Research Topics
Species | Y-F XiaoSummaryAffiliation: Medtronic Inc Country: USA Publications
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Detail Information
Publications
Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathwayYong Fu Xiao
Cardiac Rhythm Disease Management, Medtronic, Inc, 8200 Coral Sea Street NE, Mounds View, MN 55112, USA
Cardiovasc Diabetol 10:6. 2011..As the effects of GLP-1 on myocyte electrophysiology are largely unknown, this study was to assess if GLP-1 could affect the cardiac voltage-gated L-type Ca2+ current (I(Ca))...
Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemakingYong Fu Xiao
Cardiac Rhythm Disease Management, Medtronic Inc, Mounds View, MN 55112, USA
Sheng Li Xue Bao 62:1-13. 2010..Therefore, hHCN4 hysteresis potentially plays a crucial role in human SAN pacemaking activity...
Pericardial delivery of omega-3 fatty acid: a novel approach to reducing myocardial infarct sizes and arrhythmiasYong Fu Xiao
Cardiac Rhythm Disease Management, Medtronic Inc, 8200 Coral Sea Street NE, Mounds View, MN 55112, USA
Am J Physiol Heart Circ Physiol 294:H2212-8. 2008..Pericardial administration of n-3 PUFAs could represent a novel approach to treating or preventing myocardial infarctions...- Biological approaches to generating cardiac biopacemaker for bradycardiaYong Fu Xiao
Cardiac Rhythm Disease Management, Medtronic Inc, Minneapolis, MN 55432, USA
Sheng Li Xue Bao 59:562-70. 2007..Genetically engineered biological pacemaker holds great promise to potentially cure severe bradycardia if critical issues, such as their stability and longevity, are properly solved... - Cyclic AMP-dependent modulation of cardiac L-type Ca2+ and transient outward K+ channel activities by epoxyeicosatrienoic acidsYong Fu Xiao
Cardiac Rhythm Disease Management, Medtronic Inc, 7000 Central Avenue NE, B252, Minneapolis, MN 55432 3576, and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Prostaglandins Other Lipid Mediat 82:11-8. 2007..This brief review summarizes EET-induced modulation of cardiac ion channels... - Electrophysiological characterization of murine HL-5 atrial cardiomyocytesYong Fu Xiao
Cardiac Rhythm Disease Management, Medtronic Inc, 7000 Central Avenue NE, B252, Minneapolis, MN 55432 3576, USA
Am J Physiol Cell Physiol 291:C407-16. 2006..Compared with adult murine cardiomyocytes, HL-5 cells show an immature phenotype of cardiac AP morphology... - The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation of cardiac ion channels as a potential mechanismY F Xiao
Cardiac Rhythm Management, Medtronic Inc, Minneapolis, MN 55432, USA
J Membr Biol 206:141-54. 2005..In addition, the effect of the n-3 PUFAs on the human hyperpolarization-activated cyclic-nucleotide-modulated channel is presented... - Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmiasA Leaf
Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Membr Biol 206:129-39. 2005..Others and we have demonstrated that these membrane effects on the heart can prevent fatal cardiac arrhythmias in humans... - Interactions of n-3 fatty acids with ion channels in excitable tissuesA Leaf
Department of Medicine, Massachusetts General Hospital, Charleston, MA 02129, USA
Prostaglandins Leukot Essent Fatty Acids 67:113-20. 2002..Our preliminary data seem to support this membrane tension hypothesis... - Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2Yong Fu Xiao
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Mol Pharmacol 66:1607-16. 2004..In conclusion, overexpression of CYP2J2 increases ICa in CYP2J2 transgenic cardiomyocytes via a mechanism that involves cAMP-protein kinase A-dependent phosphorylation of the L-type Ca2+ channel... - Significant improvement of heart function by cotransplantation of human mesenchymal stem cells and fetal cardiomyocytes in postinfarcted pigsJiang-Yong Min
Stem Cell Research Laboratory, The Charles A. Dana Research Institute, Boston, Massachusetts, USA
Ann Thorac Surg 74:1568-75. 2002..This improvement might result from myocardial regeneration and angiogenesis in injured hearts by engrafted cells... - Potent block of inactivation-deficient Na+ channels by n-3 polyunsaturated fatty acidsYong Fu Xiao
Charles A Dana Research Institute and Harvard Thorndike Laboratory, and Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, USA
Am J Physiol Cell Physiol 290:C362-70. 2006..Our data demonstrate that the double mutations at the 409 and 410 sites in the D1-S6 region of hH1(alpha) induce inactivation-deficient I(Na) and that n-3 PUFAs inhibit mutant I(Na)... - VEGF enhances functional improvement of postinfarcted hearts by transplantation of ESC-differentiated cellsYinke Yang
Stem Cell Research Laboratory, The Charles A. Dana Research Institute and Harvard-Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Appl Physiol 93:1140-51. 2002..The novel EDCs-VEGF synergistic approach may have an important impact on future cell therapy for patients experiencing MI or heart failure... - Intracellular accumulation of mercury enhances P450 CYP1A1 expression and Cl- currents in cultured shark rectal gland cellsQingen Ke
Stem Cell Research Laboratory, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
Life Sci 70:2547-66. 2002..The subchronic effect of mercury on ICl may be due to an induction of P450 CYP1A1 and its mediated metabolites, but not due to an over-expression of Cl- channels... - Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oilsAlexander Leaf
Departments of Medicine, Massachusetts General Hospital, Boston, Mass, USA
Circulation 107:2646-52. 2003 - Fish oil fatty acids as cardiovascular drugsAlexander Leaf
