request reprint Endostatin's endpoints-Deciphering the endostatin antiangiogenic pathway
    Robert Benezra
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USA
    Cancer Cell 5:205-6. 2004
    ..This study resolves some of the controversies surrounding endostatin's biology, and provides a new direction to help dissect the molecular pathways involved in endostatin's selective tumor antiangiogenic effects...
  4. ncbi request reprint The Id proteins and angiogenesis
    R Benezra
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Oncogene 20:8334-41. 2001
    ..This section of the review issue will focus on the key observations which have led to these conclusions, speculations about potential mechanisms and the outlook for potential therapeutic interventions...
  5. pmc Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells
    Diego Fraidenraich
    Cancer Biology and Genetics Program, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 306:247-52. 2004
    ..Thus, ES cells have the potential to reverse congenital defects through Id-dependent local and long-range effects in a mammalian embryo...
  6. ncbi request reprint Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
    Shahin Rafii
    Division of Hematology Oncology, Cornell University Medical College, 1300 York Avenue, Room D601, New York, New York 10021, USA
    Nat Rev Cancer 2:826-35. 2002
  7. ncbi request reprint Embryonic stem cells prevent developmental cardiac defects in mice
    Diego Fraidenraich
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nat Clin Pract Cardiovasc Med 3:S14-7. 2006
    ..Future studies are discussed...
  8. ncbi request reprint Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors
    Marianna B Ruzinova
    Program of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Cell 4:277-89. 2003
    ..Inhibition of these factors phenocopies loss of Id in in vivo angiogenesis assays...
  9. pmc Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression
    Dingcheng Gao
    Department of Cardiothoracic Surgery, Lehman Brothers Lung Cancer Research Center, Cornell University Medical Center, New York, NY 10065, USA
    Biochim Biophys Acta 1796:33-40. 2009
    ..Thromb. Vasc. Biol. 28 (2008) 1584-1595. [5]; F. Timmermans, J. Plum, M.C. Yoder, D.A. Ingram, B. Vandekerckhove and J. Case, J. Cell. Mol. Med. 13 (2009) 87-102. [6]] and reviews by Bertolini, Voest and Yoder in this issue...
  10. pmc Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors
    Paola de Candia
    Program in Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:12337-42. 2003
    ..Thus angiogenesis inhibitors in combination with inhibitors of Hsp90 function should be evaluated for the treatment of advanced breast cancer...
  11. pmc High levels of Id1 expression define B1 type adult neural stem cells
    Hyung Song Nam
    Sloan Kettering Memorial Cancer Center, Sloan Kettering Institute, New York, NY 10065, USA
    Cell Stem Cell 5:515-26. 2009
    ..We suggest that high expression of a single transcriptional regulator, Id1, molecularly defines the long-sought-after B1 type adult neural stem cells...
  12. pmc Id1 restrains p21 expression to control endothelial progenitor cell formation
    Alessia Ciarrocchi
    Program of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 2:e1338. 2007
    ..These results demonstrate that the restraint of p21 expression by Id1 is one key element of its activity in facilitating the generation of EPCs in the BM and highlight the critical role these cells play in tumor angiogenesis...
  13. pmc Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent
    Daylon James
    Howard Hughes Medical Institute, Ansary Stem Cell Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA
    Nat Biotechnol 28:161-6. 2010
    ..Our approach provides a serum-free method for differentiation and long-term maintenance of hESC-derived endothelial cells at a scale relevant to clinical application...
  14. pmc Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization
    Jaspreet Singh Jaggi
    Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 2:e267. 2007
    ..Alpha particles are extraordinarily potent, short-ranged radiations with geometry uniquely suitable for selectively killing neovasculature...
  15. ncbi request reprint Reassessment of id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-id1 antibody
    Jonathan Perk
    Cancer Biology and Genetics Program and Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Res 66:10870-7. 2006
    ..These results suggest that further refinement of Id1 expression patterns in a variety of tumor types will be necessary to identify and study the functional roles played by Id1 in human neoplastic processes...
  16. ncbi request reprint Id proteins in development, cell cycle and cancer
    Marianna B Ruzinova
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue Box 241, New York, NY 10021, USA
    Trends Cell Biol 13:410-8. 2003
    ..Thus, the Id proteins have become important molecules for understanding basic biological processes as well as targets for potential therapeutic intervention in human disease...
  17. ncbi request reprint Id family of helix-loop-helix proteins in cancer
    Jonathan Perk
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue Box 241, New York 10021, USA
    Nat Rev Cancer 5:603-14. 2005
    ....
