Roderick S Tang

Summary

Affiliation: MedImmune Vaccines
Country: USA

Publications

  1. ncbi request reprint A host-range restricted parainfluenza virus type 3 (PIV3) expressing the human metapneumovirus (hMPV) fusion protein elicits protective immunity in African green monkeys
    Roderick S Tang
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 23:1657-67. 2005
  2. doi request reprint Development of a PIV-vectored RSV vaccine: preclinical evaluation of safety, toxicity, and enhanced disease and initial clinical testing in healthy adults
    Roderick S Tang
    MedImmune, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 26:6373-82. 2008
  3. pmc Parainfluenza virus type 3 expressing the native or soluble fusion (F) Protein of Respiratory Syncytial Virus (RSV) confers protection from RSV infection in African green monkeys
    Roderick S Tang
    MedImmune Vaccines Inc, 297 N Bernerdo Avenue, Mountain View, CA 94043, USA
    J Virol 78:11198-207. 2004
  4. ncbi request reprint Evaluation of attenuation, immunogenicity and efficacy of a bovine parainfluenza virus type 3 (PIV-3) vaccine and a recombinant chimeric bovine/human PIV-3 vaccine vector in rhesus monkeys
    Sridhar Pennathur
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    J Gen Virol 84:3253-61. 2003
  5. ncbi request reprint Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design
    Mia MacPhail
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    J Gen Virol 85:1655-63. 2004
  6. pmc Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters
    Jeanne H Schickli
    Research Dept, MedImmune, Mountain View, CA 94043, USA
    Virol J 5:69. 2008
  7. pmc An S101P substitution in the putative cleavage motif of the human metapneumovirus fusion protein is a major determinant for trypsin-independent growth in vero cells and does not alter tissue tropism in hamsters
    Jeanne H Schickli
    MedImmune Vaccines, Inc, 297 N Bernardo Ave, Mountain View, CA 94043, USA
    J Virol 79:10678-89. 2005
  8. pmc Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity
    Roderick S Tang
    MedImmune Vaccines, Inc, Mountain View, California 94043, USA
    J Virol 77:10819-28. 2003
  9. ncbi request reprint Genetic stability of RSV-F expression and the restricted growth phenotype of a live attenuated PIV3 vectored RSV vaccine candidate (MEDI-534) following restrictive growth in human lung cells
    Christine L Nelson
    MedImmune, 297North, Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 31:3756-62. 2013
  10. doi request reprint Nonclinical phenotypic and genotypic analyses of a Phase 1 pediatric respiratory syncytial virus vaccine candidate MEDI-559 (rA2cp248/404/1030ΔSH) at permissive and non-permissive temperatures
    Jeanne H Schickli
    MedImmune, Mountain View, CA 94043, United States
    Virus Res 169:38-47. 2012

