Colin Begg

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc Evaluating cancer epidemiologic risk factors using multiple primary malignancies
    Ekatherina Kuligina
    N N Petrov Institute of Oncology, Russian Federation, St Petersburg, Russia
    Epidemiology 21:366-72. 2010
  2. pmc Detecting and exploiting etiologic heterogeneity in epidemiologic studies
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Am J Epidemiol 176:512-8. 2012
  3. pmc One statistical test is sufficient for assessing new predictive markers
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 44, New York, NY 10065 USA
    BMC Med Res Methodol 11:13. 2011
  4. ncbi request reprint Impact of hospital volume on operative mortality for major cancer surgery
    C B Begg
    Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    JAMA 280:1747-51. 1998
  5. pmc Statistical tests for clonality
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd Street, Room 303, New York, New York 10021, USA
    Biometrics 63:522-30. 2007
  6. ncbi request reprint On the use of familial aggregation in population-based case probands for calculating penetrance
    Colin B Begg
    Memororial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 94:1221-6. 2002
  7. ncbi request reprint A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Epidemiol 35:756-64. 2006
  8. ncbi request reprint Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 97:1507-15. 2005
  9. ncbi request reprint The mammography controversy
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Oncologist 7:174-6. 2002
  10. ncbi request reprint Systematic reviews of diagnostic accuracy studies require study by study examination: first for heterogeneity, and then for sources of heterogeneity
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer, Center 1275 York Avenue, New York, NY 10021, USA
    J Clin Epidemiol 58:865-6. 2005

Detail Information

Publications67

  1. pmc Evaluating cancer epidemiologic risk factors using multiple primary malignancies
    Ekatherina Kuligina
    N N Petrov Institute of Oncology, Russian Federation, St Petersburg, Russia
    Epidemiology 21:366-72. 2010
    ..We explore these assumptions theoretically and empirically using published data from breast cancer studies involving bilateral breast cancer...
  2. pmc Detecting and exploiting etiologic heterogeneity in epidemiologic studies
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Am J Epidemiol 176:512-8. 2012
    ..The concepts are illustrated by using data from a breast cancer study in which results are available separately for estrogen receptor-positive (ER+) and -negative (ER-) tumors...
  3. pmc One statistical test is sufficient for assessing new predictive markers
    Andrew J Vickers
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 44, New York, NY 10065 USA
    BMC Med Res Methodol 11:13. 2011
    ..These two steps often lead to discordant conclusions...
  4. ncbi request reprint Impact of hospital volume on operative mortality for major cancer surgery
    C B Begg
    Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    JAMA 280:1747-51. 1998
    ....
  5. pmc Statistical tests for clonality
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd Street, Room 303, New York, New York 10021, USA
    Biometrics 63:522-30. 2007
    ..Nonetheless, we conclude that the method represents a simple, powerful strategy for distinguishing independent tumors from those of clonal origin...
  6. ncbi request reprint On the use of familial aggregation in population-based case probands for calculating penetrance
    Colin B Begg
    Memororial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 94:1221-6. 2002
    ..To draw attention to this problem, literature on the penetrance of breast cancer in BRCA1 and BRCA2 carriers is reviewed...
  7. ncbi request reprint A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Epidemiol 35:756-64. 2006
    ..The use of a novel case-control design in which cases have second primaries and controls are cancer survivors has been proposed for this purpose...
  8. ncbi request reprint Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 97:1507-15. 2005
    ..In this study, we examined lifetime melanoma risk among CDKN2A mutation carriers using carriers who were identified in a population-based study of melanoma...
  9. ncbi request reprint The mammography controversy
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Oncologist 7:174-6. 2002
  10. ncbi request reprint Systematic reviews of diagnostic accuracy studies require study by study examination: first for heterogeneity, and then for sources of heterogeneity
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer, Center 1275 York Avenue, New York, NY 10021, USA
    J Clin Epidemiol 58:865-6. 2005
  11. ncbi request reprint Variations in morbidity after radical prostatectomy
    Colin B Begg
    Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    N Engl J Med 346:1138-44. 2002
    ..Recent studies of surgery for cancer have demonstrated variations in outcomes among hospitals and among surgeons. We sought to examine variations in morbidity after radical prostatectomy for prostate cancer...
