P D Mehta

Summary

Country: USA

Publications

  1. ncbi request reprint Amyloid beta 38, 40, and 42 species in cerebrospinal fluid: more of the same?
    Niki S Schoonenboom
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Neurol 58:139-42. 2005
  2. ncbi request reprint Increased cerebrospinal fluid A beta38/A beta42 ratio in Alzheimer disease
    Pankaj D Mehta
    Institute for Basic Research, Staten Island, NY 10314, USA
    Neurodegener Dis 2:242-5. 2005
  3. ncbi request reprint Increased amyloid beta protein levels in children and adolescents with Down syndrome
    Pankaj D Mehta
    Department of Developmental Neurobiology, Department of Infant Development, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, United States
    J Neurol Sci 254:22-7. 2007
  4. ncbi request reprint Detection of apolipoprotein E phenotype in unconcentrated cerebrospinal fluid
    P D Mehta
    Department of Immunology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    J Clin Lab Anal 17:18-21. 2003
  5. ncbi request reprint Amyloid beta protein as a marker or risk factor of Alzheimer's disease
    Pankaj D Mehta
    NY State Institute for Basic Research, Staten Island, NY 10314, USA
    Curr Alzheimer Res 4:359-63. 2007
  6. ncbi request reprint Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome
    Pankaj D Mehta
    Division of Immunology, Department of Developmental Neurobiology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 342:155-8. 2003
  7. ncbi request reprint Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease
    P D Mehta
    Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Arch Neurol 57:100-5. 2000
  8. ncbi request reprint Increased levels of tau-like protein in patients with Down syndrome
    P D Mehta
    Department of Immunology, Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Neurosci Lett 275:159-62. 1999
  9. ncbi request reprint Increased plasma amyloid beta protein 1-42 levels in Down syndrome
    P D Mehta
    Department of Immunology, New York State Institute for Basic Research, Staten Island 10314 6399, USA
    Neurosci Lett 241:13-6. 1998
  10. ncbi request reprint Increased serum neopterin levels in adults with Down syndrome
    Pankaj D Mehta
    Department of Immunology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    J Neuroimmunol 164:129-33. 2005

