Christopher S Ambrose

Summary

Affiliation: MedImmune Vaccines
Country: USA

Publications

  1. doi request reprint A whole genome transcriptional analysis of the early immune response induced by live attenuated and inactivated influenza vaccines in young children
    Wei Zhu
    MedImmune, Translational Sciences, Gaithersburg, MD 20878, USA
    Vaccine 28:2865-76. 2010
  2. doi request reprint The healthcare and societal burden associated with influenza in vaccinated and unvaccinated European and Israeli children
    C S Ambrose
    MedImmune, One MedImmune Way, Gaithersburg, MD, 20878, USA
    Eur J Clin Microbiol Infect Dis 33:569-75. 2014
  3. pmc Burden of paediatric influenza in Western Europe: a systematic review
    Evgeniya N Antonova
    MedImmune, LLC, 1 MedImmune Way, Gaithersburg, Maryland 20878, USA
    BMC Public Health 12:968. 2012
  4. doi request reprint Improved timing of availability and administration of influenza vaccine through the US Vaccines for Children Program from 2007 to 2011
    Christopher S Ambrose
    MedImmune, LLC, Gaithersburg, MD 20878, USA
    Clin Pediatr (Phila) 52:224-30. 2013
  5. doi request reprint The safety and effectiveness of self-administration of intranasal live attenuated influenza vaccine in adults
    Christopher S Ambrose
    MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Vaccine 31:857-60. 2013
  6. doi request reprint The efficacy of intranasal live attenuated influenza vaccine in children 2 through 17 years of age: a meta-analysis of 8 randomized controlled studies
    Christopher S Ambrose
    Medical and Scientific Affairs, MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Vaccine 30:886-92. 2012
  7. doi request reprint The role of nasal IgA in children vaccinated with live attenuated influenza vaccine
    Christopher S Ambrose
    MedImmune, LLC, Gaithersburg, MD 20878, USA
    Vaccine 30:6794-801. 2012
  8. pmc The safety and efficacy of live attenuated influenza vaccine in young children with asthma or prior wheezing
    C S Ambrose
    Medical and Scientific Affairs, MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Eur J Clin Microbiol Infect Dis 31:2549-57. 2012
  9. pmc The rationale for quadrivalent influenza vaccines
    Christopher S Ambrose
    MedImmune, LLC, Gaithersburg, MD, USA
    Hum Vaccin Immunother 8:81-8. 2012
  10. ncbi request reprint Efficacy and correlates of protection for cell culture-derived and egg-derived inactivated influenza vaccines in younger adults
    Christopher S Ambrose
    MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    Expert Rev Vaccines 10:1127-30. 2011