  12. pmc A strategy for distinguishing optimal cancer subtypes
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 East 63rd Street, New York, NY 10065, USA
    Int J Cancer 129:931-7. 2011
    ..The high concordance of ER status is consistent with a growing literature demonstrating the etiologic distinctiveness of ER+ and ER- tumors...
  13. pmc The search for cancer risk factors: when can we stop looking?
    C B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 44, New York, NY 10021, USA
    Am J Public Health 91:360-4. 2001
    ..The implications of these ideas for research strategy and for public health policy are discussed...
  14. pmc Variation of breast cancer risk among BRCA1/2 carriers
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    JAMA 299:194-201. 2008
    ..The risk of breast cancer in BRCA1 and BRCA2 mutation carriers has been examined in many studies, but relatively little attention has been paid to the degree to which the risk may vary among carriers...
  15. ncbi request reprint The effect of clustering of outcomes on the association of procedure volume and surgical outcomes
    Katherine S Panageas
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Ann Intern Med 139:658-65. 2003
    ....
  16. pmc Variations among high volume surgeons in the rate of complications after radical prostatectomy: further evidence that technique matters
    Fernando J Bianco
    Departments of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Urol 173:2099-103. 2005
    ..While better outcomes are associated with high volume surgeons, the degree of variation in outcomes among surgeons has not been fully examined...
  17. pmc Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study
    Jonine L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 E 63rd St Fl 3, New York, NY 10065, USA
    J Natl Cancer Inst 102:475-83. 2010
    ..We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women...
  18. ncbi request reprint Polymorphisms in nucleotide excision repair genes and risk of multiple primary melanoma: the Genes Environment and Melanoma Study
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Carcinogenesis 27:610-8. 2006
    ..ORs for XPD and XPC genotypes were stronger for melanoma diagnosed at an early age, but tests for interaction were not statistically significant. The results provide further evidence for a role of XPD in the etiology of melanoma...
  19. pmc Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers
    Nicolas Girard
    Pao Lab, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 15:5184-90. 2009
    ..Decisions are currently made using the Martini and Melamed criteria, which are mostly based on tumor location and histologic type. New genomic tools could improve the ability to assess tumor clonality...
  20. ncbi request reprint Adjuvant chemotherapy use for Medicare beneficiaries with stage II colon cancer
    Deborah Schrag
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:3999-4005. 2002
    ..Nevertheless, patients may receive this treatment despite its uncertain benefit. The objective of this study was to determine the extent to which adjuvant chemotherapy is used for patients with stage II colon cancer...
  21. doi request reprint Physician visits prior to treatment for clinically localized prostate cancer
    Thomas L Jang
    Department of Surgery, Sidney Kimmel Center for Prostate and Urologic Cancers, New York, New York, USA
    Arch Intern Med 170:440-50. 2010
    ..We evaluated how visits to specialists and primary care physicians (PCPs) by men with localized prostate cancer are related to treatment choice...
  22. pmc The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanoma
    Marinela Capanu
    Memorial Sloan Kettering Cancer Center, 307 E 63rd Street, New York, NY 10021, U S A
    Stat Med 27:1973-92. 2008
    ..However, further research is needed to validate the application of asymptotic methods to such sparse data...
  23. ncbi request reprint The effect of changes in tumor size on breast carcinoma survival in the U.S.: 1975-1999
    Elena B Elkin
    Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer 104:1149-57. 2005
    ..The objective of the current study was to characterize within-stage migration of tumor size in breast carcinoma, and to estimate the effect of this shift on reported breast carcinoma survival...
  24. ncbi request reprint Properties of analysis methods that account for clustering in volume-outcome studies when the primary predictor is cluster size
    Katherine S Panageas
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Stat Med 26:2017-35. 2007
    ..By contrast, the cluster weighted GEE method is inefficient...
  25. ncbi request reprint CDKN2A germline mutations in individuals with cutaneous malignant melanoma
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Invest Dermatol 127:1234-43. 2007
    ..With the exception of the variant in position -34 of CDKN2A of known functional consequence, the remaining rare variants in the non-coding region have no apparent impact on risk...