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Amyloid beta 38, 40, and 42 species in cerebrospinal fluid: more of the same?
    Niki S Schoonenboom
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Neurol 58:139-42. 2005
    ..All three Abeta peptides were interrelated, particularly CSF Abeta38 and Abeta40. Diagnostic accuracy of CSF Abeta42 concentrations was not improved by applying the ratios of CSF Abeta42 to Abeta38 or Abeta40...
  2. ncbi request reprint Increased cerebrospinal fluid A beta38/A beta42 ratio in Alzheimer disease
    Pankaj D Mehta
    Institute for Basic Research, Staten Island, NY 10314, USA
    Neurodegener Dis 2:242-5. 2005
    ..Our findings suggest that the increased CSF A beta38/42 ratio found in AD patients is derived entirely from reduction of CSF A beta42 levels...
  3. ncbi request reprint Increased amyloid beta protein levels in children and adolescents with Down syndrome
    Pankaj D Mehta
    Department of Developmental Neurobiology, Department of Infant Development, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, United States
    J Neurol Sci 254:22-7. 2007
    ..Inflammation might play a role in the growth of DS brains. Neopterin is an immune activation marker for the cell-mediated immune response...
  4. ncbi request reprint Detection of apolipoprotein E phenotype in unconcentrated cerebrospinal fluid
    P D Mehta
    Department of Immunology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    J Clin Lab Anal 17:18-21. 2003
    ..When the data were compared with a set of matched plasma samples, the results were identical. The method is useful for Apo E phenotyping from fresh or frozen unconcentrated CSF, when blood or plasma is not available...
  5. ncbi request reprint Amyloid beta protein as a marker or risk factor of Alzheimer's disease
    Pankaj D Mehta
    NY State Institute for Basic Research, Staten Island, NY 10314, USA
    Curr Alzheimer Res 4:359-63. 2007
    ..Due to the heterogeneity and complex nature of the disease, it is highly unlikely that that a single marker specific for AD will be found...
  6. ncbi request reprint Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome
    Pankaj D Mehta
    Division of Immunology, Department of Developmental Neurobiology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 342:155-8. 2003
    ..The higher Abeta42 levels in old DS suggests that Abeta42 is selectively increased in plasma concurrently with the development of Alzheimer disease neuropathology...
  7. ncbi request reprint Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease
    P D Mehta
    Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Arch Neurol 57:100-5. 2000
    ..However, no information is published on plasma Abeta40 and Abeta42 levels in relation to Apo E genotype or severity of dementia in sporadic AD...
  8. ncbi request reprint Increased levels of tau-like protein in patients with Down syndrome
    P D Mehta
    Department of Immunology, Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Neurosci Lett 275:159-62. 1999
    ..0001). There was no relationship between tau-like protein levels and age, gender or apolipoprotein E phenotypes in any of the five groups...
  9. ncbi request reprint Increased plasma amyloid beta protein 1-42 levels in Down syndrome
    P D Mehta
    Department of Immunology, New York State Institute for Basic Research, Staten Island 10314 6399, USA
    Neurosci Lett 241:13-6. 1998
    ..A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were higher in DS than controls or MR persons. The findings are consistent with those seen in DS brains...
  10. ncbi request reprint Increased serum neopterin levels in adults with Down syndrome
    Pankaj D Mehta
    Department of Immunology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    J Neuroimmunol 164:129-33. 2005
    ..This lack of correlation between neopterin and Abeta levels suggests that the higher neopterin concentrations in DS group reflect inflammatory cell activation rather than AD neuropathology...
  11. ncbi request reprint Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
    P D Mehta
    Department of Immunology, Institute for Basic Research in Developmental Disabilities, Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 304:102-6. 2001
    ..The data suggest that plasma ACT crosses the blood-brain barrier. However, a lack of correlation between CSF Abeta40 and Abeta42 levels with those of plasma suggests that Abeta in CSF and plasma originates from different sources...
  12. ncbi request reprint Effect of treatment on oligoclonal IgG bands and intrathecal IgG synthesis in sequential cerebrospinal fluid and serum from patients with subacute sclerosing panencephalitis
    P D Mehta
    Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314
    J Neurol Sci 109:64-8. 1992
    ..We conclude that treatment of SSPE patients with isoprinosine or with isoprinosine and alpha-interferon had no significant effect on the CSF oligoclonal band profiles or IgG synthesis within the central nervous system...
  13. ncbi request reprint Apolipoprotein E (APOE) phenotype and APOE concentrations in multiple sclerosis and acute herpes zoster
    T Pirttila
    Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    Acta Neurol Scand 102:94-8. 2000
    ..The aim of the study was to examine if apoE polymorphism or apoE levels contribute to the severity of the disease in patients with multiple sclerosis or the outcome of nerve damage in patients with herpes zoster infection...
  14. ncbi request reprint Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome
    N Schupf
    Department of Psychology and Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurosci Lett 301:199-203. 2001
    ....
  15. ncbi request reprint Alpha2 macroglobulin elevation without an acute phase response in depressed adults with Down's syndrome: implications
    J A Tsiouris
    George A Jervis Clinic, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Intellect Disabil Res 44:644-53. 2000
