Research Topics
| Christopher S AmbroseSummaryAffiliation: MedImmune Vaccines Country: USA Publications
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Detail Information
Publications
A whole genome transcriptional analysis of the early immune response induced by live attenuated and inactivated influenza vaccines in young childrenWei Zhu
MedImmune, Translational Sciences, Gaithersburg, MD 20878, USA
Vaccine 28:2865-76. 2010....- Improved timing of availability and administration of influenza vaccine through the US Vaccines for Children Program from 2007 to 2011Christopher S Ambrose
MedImmune, LLC, Gaithersburg, MD 20878, USA
Clin Pediatr (Phila) 52:224-30. 2013..5% (P < .001) in 2007-2008, 45.9% and 55.1% (P < .001) in 2008-2009, and 50.0% and 52.9% (P < .001) in 2010-2011, respectively. Despite delays, earlier VFC shipment in 2010-2011 enabled greater equity in 2-dose compliance... - The safety and effectiveness of self-administration of intranasal live attenuated influenza vaccine in adultsChristopher S Ambrose
MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
Vaccine 31:857-60. 2013..SA-LAIV and HCP-LAIV appeared similarly effective against influenza-like illness and had comparable safety profiles... - The efficacy of intranasal live attenuated influenza vaccine in children 2 through 17 years of age: a meta-analysis of 8 randomized controlled studiesChristopher S Ambrose
Medical and Scientific Affairs, MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
Vaccine 30:886-92. 2012..The objective of the current analysis was to integrate available LAIV efficacy data in children aged 2-17 years, the group for whom LAIV is approved for use... - The role of nasal IgA in children vaccinated with live attenuated influenza vaccineChristopher S Ambrose
MedImmune, LLC, Gaithersburg, MD 20878, USA
Vaccine 30:6794-801. 2012..The role of IgA in providing protection against influenza in children vaccinated with live attenuated influenza vaccine (LAIV) has not been well described... 
The safety and efficacy of live attenuated influenza vaccine in young children with asthma or prior wheezingC S Ambrose
Medical and Scientific Affairs, MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
Eur J Clin Microbiol Infect Dis 31:2549-57. 2012..Data regarding LAIV use are limited among individuals with severe asthma or active wheezing within the 7 days before vaccination...- The rationale for quadrivalent influenza vaccinesChristopher S Ambrose
MedImmune, LLC, Gaithersburg, MD, USA
Hum Vaccin Immunother 8:81-8. 2012.... - An integrated, multistudy analysis of the safety of Ann Arbor strain live attenuated influenza vaccine in children aged 2-17 yearsChristopher S Ambrose
MedImmune LLC, Gaithersburg, MD, USA
Influenza Other Respi Viruses 5:389-97. 2011..Trivalent, Ann Arbor strain, live attenuated influenza vaccine (LAIV) is approved in several countries for use in eligible children aged ≥2 years... 
Efficacy and correlates of protection for cell culture-derived and egg-derived inactivated influenza vaccines in younger adultsChristopher S Ambrose
MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
Expert Rev Vaccines 10:1127-30. 2011..However, further analysis of the correlation appears warranted in the Barrett study and in future studies to better describe antibody-induced and vaccine-induced protection from influenza illness...- Evidence of homosubtypic but not heterosubtypic immunity in young children following wild-type influenza illnessChristopher S Ambrose
Medical and Scientific Affairs, Gaithersburg, MD, USA
Pediatr Infect Dis J 30:900-1. 2011..This analysis supports previous observations that children do not develop lasting, clinically significant heterosubtypic protection after influenza illness... - Factors associated with increased vaccination in 2009 H1N1 school-located influenza vaccination programsChristopher S Ambrose
MedImmune, LLC, Gaithersburg, MD, USA
Hum Vaccin 7:864-7. 2011..28, p = 0.05 and 16 vs. 30, p < 0.01, respectively). These data suggest that future SLIV programs may achieve higher uptake rates if conducted during school hours with advance parental consent and when parental demand is highest... - The relative efficacy of trivalent live attenuated and inactivated influenza vaccines in children and adultsChristopher S Ambrose
MedImmune, Gaithersburg, MD 20878, USA
Influenza Other Respi Viruses 5:67-75. 2011..Studies should examine the role of pre-existing immunity as well as vaccine impact on influenza illness of varying severity... - Duration of protection provided by live attenuated influenza vaccine in childrenChristopher S Ambrose
MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
Pediatr Infect Dis J 27:744-8. 2008..Reliable availability of influenza vaccine before October could enable the vaccination of many children who might not otherwise be vaccinated... - Genetic sequence analysis of influenza viruses and illness severity in ill children previously vaccinated with live attenuated or inactivated influenza vaccineChin Fen Yang
MedImmune, Gaithersburg, MD, USA
Vaccine 28:5128-34. 2010..Viruses of each influenza B lineage caused more illnesses than A/H1N1 viruses; strategies to enhance protection against multiple influenza B lineages should be pursued... - In-office influenza vaccination by US pediatric providers varies greatly and is higher among smaller officesSeth L Toback
MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