  26. pmc Estimating the empirical Lorenz curve and Gini coefficient in the presence of error with nested data
    Chaya S Moskowitz
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 307 East 63rd Street, 3rd Floor, New York, NY 10021, USA
    Stat Med 27:3191-208. 2008
    ..This work is motivated by a health outcomes application that seeks to assess the concentration of black patient visits among primary care physicians. The methods are illustrated on data from this study...
  27. pmc Sun protection and skin self-examination in melanoma survivors
    Urvi J Mujumdar
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Psychooncology 18:1106-15. 2009
    ..Skin self-examination (SSE) and sun protection are standard clinical recommendations to minimize risk. In this study we examined performance of these behaviors in individuals with melanoma drawn from the general population...
  28. doi request reprint DNA damage and repair capacity in patients with lung cancer: prediction of multiple primary tumors
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 26:3560-6. 2008
    ..Therefore, we evaluated constitutive and induced DNA damage, and repair capacity, in patients with multiple NSCLCs (cases) and compared the results to those obtained in patients with a single NSCLC (controls)...
  29. pmc Comparison of properties of tests for assessing tumor clonality
    Irina Ostrovnaya
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Biometrics 64:1018-22. 2008
    ..Much of the efficiency deficit can be recovered, however, by restricting the allelic imbalance parameter estimate to a prespecified range, assuming that this parameter is in the prespecified range...
  30. pmc Disenrollment from Medicare managed care among beneficiaries with and without a cancer diagnosis
    Elena B Elkin
    Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 44, New York, NY 10021, USA
    J Natl Cancer Inst 100:1013-21. 2008
    ..We compared rates of voluntary disenrollment from Medicare managed care to traditional fee-for-service Medicare among Medicare managed care enrollees with and without a cancer diagnosis...
  31. ncbi request reprint Cystectomy for muscle-invasive bladder cancer: patterns and outcomes of care in the Medicare population
    Deborah Schrag
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Urology 65:1118-25. 2005
    ..To describe the population-based patterns of care among patients with muscle-invasive bladder cancer...
  32. ncbi request reprint Variation of serum prostate-specific antigen levels: an evaluation of year-to-year fluctuations
    James A Eastham
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    JAMA 289:2695-700. 2003
    ..While PSA testing has resulted in an increase in prostate cancer detection, its routine use has been questioned because of a lack of specificity...
  33. ncbi request reprint Surgeon volume compared to hospital volume as a predictor of outcome following primary colon cancer resection
    Deborah Schrag
    Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Surg Oncol 83:68-78; discussion 78-9. 2003
    ..However, the importance of surgeon case volume as a determinant of outcome has been less well studied, and it is unclear whether hospital or surgeon volume is the more powerful predictor of outcomes...
  34. ncbi request reprint Adherence to surveillance among patients with superficial bladder cancer
    Deborah Schrag
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 95:588-97. 2003
    ..We examined the degree to which bladder cancer patients undergo the recommended surveillance procedures and identified patient and primary care provider characteristics associated with nonadherence to these recommendations...
  35. pmc Hospital and surgeon procedure volume as predictors of outcome following rectal cancer resection
    Deborah Schrag
    Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Department of Medicine, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 236:583-92. 2002
    ..To compare surgeon and hospital procedure volume as predictors of outcomes for patients with rectal cancer...
  36. ncbi request reprint Lack of effect of a low-fat, high-fruit, -vegetable, and -fiber diet on serum prostate-specific antigen of men without prostate cancer: results from a randomized trial
    Moshe Shike
    Memorial Sloan Kettering Cancer Center, New York, NY, and National Cancer Institute, Bethesda, MD
    J Clin Oncol 20:3592-8. 2002
    ..To determine whether a diet low in fat and high in fruits, vegetables, and fiber may be protective against prostate cancer by having an impact on serial levels of serum prostate-specific antigen (PSA)...