    ..Further studies are needed to confirm that alpha2M elevation is specific to depression and that it might provide a helpful marker for the diagnosis of depression in people with ID...
  16. ncbi request reprint Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease
    R Mayeux
    Taub Alzheimer s Disease Research Center, Staten Island, NY, USA
    Ann Neurol 46:412-6. 1999
    ....
  17. ncbi request reprint Increased levels of beta 2-microglobulin, soluble interleukin-2 receptor, and soluble CD8 in patients with subacute sclerosing panencephalitis
    P D Mehta
    Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314
    Clin Immunol Immunopathol 65:53-9. 1992
    ..In contrast, serum beta 2-M decreased during periods of worsening and increased during improvement. The measurement of serum beta 2-M and CSF sCD8 may be useful in SSPE patients as markers to monitor disease activity...
  18. pmc Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease
    Martin J Sadowski
    Department of Neurology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 103:18787-92. 2006
    ..Furthermore, behavioral studies demonstrated that treatment with Abeta12-28P prevents a memory deficit in transgenic animals. These findings provide evidence of another therapeutic approach for AD...
  19. pmc Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA
    Acta Neuropathol 113:389-402. 2007
    ....
  20. pmc Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, PO Box 16, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 64:1007-13. 2007
    ..Individuals with Down syndrome have increased levels of beta-amyloid peptides and an increased risk for AD...
  21. pmc Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaints
    Lisa Mosconi
    Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
    Biol Psychiatry 63:609-18. 2008
    ....
  22. ncbi request reprint Plasma Abeta42 correlates positively with increased body fat in healthy individuals
    Kelvin Balakrishnan
    The Sir James McCusker Alzheimer s Disease Research Unit, C Hollywood Private Hospital, Monash Avenue, Nedlands WA 6009, Australia
    J Alzheimers Dis 8:269-82. 2005
    ..Longitudinal studies involving larger cohorts are required to determine if elevated body fat may predispose individuals to AD through increasing Abeta42 levels throughout early to late adulthood...
  23. ncbi request reprint Selective reductions in plasma Abeta 1-42 in healthy elderly subjects during longitudinal follow-up: a preliminary report
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan S Kline Institute, 140 Old Orangeburg Rd, Bldg 35, Orangeburg, NY 10962, USA
    Am J Geriatr Psychiatry 13:914-7. 2005
    ..Longitudinal changes in plasma beta amyloid protein 1-42 and 1-40 (Abeta42 and Abeta40) levels and possible relationships with cognitive decline and apolipoprotein (APOE) genotype were studied in healthy elderly individuals...
  24. ncbi request reprint Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease
    Judith Miklossy
    Centre for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Neurobiol Aging 24:655-62. 2003
    ....
  25. ncbi request reprint Humoral immune response to fibrillar beta-amyloid peptide
    David L Miller
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Biochemistry 42:11682-92. 2003
    ....
  26. ncbi request reprint Luteinizing hormone levels are positively correlated with plasma amyloid-beta protein levels in elderly men
    Giuseppe Verdile
    Centre of Excellence for Alzheimer s Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia
    J Alzheimers Dis 14:201-8. 2008
    ..Larger, longitudinal human studies are needed to determine the significance of LH in the pathogenesis of AD...
  27. ncbi request reprint Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
    Anne M Cataldo
    Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neurobiol Aging 25:1263-72. 2004
    ....
  28. ncbi request reprint Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque
    J Jacob Kulstad
    Geriatric Research, Education, and Clinical Center, Veteran s Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neuropathol Exp Neurol 64:139-46. 2005
    ..These findings support the notion that glucocorticoids regulate IDE and provide a mechanism whereby increased glucocorticoid levels may contribute to AD pathology...
  29. ncbi request reprint Differences and similarities between two frequently used assays for amyloid beta 42 in cerebrospinal fluid
    Niki S M Schoonenboom
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Chem 51:1057-60. 2005
  30. ncbi request reprint Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
    ..Little solid information is available on the possible risks for neuronal injury in amateur boxing...
  31. ncbi request reprint Humoral immune responses to peptides derived from the beta-amyloid peptide C-terminal sequence
    David L Miller
    New York State Institute for Basic Research in Developmental Disabilities Staten Island, NY 10314, USA
    Amyloid 14:39-50. 2007
    ..This information is necessary to develop sensitive and specific immunoassays to quantify Abeta isoforms in brain extracts and in body fluids...
  32. ncbi request reprint Elevation in plasma Abeta42 in geriatric depression: a pilot study
    Nunzio Pomara
    Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Neurochem Res 31:341-9. 2006
    ....
  33. ncbi request reprint Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's disease
    Richard A Frank
    Pharmacia Corporation, Mailstop 134, Peapack, NJ 07977, USA
    Neurobiol Aging 24:521-36. 2003
  34. ncbi request reprint Elevated levels of serum alpha(2) macroglobulin in wild black bears during hibernation
    Ashfaq M Sheikh
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York State, NY 10314, USA
    Biochimie 85:1027-32. 2003
    ..The levels of serum alpha(2)M were significantly increased during hibernating state as compared to active state of bears indicating its protective role from the consequences of the metabolic depression during hibernation...