Salil K Das

Summary

Affiliation: Meharry Medical College
Country: USA

Publications

  1. ncbi request reprint Translocator protein (TSPO) in breast cancer
    S Mukherjee
    Department of Biochemistry and Cancer Biology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
    Curr Mol Med 12:443-57. 2012
  2. ncbi request reprint Decrease in brain POMC mRNA expression and onset of obesity in guinea pigs exposed to 2-chloroethyl ethyl sulfide, a mustard analogue
    Salil K Das
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 339:55-8. 2006
  3. ncbi request reprint Differential effect of cadmium on cholinephosphotransferase activity in normal and cancerous human mammary epithelial cell lines
    Somdutta Sinha Roy
    Department of Biochemistry and Department of Pharmacology, Meharry Medical College, Nashville, TN, USA
    Mol Cancer Ther 3:199-204. 2004
  4. ncbi request reprint Harmful health effects of cigarette smoking
    Salil K Das
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Mol Cell Biochem 253:159-65. 2003
  5. ncbi request reprint Prophylactic protection by N-acetylcysteine against the pulmonary injury induced by 2-chloroethyl ethyl sulfide, a mustard analogue
    Salil K Das
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 17:177-84. 2003
  6. ncbi request reprint Induction of pro-renin converting enzyme mk9 by thyroid hormone in the guinea-pig liver
    S K Das
    Department of Biochemistry, Meharry Medical College, 1005 D B Todd Boulevard, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 293:412-5. 2002
  7. ncbi request reprint Mainstream and sidestream cigarette smoke exposure increases Ca2+-dependent phospholipid binding proteins in guinea pig alveolar type II cells
    Salil K Das
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Mol Cell Biochem 231:37-42. 2002
  8. ncbi request reprint Signal transduction events in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog
    Diptendu Chatterjee
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 17:114-21. 2003
  9. doi request reprint Role of MAPK/AP-1 signaling pathway in the protection of CEES-induced lung injury by antioxidant liposome
    Sutapa Mukhopadhyay
    Department of Cancer Biology, Meharry Medical College, 1005 David Todd Blvd, Nashville, TN 37208, USA
    Toxicology 261:143-51. 2009
  10. doi request reprint Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats
    Somdutta Sinha Roy
    Department of Cancer Biology, Meharry Medical College, Nashville, TN 37208, United States
    Life Sci 83:661-5. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Translocator protein (TSPO) in breast cancer
    S Mukherjee
    Department of Biochemistry and Cancer Biology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
    Curr Mol Med 12:443-57. 2012
    ..This chapter provides insight into the potential of TSPO as a rational target for the development of novel therapeutics for breast cancer...
  2. ncbi request reprint Decrease in brain POMC mRNA expression and onset of obesity in guinea pigs exposed to 2-chloroethyl ethyl sulfide, a mustard analogue
    Salil K Das
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 339:55-8. 2006
    ..This reduction in POMC message is consistent with the onset of obesity in the animals. We hypothesize that the POMC melanocortin pathway provides a mechanistic basis for the observed effects of sulfur mustard on body weight...
  3. ncbi request reprint Differential effect of cadmium on cholinephosphotransferase activity in normal and cancerous human mammary epithelial cell lines
    Somdutta Sinha Roy
    Department of Biochemistry and Department of Pharmacology, Meharry Medical College, Nashville, TN, USA
    Mol Cancer Ther 3:199-204. 2004
    ..CPT gene expression increased with cadmium as evident from slot blots. Mutation in the nucleotide sequence was also observed as the result of cadmium but this did not result into amino acid sequence changes...
  4. ncbi request reprint Harmful health effects of cigarette smoking
    Salil K Das
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Mol Cell Biochem 253:159-65. 2003
    ..Exposure to environmental tobacco smoke contributes to health problems in children and is a significant risk factor for asthma. Cigarette smoke contains several carcinogens that alter biochemical defense systems leading to lung cancer...
  5. ncbi request reprint Prophylactic protection by N-acetylcysteine against the pulmonary injury induced by 2-chloroethyl ethyl sulfide, a mustard analogue
    Salil K Das
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 17:177-84. 2003
    ..Pretreatment with NAC for 3 and 30 days protected against 69-76% of the acute lung injury. Therefore, NAC may be an antidote for CEES-induced lung injury...