Detail Information

Publications36

  1. doi request reprint A whole genome transcriptional analysis of the early immune response induced by live attenuated and inactivated influenza vaccines in young children
    Wei Zhu
    MedImmune, Translational Sciences, Gaithersburg, MD 20878, USA
    Vaccine 28:2865-76. 2010
    ....
  2. doi request reprint The healthcare and societal burden associated with influenza in vaccinated and unvaccinated European and Israeli children
    C S Ambrose
    MedImmune, One MedImmune Way, Gaithersburg, MD, 20878, USA
    Eur J Clin Microbiol Infect Dis 33:569-75. 2014
    ..These data underscore the potential benefits of annual vaccination of children against influenza...
  3. pmc Burden of paediatric influenza in Western Europe: a systematic review
    Evgeniya N Antonova
    MedImmune, LLC, 1 MedImmune Way, Gaithersburg, Maryland 20878, USA
    BMC Public Health 12:968. 2012
    ..Our aim was to summarise influenza burden (in terms of health outcomes and economic burden) in children in Western Europe via a systematic literature review...
  4. doi request reprint Improved timing of availability and administration of influenza vaccine through the US Vaccines for Children Program from 2007 to 2011
    Christopher S Ambrose
    MedImmune, LLC, Gaithersburg, MD 20878, USA
    Clin Pediatr (Phila) 52:224-30. 2013
    ..5% (P < .001) in 2007-2008, 45.9% and 55.1% (P < .001) in 2008-2009, and 50.0% and 52.9% (P < .001) in 2010-2011, respectively. Despite delays, earlier VFC shipment in 2010-2011 enabled greater equity in 2-dose compliance...
  5. doi request reprint The safety and effectiveness of self-administration of intranasal live attenuated influenza vaccine in adults
    Christopher S Ambrose
    MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Vaccine 31:857-60. 2013
    ..SA-LAIV and HCP-LAIV appeared similarly effective against influenza-like illness and had comparable safety profiles...
  6. doi request reprint The efficacy of intranasal live attenuated influenza vaccine in children 2 through 17 years of age: a meta-analysis of 8 randomized controlled studies
    Christopher S Ambrose
    Medical and Scientific Affairs, MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Vaccine 30:886-92. 2012
    ..The objective of the current analysis was to integrate available LAIV efficacy data in children aged 2-17 years, the group for whom LAIV is approved for use...
  7. doi request reprint The role of nasal IgA in children vaccinated with live attenuated influenza vaccine
    Christopher S Ambrose
    MedImmune, LLC, Gaithersburg, MD 20878, USA
    Vaccine 30:6794-801. 2012
    ..The role of IgA in providing protection against influenza in children vaccinated with live attenuated influenza vaccine (LAIV) has not been well described...
  8. pmc The safety and efficacy of live attenuated influenza vaccine in young children with asthma or prior wheezing
    C S Ambrose
    Medical and Scientific Affairs, MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Eur J Clin Microbiol Infect Dis 31:2549-57. 2012
    ..Data regarding LAIV use are limited among individuals with severe asthma or active wheezing within the 7 days before vaccination...
  9. pmc The rationale for quadrivalent influenza vaccines
    Christopher S Ambrose
    MedImmune, LLC, Gaithersburg, MD, USA
    Hum Vaccin Immunother 8:81-8. 2012
    ....
  10. ncbi request reprint Efficacy and correlates of protection for cell culture-derived and egg-derived inactivated influenza vaccines in younger adults
    Christopher S Ambrose
    MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    Expert Rev Vaccines 10:1127-30. 2011
    ..However, further analysis of the correlation appears warranted in the Barrett study and in future studies to better describe antibody-induced and vaccine-induced protection from influenza illness...
  11. pmc An integrated, multistudy analysis of the safety of Ann Arbor strain live attenuated influenza vaccine in children aged 2-17 years
    Christopher S Ambrose
    MedImmune LLC, Gaithersburg, MD, USA
    Influenza Other Respir Viruses 5:389-97. 2011
    ..Trivalent, Ann Arbor strain, live attenuated influenza vaccine (LAIV) is approved in several countries for use in eligible children aged ≥2 years...
  12. doi request reprint Evidence of homosubtypic but not heterosubtypic immunity in young children following wild-type influenza illness
    Christopher S Ambrose
    Medical and Scientific Affairs, Gaithersburg, MD, USA
    Pediatr Infect Dis J 30:900-1. 2011
    ..This analysis supports previous observations that children do not develop lasting, clinically significant heterosubtypic protection after influenza illness...
  13. pmc Factors associated with increased vaccination in 2009 H1N1 school-located influenza vaccination programs
