Affiliation: Meharry Medical College
Smith J, Singha U, Misra S, Chaudhuri M. Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei. mSphere. 2018;3: pubmed publisher
..brucei, and play an essential role in the stability of the TbTim17 complexes. Therefore, these divergent proteins are critical for mitochondrial protein biogenesis in T. brucei. ..
Chaudhuri M, Ott R, Hill G. Trypanosome alternative oxidase: from molecule to function. Trends Parasitol. 2006;22:484-91 pubmed
..Alternative oxidases similar to TAO have been found in a wide variety of organisms but not in mammals, thus rendering TAO an important chemotherapeutic target for African trypanosomiasis. ..
Weems E, Singha U, Hamilton V, Smith J, Waegemann K, Mokranjac D, et al
. Functional complementation analyses reveal that the single PRAT family protein of trypanosoma brucei is a divergent homolog of Tim17 in saccharomyces cerevisiae. Eukaryot Cell. 2015;14:286-96 pubmed publisher
..In addition, ScTim22 could not be sorted properly in the T. brucei mitochondrion and thus failed to complement the function of TbTim17. ..
Fullerton M, Singha U, Duncan M, Chaudhuri M. Down regulation of Tim50 in Trypanosoma brucei increases tolerance to oxidative stress. Mol Biochem Parasitol. 2015;199:9-18 pubmed publisher
..Together, these results suggest that TbTim50 acts as a stress sensor and that down regulation of Tim50 could be a survival mechanism for T. brucei exposed to oxidative stress. ..
Singha U, Hamilton V, Chaudhuri M. Tim62, a Novel Mitochondrial Protein in Trypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex. J Biol Chem. 2015;290:23226-39 pubmed publisher
..TbTim62 KD destabilizes this complex, and unassembled TbTim17 degrades. Therefore, TbTim62 acts as a novel regulatory factor to maintain the levels of TIM in T. brucei mitochondria. ..
Chaudhuri M, Ott R, Saha L, Williams S, Hill G. The trypanosome alternative oxidase exists as a monomer in Trypanosoma brucei mitochondria. Parasitol Res. 2005;96:178-83 pubmed
..However, it exists as a monomer in Trypanosoma brucei mitochondria. ..
Weems E, Singha U, Smith J, Chaudhuri M. The divergent N-terminal domain of Tim17 is critical for its assembly in the TIM complex in Trypanosoma brucei. Mol Biochem Parasitol. 2017;218:4-15 pubmed publisher
..Together, these results show that the N-terminal domain of TbTim17 plays unique and essential roles for its sorting and assembly into the TbTim17 protein complex. ..