Tim Ahles

Summary

Affiliation: Memorial Sloan-Kettering Cancer Center
Country: USA

Publications

  1. pmc A controlled trial of methods for managing pain in primary care patients with or without co-occurring psychosocial problems
    Tim A Ahles
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Ann Fam Med 4:341-50. 2006
  2. pmc Brain vulnerability to chemotherapy toxicities
    Tim A Ahles
    Neurocognitive Research laboratory, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Psychooncology 21:1141-8. 2012
  3. pmc Cancer- and cancer treatment-associated cognitive change: an update on the state of the science
    Tim A Ahles
    Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
    J Clin Oncol 30:3675-86. 2012
  4. pmc Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve
    Tim A Ahles
    Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
    J Clin Oncol 28:4434-40. 2010
  5. pmc Cognitive function in breast cancer patients prior to adjuvant treatment
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology, The Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center Lebanon, Lebanon, NH, USA
    Breast Cancer Res Treat 110:143-52. 2008
  6. pmc Candidate mechanisms for chemotherapy-induced cognitive changes
    Tim A Ahles
    Department of Psychiatry and Behavioural Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Rev Cancer 7:192-201. 2007
  7. ncbi request reprint Psychometric update of the Functional Interference Estimate: a brief measure of pain functional interference
    Robert J Ferguson
    Department of Psychiatry, Behavioral Medicine Section, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Pain Symptom Manage 28:389-95. 2004
  8. ncbi request reprint Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, New Hampshire Hospital, Concord, NH, USA
    J Clin Oncol 20:485-93. 2002
  9. ncbi request reprint Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments
    Thomas W McAllister
    Department of Psychiatry, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Curr Psychiatry Rep 6:364-71. 2004
  10. ncbi request reprint Low neuropsychologic performance among adult cancer survivors treated with chemotherapy
    Robert J Ferguson
    Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Curr Neurol Neurosci Rep 3:215-22. 2003