    Christopher S Ambrose
    MedImmune, LLC, Gaithersburg, MD, USA
    Hum Vaccin 7:864-7. 2011
    ..28, p = 0.05 and 16 vs. 30, p < 0.01, respectively). These data suggest that future SLIV programs may achieve higher uptake rates if conducted during school hours with advance parental consent and when parental demand is highest...
  14. pmc The relative efficacy of trivalent live attenuated and inactivated influenza vaccines in children and adults
    Christopher S Ambrose
    MedImmune, Gaithersburg, MD 20878, USA
    Influenza Other Respir Viruses 5:67-75. 2011
    ..Studies should examine the role of pre-existing immunity as well as vaccine impact on influenza illness of varying severity...
  15. doi request reprint Duration of protection provided by live attenuated influenza vaccine in children
    Christopher S Ambrose
    MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    Pediatr Infect Dis J 27:744-8. 2008
    ..Reliable availability of influenza vaccine before October could enable the vaccination of many children who might not otherwise be vaccinated...
  16. doi request reprint Genetic sequence analysis of influenza viruses and illness severity in ill children previously vaccinated with live attenuated or inactivated influenza vaccine
    Chin Fen Yang
    MedImmune, Gaithersburg, MD, USA
    Vaccine 28:5128-34. 2010
    ..Viruses of each influenza B lineage caused more illnesses than A/H1N1 viruses; strategies to enhance protection against multiple influenza B lineages should be pursued...
  17. doi request reprint Quadrivalent Ann Arbor strain live-attenuated influenza vaccine
    Seth L Toback
    MedImmune, LLC, Gaithersburg, MD, USA
    Expert Rev Vaccines 11:1293-303. 2012
    ..Q/LAIV was recently approved for use in the USA in eligible individuals 2-49 years of age. This review summarizes clinical trial data in support of Q/LAIV...
  18. doi request reprint In-office influenza vaccination by US pediatric providers varies greatly and is higher among smaller offices
    Seth L Toback
    MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Clin Pediatr (Phila) 51:551-9. 2012
    ..A greater understanding of interoffice variability in influenza vaccine delivery by US pediatric providers should allow for the creation of more effective strategies to improve pediatric influenza vaccination rates...
  19. doi request reprint Shedding of Ann Arbor strain live attenuated influenza vaccine virus in children 6-59 months of age
    Raburn M Mallory
    MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Vaccine 29:4322-7. 2011
    ..The incidence, duration, and other parameters of viral shedding after vaccination with LAIV have not been fully described in children ≤ 5 years of age...
  20. doi request reprint Maternal outcomes among pregnant women receiving live attenuated influenza vaccine
    Seth L Toback
    MedImmune, LLC, Gaithersburg, MD 20878, USA
    Influenza Other Respir Viruses 6:44-51. 2012
    ..Data regarding maternal outcomes after LAIV administration during pregnancy are limited...
  21. pmc Safety and immunogenicity following administration of a live, attenuated monovalent 2009 H1N1 influenza vaccine to children and adults in two randomized controlled trials
    Raburn M Mallory
    MedImmune, LLC, Gaithersburg, Maryland, United States of America
    PLoS ONE 5:e13755. 2010
    ..The safety, tolerability, and immunogenicity of a monovalent intranasal 2009 A/H1N1 live attenuated influenza vaccine (LAIV) were evaluated in children and adults...
  22. pmc A survey of pediatricians' attitudes regarding influenza immunization in children
    Daniel J Levy
    Child and Teen Wellness Center, Owings Mills, MD, USA
    BMC Pediatr 9:8. 2009
    ..Recommendations for vaccination of children against influenza have been revised several times since 2002, and as of 2008 include all children 6 months to 18 years of age. Nevertheless, influenza immunization rates have remained low...
  23. doi request reprint The efficacy of live attenuated and inactivated influenza vaccines in children as a function of time postvaccination
    Christopher S Ambrose
    MedImmune LLC, Gaithersburg, MD, USA
    Pediatr Infect Dis J 29:806-11. 2010
    ..Three large, randomized studies compared LAIV and TIV efficacy in children, providing the opportunity to examine the impact of time on the relative efficacy of the 2 vaccines...
  24. doi request reprint A postlicensure evaluation of the safety of Ann Arbor strain live attenuated influenza vaccine in children 24-59 months of age
    Seth L Toback
    MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Vaccine 31:1812-8. 2013
    ..At that time, a postlicensure commitment was made to describe the safety of LAIV within a cohort of eligible children aged 2-5 years...
