Y-F Xiao

Summary

Affiliation: Medtronic Inc
Country: USA

Publications

  1. pmc Cell and gene therapy for arrhythmias: Repair of cardiac conduction damage
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, 8200 Coral Sea Street NE, Mounds View, MN 55112, USA
    J Geriatr Cardiol 8:147-58. 2011
  2. ncbi request reprint Electrophysiological characterization of murine HL-5 atrial cardiomyocytes
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, 7000 Central Avenue NE, B252, Minneapolis, MN 55432 3576, USA
    Am J Physiol Cell Physiol 291:C407-16. 2006
  3. ncbi request reprint Cyclic AMP-dependent modulation of cardiac L-type Ca2+ and transient outward K+ channel activities by epoxyeicosatrienoic acids
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, 7000 Central Avenue NE, B252, Minneapolis, MN 55432 3576, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Prostaglandins Other Lipid Mediat 82:11-8. 2007
  4. ncbi request reprint Biological approaches to generating cardiac biopacemaker for bradycardia
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, Minneapolis, MN 55432, USA
    Sheng Li Xue Bao 59:562-70. 2007
  5. doi request reprint Pericardial delivery of omega-3 fatty acid: a novel approach to reducing myocardial infarct sizes and arrhythmias
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, 8200 Coral Sea Street NE, Mounds View, MN 55112, USA
    Am J Physiol Heart Circ Physiol 294:H2212-8. 2008
  6. ncbi request reprint Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, Mounds View, MN 55112, USA
    Sheng Li Xue Bao 62:1-13. 2010
  7. ncbi request reprint The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation of cardiac ion channels as a potential mechanism
    Y F Xiao
    Cardiac Rhythm Management, Medtronic Inc, Minneapolis, MN 55432, USA
    J Membr Biol 206:141-54. 2005
  8. pmc Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic, Inc, 8200 Coral Sea Street NE, Mounds View, MN 55112, USA
    Cardiovasc Diabetol 10:6. 2011
  9. ncbi request reprint Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias
    A Leaf
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Membr Biol 206:129-39. 2005
  10. ncbi request reprint Interactions of n-3 fatty acids with ion channels in excitable tissues
    A Leaf
    Department of Medicine, Massachusetts General Hospital, Charleston, MA 02129, USA
    Prostaglandins Leukot Essent Fatty Acids 67:113-20. 2002