Research Grants

Detail Information

Publications34

  1. pmc A controlled trial of methods for managing pain in primary care patients with or without co-occurring psychosocial problems
    Tim A Ahles
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Ann Fam Med 4:341-50. 2006
    ..Pain, a common reason for visits to primary care physicians, is often not well managed. The objective of this study was to determine the effectiveness of pain management interventions suitable for primary care physicians...
  2. pmc Brain vulnerability to chemotherapy toxicities
    Tim A Ahles
    Neurocognitive Research laboratory, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Psychooncology 21:1141-8. 2012
    ..Models of aging are also reviewed in support of the proposal that cognitive changes associated with cancer and cancer treatments can be viewed in the context of factors that affect the trajectory of normal aging...
  3. pmc Cancer- and cancer treatment-associated cognitive change: an update on the state of the science
    Tim A Ahles
    Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
    J Clin Oncol 30:3675-86. 2012
    ....
  4. pmc Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve
    Tim A Ahles
    Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
    J Clin Oncol 28:4434-40. 2010
    ..To examine the impact of age and cognitive reserve on cognitive functioning in patients with breast cancer who are receiving adjuvant treatments...
  5. pmc Cognitive function in breast cancer patients prior to adjuvant treatment
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology, The Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center Lebanon, Lebanon, NH, USA
    Breast Cancer Res Treat 110:143-52. 2008
    ..To compare the neuropsychological functioning of breast cancer patients with invasive cancer and noninvasive cancer prior to adjuvant treatment...
  6. pmc Candidate mechanisms for chemotherapy-induced cognitive changes
    Tim A Ahles
    Department of Psychiatry and Behavioural Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Rev Cancer 7:192-201. 2007
    ....
  7. ncbi request reprint Psychometric update of the Functional Interference Estimate: a brief measure of pain functional interference
    Robert J Ferguson
    Department of Psychiatry, Behavioral Medicine Section, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Pain Symptom Manage 28:389-95. 2004
    ..g., SF-36 and Dartmouth COOP Charts). Because of its brevity and flexibility, the FIE may be a useful self-report measure of pain functional interference in clinical research on pain...
  8. ncbi request reprint Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, New Hampshire Hospital, Concord, NH, USA
    J Clin Oncol 20:485-93. 2002
    ..The primary purpose of this study was to compare the neuropsychologic functioning of long-term survivors of breast cancer and lymphoma who had been treated with standard-dose systemic chemotherapy or local therapy only...
  9. ncbi request reprint Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments
    Thomas W McAllister
    Department of Psychiatry, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Curr Psychiatry Rep 6:364-71. 2004
    ..Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described...
  10. ncbi request reprint Low neuropsychologic performance among adult cancer survivors treated with chemotherapy
    Robert J Ferguson
    Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Curr Neurol Neurosci Rep 3:215-22. 2003
    ..Future research directions, with emphasis on longitudinal research design as well as treatment implications, are discussed...
  11. ncbi request reprint Breast cancer chemotherapy-related cognitive dysfunction
    Tim A Ahles
    1Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Clin Breast Cancer 3:S84-90. 2002
    ..techniques and the development of animal models to study the mechanisms of chemotherapy-induced changes in cognitive functioning, and the development of interventions to prevent or reduce the negative cognitive effects of chemotherapy..
  12. ncbi request reprint Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives
    Andrew J Saykin
    Brain Imaging Laboratory, Dartmouth Medical School, Lebanon, NH 03756, USA
    Semin Clin Neuropsychiatry 8:201-16. 2003
    ..Large-scale prospective studies are needed to help isolate the pathophysiological mechanisms underlying the cognitive deficits associated with chemotherapy...
  13. doi request reprint Neurocognitive changes in cancer survivors
    Denise D Correa
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA
    Cancer J 14:396-400. 2008
    ....
  14. ncbi request reprint Cognitive adverse effects of chemotherapy in breast cancer patients
    Denise D Correa
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York 10022, USA
    Curr Opin Support Palliat Care 1:57-62. 2007
    ..This article reviews the most recent literature on chemotherapy-associated cognitive changes in women with breast cancer...
  15. doi request reprint Association of pre-operative brain pathology with post-operative delirium in a cohort of non-small cell lung cancer patients undergoing surgical resection
    James C Root
    Memorial Sloan Kettering Cancer Center, Department of Psychiatry and Behavioral Sciences, New York, NY, USA
    Psychooncology 22:2087-94. 2013
    ..Standard of care structural magnetic resonance imaging (MRIs) from a cohort of surgical candidates prior to surgery were analyzed for white matter hyperintensities and cerebral atrophy...
  16. pmc Quality of life of long-term survivors of breast cancer and lymphoma treated with standard-dose chemotherapy or local therapy
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756, USA
    J Clin Oncol 23:4399-405. 2005
    ..This study compared the quality of life (QOL) of long-term survivors of breast cancer and lymphoma who had been treated with standard-dose systemic chemotherapy or local therapy only...
  17. pmc Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes
    Chantel D Sloan
    Department of Genetics and Community and Family Medicine, Computational Genetics Laboratory, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1060-9. 2010
    ..The results are consistent with polygenic influences on early neurodegenerative changes and demonstrate the effectiveness of hierarchical clustering in identifying genetic associations among multiple related phenotypic endpoints...
  18. ncbi request reprint Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480
    Tim A Ahles
    Norris Cotton Cancer Center, Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer 101:2202-8. 2004
    ..The primary purpose of the current study was to evaluate whether there was evidence of palliative effects associated with suramin at any of the three doses administered in the original clinical trial...
  19. pmc Sensitivity and specificity of the Distress Thermometer for depression in newly diagnosed breast cancer patients
    Mark T Hegel
    Department of Psychiatry, Dartmouth Hitchcock MedicalCenter, Lebanon, NH 03756, USA
    Psychooncology 17:556-60. 2008
    ..This study evaluated the receiver operating characteristics (ROC) of the single-item Distress Thermometer (DT) for detecting depression in women newly diagnosed with Stage I-III breast cancer...
  20. pmc Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: the Project ENABLE II randomized controlled trial
    Marie Bakitas
    Department of Anesthesiology, Section of Palliative Medicine, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    JAMA 302:741-9. 2009
    ..There are few randomized controlled trials on the effectiveness of palliative care interventions to improve the care of patients with advanced cancer...
  21. ncbi request reprint Ongoing distress from emotional trauma is related to pain, mood, and physical function in a primary care population
    Janette L Seville
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pain Symptom Manage 25:256-63. 2003
    ..However, the report that one continued to be bothered by thoughts of a trauma was associated with greater impairments in functioning...
  22. ncbi request reprint Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer
    Mark T Hegel
    Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer 107:2924-31. 2006
    ..Emotional distress and psychiatric syndromes are prevalent in the breast cancer population at large. However, to date there is a paucity of literature specifically concerning presurgical breast cancer patients...
  23. ncbi request reprint Improving pain relief in a rural cancer center
    Tammy E Baltic
    Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer Pract 10:S39-44. 2002
    ..The purpose of this article is to describe barriers to cancer pain management and strategies for making improvements in an academic rural cancer center...
  24. ncbi request reprint Palliative care program effectiveness research: developing rigor in sampling design, conduct, and reporting
    Marie A Bakitas
    Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, and Yale University, New Haven, Connecticut, USA
    J Pain Symptom Manage 31:270-84. 2006
    ....
  25. pmc Reliability and validity of the Functional Assessment of Chronic Illness Therapy-Palliative care (FACIT-Pal) scale
    Kathleen Doyle Lyons
    Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA
    J Pain Symptom Manage 37:23-32. 2009
    ..40, P<0.001). The findings support the internal consistency reliability and validity of the FACIT-Pal as a measure of health-related quality of life for persons with advanced cancer...
  26. ncbi request reprint Do systemic cancer treatments affect cognitive function?
    Tim A Ahles
    Lancet Oncol 5:270-1. 2004
  27. ncbi request reprint Partner-guided cancer pain management at the end of life: a preliminary study
    Francis J Keefe
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Pain Symptom Manage 29:263-72. 2005
    ..Given the significance of pain at the end of life, future research in this area appears warranted...
  28. ncbi request reprint Cognitive impairment associated with chemotherapy for cancer: report of a workshop
    Ian F Tannock
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada
    J Clin Oncol 22:2233-9. 2004
    ....
  29. pmc Brain structure and function differences in monozygotic twins: possible effects of breast cancer chemotherapy
    Robert J Ferguson
    Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA
    J Clin Oncol 25:3866-70. 2007
    ..Late cognitive effects after chemotherapy can have a deleterious impact on survivor quality of life and functional health; however, the etiology of chemotherapy-related cognitive dysfunction remains unknown...
  30. pmc Cognitive-behavioral management of chemotherapy-related cognitive change
    Robert J Ferguson
    Department of Rehabilitation Medicine, Eastern Maine Medical Center, Bangor, ME 04401, USA
    Psychooncology 16:772-7. 2007
    ..Given these results, the treatment appears to be a feasible and practical cognitive-behavioral program that warrants continued evaluation among cancer survivors who experience persistent cognitive dysfunction...
  31. ncbi request reprint The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, USA
    Psychooncology 12:612-9. 2003
    ....
  32. ncbi request reprint Effect of dose-intensive chemotherapy on quality of life
    Tim A Ahles
    Lancet Oncol 6:258-9. 2005
  33. ncbi request reprint The self-efficacy of family caregivers for helping cancer patients manage pain at end-of-life
    Francis J Keefe
    Pain Prevention and Treatment Research, Box 3159, Duke University Medical Center, Durham, NC 27710, USA
    Pain 103:157-62. 2003
    ..Considered overall, the results of this study suggest that caregiver self-efficacy in pain management is important in understanding how caregivers adjust to the demands of caring for cancer patients who have pain at the end of life...
  34. pmc Proxy perspectives regarding end-of-life care for persons with cancer
    Marie Bakitas
    School of Nursing, Yale University, New Haven, Connecticut, USA
    Cancer 112:1854-61. 2008
    ..Family proxies have been proposed as valuable informants regarding the quality of end-of-life care. This article describes family proxy perspectives concerning care at the end of life in patients who died of advanced cancer...

