Jeanne H Schickli

Summary

Affiliation: MedImmune Vaccines
Country: USA

Publications

  1. pmc Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity
    Roderick S Tang
    MedImmune Vaccines, Inc, Mountain View, California 94043, USA
    J Virol 77:10819-28. 2003
  2. doi request reprint Nonclinical phenotypic and genotypic analyses of a Phase 1 pediatric respiratory syncytial virus vaccine candidate MEDI-559 (rA2cp248/404/1030ΔSH) at permissive and non-permissive temperatures
    Jeanne H Schickli
    MedImmune, Mountain View, CA 94043, United States
    Virus Res 169:38-47. 2012
  3. ncbi request reprint Challenges in developing a pediatric RSV vaccine
    Jeanne H Schickli
    Research Department, MedImmune, Mountain View, CA, USA
    Hum Vaccin 5:582-91. 2009
  4. pmc Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters
    Jeanne H Schickli
    Research Dept, MedImmune, Mountain View, CA 94043, USA
    Virol J 5:69. 2008
  5. pmc An S101P substitution in the putative cleavage motif of the human metapneumovirus fusion protein is a major determinant for trypsin-independent growth in vero cells and does not alter tissue tropism in hamsters
    Jeanne H Schickli
    MedImmune Vaccines, Inc, 297 N Bernardo Ave, Mountain View, CA 94043, USA
    J Virol 79:10678-89. 2005
  6. pmc Parainfluenza virus type 3 expressing the native or soluble fusion (F) Protein of Respiratory Syncytial Virus (RSV) confers protection from RSV infection in African green monkeys
    Roderick S Tang
    MedImmune Vaccines Inc, 297 N Bernerdo Avenue, Mountain View, CA 94043, USA
    J Virol 78:11198-207. 2004
  7. ncbi request reprint Evaluation of attenuation, immunogenicity and efficacy of a bovine parainfluenza virus type 3 (PIV-3) vaccine and a recombinant chimeric bovine/human PIV-3 vaccine vector in rhesus monkeys
    Sridhar Pennathur
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    J Gen Virol 84:3253-61. 2003
  8. ncbi request reprint A host-range restricted parainfluenza virus type 3 (PIV3) expressing the human metapneumovirus (hMPV) fusion protein elicits protective immunity in African green monkeys
    Roderick S Tang
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 23:1657-67. 2005
  9. ncbi request reprint Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design
    Mia MacPhail
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    J Gen Virol 85:1655-63. 2004
  10. pmc A single amino acid in the F2 subunit of respiratory syncytial virus fusion protein alters growth and fusogenicity
    Heather A Lawlor
    MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    J Gen Virol 94:2627-35. 2013