Collaborators

Detail Information

Publications33

  1. pmc Cell and gene therapy for arrhythmias: Repair of cardiac conduction damage
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, 8200 Coral Sea Street NE, Mounds View, MN 55112, USA
    J Geriatr Cardiol 8:147-58. 2011
    ..This review summarizes some highlights of recent research progress in this field...
  2. ncbi request reprint Electrophysiological characterization of murine HL-5 atrial cardiomyocytes
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, 7000 Central Avenue NE, B252, Minneapolis, MN 55432 3576, USA
    Am J Physiol Cell Physiol 291:C407-16. 2006
    ..Compared with adult murine cardiomyocytes, HL-5 cells show an immature phenotype of cardiac AP morphology...
  3. ncbi request reprint Cyclic AMP-dependent modulation of cardiac L-type Ca2+ and transient outward K+ channel activities by epoxyeicosatrienoic acids
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, 7000 Central Avenue NE, B252, Minneapolis, MN 55432 3576, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Prostaglandins Other Lipid Mediat 82:11-8. 2007
    ..This brief review summarizes EET-induced modulation of cardiac ion channels...
  4. ncbi request reprint Biological approaches to generating cardiac biopacemaker for bradycardia
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, Minneapolis, MN 55432, USA
    Sheng Li Xue Bao 59:562-70. 2007
    ..Genetically engineered biological pacemaker holds great promise to potentially cure severe bradycardia if critical issues, such as their stability and longevity, are properly solved...
  5. doi request reprint Pericardial delivery of omega-3 fatty acid: a novel approach to reducing myocardial infarct sizes and arrhythmias
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, 8200 Coral Sea Street NE, Mounds View, MN 55112, USA
    Am J Physiol Heart Circ Physiol 294:H2212-8. 2008
    ..Pericardial administration of n-3 PUFAs could represent a novel approach to treating or preventing myocardial infarctions...
  6. ncbi request reprint Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic Inc, Mounds View, MN 55112, USA
    Sheng Li Xue Bao 62:1-13. 2010
    ..Therefore, hHCN4 hysteresis potentially plays a crucial role in human SAN pacemaking activity...
  7. ncbi request reprint The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation of cardiac ion channels as a potential mechanism
    Y F Xiao
    Cardiac Rhythm Management, Medtronic Inc, Minneapolis, MN 55432, USA
    J Membr Biol 206:141-54. 2005
    ..In addition, the effect of the n-3 PUFAs on the human hyperpolarization-activated cyclic-nucleotide-modulated channel is presented...
  8. pmc Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway
    Yong Fu Xiao
    Cardiac Rhythm Disease Management, Medtronic, Inc, 8200 Coral Sea Street NE, Mounds View, MN 55112, USA
    Cardiovasc Diabetol 10:6. 2011
    ..As the effects of GLP-1 on myocyte electrophysiology are largely unknown, this study was to assess if GLP-1 could affect the cardiac voltage-gated L-type Ca2+ current (I(Ca))...
  9. ncbi request reprint Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias
    A Leaf
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Membr Biol 206:129-39. 2005
    ..Others and we have demonstrated that these membrane effects on the heart can prevent fatal cardiac arrhythmias in humans...
  10. ncbi request reprint Interactions of n-3 fatty acids with ion channels in excitable tissues
    A Leaf
    Department of Medicine, Massachusetts General Hospital, Charleston, MA 02129, USA
    Prostaglandins Leukot Essent Fatty Acids 67:113-20. 2002
    ..Our preliminary data seem to support this membrane tension hypothesis...
  11. ncbi request reprint Significant improvement of heart function by cotransplantation of human mesenchymal stem cells and fetal cardiomyocytes in postinfarcted pigs
    Jiang Yong Min
    Stem Cell Research Laboratory, the Charles A Dana Research Institute, Boston, Massachusetts, USA
    Ann Thorac Surg 74:1568-75. 2002
    ....
  12. ncbi request reprint Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2
    Yong Fu Xiao
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Mol Pharmacol 66:1607-16. 2004
    ..In conclusion, overexpression of CYP2J2 increases ICa in CYP2J2 transgenic cardiomyocytes via a mechanism that involves cAMP-protein kinase A-dependent phosphorylation of the L-type Ca2+ channel...
  13. ncbi request reprint Potent block of inactivation-deficient Na+ channels by n-3 polyunsaturated fatty acids
    Yong Fu Xiao
    Charles A Dana Research Institute and Harvard Thorndike Laboratory, and Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, USA
    Am J Physiol Cell Physiol 290:C362-70. 2006
    ..Our data demonstrate that the double mutations at the 409 and 410 sites in the D1-S6 region of hH1(alpha) induce inactivation-deficient I(Na) and that n-3 PUFAs inhibit mutant I(Na)...
  14. ncbi request reprint Intracellular accumulation of mercury enhances P450 CYP1A1 expression and Cl- currents in cultured shark rectal gland cells
    Qingen Ke
    Stem Cell Research Laboratory, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Life Sci 70:2547-66. 2002
    ..The subchronic effect of mercury on ICl may be due to an induction of P450 CYP1A1 and its mediated metabolites, but not due to an over-expression of Cl- channels...
  15. ncbi request reprint VEGF enhances functional improvement of postinfarcted hearts by transplantation of ESC-differentiated cells
    Yinke Yang
    Stem Cell Research Laboratory, The Charles A Dana Research Institute and Harvard Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Appl Physiol 93:1140-51. 2002
    ..The novel EDCs-VEGF synergistic approach may have an important impact on future cell therapy for patients experiencing MI or heart failure...
  16. ncbi request reprint Electrophysiologic properties of lidocaine, cocaine, and n-3 fatty-acids block of cardiac Na+ channels
    Yong Fu Xiao
    Department of Medicine, Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Eur J Pharmacol 485:31-41. 2004
    ....