Research Grants8

  1. Cognitive Effects of Cancer Chemotherapy
    Tim Ahles; Fiscal Year: 2005
    ..post-menopausal at diagnosis), and use of tamoxifen (breast cancer only). ..
  2. Cognitive Effects of Cancer Chemotherapy
    Tim Ahles; Fiscal Year: 2001
    ..post-menopausal at diagnosis), and use of tamoxifen (breast cancer only). ..
  3. Cognitive Effects of Cancer Chemotherapy
    Tim Ahles; Fiscal Year: 2002
    ..post-menopausal at diagnosis), and use of tamoxifen (breast cancer only). ..
  4. Improving Palliative Care for Patients with Cancer
    Tim Ahles; Fiscal Year: 2003
    ....
  5. Cognitive Effects of Cancer Chemotherapy
    Tim Ahles; Fiscal Year: 2003
    ..post-menopausal at diagnosis), and use of tamoxifen (breast cancer only). ..
  6. Improving Palliative Care for Patients with Cancer
    Tim Ahles; Fiscal Year: 2004
    ....
  7. Cognitive Effects of Cancer Chemotherapy
    Tim Ahles; Fiscal Year: 2004
    ..post-menopausal at diagnosis), and use of tamoxifen (breast cancer only). ..
  8. Improving Palliative Care for Patients with Cancer
    Tim Ahles; Fiscal Year: 2005
    ....