  25. doi request reprint Trends in U.S. pediatric influenza vaccination from 2006 to 2010 among children with private insurance
    Seth L Toback
    MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
    Vaccine 29:4225-9. 2011
    ..While pediatric influenza vaccination occurred earlier each year, vaccination in later months has not increased in recent seasons, despite efforts to extend the vaccination season...
  26. pmc Current experience with school-located influenza vaccination programs in the United States: a review of the medical literature
    Harry F Hull
    HF Hull and Associates, LLC, St Paul, MN, USA
    Hum Vaccin 7:153-60. 2011
    ..The greatest need for future U.S. SLIV program implementation is the development of a financially sustainable model that can be replicated annually on a national scale...
  27. doi request reprint Effectiveness of intranasal live attenuated influenza vaccine against all-cause acute otitis media in children
    Terho Heikkinen
    Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
    Pediatr Infect Dis J 32:669-74. 2013
    ..However, the annual effectiveness of LAIV against all-cause AOM is unknown...
  28. doi request reprint A multi-season national estimate of adult influenza vaccination by U.S. office-based pediatricians, 2006-2011
    Seth L Toback
    MedImmune, LLC, Medical and Scientific Affairs, One MedImmune Way, Gaithersburg, MD 20878, USA
    Influenza Other Respir Viruses 6:231-4. 2012
    ....
  29. ncbi request reprint Live attenuated influenza vaccine in children
    Christopher S Ambrose
    MedImmune, Inc, Gaithersburg, MD 20878, USA
    Semin Pediatr Infect Dis 17:206-12. 2006
    ..Additional large-scale safety and efficacy studies in young children, including a formal risk-benefit assessment, are ongoing. The results of these analyses will guide potential future use in young children...
  30. pmc Influenza vaccination of parents and guardians by US pediatricians
    Seth L Toback
    MedImmune, LLC, Gaithersburg, MD USA
    Hum Vaccin 7:436-40. 2011
    ..Efforts should be taken to address barriers to parental vaccination so that pediatricians are better able to vaccinate parents/guardians of their patients against influenza...
  31. doi request reprint The impact of school-located influenza vaccination programs on student absenteeism: a review of the U.S. literature
    Harry F Hull
    HF Hull and Associates, LLC, St Paul, MN, USA
    J Sch Nurs 27:34-42. 2011
    ..Additional research into sustainable funding sources and the comprehensive effects of SLIV programs on students, families, staff, and the community is warranted...
  32. pmc Current status of live attenuated influenza vaccine in the United States for seasonal and pandemic influenza
    Christopher S Ambrose
    MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
    Influenza Other Respir Viruses 2:193-202. 2008
    ..Formulations of LAIV against pandemic influenza strains, including H5N1, H9N2, and H7N3, are currently being tested in preclinical and phase I clinical studies...
  33. ncbi request reprint Respiratory Syncytial Virus Disease in Preterm Infants in the US Born at 32-35 Weeks Gestation Not Receiving Immunoprophylaxis
    Christopher S Ambrose
    From the MedImmune Medical and Scientific Affairs, Gaithersburg, MD Departments of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, GA Department of Pediatrics, University of Colorado, School of Medicine, and Department of Pediatrics, Children s Hospital Colorado, Aurora, CO former employee of MedImmune, Gaithersburg, MD Department of Pediatrics, University of Illinois, Chicago, IL and Current AstraZeneca, U S Medical Affairs, Gaithersburg, MD
    Pediatr Infect Dis J 33:576-82. 2014
    ..The Respiratory Syncytial Virus (RSV) Respiratory Events Among Preterm Infants Outcomes and Risk Tracking (REPORT) study evaluated RSV disease burden in US preterm infants 32-35 weeks gestational age (wGA) not receiving RSV prophylaxis...
  34. doi request reprint Clinical guidance on the use of live attenuated influenza vaccine after inadvertent freezing and warming
    Seth L Toback
    MedImmune, Gaithersburg, MD, USA
    J Pediatr Nurs 27:163-7. 2012
    ..If a particular annual formulation of LAIV is exposed to temperatures outside of the recommended storage range, practitioners should contact the manufacturer for guidance regarding proper vaccine handling...
  35. doi request reprint Shedding and immunogenicity of live attenuated influenza vaccine virus in subjects 5-49 years of age
    Stan L Block
    Kentucky Pediatric and Adult Research, Bardstown, KY 40004, United States
    Vaccine 26:4940-6. 2008
    ..Live attenuated influenza vaccine (LAIV) is indicated for influenza prevention in persons 2-49 years of age. This study describes the incidence and duration of vaccine virus shedding and serum immune responses after receipt of LAIV...