Collaborators

Detail Information

Publications13

  1. pmc Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity
    Roderick S Tang
    MedImmune Vaccines, Inc, Mountain View, California 94043, USA
    J Virol 77:10819-28. 2003
    ....
  2. doi request reprint Nonclinical phenotypic and genotypic analyses of a Phase 1 pediatric respiratory syncytial virus vaccine candidate MEDI-559 (rA2cp248/404/1030ΔSH) at permissive and non-permissive temperatures
    Jeanne H Schickli
    MedImmune, Mountain View, CA 94043, United States
    Virus Res 169:38-47. 2012
    ..All the tsi viruses have small plaque phenotypes and are highly attenuated in the lungs of cotton rats...
  3. ncbi request reprint Challenges in developing a pediatric RSV vaccine
    Jeanne H Schickli
    Research Department, MedImmune, Mountain View, CA, USA
    Hum Vaccin 5:582-91. 2009
    ....
  4. pmc Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters
    Jeanne H Schickli
    Research Dept, MedImmune, Mountain View, CA 94043, USA
    Virol J 5:69. 2008
    ..Using a variant of hMPV/NL/1/00 that does not require trypsin supplementation for growth in tissue culture, we deleted the M2-2 gene and evaluated the replication of rhMPV/DeltaM2-2 virus in vitro and in vivo...
  5. pmc An S101P substitution in the putative cleavage motif of the human metapneumovirus fusion protein is a major determinant for trypsin-independent growth in vero cells and does not alter tissue tropism in hamsters
    Jeanne H Schickli
    MedImmune Vaccines, Inc, 297 N Bernardo Ave, Mountain View, CA 94043, USA
    J Virol 79:10678-89. 2005
    ..The ability of these hMPV strains to replicate efficiently in the absence of trypsin should greatly facilitate the generation, preclinical testing, and manufacturing of attenuated hMPV vaccine candidates...
  6. pmc Parainfluenza virus type 3 expressing the native or soluble fusion (F) Protein of Respiratory Syncytial Virus (RSV) confers protection from RSV infection in African green monkeys
    Roderick S Tang
    MedImmune Vaccines Inc, 297 N Bernerdo Avenue, Mountain View, CA 94043, USA
    J Virol 78:11198-207. 2004
    ..The PIV3-vectored RSV vaccines evaluated here further underscore the utility of this vector system for developing safe and immunogenic pediatric respiratory virus vaccines...
  7. ncbi request reprint Evaluation of attenuation, immunogenicity and efficacy of a bovine parainfluenza virus type 3 (PIV-3) vaccine and a recombinant chimeric bovine/human PIV-3 vaccine vector in rhesus monkeys
    Sridhar Pennathur
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    J Gen Virol 84:3253-61. 2003
    ..These results support the use of bPIV-3 vaccines propagated in Vero cells in human clinical trials and the use of b/hPIV-3 as a virus vaccine vector to express foreign viral antigens...
  8. ncbi request reprint A host-range restricted parainfluenza virus type 3 (PIV3) expressing the human metapneumovirus (hMPV) fusion protein elicits protective immunity in African green monkeys
    Roderick S Tang
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    Vaccine 23:1657-67. 2005
    ..These studies showed that b/h PIV3/hMPV F2 was immunogenic, protective and attenuated in non-human primates and warrants further evaluation in humans as a vaccine candidate for prevention of hMPV-associated respiratory tract diseases...
  9. ncbi request reprint Identification of small-animal and primate models for evaluation of vaccine candidates for human metapneumovirus (hMPV) and implications for hMPV vaccine design
    Mia MacPhail
    MedImmune Vaccines Inc, 297 North Bernardo Avenue, Mountain View, CA 94043, USA
    J Gen Virol 85:1655-63. 2004
    ..Although these animal models do not mimic human hMPV disease signs, they will nevertheless be invaluable for the future evaluation of hMPV antivirals, mAbs and vaccines...
  10. pmc A single amino acid in the F2 subunit of respiratory syncytial virus fusion protein alters growth and fusogenicity
    Heather A Lawlor
    MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    J Gen Virol 94:2627-35. 2013
    ..Syncytium-formation experiments with RSV F protein carrying mutations at aa 66 suggested that a change in charge at this residue within the F2 fragment can have a significant impact on fusion. ..
  11. doi request reprint Implication of respiratory syncytial virus (RSV) F transgene sequence heterogeneity observed in Phase 1 evaluation of MEDI-534, a live attenuated parainfluenza type 3 vectored RSV vaccine
    Chin Fen Yang
    MedImmune, 297 North Bernardo Avenue, Mountain View, CA 94043, United States
    Vaccine 31:2822-7. 2013
    ..An association between shedding of variants and lower RSV F serological response was observed but it was not possible to establish a definitive clinical significance due to the small number of subjects in this study...
  12. pmc The N-terminal region of the murine coronavirus spike glycoprotein is associated with the extended host range of viruses from persistently infected murine cells
    Jeanne H Schickli
    Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 78:9073-83. 2004
    ..Thus, 21 amino acid substitutions and a 7-amino-acid insert in the N-terminal region of the S glycoprotein of MHV/BHK confer the ability to bind and in some cases infect cells of nonmurine species...
  13. pmc Recovery of human metapneumovirus genetic lineages a and B from cloned cDNA
    Sander Herfst
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Virol 78:8264-70. 2004
    ..The recombinant viruses replicated with kinetics similar to those of the parental viruses in Vero cells. This reverse genetics system provides an important new tool for applied and fundamental research...