Departments of Medicine, aMassachusetts General Hospital, Boston, MA, USA
Curr Vasc Pharmacol 6:1-12. 2008..The bold, underlined abbreviation will appear in the text to identify the fatty acid being discussed... - Electrophysiologic properties of lidocaine, cocaine, and n-3 fatty-acids block of cardiac Na+ channelsYong-Fu Xiao
Department of Medicine, Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Eur J Pharmacol 485:31-41. 2004.... - Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cellsJiang-Yong Min
Stem Cell Research Laboratory, The Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Thorac Cardiovasc Surg 125:361-9. 2003..CONCLUSIONS: Engrafted embryonic stem cells differentiated into cardiomyocytes in injured myocardium, caused an angiogenetic effect, and subsequently improved cardiac function during the 32-week observation period... - Induction of cardiac cytochrome p450 in cocaine-treated miceJu-Feng Wang
Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Exp Biol Med (Maywood) 227:182-8. 2002..We speculate that induction of P450 isoforms may cause cardiac injury due to cocaine metabolites locally catalyzed by P450 or the increase in P450 expression itself... - Enhancement of nitric oxide production by methylecgonidine in cultured neonatal rat cardiomyocytesYinke Yang
The Charles A. Dana Research Institute and Harvard-Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, MA 02215, USA
Br J Pharmacol 135:188-96. 2002..4. Our data demonstrate that MEG significantly enhanced NO production in cultured cardiomyocytes and that the enhancement of NO production may result from MEG stimulation of muscarinic M(2) receptors... - Successful implantation of intravenously administered stem cells correlates with severity of inflammation in murine myocarditisSohail Malek
Charles A. Dana Research Institute and the Harvard-Thorndike Laboratories of Beth Israel Deaconess Medical Center, The Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02135, USA
Pflugers Arch 452:268-75. 2006..We conclude that factors released from myocardium during inflammation are important for enhancing the homing, migration, and implantation of systemically infused stem cells... - Cardiac application of embryonic stem cellsYong Fu Xiao
Stem Cell Research Laboratory, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Sheng Li Xue Bao 55:493-504. 2003..However, many ethical, political, and scientific barriers have to be overcome before clinical utilization of human ESCs and their differentiated cells for treating end-stage cardiac diseases... - Immunosuppression and xenotransplantation of cells for cardiac repairYong Fu Xiao
Stem Cell Research Laboratory, the Charles A Dana Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Ann Thorac Surg 77:737-44. 2004.... - Inhibitory effect of n-3 fish oil fatty acids on cardiac Na+/Ca2+ exchange currents in HEK293t cellsYong-Fu Xiao
Harvard Medical School, Boston, MA 02215, USA
Biochem Biophys Res Commun 321:116-23. 2004..Our data demonstrate that the n-3 PUFAs significantly suppress cardiac I(NCX1), which is probably one of their protective effects against lethal arrhythmias... - In vivo MRI of embryonic stem cells in a mouse model of myocardial infarctionNathan Himes
Department of Radiology, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
Magn Reson Med 52:1214-9. 2004..These findings support the ability of MRI to test the long-term therapeutic potential of embryonic stem cells in small animals in the setting of myocardial infarction... - Embryonic stem cells attenuate viral myocarditis in murine modelJu-Feng Wang
Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Cell Transplant 11:753-8. 2002..These results demonstrated the ability of stem cells to mitigate the effects of viral infection on the heart and illustrated their potential therapeutic application to other mammalian species, including humans... - Omega-3 fatty acids and ventricular arrhythmiasAlexander Leaf
Department of Medicine, Massachusetts General Hospital, Boston, Mass, USA
World Rev Nutr Diet 94:129-38. 2005 - Vascular endothelial growth factor promotes cardiomyocyte differentiation of embryonic stem cellsYu Chen
Harvard Medical School, Boston, MA 02215, USA
Am J Physiol Heart Circ Physiol 291:H1653-8. 2006..These findings may be of significance for stem cell and growth factor therapies to regenerate failing cardiomyocytes... - Cardiomyocytes overexpressing TNF-alpha attract migration of embryonic stem cells via activation of p38 and c-Jun amino-terminal kinaseYu Chen
Stem Cells Research Laboratory, The Charles A. Dana Research Institute and Harvard-Thorndike Laboratory, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
FASEB J 17:2231-9. 2003..Our data demonstrate that excessive TNF-alpha stimulates TNF-RII and enhances migration of ESCs in vitro. Activation of p38 and JNK is required for TNF-alpha-enhanced ESC migration... - Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic miceQingen Ke
National Institutes of Health NIEHS, 111 T W Alexander Drive, Building 101, Room D236, Research Triangle Park, NC 27709, USA
Mol Pharmacol 72:1063-73. 2007..Together, our data demonstrate that shortening of the action potential in CYP2J2 Tr cardiomyocytes is associated with enhanced I(to,peak) via an EET-dependent, cAMP-mediated mechanism... - Transplantation of embryonic stem cells improves cardiac function in postinfarcted ratsJiang-Yong Min
The Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Boston Massachusetts 02215, USA
J Appl Physiol 92:288-96. 2002..The present data demonstrate that ES cell transplantation is a feasible and novel approach to improve ventricular function in infarcted failing hearts...