Mary Baylies

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. ncbi request reprint Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster
    Karen Beckett
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Science at Cornell University, New York, NY 10021, USA
    Dev Biol 299:176-92. 2006
  2. pmc The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled
    Ana Carmena
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America Instituto de Neurosciencias de Alicante, Consejo Superior de Investigaciones Científicas University Miguel Hernandez, Unidad de Neurobiologia del Desarrollo, Alicante, Spain
    PLoS ONE 1:e66. 2006
  3. pmc Akirin: a context-dependent link between transcription and chromatin remodeling
    Scott J Nowak
    Department of Biology and Physics, Kennesaw State University, GA, USA
    Bioarchitecture 2:209-13. 2012
  4. pmc Akirin links twist-regulated transcription with the Brahma chromatin remodeling complex during embryogenesis
    Scott J Nowak
    Program in Developmental Biology, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Genet 8:e1002547. 2012
  5. ncbi request reprint Invertebrate myogenesis: looking back to the future of muscle development
    M K Baylies
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA
    Curr Opin Genet Dev 11:431-9. 2001
  6. ncbi request reprint The specification of muscle in Drosophila
    M K Baylies
    Molecular Biology Program, Memorial Sloan Kettering Cancer Institute, New York, New York 10021, USA
    Cold Spring Harb Symp Quant Biol 62:385-93. 1997
  7. ncbi request reprint Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development
    I Castanon
    Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Development 128:3145-59. 2001
  8. pmc Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila
    P Morcillo
    Molecular Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021 USA
    Genes Dev 11:2729-40. 1997
  9. ncbi request reprint The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2
    R Artero
    Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Science, Cornell University, 1275 York Avenue, New York, New York 10021, USA
    Dev Biol 195:131-43. 1998
  10. ncbi request reprint The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling
    R D Artero
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Development 128:4251-64. 2001

Collaborators

  • Karen Beckett
  • Ana Carmena
  • M Mlodzik
  • Marc S Halfon
  • Jose A Botella
  • H T Nguyen
  • D Dorsett
  • A Prokop
  • Alan M Michelson
  • Scott J Nowak
  • Brian E Richardson
  • Virginia T Cox
  • Irinka Castanon
  • Ming Ching Wong
  • Jose V Llorens
  • I Castanon
  • Ruben D Artero
  • Alexis Tapanes-Castillo
  • Ruben Artero
  • Hitoshi Aihara
  • R D Artero
  • Katie Gonzalez
  • Yutaka Nibu
  • Juan A Navarro
  • S Schneuwly
  • María J Martínez-Sebastián
  • María D Moltó
  • R Artero
  • Amparo Garcia-Lopez
  • Lidon Monferrer
  • P Morcillo
  • Matthew P Scott
  • Eileen E Furlong
  • S Von Stetina
  • J Kass
  • I Pueyo
  • G Begemann
  • N Paricio
  • M Perez-Alonso
  • C Rosen

