Chin Fen Yang

Summary

Affiliation: MedImmune Vaccines
Country: USA

Publications

  1. doi request reprint Implication of respiratory syncytial virus (RSV) F transgene sequence heterogeneity observed in Phase 1 evaluation of MEDI-534, a live attenuated parainfluenza type 3 vectored RSV vaccine
    Chin Fen Yang
    MedImmune, 297 North Bernardo Avenue, Mountain View, CA 94043, United States
    Vaccine 31:2822-7. 2013
  2. pmc Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years
    Chin Fen Yang
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Virol J 6:138. 2009
  3. pmc Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66
    Erich Hoffmann
    MedImmune Vaccines, Inc, Mountain View, CA 94043, USA
    J Virol 79:11014-21. 2005
  4. pmc Human metapneumovirus G protein is highly conserved within but not between genetic lineages
    Chin Fen Yang
    MedImmune Vaccines, LLC, Mountain View, CA, USA
    Arch Virol 158:1245-52. 2013
  5. pmc Rescue of influenza B virus from eight plasmids
    Erich Hoffmann
    MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Proc Natl Acad Sci U S A 99:11411-6. 2002
  6. doi request reprint Genetic sequence analysis of influenza viruses and illness severity in ill children previously vaccinated with live attenuated or inactivated influenza vaccine
    Chin Fen Yang
    MedImmune, Gaithersburg, MD, USA
    Vaccine 28:5128-34. 2010
  7. pmc Population-based incidence of human metapneumovirus infection among hospitalized children
    John V Williams
    Department of Pediatrics, Vanderbilt University Schoolof Medicine, and Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 2581, USA
    J Infect Dis 201:1890-8. 2010
  8. pmc Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab
    Qing Zhu
    Department of Infectious Disease Vaccines, MedImmune, Gaithersburg, Maryland, USA
    J Infect Dis 203:674-82. 2011
  9. doi request reprint The hemagglutinin protein of influenza A/Vietnam/1203/2004 (H5N1) contributes to hyperinduction of proinflammatory cytokines in human epithelial cells
    Xing Cheng
    MedImmune, 319 North Bernardo Avenue, Mountain View, CA 93043, USA
    Virology 406:28-36. 2010
  10. pmc The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience
    John V Williams
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Infect Dis 193:387-95. 2006

Collaborators

Detail Information

Publications13

  1. doi request reprint Implication of respiratory syncytial virus (RSV) F transgene sequence heterogeneity observed in Phase 1 evaluation of MEDI-534, a live attenuated parainfluenza type 3 vectored RSV vaccine
    Chin Fen Yang
    MedImmune, 297 North Bernardo Avenue, Mountain View, CA 94043, United States
    Vaccine 31:2822-7. 2013
    ..An association between shedding of variants and lower RSV F serological response was observed but it was not possible to establish a definitive clinical significance due to the small number of subjects in this study...
  2. pmc Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years
    Chin Fen Yang
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
    Virol J 6:138. 2009
    ..Human metapneumovirus (HMPV) is an important cause of acute respiratory illness in children. We examined the diversity and molecular evolution of HMPV using 85 full-length F (fusion) gene sequences collected over a 20-year period...
  3. pmc Multiple gene segments control the temperature sensitivity and attenuation phenotypes of ca B/Ann Arbor/1/66
    Erich Hoffmann
    MedImmune Vaccines, Inc, Mountain View, CA 94043, USA
    J Virol 79:11014-21. 2005
    ....
  4. pmc Human metapneumovirus G protein is highly conserved within but not between genetic lineages
    Chin Fen Yang
    MedImmune Vaccines, LLC, Mountain View, CA, USA
    Arch Virol 158:1245-52. 2013
    ..HMPV G was conserved within lineages over 20 years, suggesting functional constraints on diversity. However, G was poorly conserved between subgroups, pointing to potentially distinct roles for G among different viral lineages...
  5. pmc Rescue of influenza B virus from eight plasmids
    Erich Hoffmann
    MedImmune Vaccines, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Proc Natl Acad Sci U S A 99:11411-6. 2002
    ..Our results demonstrate that the eight-plasmid system can be used for the generation of high yields of influenza B virus vaccines expressing current HA and NA glycoproteins from either of the two lineages of influenza B virus...
  6. doi request reprint Genetic sequence analysis of influenza viruses and illness severity in ill children previously vaccinated with live attenuated or inactivated influenza vaccine
    Chin Fen Yang
    MedImmune, Gaithersburg, MD, USA
    Vaccine 28:5128-34. 2010
    ..Viruses of each influenza B lineage caused more illnesses than A/H1N1 viruses; strategies to enhance protection against multiple influenza B lineages should be pursued...
  7. pmc Population-based incidence of human metapneumovirus infection among hospitalized children
    John V Williams
    Department of Pediatrics, Vanderbilt University Schoolof Medicine, and Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 2581, USA
    J Infect Dis 201:1890-8. 2010
    ..Human metapneumovirus (HMPV) is a leading cause of acute respiratory illness (ARI) in children. Population-based incidence rates and comprehensive clinical characterizations of disease have not been established...
  8. pmc Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab
    Qing Zhu
    Department of Infectious Disease Vaccines, MedImmune, Gaithersburg, Maryland, USA
    J Infect Dis 203:674-82. 2011
    ..Although palivizumab escape mutants have been generated in the laboratory, the development of resistant RSV in patients receiving palivizumab has not been reported previously...
  9. doi request reprint The hemagglutinin protein of influenza A/Vietnam/1203/2004 (H5N1) contributes to hyperinduction of proinflammatory cytokines in human epithelial cells
    Xing Cheng
    MedImmune, 319 North Bernardo Avenue, Mountain View, CA 93043, USA
    Virology 406:28-36. 2010
    ..The full implications of cytokine induction in vaccine virus-induced immune responses remain to be explored...
  10. pmc The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience
    John V Williams
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Infect Dis 193:387-95. 2006
    ..The role that human metapneumovirus (hMPV) plays in the etiology of upper respiratory tract infections (URIs) in children over a period of many years has not been evaluated previously...
  11. pmc Molecular and cellular response profiles induced by the TLR4 agonist-based adjuvant Glucopyranosyl Lipid A
    Stacie L Lambert
    MedImmune LLC, Mountain View, CA, USA
    PLoS ONE 7:e51618. 2012
    ..These compounds can be formulated as part of novel adjuvants to enhance vaccine medicated immune responses. However, the contribution of the formulation to the innate in vivo activity of TLR4 agonist compounds is not well understood...
  12. ncbi request reprint Cross-reactive H1N1 antibody responses to a live attenuated influenza vaccine in children: implication for selection of vaccine strains
    Min Shi Lee
    MedImmune Vaccines, Mountain View, California 94043, USA
    J Infect Dis 188:1362-6. 2003
    ..The observed differences in HAI cross-reactivity seem to be partly related to the number of amino acid (aa) differences on the hemagglutinin 1 domain (328 aa residues) rather than the hemagglutinin protein (550 aa residues)...
  13. ncbi request reprint Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60
    Hong Jin
    MedImmune Vaccines, Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Virology 306:18-24. 2003
    ..In addition, PB1(2005) (A661T) also contributed to the ts phenotype. The identification of multiple genetic loci that control the MDV-A ts phenotype provides a molecular basis for the observed genetic stability of FluMist vaccines...