Research Topics
Genomes and GenesSpecies | Mary BayliesSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
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Detail Information
Publications
Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogasterKaren Beckett
Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Science at Cornell University, New York, NY 10021, USA
Dev Biol 299:176-92. 2006..We propose that Pcs fulfils its distinct roles during development by the regulation of multiple NRTKs...
The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and DishevelledAna Carmena
Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America Instituto de Neurosciencias de Alicante, Consejo Superior de Investigaciones Científicas University Miguel Hernandez, Unidad de Neurobiologia del Desarrollo, Alicante, Spain
PLoS ONE 1:e66. 2006..We propose a model in which Cno, through those interactions, actively coordinates, at the membrane level, Ras-MAPK, N and Wg signaling pathways during progenitor specification...- Invertebrate myogenesis: looking back to the future of muscle developmentM K Baylies
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA
Curr Opin Genet Dev 11:431-9. 2001..Drosophila myogenesis has become a highly informative model for understanding the interplay between the signaling and transcriptional networks that underlie cell-fate specification during embryonic development... - The specification of muscle in DrosophilaM K Baylies
Molecular Biology Program, Memorial Sloan-Kettering Cancer Institute, New York, New York 10021, USA
Cold Spring Harb Symp Quant Biol 62:385-93. 1997 - Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm developmentI Castanon
Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Development 128:3145-59. 2001..Moreover, this work provides a paradigm for understanding how the same protein controls a sequence of events within a single lineage... 
Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in DrosophilaP Morcillo
Molecular Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, New York 10021 USA
Genes Dev 11:2729-40. 1997..We suggest that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions...- The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2R Artero
Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Science, Cornell University, 1275 York Avenue, New York, New York 10021, USA
Dev Biol 195:131-43. 1998..mbl, therefore, may act as a critical element in the execution of two Dmef2-dependent processes in the terminal differentiation of muscles... - The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signalingR D Artero
Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Development 128:4251-64. 2001..We propose that the temporal pattern of hbs expression within fusion-competent myoblasts may reflect previously undescribed functional differences within this myoblast population... - Notch and Ras signaling pathway effector genes expressed in fusion competent and founder cells during Drosophila myogenesisRuben Artero
Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Development 130:6257-72. 2003..Whereas genes such as phyllopod play a crucial role during specification of particular muscles, others such as tartan are necessary for normal muscle morphogenesis... - Causative role of oxidative stress in a Drosophila model of Friedreich ataxiaJose V Llorens
Departament de Genetica, Universitat de Valencia, Carrer Doctor Moliner 50, 46100 Burjassot, Valencia, Spain
FASEB J 21:333-44. 2007..We propose that in FA, the oxidative mediated inactivation of aconitase, which occurs normally during the aging process, is enhanced due to the lack of frataxin... - Delivery of wingless to the ventral mesoderm by the developing central nervous system ensures proper patterning of individual slouch-positive muscle progenitorsVirginia T Cox
Program in Developmental Biology, Weill Graduate School of Medical Sciences at Cornell University and Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Dev Biol 287:403-15. 2005..It also provides a means for one signaling pathway to be used reiteratively throughout development to impart unique positional and character information within a target field... - Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signalingVirginia T Cox
Program in Developmental Biology, Weill Graduate School of Medical Sciences at Cornell University and Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
Development 132:713-24. 2005..This dual requirement for Wg provides a paradigm for understanding how one signaling pathway can act over time to create a diverse array of patterning outcomes... - Notch signaling patterns Drosophila mesodermal segments by regulating the bHLH transcription factor twistAlexis Tapanes-Castillo
Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences at Cornell University, 1275 York Avenue, New York, NY 10021, USA
Development 131:2359-72. 2004..Since this same cassette of Notch, Su(H) and bHLH regulators is active during vertebrate mesodermal segmentation and/or subdivision, our work suggests a conserved mechanism for Notch in early mesodermal patterning... - A Twist in fate: evolutionary comparison of Twist structure and functionIrinka Castanon
Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Gene 287:11-22. 2002..Conserved principles and the molecular mechanisms underlying them are discussed... - Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesodermAna Carmena
Program in Molecular Biology, Memorial Sloan Kettering Cancer Institute, New York, New York 10021, USA
Dev Biol 244:226-42. 2002..These reciprocal interactions combine to generate the signal thresholds that are essential for proper specification of progenitors and nonprogenitors from groups of initially equivalent cells... - Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesisMing Ching Wong
Weill Graduate School of Medical Sciences, Cornell University, New York, NY, USA
Dev Biol 317:417-29. 2008..Taken together, we present evidence that the repressive activity of the Twi/Da dimer is dependent on the Da REP domain and that the activity of the REP domain is sensitive to tissue context and developmental timing... - SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusionBrian E Richardson
Program in Developmental Biology, Sloan Kettering Institute, New York, NY 10021, USA
Development 134:4357-67. 2007..Our data identify a new paradigm for understanding the mechanisms underlying fusion in myoblasts and other tissues... - Expression and functional analysis of a novel Fusion Competent Myoblast specific GAL4 driverKaren Beckett
Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Gene Expr Patterns 8:87-91. 2008..This novel GAL4 driver will provide a useful reagent to study Drosophila myoblast fusion and muscle differentiation... - 3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusionKaren Beckett
Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Dev Biol 309:113-25. 2007..5 h. Altogether, our data have led us to propose a new model of myoblast fusion where the frequency of myoblast fusion events may be influenced by the spatial arrangements of FCs and FCMs... - Serpent and a hibris reporter are co-expressed in migrating cells during Drosophila hematopoiesis and Malpighian tubule formationRuben D Artero
Laboratory of Developmental Genetics, Dept of Genetics, University of Valencia, Dr Moliner 50, ES 46100 Burjasot, Spain
Hereditas 143:117-22. 2006..We also show that hibris function is not essential for prohemocyte migration out of the procephalic mesoderm NOR maintenance of Serpent expression in prohemocytes... - The development of the Drosophila larval body wall musclesKaren Beckett
Program in Developmental Biology, Sloan-Kettering Institute, Memorial Sloan-Kettering, Cancer Center, Weill Graduate School of Medical Science, Cornell University New York, New York 10021, USA
Int Rev Neurobiol 75:55-70. 2006 - Myoblast fusion in fly and vertebrates: new genes, new processes and new perspectivesBrian E Richardson
Sloan Kettering Institute, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
Traffic 9:1050-9. 2008..In particular, we highlight what has been learned about the requirement of a specific actin structure at the site of fusion. We also place these findings from Drosophila within the context of myoblast fusion in vertebrates...
Research Grants
- Mechanisms Regulating Myoblast Fusion in DrosophilaMary Baylies; Fiscal Year: 2009..An essential model of myoblast fusion will be developed using the strengths of two model systems, Drosophila and the mouse C2C12 myoblasts. ..
- Mechanisms Regulating Myoblast Fusion in DrosophilaMary Baylies; Fiscal Year: 2009....
- Mechanisms Regulating Myoblast Fusion in DrosophilaMary Baylies; Fiscal Year: 2007....
- CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILAMary Baylies; Fiscal Year: 2007..Our work in Drosophila on the mechanisms and targets of these regulators' action will provide insight as to the underlying causes of these diseases and will help to reveal potential therapies. ..
- CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILAMary Baylies; Fiscal Year: 2003..Indeed, mutations in homologues of Twist, Wg, and N in mouse and human lead to developmental abnormalities and our work will have a direct impact on understanding these defects and diseases. ..
- Mechanisms Regulating Myoblast Fusion in DrosophilaMary K Baylies; Fiscal Year: 2010....