  6. ncbi request reprint Induction of pro-renin converting enzyme mk9 by thyroid hormone in the guinea-pig liver
    S K Das
    Department of Biochemistry, Meharry Medical College, 1005 D B Todd Boulevard, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 293:412-5. 2002
    ..Forty-eight hours following the last injection, the liver was processed for Northern blot analysis using labeled mK9, mK13, and mK22 specific RNA probes. Only mK9 was found to be transcriptionally regulated by the hormone...
  7. ncbi request reprint Mainstream and sidestream cigarette smoke exposure increases Ca2+-dependent phospholipid binding proteins in guinea pig alveolar type II cells
    Salil K Das
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Mol Cell Biochem 231:37-42. 2002
    ..The mechanism by which smoke exposure causes an elevation in the levels of PLBP in alveolar type II cells and lung lavage remains to be investigated...
  8. ncbi request reprint Signal transduction events in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog
    Diptendu Chatterjee
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 17:114-21. 2003
    ..Since NF-kappa B disappeared after 2 h, the cells continued being damaged owing to accumulation of ceramides and activation of several caspases, leading to apoptosis...
  9. doi request reprint Role of MAPK/AP-1 signaling pathway in the protection of CEES-induced lung injury by antioxidant liposome
    Sutapa Mukhopadhyay
    Department of Cancer Biology, Meharry Medical College, 1005 David Todd Blvd, Nashville, TN 37208, USA
    Toxicology 261:143-51. 2009
    ..This suggests that the protective effect of antioxidant liposome against CEES-induced lung damage is mediated via control of AP-1 signaling...
  10. doi request reprint Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats
    Somdutta Sinha Roy
    Department of Cancer Biology, Meharry Medical College, Nashville, TN 37208, United States
    Life Sci 83:661-5. 2008
    ..The present study aims to establish that cholinephosphotransferase (CPT), the terminal enzyme for the de novo biosynthesis of phosphatidylcholine (PC), can be used as a biomarker for breast cancer in an animal model...
  11. doi request reprint Activation of MAPK/AP-1 signaling pathway in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard gas analog
    Sutapa Mukhopadhyay
    Department of Cancer Biology, Meharry Medical College, 1005 David Todd Blvd, Nashville, TN 37208, USA
    Toxicol Lett 181:112-7. 2008
    ..Further studies are needed to clarify whether the observed effects are the adaptive responses of the lung or they contribute to the lung injury...
  12. doi request reprint Antiproliferative effect of peripheral benzodiazepine receptor antagonist PK11195 in rat mammary tumor cells
    Sutapa Mukhopadhyay
    Department of Cancer Biology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
    Mol Cell Biochem 340:203-13. 2010
    ..However, the inhibition of cell proliferation by PK11195 was counteracted by Ro5-4864, a PBR agonist. Thus, PBR antagonist may be a potential therapeutic agent for the control of aggressiveness of breast cancer...
  13. ncbi request reprint Modulation of the expression of superoxide dismutase gene in lung injury by 2-chloroethyl ethyl sulfide, a mustard analog
    Sutapa Mukhopadhyay
    Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 20:142-9. 2006
    ..Studies are underway in our laboratory to investigate whether mustard gas induced inactivation of SOD-3 in lung is similarly mediated by a change in Cys-Cys disulfide bonding...
  14. doi request reprint Induction of neuronal damage in guinea pig brain by intratracheal infusion of 2-chloroethyl ethyl sulfide, a mustard gas analog
    Jessica Gadsden-Gray
    Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 26:23-30. 2012
    ..Furthermore, the present study indicates for the first time that intratracheal infusion of a single dose of CEES can cause neuroinflammation, which may lead to neurological disorders in later part of life...
  15. ncbi request reprint Inhibition of cholinephosphotransferase activity in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog
    Somdutta Sinha Roy
    Department of Biochemistry, Meharry Medical College, 1005 David Todd Blvd, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 19:289-97. 2005
    ..CEES induced ceramide accumulation may thus play an important role in the development of ARDS by modulating CPT enzyme...
  16. doi request reprint Protection of half sulfur mustard gas-induced lung injury in guinea pigs by antioxidant liposomes
    Shyamali Mukherjee
    Department of Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 23:143-53. 2009
    ..Thus, antioxidant liposomes containing both NAC and vitamin E are an effective antidote against CEES-induced lung injury...