Collaborators

Detail Information

Publications15

  1. ncbi request reprint A host-range restricted parainfluenza virus type 3 (PIV3) expressing the human metapneumovirus (hMPV) fusion protein elicits protective immunity in African green monkeys
    Roderick S Tang
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 23:1657-67. 2005
    ..These studies showed that b/h PIV3/hMPV F2 was immunogenic, protective and attenuated in non-human primates and warrants further evaluation in humans as a vaccine candidate for prevention of hMPV-associated respiratory tract diseases...
  2. doi request reprint Development of a PIV-vectored RSV vaccine: preclinical evaluation of safety, toxicity, and enhanced disease and initial clinical testing in healthy adults
    Roderick S Tang
    MedImmune, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 26:6373-82. 2008
    ..In adults, MEDI-534 was highly restricted in replication, did not boost RSV and PIV3 antibody titers, and produced no medically significant vaccine-related adverse events thereby warranting further evaluation in pediatric populations...
  3. pmc Parainfluenza virus type 3 expressing the native or soluble fusion (F) Protein of Respiratory Syncytial Virus (RSV) confers protection from RSV infection in African green monkeys
    Roderick S Tang
    MedImmune Vaccines Inc, 297 N Bernerdo Avenue, Mountain View, CA 94043, USA
    J Virol 78:11198-207. 2004
    ..The PIV3-vectored RSV vaccines evaluated here further underscore the utility of this vector system for developing safe and immunogenic pediatric respiratory virus vaccines...
  4. ncbi request reprint Evaluation of attenuation, immunogenicity and efficacy of a bovine parainfluenza virus type 3 (PIV-3) vaccine and a recombinant chimeric bovine/human PIV-3 vaccine vector in rhesus monkeys
    Sridhar Pennathur
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    J Gen Virol 84:3253-61. 2003
    ..These results support the use of bPIV-3 vaccines propagated in Vero cells in human clinical trials and the use of b/hPIV-3 as a virus vaccine vector to express foreign viral antigens...
  5. ncbi request reprint Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design
    Mia MacPhail
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    J Gen Virol 85:1655-63. 2004
    ..Although these animal models do not mimic human hMPV disease signs, they will nevertheless be invaluable for the future evaluation of hMPV antivirals, mAbs and vaccines...
  6. pmc Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters
    Jeanne H Schickli
    Research Dept, MedImmune, Mountain View, CA 94043, USA
    Virol J 5:69. 2008
    ..Using a variant of hMPV/NL/1/00 that does not require trypsin supplementation for growth in tissue culture, we deleted the M2-2 gene and evaluated the replication of rhMPV/DeltaM2-2 virus in vitro and in vivo...
  7. pmc An S101P substitution in the putative cleavage motif of the human metapneumovirus fusion protein is a major determinant for trypsin-independent growth in vero cells and does not alter tissue tropism in hamsters
    Jeanne H Schickli
    MedImmune Vaccines, Inc, 297 N Bernardo Ave, Mountain View, CA 94043, USA
    J Virol 79:10678-89. 2005
    ..The ability of these hMPV strains to replicate efficiently in the absence of trypsin should greatly facilitate the generation, preclinical testing, and manufacturing of attenuated hMPV vaccine candidates...
  8. pmc Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity
    Roderick S Tang
    MedImmune Vaccines, Inc, Mountain View, California 94043, USA
    J Virol 77:10819-28. 2003
    ....
  9. ncbi request reprint Genetic stability of RSV-F expression and the restricted growth phenotype of a live attenuated PIV3 vectored RSV vaccine candidate (MEDI-534) following restrictive growth in human lung cells
    Christine L Nelson
    MedImmune, 297North, Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 31:3756-62. 2013
    ..The utility and limits of MRC-5 cells for characterizing the attenuation and RSV-F expression of MEDI-534 is discussed. ..
  10. doi request reprint Nonclinical phenotypic and genotypic analyses of a Phase 1 pediatric respiratory syncytial virus vaccine candidate MEDI-559 (rA2cp248/404/1030ΔSH) at permissive and non-permissive temperatures
    Jeanne H Schickli
    MedImmune, Mountain View, CA 94043, United States
    Virus Res 169:38-47. 2012
    ..All the tsi viruses have small plaque phenotypes and are highly attenuated in the lungs of cotton rats...
  11. doi request reprint Implication of respiratory syncytial virus (RSV) F transgene sequence heterogeneity observed in Phase 1 evaluation of MEDI-534, a live attenuated parainfluenza type 3 vectored RSV vaccine
    Chin Fen Yang
    MedImmune, 297 North Bernardo Avenue, Mountain View, CA 94043, United States
    Vaccine 31:2822-7. 2013
    ..An association between shedding of variants and lower RSV F serological response was observed but it was not possible to establish a definitive clinical significance due to the small number of subjects in this study...
  12. pmc A single amino acid in the F2 subunit of respiratory syncytial virus fusion protein alters growth and fusogenicity
    Heather A Lawlor
    MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    J Gen Virol 94:2627-35. 2013
    ..Syncytium-formation experiments with RSV F protein carrying mutations at aa 66 suggested that a change in charge at this residue within the F2 fragment can have a significant impact on fusion. ..
  13. ncbi request reprint Challenges in developing a pediatric RSV vaccine
    Jeanne H Schickli
    Research Department, MedImmune, Mountain View, CA, USA
    Hum Vaccin 5:582-91. 2009
    ....
  14. pmc Adults 65 years old and older have reduced numbers of functional memory T cells to respiratory syncytial virus fusion protein
    Anu Cherukuri
    Infectious Diseases Vaccines Research, MedImmune, LLC, Mountain View, California, USA
    Clin Vaccine Immunol 20:239-47. 2013
    ..0% ± 1.6% versus 5.0% ± 1.6%) were measured in PBMC from elderly than young adults. These results suggest that deficient RSV F-specific T cell responses contribute to susceptibility to severe RSV disease in elderly adults...
  15. ncbi request reprint Clustered charge-to-alanine mutagenesis of human respiratory syncytial virus L polymerase generates temperature-sensitive viruses
    Roderick S Tang
    MedImmune Vaccines, Mountain View, California 94043, USA
    Virology 302:207-16. 2002
    ..Five combination mutants were recovered that exhibited shut-off temperatures ranging from 36 to 39 degrees C in tissue culture and restricted replication in the respiratory tracts of cotton rats...