  37. ncbi request reprint Variations among individual surgeons in the rate of positive surgical margins in radical prostatectomy specimens
    James A Eastham
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Urol 170:2292-5. 2003
    ..We examined variations in the rate of positive surgical margins among surgeons after controlling for the severity of disease and volume of cases per surgeon...
  38. ncbi request reprint Two-stage designs for gene-disease association studies with sample size constraints
    Jaya M Satagopan
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Biometrics 60:589-97. 2004
    ....
  39. ncbi request reprint Variations in lung cancer risk among smokers
    Peter B Bach
    The Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Natl Cancer Inst 95:470-8. 2003
    ..We sought to determine whether the risk of lung cancer varies predictably among smokers...
  40. ncbi request reprint Two-stage designs for gene-disease association studies
    Jaya M Satagopan
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Biometrics 58:163-70. 2002
    ..This translates to screening all the markers on approximately one quarter of the required sample size in stage 1...
  41. ncbi request reprint Reporting participation in case-control studies
    Sara H Olson
    Department of Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Epidemiology 13:123-6. 2002
    ..Standardized reporting will allow an evaluation of the success of various methods in recruiting potential participants, and will contribute important information for assessing the validity of individual studies...
  42. ncbi request reprint Familial aggregation of melanoma risks in a large population-based sample of melanoma cases
    Colin B Begg
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Causes Control 15:957-65. 2004
    ..In this study we use information from a large series of incident cases of melanoma from an international population-based study to examine the patterns of incidence of melanoma in the first-degree relatives of these cases...
  43. ncbi request reprint Benchmarking lung cancer mortality rates in current and former smokers
    Peter B Bach
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 221, New York, NY 10021, USA
    Chest 126:1742-9. 2004
    ..The model is intended for use in analyzing a population of subjects who are undergoing lung cancer screening or receiving lung cancer chemoprevention, to determine whether the intervention has altered lung cancer mortality...
  44. ncbi request reprint Resurrecting treatment histories of dead patients: a study design that should be laid to rest
    Peter B Bach
    The Health Outcomes Research Group, The Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    JAMA 292:2765-70. 2004
    ..We conclude that studying care received prior to death can lead to invalid conclusions about the quality or type of care provided to dying patients...
  45. pmc Evaluation of the clonal origin of multiple primary melanomas using molecular profiling
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Invest Dermatol 129:1972-82. 2009
    ....
  46. ncbi request reprint HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses
    Robert C Millikan
    Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 89:309-12. 2005
    ..The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer...
  47. ncbi request reprint Computed tomography screening and lung cancer outcomes
    Peter B Bach
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    JAMA 297:953-61. 2007
    ..Randomized controlled trials assessing CT screening are currently under way...
  48. pmc Testing clonal relatedness of tumors using array comparative genomic hybridization: a statistical challenge
    Irina Ostrovnaya
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 16:1358-67. 2010
    ....
  49. ncbi request reprint Survival of blacks and whites after a cancer diagnosis
    Peter B Bach
    Health Outcomes Research Group, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    JAMA 287:2106-13. 2002
    ..Yet, few studies have evaluated whether lower-quality treatment and shorter overall life expectancy due to a greater burden of other illnesses may explain the survival discrepancy...
  50. ncbi request reprint Reflections on publication criteria for genetic association studies
    Colin B Begg
    Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Epidemiol Biomarkers Prev 14:1364-5. 2005
  51. ncbi request reprint Letter to the editor of Biometrics
    Colin B Begg
    Biometrics 63:964-5; author reply 965-6. 2007
  52. ncbi request reprint Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:15-25. 2006
    ..These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer...
  53. ncbi request reprint Reflections on the landmark studies of beta-carotene supplementation
    Anna J Duffield-Lillico
    J Natl Cancer Inst 96:1729-31. 2004
  54. ncbi request reprint The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study
    Marianne Berwick
    University of New Mexico, Department of Internal Medicine, New Mexico Cancer Research Facility, MSC08 4630, Room 103A, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Cancer Epidemiol Biomarkers Prev 15:1520-5. 2006
    ..The results suggest that the relative risk of mutation carriers in the population may be lower than currently believed and that different mutations on the CDKN2A gene may confer substantially different risks of melanoma...