  18. ncbi request reprint Utilization of bone marrow-derived endothelial cell precursors in spontaneous prostate tumors varies with tumor grade
    Haiqing Li
    Program of Cell Biology and Genetics, Weill Graduate School of Medical Sciences, Cornell University Medical College, New York, New York 10021, USA
    Cancer Res 64:6137-43. 2004
    ....
  19. pmc Mad2 phosphorylation regulates its association with Mad1 and the APC/C
    Katja Wassmann
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Box 241, 1275 York Avenue, New York, NY 10021, USA
    EMBO J 22:797-806. 2003
    ..These data suggest that the phosphorylation state of Mad2 regulates its checkpoint activity by modulating its association with Mad1 and the APC/C...

Research Grants18

  1. Role of Mitotic Checkpoint Defects in Mouse Tumor Models
    Robert Benezra; Fiscal Year: 2009
    ..How chromosome instability contributes to the initiation and progression of disease will be explored. These experiments should allow us to shed further light on the role of mitotic checkpoint abnormalities in human disease. ..
  2. Role of Mitotic Checkpoint Defects in Mouse Tumor Models
    Robert Benezra; Fiscal Year: 2007
    ..How chromosome instability contributes to the initiation and progression of disease will be explored. These experiments should allow us to shed further light on the role of mitotic checkpoint abnormalities in human disease. ..
  3. Id proteins & neovascularization of spontaneous tumors
    Robert Benezra; Fiscal Year: 2007
    ..These studies will further our understanding of the role of Id proteins in postnatal angiogenesis and more generally the molecular mechanisms of neoangiogenesis in spontaneous tumors. ..
  4. Role of Mitotic Checkpoint Defects in Mouse Tumor Models
    Robert Benezra; Fiscal Year: 2006
    ..How chromosome instability contributes to the initiation and progression of disease will be explored. These experiments should allow us to shed further light on the role of mitotic checkpoint abnormalities in human disease. ..
  5. Id proteins & neovascularization of spontaneous tumors
    Robert Benezra; Fiscal Year: 2006
    ..These studies will further our understanding of the role of Id proteins in postnatal angiogenesis and more generally the molecular mechanisms of neoangiogenesis in spontaneous tumors. ..
  6. Id proteins & neovascularization of spontaneous tumors
    Robert Benezra; Fiscal Year: 2005
    ..These studies will further our understanding of the role of Id proteins in postnatal angiogenesis and more generally the molecular mechanisms of neoangiogenesis in spontaneous tumors. ..
  7. Id proteins & neovascularization of spontaneous tumors
    Robert Benezra; Fiscal Year: 2004
    ..These studies will further our understanding of the role of Id proteins in postnatal angiogenesis and more generally the molecular mechanisms of neoangiogenesis in spontaneous tumors. ..
  8. MITOTIC CHECKPOINT GENE MAD2 IN VERTEBRATES
    Robert Benezra; Fiscal Year: 2004
    ..In this way, the role of the mitotic checkpoint pathway in cancer initiation and/or progression in mammals will be assessed. ..
  9. MITOTIC CHECKPOINT GENE MAD2 IN VERTEBRATES
    Robert Benezra; Fiscal Year: 2003
    ..In this way, the role of the mitotic checkpoint pathway in cancer initiation and/or progression in mammals will be assessed. ..
  10. MITOTIC CHECKPOINT GENE MAD2 IN VERTEBRATES
    Robert Benezra; Fiscal Year: 2002
    ..In this way, the role of the mitotic checkpoint pathway in cancer initiation and/or progression in mammals will be assessed. ..
  11. MITOTIC CHECKPOINT GENE MAD2 IN VERTEBRATES
    Robert Benezra; Fiscal Year: 2001
    ..In this way, the role of the mitotic checkpoint pathway in cancer initiation and/or progression in mammals will be assessed. ..
  12. HUMAN MITOTIC CHECKPOINT GENE--HSMAD2
    Robert Benezra; Fiscal Year: 2000
    ..In addition, MAD2 will be disrupted in both ES cells and mice to determine the contribution made by MAD2 to mitotic checkpoint control in mammalian cells. ..
  13. HUMAN MITOTIC CHECKPOINT GENE--HSMAD2
    Robert Benezra; Fiscal Year: 1999
    ..In addition, MAD2 will be disrupted in both ES cells and mice to determine the contribution made by MAD2 to mitotic checkpoint control in mammalian cells. ..
  14. Role of Mitotic Checkpoint Defects in Mouse Tumor Models
    ROBERT I BENEZRA; Fiscal Year: 2010
    ..How chromosome instability contributes to the initiation and progression of disease will be explored. These experiments should allow us to shed further light on the role of mitotic checkpoint abnormalities in human disease. ..