  17. ncbi request reprint Fish oil fatty acids as cardiovascular drugs
    Alexander Leaf
    Departments of Medicine, aMassachusetts General Hospital, Boston, MA, USA
    Curr Vasc Pharmacol 6:1-12. 2008
    ..The bold, underlined abbreviation will appear in the text to identify the fatty acid being discussed...
  18. ncbi request reprint Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils
    Alexander Leaf
    Departments of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    Circulation 107:2646-52. 2003
  19. ncbi request reprint Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells
    Jiang Yong Min
    Stem Cell Research Laboratory, The Charles A Dana Research Institute and The Harvard Thorndike Laboratory, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Thorac Cardiovasc Surg 125:361-9. 2003
    ..This study was designed to investigate the feasibility of and potential functional improvement with embryonic stem cell transplantation in rats 32 weeks after myocardial infarction...
  20. ncbi request reprint Successful implantation of intravenously administered stem cells correlates with severity of inflammation in murine myocarditis
    Sohail Malek
    Charles A Dana Research Institute and the Harvard Thorndike Laboratories of Beth Israel Deaconess Medical Center, The Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02135, USA
    Pflugers Arch 452:268-75. 2006
    ..We conclude that factors released from myocardium during inflammation are important for enhancing the homing, migration, and implantation of systemically infused stem cells...
  21. pmc Enhancement of nitric oxide production by methylecgonidine in cultured neonatal rat cardiomyocytes
    Yinke Yang
    The Charles A Dana Research Institute and Harvard Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, MA 02215, USA
    Br J Pharmacol 135:188-96. 2002
    ..4. Our data demonstrate that MEG significantly enhanced NO production in cultured cardiomyocytes and that the enhancement of NO production may result from MEG stimulation of muscarinic M(2) receptors...
  22. ncbi request reprint In vivo MRI of embryonic stem cells in a mouse model of myocardial infarction
    Nathan Himes
    Department of Radiology, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Magn Reson Med 52:1214-9. 2004
    ..These findings support the ability of MRI to test the long-term therapeutic potential of embryonic stem cells in small animals in the setting of myocardial infarction...
  23. ncbi request reprint Inhibitory effect of n-3 fish oil fatty acids on cardiac Na+/Ca2+ exchange currents in HEK293t cells
    Yong Fu Xiao
    Harvard Medical School, Boston, MA 02215, USA
    Biochem Biophys Res Commun 321:116-23. 2004
    ..Our data demonstrate that the n-3 PUFAs significantly suppress cardiac I(NCX1), which is probably one of their protective effects against lethal arrhythmias...
  24. ncbi request reprint Induction of cardiac cytochrome p450 in cocaine-treated mice
    Ju Feng Wang
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Exp Biol Med (Maywood) 227:182-8. 2002
    ..We speculate that induction of P450 isoforms may cause cardiac injury due to cocaine metabolites locally catalyzed by P450 or the increase in P450 expression itself...
  25. ncbi request reprint Immunosuppression and xenotransplantation of cells for cardiac repair
    Yong Fu Xiao
    Stem Cell Research Laboratory, the Charles A Dana Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Ann Thorac Surg 77:737-44. 2004
    ....
  26. ncbi request reprint Embryonic stem cells attenuate viral myocarditis in murine model
    Ju Feng Wang
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Transplant 11:753-8. 2002
    ..These results demonstrated the ability of stem cells to mitigate the effects of viral infection on the heart and illustrated their potential therapeutic application to other mammalian species, including humans...
  27. ncbi request reprint Cardiac application of embryonic stem cells
    Yong Fu Xiao
    Stem Cell Research Laboratory, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Sheng Li Xue Bao 55:493-504. 2003
    ..However, many ethical, political, and scientific barriers have to be overcome before clinical utilization of human ESCs and their differentiated cells for treating end-stage cardiac diseases...
  28. ncbi request reprint Omega-3 fatty acids and ventricular arrhythmias
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    World Rev Nutr Diet 94:129-38. 2005
  29. ncbi request reprint Cardiomyocytes overexpressing TNF-alpha attract migration of embryonic stem cells via activation of p38 and c-Jun amino-terminal kinase
    Yu Chen
    Stem Cells Research Laboratory, The Charles A Dana Research Institute and Harvard Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 17:2231-9. 2003
    ..Our data demonstrate that excessive TNF-alpha stimulates TNF-RII and enhances migration of ESCs in vitro. Activation of p38 and JNK is required for TNF-alpha-enhanced ESC migration...
  30. ncbi request reprint Vascular endothelial growth factor promotes cardiomyocyte differentiation of embryonic stem cells
    Yu Chen
    Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 291:H1653-8. 2006
    ..These findings may be of significance for stem cell and growth factor therapies to regenerate failing cardiomyocytes...
  31. pmc Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice
    Qingen Ke
    National Institutes of Health NIEHS, 111 T W Alexander Drive, Building 101, Room D236, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 72:1063-73. 2007
    ..Together, our data demonstrate that shortening of the action potential in CYP2J2 Tr cardiomyocytes is associated with enhanced I(to,peak) via an EET-dependent, cAMP-mediated mechanism...
  32. ncbi request reprint Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats
    Jiang Yong Min
    The Charles A Dana Research Institute and The Harvard Thorndike Laboratory, Boston Massachusetts 02215, USA
    J Appl Physiol 92:288-96. 2002
    ..The present data demonstrate that ES cell transplantation is a feasible and novel approach to improve ventricular function in infarcted failing hearts...