Detail Information

Publications25

  1. ncbi request reprint Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster
    Karen Beckett
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Science at Cornell University, New York, NY 10021, USA
    Dev Biol 299:176-92. 2006
    ..We propose that Pcs fulfils its distinct roles during development by the regulation of multiple NRTKs...
  2. pmc The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled
    Ana Carmena
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America Instituto de Neurosciencias de Alicante, Consejo Superior de Investigaciones Científicas University Miguel Hernandez, Unidad de Neurobiologia del Desarrollo, Alicante, Spain
    PLoS ONE 1:e66. 2006
    ..We propose a model in which Cno, through those interactions, actively coordinates, at the membrane level, Ras-MAPK, N and Wg signaling pathways during progenitor specification...
  3. pmc Akirin: a context-dependent link between transcription and chromatin remodeling
    Scott J Nowak
    Department of Biology and Physics, Kennesaw State University, GA, USA
    Bioarchitecture 2:209-13. 2012
    ..This role for the Akirin protein suggests a novel regulatory mode for regulating gene expression during development...
  4. pmc Akirin links twist-regulated transcription with the Brahma chromatin remodeling complex during embryogenesis
    Scott J Nowak
    Program in Developmental Biology, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Genet 8:e1002547. 2012
    ....
  5. ncbi request reprint Invertebrate myogenesis: looking back to the future of muscle development
    M K Baylies
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA
    Curr Opin Genet Dev 11:431-9. 2001
    ..Drosophila myogenesis has become a highly informative model for understanding the interplay between the signaling and transcriptional networks that underlie cell-fate specification during embryonic development...
  6. ncbi request reprint The specification of muscle in Drosophila
    M K Baylies
    Molecular Biology Program, Memorial Sloan Kettering Cancer Institute, New York, New York 10021, USA
    Cold Spring Harb Symp Quant Biol 62:385-93. 1997
  7. ncbi request reprint Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development
    I Castanon
    Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Development 128:3145-59. 2001
    ..Moreover, this work provides a paradigm for understanding how the same protein controls a sequence of events within a single lineage...
  8. pmc Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila
    P Morcillo
    Molecular Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021 USA
    Genes Dev 11:2729-40. 1997
    ..We suggest that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions...
  9. ncbi request reprint The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2
    R Artero
    Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Science, Cornell University, 1275 York Avenue, New York, New York 10021, USA
    Dev Biol 195:131-43. 1998
    ..mbl, therefore, may act as a critical element in the execution of two Dmef2-dependent processes in the terminal differentiation of muscles...
  10. ncbi request reprint The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling
    R D Artero
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Development 128:4251-64. 2001
    ..We propose that the temporal pattern of hbs expression within fusion-competent myoblasts may reflect previously undescribed functional differences within this myoblast population...
  11. ncbi request reprint Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesis
    Ruben Artero
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Development 130:6257-72. 2003
    ..Whereas genes such as phyllopod play a crucial role during specification of particular muscles, others such as tartan are necessary for normal muscle morphogenesis...
  12. ncbi request reprint Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm
    Ana Carmena
    Program in Molecular Biology, Memorial Sloan Kettering Cancer Institute, New York, New York 10021, USA
    Dev Biol 244:226-42. 2002
    ..These reciprocal interactions combine to generate the signal thresholds that are essential for proper specification of progenitors and nonprogenitors from groups of initially equivalent cells...
  13. ncbi request reprint Causative role of oxidative stress in a Drosophila model of Friedreich ataxia
    Jose V Llorens
    Departament de Genetica, Universitat de Valencia, Carrer Doctor Moliner 50, 46100 Burjassot, Valencia, Spain
    FASEB J 21:333-44. 2007
    ..We propose that in FA, the oxidative mediated inactivation of aconitase, which occurs normally during the aging process, is enhanced due to the lack of frataxin...
  14. ncbi request reprint A Twist in fate: evolutionary comparison of Twist structure and function
    Irinka Castanon
    Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 287:11-22. 2002
    ..Conserved principles and the molecular mechanisms underlying them are discussed...
  15. ncbi request reprint Delivery of wingless to the ventral mesoderm by the developing central nervous system ensures proper patterning of individual slouch-positive muscle progenitors
    Virginia T Cox
    Program in Developmental Biology, Weill Graduate School of Medical Sciences at Cornell University and Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Dev Biol 287:403-15. 2005
    ..It also provides a means for one signaling pathway to be used reiteratively throughout development to impart unique positional and character information within a target field...
  16. ncbi request reprint Notch signaling patterns Drosophila mesodermal segments by regulating the bHLH transcription factor twist
    Alexis Tapanes-Castillo
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences at Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Development 131:2359-72. 2004
    ..Since this same cassette of Notch, Su(H) and bHLH regulators is active during vertebrate mesodermal segmentation and/or subdivision, our work suggests a conserved mechanism for Notch in early mesodermal patterning...
  17. ncbi request reprint Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling
    Virginia T Cox
    Program in Developmental Biology, Weill Graduate School of Medical Sciences at Cornell University and Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Development 132:713-24. 2005
    ..This dual requirement for Wg provides a paradigm for understanding how one signaling pathway can act over time to create a diverse array of patterning outcomes...
  18. ncbi request reprint The development of the Drosophila larval body wall muscles
    Karen Beckett
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering, Cancer Center, Weill Graduate School of Medical Science, Cornell University New York, New York 10021, USA
    Int Rev Neurobiol 75:55-70. 2006
  19. pmc Myoblast fusion in fly and vertebrates: new genes, new processes and new perspectives
    Brian E Richardson
    Sloan Kettering Institute, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
    Traffic 9:1050-9. 2008
    ..In particular, we highlight what has been learned about the requirement of a specific actin structure at the site of fusion. We also place these findings from Drosophila within the context of myoblast fusion in vertebrates...
  20. pmc Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis
    Ming Ching Wong
    Weill Graduate School of Medical Sciences, Cornell University, New York, NY, USA
    Dev Biol 317:417-29. 2008
    ..Taken together, we present evidence that the repressive activity of the Twi/Da dimer is dependent on the Da REP domain and that the activity of the REP domain is sensitive to tissue context and developmental timing...
  21. pmc SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion
    Brian E Richardson
    Program in Developmental Biology, Sloan Kettering Institute, New York, NY 10021, USA
    Development 134:4357-67. 2007
    ..Our data identify a new paradigm for understanding the mechanisms underlying fusion in myoblasts and other tissues...
  22. pmc Expression and functional analysis of a novel Fusion Competent Myoblast specific GAL4 driver
    Karen Beckett
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene Expr Patterns 8:87-91. 2008
    ..This novel GAL4 driver will provide a useful reagent to study Drosophila myoblast fusion and muscle differentiation...
  23. pmc 3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion
    Karen Beckett
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Dev Biol 309:113-25. 2007
    ..5 h. Altogether, our data have led us to propose a new model of myoblast fusion where the frequency of myoblast fusion events may be influenced by the spatial arrangements of FCs and FCMs...
  24. ncbi request reprint Serpent and a hibris reporter are co-expressed in migrating cells during Drosophila hematopoiesis and Malpighian tubule formation
    Ruben D Artero
    Laboratory of Developmental Genetics, Dept of Genetics, University of Valencia, Dr Moliner 50, ES 46100 Burjasot, Spain
    Hereditas 143:117-22. 2006
    ..We also show that hibris function is not essential for prohemocyte migration out of the procephalic mesoderm NOR maintenance of Serpent expression in prohemocytes...

Research Grants13

  1. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary Baylies; Fiscal Year: 2009
    ..An essential model of myoblast fusion will be developed using the strengths of two model systems, Drosophila and the mouse C2C12 myoblasts. ..
  2. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary Baylies; Fiscal Year: 2009
    ....
  3. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary Baylies; Fiscal Year: 2007
    ....
  4. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2007
    ..Our work in Drosophila on the mechanisms and targets of these regulators' action will provide insight as to the underlying causes of these diseases and will help to reveal potential therapies. ..
  5. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2003
    ..Indeed, mutations in homologues of Twist, Wg, and N in mouse and human lead to developmental abnormalities and our work will have a direct impact on understanding these defects and diseases. ..
  6. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....