  17. doi request reprint Antioxidant liposomes protect against CEES-induced lung injury by decreasing SAF-1/MAZ-mediated inflammation in the guinea pig lung
    Sutapa Mukhopadhyay
    Department of Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 24:187-94. 2010
    ..This might suggest that antioxidant liposomes might offer a potential therapeutic strategy against inflammatory diseases associated with activation of these bioactive molecules...
  18. ncbi request reprint Control of peripheral benzodiazepine receptor-mediated breast cancer in rats by soy protein
    Sutapa Mukhopadhyay
    Department of Biomedical Science, Meharry Medical College, Nashville, Tennessee 37208, USA
    Mol Carcinog 47:310-9. 2008
    ..These data suggest that soy protein inhibits breast tumor development by decreasing the expression of the tumor-promoting gene, which encodes PBRs...
  19. ncbi request reprint Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist
    Jacqueline Akech
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 333:35-41. 2005
    ..Biosynthesis of PC was increased in breast cancer cell lines upon treatment. We therefore propose that Ro5-4864 facilitates PC formation, a process important in membrane biogenesis for proliferating cells...
  20. pmc Desensitization of beta-adrenergic receptors in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog
    Syeda M Kabir
    Department of Cancer Biology, Meharry Medical College, 1005 David Todd Blvd, Nashville, TN 37208, USA
    J Biochem Mol Toxicol 23:59-70. 2009
    ..Thus, our study indicates that CEES-induced lung injury is associated with desensitization of beta(2)-AR...
  21. ncbi request reprint Evidence of hair loss after subacute exposure to 2-chloroethyl ethyl sulfide, a mustard analog, and beneficial effects of N-acetyl cysteine
    Diptendu Chatterjee
    Department of Biochemistry, Meharry Medical College, TN 37208, USA
    J Biochem Mol Toxicol 18:150-3. 2004
    ..Hence, sudden hair loss might be a good biomarker for subacute exposure of mustard gas to subjects at risks when the victims might have no other visible symptom of toxicity...
  22. pmc Uptake of all-trans retinoic acid-containing aerosol by inhalation to lungs in a guinea pig model system--a pilot study
    Michael W Schäffer
    Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, Tennessee 37208, USA
    Exp Lung Res 36:593-601. 2010
    ..8 ± 7.7 ng·g(-1) wet weight, respectively). The application of this aerosolized ATRA also induced a dose-dependent protein expression of the cellular retinol-binding protein 1 (CRBP-1) in lung, without apparent harmful side effects...
  23. ncbi request reprint Increased expression of peripheral benzodiazepine receptor (PBR) in dimethylbenz[a]anthracene-induced mammary tumors in rats
    Sutapa Mukhopadhyay
    Division of Cancer Biology, Department of Biomedical Sciences, Meharry Medical College, Nashville, TN, USA
    Glycoconj J 23:199-207. 2006
    ..In conclusion, these data suggest that PBR ligand binding, and PBR-mediated cholesterol transport into the nucleus may be involved in the development of mammary gland adenocarcinoma, thus participating in the advancement of the disease...
  24. ncbi request reprint Cigarette smoke and dopaminergic system
    Leah R Miller
    Division of Cancer Biology, Department of Biomedical Sciences, Meharry Medical College, Nashville TN 37208, USA
    J Biochem Mol Toxicol 21:325-35. 2007
    ..The mechanism by which cigarette smoke exposure increases locomotor activity remains to be elucidated but may include modulation of dopamine neuron activity that emerges after repeated direct smoke exposure...
  25. ncbi request reprint Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells
    Aparajita Ghosh
    Department of Biochemistry, Meharry Medical College, 1005 D B Todd Boulevard, Nashville, TN 37208 3599, USA
    Biochem Biophys Res Commun 297:1043-8. 2002
    ..Biochemical approach also reveals a 1.5-fold stimulation in CPT activity in 11-9-14 cells compared to that of the MCF-12A cells...
  26. doi request reprint Identification of lutein, a dietary antioxidant carotenoid in guinea pig tissues
    Michael W Schäffer
    Department of Cancer Biology, Meharry Medical College, 1005 David Todd Boulevard, Nashville, TN 37208, USA
    Biochem Biophys Res Commun 374:378-81. 2008
    ..The presence of lutein in lung and other tissues may be significant in term of its antioxidant capacity of these organs...
