Research Topics
| Tim AhlesSummaryAffiliation: Memorial Sloan-Kettering Cancer Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
A controlled trial of methods for managing pain in primary care patients with or without co-occurring psychosocial problemsTim A Ahles
Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Ann Fam Med 4:341-50. 2006..Pain, a common reason for visits to primary care physicians, is often not well managed. The objective of this study was to determine the effectiveness of pain management interventions suitable for primary care physicians...
Cancer- and cancer treatment-associated cognitive change: an update on the state of the scienceTim A Ahles
Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
J Clin Oncol 30:3675-86. 2012....- Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserveTim A Ahles
Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
J Clin Oncol 28:4434-40. 2010..To examine the impact of age and cognitive reserve on cognitive functioning in patients with breast cancer who are receiving adjuvant treatments... - Cognitive function in breast cancer patients prior to adjuvant treatmentTim A Ahles
Department of Psychiatry and Center for Psycho Oncology, The Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center Lebanon, Lebanon, NH, USA
Breast Cancer Res Treat 110:143-52. 2008..To compare the neuropsychological functioning of breast cancer patients with invasive cancer and noninvasive cancer prior to adjuvant treatment... - Candidate mechanisms for chemotherapy-induced cognitive changesTim A Ahles
Department of Psychiatry and Behavioural Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Nat Rev Cancer 7:192-201. 2007.... 
Psychometric update of the Functional Interference Estimate: a brief measure of pain functional interferenceRobert J Ferguson
Department of Psychiatry, Behavioral Medicine Section, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
J Pain Symptom Manage 28:389-95. 2004..g., SF-36 and Dartmouth COOP Charts). Because of its brevity and flexibility, the FIE may be a useful self-report measure of pain functional interference in clinical research on pain...- Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphomaTim A Ahles
Department of Psychiatry and Center for Psycho Oncology Research, New Hampshire Hospital, Concord, NH, USA
J Clin Oncol 20:485-93. 2002..The primary purpose of this study was to compare the neuropsychologic functioning of long-term survivors of breast cancer and lymphoma who had been treated with standard-dose systemic chemotherapy or local therapy only... - Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatmentsThomas W McAllister
Department of Psychiatry, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Curr Psychiatry Rep 6:364-71. 2004..Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described... - Breast cancer chemotherapy-related cognitive dysfunctionTim A Ahles
1Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Clin Breast Cancer 3:S84-90. 2002..techniques and the development of animal models to study the mechanisms of chemotherapy-induced changes in cognitive functioning, and the development of interventions to prevent or reduce the negative cognitive effects of chemotherapy.. - Low neuropsychologic performance among adult cancer survivors treated with chemotherapyRobert J Ferguson
Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
Curr Neurol Neurosci Rep 3:215-22. 2003..Future research directions, with emphasis on longitudinal research design as well as treatment implications, are discussed... - Cognitive adverse effects of chemotherapy in breast cancer patientsDenise D Correa
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York 10022, USA
Curr Opin Support Palliat Care 1:57-62. 2007..This article reviews the most recent literature on chemotherapy-associated cognitive changes in women with breast cancer... - Neurocognitive changes in cancer survivorsDenise D Correa
Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
Cancer J 14:396-400. 2008.... - Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectivesAndrew J Saykin
Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
Semin Clin Neuropsychiatry 8:201-16. 2003..Large-scale prospective studies are needed to help isolate the pathophysiological mechanisms underlying the cognitive deficits associated with chemotherapy... - Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypesChantel D Sloan
Department of Genetics and Community and Family Medicine, Computational Genetics Laboratory, Dartmouth Medical School, Lebanon, New Hampshire, USA
Am J Med Genet B Neuropsychiatr Genet 153:1060-9. 2010..The results are consistent with polygenic influences on early neurodegenerative changes and demonstrate the effectiveness of hierarchical clustering in identifying genetic associations among multiple related phenotypic endpoints... - Quality of life of long-term survivors of breast cancer and lymphoma treated with standard-dose chemotherapy or local therapyTim A Ahles
Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
J Clin Oncol 23:4399-405. 2005..This study compared the quality of life (QOL) of long-term survivors of breast cancer and lymphoma who had been treated with standard-dose systemic chemotherapy or local therapy only... - Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: the Project ENABLE II randomized controlled trialMarie Bakitas
Department of Anesthesiology, Section of Palliative Medicine, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