  55. ncbi request reprint Re: All-cause mortality in randomized trials of cancer screening
    Colin B Begg
    J Natl Cancer Inst 94:863-4; author reply 865-6. 2002
  56. ncbi request reprint Ambient UV, personal sun exposure and risk of multiple primary melanomas
    Anne Kricker
    School of Public Health, University of Sydney, Edward Ford Building A27, NSW, 2006, Australia, and Women s College Hospital, Toronto, ON, Canada
    Cancer Causes Control 18:295-304. 2007
    ..Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one melanoma...
  57. ncbi request reprint Measuring complications of cancer treatment using the SEER-Medicare data
    Arnold L Potosky
    Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892 7344, USA
    Med Care 40:IV-62-8. 2002
    ..One category of outcomes amenable to research using Medicare claims is complications of cancer treatments: the unintentional, adverse side effects or sequelae of interventions used to treat or palliate cancer patients...
  58. ncbi request reprint Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology Study
    Lisbeth Bertelsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    J Natl Cancer Inst 100:32-40. 2008
    ..However, less is known about how long the risk is reduced and the impact of factors such as age and menopausal status...
  59. ncbi request reprint Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 16:991-7. 2007
    ..The association of BRAF mutations with early-life UV exposure provides evidence in support of childhood sun protection for melanoma prevention...
  60. ncbi request reprint Kin-cohort evaluation of relative risks of genetic variants
    Catherine L Saunders
    Cancer Research UK, Genetic Epidemiology Division, University of Leeds, Leeds, UK
    Genet Epidemiol 24:220-9. 2003
    ..Genet Epidemiol 24:220-229, 2003...
  61. ncbi request reprint Taking stock of volume-outcome studies
    Colin B Begg
    J Clin Oncol 21:393-4. 2003
  62. ncbi request reprint Reproductive history and risk of second primary breast cancer: the WECARE study
    Joan A Largent
    Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, CA 92697 7555, USA
    Cancer Epidemiol Biomarkers Prev 16:906-11. 2007
    ..Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results...
  63. pmc Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
    Patrick Concannon
    Department of Biochemistry and Molecular Genetics and Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    Cancer Res 68:6486-91. 2008
    ..1-0.6; c.6348-54T>C RR, 0.2; 95% CI, 0.1-0.8]. These data suggest that some alleles of ATM may exert an antineoplastic effect, perhaps by altering the activity of ATM as an initiator of DNA damage responses or a regulator of p53...
  64. ncbi request reprint Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer Res 66:9330-7. 2006
    ....
  65. ncbi request reprint A comparison of methods to detect publication bias in meta-analysis by P. Macaskill, S. D. Walter and L. Irwig, Statistics in Medicine, 2001; 20:641-654
    Colin B Begg
    Stat Med 21:1803; author reply 1804. 2002
  66. ncbi request reprint Attribution of deaths following cancer treatment
    Colin B Begg
    J Natl Cancer Inst 94:1044-5. 2002
  67. ncbi request reprint Multiple imputation for correcting verification bias by Ofer Harel and Xiao-Hua Zhou, Statistics in Medicine 2006; 25:3769-3786
    James A Hanley
    Stat Med 26:3046-7; author reply 3047-50. 2007

Research Grants8

  1. Minicomputer Upgrade for the Clinical Resarch Database
    Colin Begg; Fiscal Year: 2002
    ..This proposal is a request for funds to upgrade the hardware platform once again to maintain the performance of the system in the face of these rapidly increasing demands. ..
  2. A Method for Validating Gene - Disease Associations
    Colin Begg; Fiscal Year: 2004
    ..abstract_text> ..
  3. Epidemiologic Parameters of Rare Cancer Risk Factors
    Colin Begg; Fiscal Year: 2005
    ..All of these aims are motivated by an international study of the genetic epidemiology of melanoma that is currently in progress. ..
  4. Statistical Methods for Identifying Clonal Tumors
    Colin B Begg; Fiscal Year: 2010
    ....
  5. Statistical Methods for Identifying Clonal Tumors
    Colin B Begg; Fiscal Year: 2011
    ....