  27. ncbi request reprint Beneficial effects of soy protein in the initiation and progression against dimethylbenz [a] anthracene-induced breast tumors in female rats
    Sutapa Mukhopadhyay
    Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA
    Mol Cell Biochem 290:169-76. 2006
    ..These findings suggest that the soy protein may protect against the development of a more aggressive breast carcinoma...
  28. ncbi request reprint Effects of oxidized low density lipoprotein on nitric oxide synthetase and protein kinase C activities in bovine endothelial cells
    S Mukherjee
    Dept of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Cell Mol Biol (Noisy-le-grand) 47:1051-8. 2001
    ..Inhibition of Gi-protein then leads to reduced release of NO from endothelial cells and thus causes endothelial dysfunction...
  29. ncbi request reprint Beta-adrenoreceptors of multiple affinities in a clonal capillary endothelial cell line and its functional implication
    S K Das
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208
    Mol Cell Biochem 140:49-54. 1994
    ....
  30. ncbi request reprint Benzo(a)pyrene-induced acute neurotoxicity in the F-344 rat: role of oxidative stress
    Crystal R Saunders
    Department of Pharmacology, Meharry Medical College, Nashville, TN 37208, USA
    J Appl Toxicol 26:427-38. 2006
    ..These findings suggest that B(a)P-induced acute neurobehavioral toxicity may occur through oxidative stress due to inhibition of the brain antioxidant scavenging system...
  31. ncbi request reprint Molecular cloning and characterization of the guinea pig cholinephosphotransferase gene
    Asit K Chakraborty
    Department of Biochemistry, Meharry Medical College, 1005 David Todd Boulevard, Nashville, TN 37208 3599, USA
    Biochem Biophys Res Commun 312:1104-10. 2003
    ..The probable differences in genomic organization and its expression in different cancer cells have been discussed here having CPT as an important target for cancer drug development...
  32. ncbi request reprint Therapeutic uses of antioxidant liposomes
    William L Stone
    Department of Pediatrics, East Tennessee State University, Johnson City, TN, USA
    Methods Mol Biol 199:145-61. 2002
  33. ncbi request reprint Regulation of cholinephosphotransferase by thyroid hormone
    D Chatterjee
    Department of Biochemistry, Meharry Medical College, 1005 D.B. Todd Boulevard, Nashville, Tennessee 37210, USA
    Biochem Biophys Res Commun 282:861-4. 2001
    ..Furthermore, it strengthens our previous finding that yeast CPT and guinea pig CPT have high homology in their sequence as both the oligonucleotide probes gave the similar type of Northern blot in the present study...
  34. ncbi request reprint Passive cigarette smoke and the renal glyoxalase system
    Swati Biswas
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Mol Cell Biochem 229:153-6. 2002
    ..Both enzymes help in the detoxification of cigarette smoke induced chemicals and biochemicals...
  35. ncbi request reprint Oltipraz protects the passive smoke induced changes in renal glyoxalase system of rats
    Swati Biswas
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Mol Cell Biochem 233:27-30. 2002
    ..However, the activity approached the basal level after 12 weeks of exposure. Furthermore, oltipraz treatment maintained the activity of both glyoxalase closer to the basal levels...
  36. ncbi request reprint Development and characterization of cholinephosphotransferase antibody
    D Chatterjee
    Department of Biochemistry, Meharry Medical College, 1005 D.B. Todd Boulevard, Nashville, Tennessee 37210, USA
    Biochem Biophys Res Commun 285:965-8. 2001
    ..Further analysis revealed that the antibody inhibited CPT activity in both subcellular fractions in a dose dependent manner, thus confirming the specificity of the antibody against both subcellular CPT...
  37. ncbi request reprint Effects of centrophenoxine on cholinephosphotransferase activity in maternal and fetal guinea pig lung
    I E Stith
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208
    Exp Lung Res 15:587-96. 1989
    ..Furthermore, while centrophenoxine injection does not change the total phosphatidylcholine content of adult lung, the acyl group composition of phosphatidylcholine was modulated...
  38. ncbi request reprint Attenuation of half sulfur mustard gas-induced acute lung injury in rats
    Shannon D McClintock
    The University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA
    J Appl Toxicol 26:126-31. 2006
    ..These data indicate that CEES-induced injury of rat lungs can be substantially diminished by the presence of reducing agents or anti-oxidant enzymes delivered via liposomes...