JAMA 302:741-9. 2009..There are few randomized controlled trials on the effectiveness of palliative care interventions to improve the care of patients with advanced cancer... - Reliability and validity of the Functional Assessment of Chronic Illness Therapy-Palliative care (FACIT-Pal) scaleKathleen Doyle Lyons
Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA
J Pain Symptom Manage 37:23-32. 2009..40, P<0.001). The findings support the internal consistency reliability and validity of the FACIT-Pal as a measure of health-related quality of life for persons with advanced cancer... - Improving pain relief in a rural cancer centerTammy E Baltic
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Cancer Pract 10:S39-44. 2002..Using a quality improvement approach rather than a traditional didactic approach, and fostering communication, trust, and collegiality at our outreach sites were pivotal to our success... - Sensitivity and specificity of the Distress Thermometer for depression in newly diagnosed breast cancer patientsMark T Hegel
Department of Psychiatry, Dartmouth Hitchcock MedicalCenter, Lebanon, NH 03756, USA
Psychooncology 17:556-60. 2008..This study evaluated the receiver operating characteristics (ROC) of the single-item Distress Thermometer (DT) for detecting depression in women newly diagnosed with Stage I-III breast cancer... - Palliative care program effectiveness research: developing rigor in sampling design, conduct, and reportingMarie A Bakitas
Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, and Yale University, New Haven, Connecticut, USA
J Pain Symptom Manage 31:270-84. 2006.... - Ongoing distress from emotional trauma is related to pain, mood, and physical function in a primary care populationJanette L Seville
Department of Psychiatry, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
J Pain Symptom Manage 25:256-63. 2003..However, the report that one continued to be bothered by thoughts of a trauma was associated with greater impairments in functioning... - Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancerMark T Hegel
Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA
Cancer 107:2924-31. 2006..Emotional distress and psychiatric syndromes are prevalent in the breast cancer population at large. However, to date there is a paucity of literature specifically concerning presurgical breast cancer patients... - Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480Tim A Ahles
Norris Cotton Cancer Center, Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
Cancer 101:2202-8. 2004..The primary purpose of the current study was to evaluate whether there was evidence of palliative effects associated with suramin at any of the three doses administered in the original clinical trial... - Cognitive-behavioral management of chemotherapy-related cognitive changeRobert J Ferguson
Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA
Psychooncology 16:772-7. 2007..Given these results, the treatment appears to be a feasible and practical cognitive-behavioral program that warrants continued evaluation among cancer survivors who experience persistent cognitive dysfunction... - Cognitive impairment associated with chemotherapy for cancer: report of a workshopIan F Tannock
Department of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada
J Clin Oncol 22:2233-9. 2004.... - The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapyTim A Ahles
Department of Psychiatry and Center for Psycho Oncology Research, USA
Psychooncology 12:612-9. 2003.... - Partner-guided cancer pain management at the end of life: a preliminary studyFrancis J Keefe
Duke University Medical Center, Durham, North Carolina 27710, USA
J Pain Symptom Manage 29:263-72. 2005..Given the significance of pain at the end of life, future research in this area appears warranted... - Do systemic cancer treatments affect cognitive function?Tim A Ahles
Lancet Oncol 5:270-1. 2004 - Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapyRobert J Ferguson
Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA
J Clin Oncol 25:3866-70. 2007..Late cognitive effects after chemotherapy can have a deleterious impact on survivor quality of life and functional health; however, the etiology of chemotherapy-related cognitive dysfunction remains unknown... - The self-efficacy of family caregivers for helping cancer patients manage pain at end-of-lifeFrancis J Keefe
Pain Prevention and Treatment Research, Box 3159, Duke University Medical Center, Durham, NC 27710, USA
Pain 103:157-62. 2003..Considered overall, the results of this study suggest that caregiver self-efficacy in pain management is important in understanding how caregivers adjust to the demands of caring for cancer patients who have pain at the end of life... - Proxy perspectives regarding end-of-life care for persons with cancerMarie Bakitas
School of Nursing, Yale University, New Haven, Connecticut, USA
Cancer 112:1854-61. 2008..Family proxies have been proposed as valuable informants regarding the quality of end-of-life care. This article describes family proxy perspectives concerning care at the end of life in patients who died of advanced cancer... - Effect of dose-intensive chemotherapy on quality of lifeTim A Ahles
Lancet Oncol 6:258-9. 2005
Research Grants
- Cognitive Effects of Cancer ChemotherapyTim Ahles; Fiscal Year: 2005..post-menopausal at diagnosis), and use of tamoxifen (breast cancer only). ..
- Improving Palliative Care for Patients with CancerTim Ahles; Fiscal Year: 2005....