Research Topics
| P D MehtaSummaryCountry: USA Publications
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Detail Information
Publications
Amyloid beta 38, 40, and 42 species in cerebrospinal fluid: more of the same?Niki S Schoonenboom
Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
Ann Neurol 58:139-42. 2005..All three Abeta peptides were interrelated, particularly CSF Abeta38 and Abeta40. Diagnostic accuracy of CSF Abeta42 concentrations was not improved by applying the ratios of CSF Abeta42 to Abeta38 or Abeta40...- Increased cerebrospinal fluid A beta38/A beta42 ratio in Alzheimer diseasePankaj D Mehta
Institute for Basic Research, Staten Island, NY 10314, USA
Neurodegener Dis 2:242-5. 2005..Our findings suggest that the increased CSF A beta38/42 ratio found in AD patients is derived entirely from reduction of CSF A beta42 levels... - Increased amyloid beta protein levels in children and adolescents with Down syndromePankaj D Mehta
Department of Developmental Neurobiology, Department of Infant Development, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, United States
J Neurol Sci 254:22-7. 2007..Inflammation might play a role in the growth of DS brains. Neopterin is an immune activation marker for the cell-mediated immune response... - Detection of apolipoprotein E phenotype in unconcentrated cerebrospinal fluidP D Mehta
Department of Immunology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
J Clin Lab Anal 17:18-21. 2003..When the data were compared with a set of matched plasma samples, the results were identical. The method is useful for Apo E phenotyping from fresh or frozen unconcentrated CSF, when blood or plasma is not available... - Amyloid beta protein as a marker or risk factor of Alzheimer's diseasePankaj D Mehta
NY State Institute for Basic Research, Staten Island, NY 10314, USA
Curr Alzheimer Res 4:359-63. 2007..Due to the heterogeneity and complex nature of the disease, it is highly unlikely that that a single marker specific for AD will be found... - Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down SyndromePankaj D Mehta
Division of Immunology, Department of Developmental Neurobiology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
Neurosci Lett 342:155-8. 2003..The higher Abeta42 levels in old DS suggests that Abeta42 is selectively increased in plasma concurrently with the development of Alzheimer disease neuropathology... - Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer diseaseP D Mehta
Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
Arch Neurol 57:100-5. 2000..However, no information is published on plasma Abeta40 and Abeta42 levels in relation to Apo E genotype or severity of dementia in sporadic AD... - Increased levels of tau-like protein in patients with Down syndromeP D Mehta
Department of Immunology, Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
Neurosci Lett 275:159-62. 1999..0001). There was no relationship between tau-like protein levels and age, gender or apolipoprotein E phenotypes in any of the five groups... - Increased plasma amyloid beta protein 1-42 levels in Down syndromeP D Mehta
Department of Immunology, New York State Institute for Basic Research, Staten Island 10314 6399, USA
Neurosci Lett 241:13-6. 1998..A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were higher in DS than controls or MR persons. The findings are consistent with those seen in DS brains... - Increased serum neopterin levels in adults with Down syndromePankaj D Mehta
Department of Immunology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
J Neuroimmunol 164:129-33. 2005..This lack of correlation between neopterin and Abeta levels suggests that the higher neopterin concentrations in DS group reflect inflammatory cell activation rather than AD neuropathology... - Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer diseaseP D Mehta
Department of Immunology, Institute for Basic Research in Developmental Disabilities, Forest Hill Road, Staten Island, NY 10314 6399, USA
Neurosci Lett 304:102-6. 2001..The data suggest that plasma ACT crosses the blood-brain barrier. However, a lack of correlation between CSF Abeta40 and Abeta42 levels with those of plasma suggests that Abeta in CSF and plasma originates from different sources... - Effect of treatment on oligoclonal IgG bands and intrathecal IgG synthesis in sequential cerebrospinal fluid and serum from patients with subacute sclerosing panencephalitisP D Mehta
Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314
J Neurol Sci 109:64-8. 1992..We conclude that treatment of SSPE patients with isoprinosine or with isoprinosine and alpha-interferon had no significant effect on the CSF oligoclonal band profiles or IgG synthesis within the central nervous system... - Apolipoprotein E (APOE) phenotype and APOE concentrations in multiple sclerosis and acute herpes zosterT Pirttila
Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Acta Neurol Scand 102:94-8. 2000..The aim of the study was to examine if apoE polymorphism or apoE levels contribute to the severity of the disease in patients with multiple sclerosis or the outcome of nerve damage in patients with herpes zoster infection... - Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndromeN Schupf
Department of Psychology and Laboratory of Epidemiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
Neurosci Lett 301:199-203. 2001.... - Alpha2 macroglobulin elevation without an acute phase response in depressed adults with Down's syndrome: implicationsJ A Tsiouris
George A Jervis Clinic, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
J Intellect Disabil Res 44:644-53. 2000..Further studies are needed to confirm that alpha2M elevation is specific to depression and that it might provide a helpful marker for the diagnosis of depression in people with ID... - Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's diseaseR Mayeux
Taub Alzheimer s Disease Research Center, Staten Island, NY, USA
Ann Neurol 46:412-6. 1999.... - Increased levels of beta 2-microglobulin, soluble interleukin-2 receptor, and soluble CD8 in patients with subacute sclerosing panencephalitisP D Mehta
Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314
Clin Immunol Immunopathol 65:53-9. 1992..In contrast, serum beta 2-M decreased during periods of worsening and increased during improvement. The measurement of serum beta 2-M and CSF sCD8 may be useful in SSPE patients as markers to monitor disease activity... 
Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's diseaseMartin J Sadowski
Department of Neurology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Proc Natl Acad Sci U S A 103:18787-92. 2006..Furthermore, behavioral studies demonstrated that treatment with Abeta12-28P prevents a memory deficit in transgenic animals. These findings provide evidence of another therapeutic approach for AD...- Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degenerationJerzy Wegiel
Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA
Acta Neuropathol 113:389-402. 2007.... - Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndromeNicole Schupf
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, PO Box 16, 630 W 168th St, New York, NY 10032, USA
Arch Neurol 64:1007-13. 2007..Individuals with Down syndrome have increased levels of beta-amyloid peptides and an increased risk for AD... - Hypometabolism and altered cerebrospinal fluid markers in normal apolipoprotein E E4 carriers with subjective memory complaintsLisa Mosconi
Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
Biol Psychiatry 63:609-18. 2008.... - Plasma Abeta42 correlates positively with increased body fat in healthy individualsKelvin Balakrishnan
The Sir James McCusker Alzheimer's Disease Research Unit, C/- Hollywood Private Hospital, Monash Avenue, Nedlands WA 6009, Australia
J Alzheimers Dis 8:269-82. 2005..Longitudinal studies involving larger cohorts are required to determine if elevated body fat may predispose individuals to AD through increasing Abeta42 levels throughout early to late adulthood... - Selective reductions in plasma Abeta 1-42 in healthy elderly subjects during longitudinal follow-up: a preliminary reportNunzio Pomara
Geriatric Psychiatry Program, Nathan S Kline Institute, 140 Old Orangeburg Rd, Bldg 35, Orangeburg, NY 10962, USA
Am J Geriatr Psychiatry 13:914-7. 2005..Longitudinal changes in plasma beta amyloid protein 1-42 and 1-40 (Abeta42 and Abeta40) levels and possible relationships with cognitive decline and apolipoprotein (APOE) genotype were studied in healthy elderly individuals... - Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's diseaseJudith Miklossy
Centre for Neurovirology and Cancer Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Neurobiol Aging 24:655-62. 2003.... - Humoral immune response to fibrillar beta-amyloid peptideDavid L Miller
New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
Biochemistry 42:11682-92. 2003.... - Luteinizing hormone levels are positively correlated with plasma amyloid-beta protein levels in elderly menGiuseppe Verdile
Centre of Excellence for Alzheimer s Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia
J Alzheimers Dis 14:201-8. 2008..Larger, longitudinal human studies are needed to determine the significance of LH in the pathogenesis of AD... - Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndromeAnne M Cataldo
Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neurobiol Aging 25:1263-72. 2004.... - Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaqueJ Jacob Kulstad
Geriatric Research, Education, and Clinical Center, Veteran's Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Neuropathol Exp Neurol 64:139-46. 2005..These findings support the notion that glucocorticoids regulate IDE and provide a mechanism whereby increased glucocorticoid levels may contribute to AD pathology... - Differences and similarities between two frequently used assays for amyloid beta 42 in cerebrospinal fluidNiki S M Schoonenboom
Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
Clin Chem 51:1057-60. 2005 - Neurochemical aftermath of amateur boxingHenrik Zetterberg
Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Arch Neurol 63:1277-80. 2006..Little solid information is available on the possible risks for neuronal injury in amateur boxing... - Humoral immune responses to peptides derived from the beta-amyloid peptide C-terminal sequenceDavid L Miller
New York State Institute for Basic Research in Developmental Disabilities Staten Island, NY 10314, USA
Amyloid 14:39-50. 2007..This information is necessary to develop sensitive and specific immunoassays to quantify Abeta isoforms in brain extracts and in body fluids... - Elevation in plasma Abeta42 in geriatric depression: a pilot studyNunzio Pomara
Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA
Neurochem Res 31:341-9. 2006.... - Biological markers for therapeutic trials in Alzheimer's disease. Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer's diseaseRichard A Frank
Pharmacia Corporation, Mailstop 134, Peapack, NJ 07977, USA
Neurobiol Aging 24:521-36. 2003 - Elevated levels of serum alpha(2) macroglobulin in wild black bears during hibernationAshfaq M Sheikh
NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York State, NY 10314, USA
Biochimie 85:1027-32. 2003..The levels of serum alpha(2)M were significantly increased during hibernating state as compared to active state of bears indicating its protective role from the consequences of the metabolic depression during hibernation...