Clin Pediatr (Phila) 51:551-9. 2012..A greater understanding of interoffice variability in influenza vaccine delivery by US pediatric providers should allow for the creation of more effective strategies to improve pediatric influenza vaccination rates... - Shedding of Ann Arbor strain live attenuated influenza vaccine virus in children 6-59 months of ageRaburn M Mallory
MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
Vaccine 29:4322-7. 2011..The incidence, duration, and other parameters of viral shedding after vaccination with LAIV have not been fully described in children ≤ 5 years of age... - Safety and immunogenicity following administration of a live, attenuated monovalent 2009 H1N1 influenza vaccine to children and adults in two randomized controlled trialsRaburn M Mallory
MedImmune, LLC, Gaithersburg, Maryland, United States of America
PLoS ONE 5:e13755. 2010..The safety, tolerability, and immunogenicity of a monovalent intranasal 2009 A/H1N1 live attenuated influenza vaccine (LAIV) were evaluated in children and adults... - A survey of pediatricians' attitudes regarding influenza immunization in childrenDaniel J Levy
Child and Teen Wellness Center, Owings Mills, MD, USA
BMC Pediatr 9:8. 2009..Recommendations for vaccination of children against influenza have been revised several times since 2002, and as of 2008 include all children 6 months to 18 years of age. Nevertheless, influenza immunization rates have remained low... - The efficacy of live attenuated and inactivated influenza vaccines in children as a function of time postvaccinationChristopher S Ambrose
MedImmune LLC, Gaithersburg, MD, USA
Pediatr Infect Dis J 29:806-11. 2010..Three large, randomized studies compared LAIV and TIV efficacy in children, providing the opportunity to examine the impact of time on the relative efficacy of the 2 vaccines... - Trends in U.S. pediatric influenza vaccination from 2006 to 2010 among children with private insuranceSeth L Toback
MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
Vaccine 29:4225-9. 2011..While pediatric influenza vaccination occurred earlier each year, vaccination in later months has not increased in recent seasons, despite efforts to extend the vaccination season... - Quadrivalent Ann Arbor strain live-attenuated influenza vaccineSeth L Toback
MedImmune, LLC, Gaithersburg, MD, USA
Expert Rev Vaccines 11:1293-303. 2012..Q/LAIV was recently approved for use in the USA in eligible individuals 2-49 years of age. This review summarizes clinical trial data in support of Q/LAIV... - Maternal outcomes among pregnant women receiving live attenuated influenza vaccineSeth L Toback
MedImmune, LLC, Gaithersburg, MD 20878, USA
Influenza Other Respi Viruses 6:44-51. 2012..Data regarding maternal outcomes after LAIV administration during pregnancy are limited... - Current experience with school-located influenza vaccination programs in the United States: a review of the medical literatureHarry F Hull
HF Hull and Associates, LLC, St Paul, MN, USA
Hum Vaccin 7:153-60. 2011..The greatest need for future U.S. SLIV program implementation is the development of a financially sustainable model that can be replicated annually on a national scale... - A multi-season national estimate of adult influenza vaccination by U.S. office-based pediatricians, 2006-2011Seth L Toback
MedImmune, LLC, Medical and Scientific Affairs, One MedImmune Way, Gaithersburg, MD 20878, USA
Influenza Other Respi Viruses 6:231-4. 2012.... - Live attenuated influenza vaccine in childrenChristopher S Ambrose
MedImmune, Inc, Gaithersburg, MD 20878, USA
Semin Pediatr Infect Dis 17:206-12. 2006..Additional large-scale safety and efficacy studies in young children, including a formal risk-benefit assessment, are ongoing. The results of these analyses will guide potential future use in young children... - Influenza vaccination of parents and guardians by US pediatriciansSeth L Toback
MedImmune, LLC, Gaithersburg, MD USA
Hum Vaccin 7:436-40. 2011..Efforts should be taken to address barriers to parental vaccination so that pediatricians are better able to vaccinate parents/guardians of their patients against influenza... - The impact of school-located influenza vaccination programs on student absenteeism: a review of the U.S. literatureHarry F Hull
HF Hull and Associates, LLC, St Paul, MN, USA
J Sch Nurs 27:34-42. 2011..Additional research into sustainable funding sources and the comprehensive effects of SLIV programs on students, families, staff, and the community is warranted... - Current status of live attenuated influenza vaccine in the United States for seasonal and pandemic influenzaChristopher S Ambrose
MedImmune, One MedImmune Way, Gaithersburg, MD 20878, USA
Influenza Other Respi Viruses 2:193-202. 2008..Formulations of LAIV against pandemic influenza strains, including H5N1, H9N2, and H7N3, are currently being tested in preclinical and phase I clinical studies... - A postlicensure evaluation of the safety of Ann Arbor strain live attenuated influenza vaccine in children 24-59 months of ageSeth L Toback
MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA
Vaccine 31:1812-8. 2013..At that time, a postlicensure commitment was made to describe the safety of LAIV within a cohort of eligible children aged 2-5 years... - Clinical guidance on the use of live attenuated influenza vaccine after inadvertent freezing and warmingSeth L Toback
MedImmune, Gaithersburg, MD, USA
J Pediatr Nurs 27:163-7. 2012..If a particular annual formulation of LAIV is exposed to temperatures outside of the recommended storage range, practitioners should contact the manufacturer for guidance regarding proper vaccine handling... - Shedding and immunogenicity of live attenuated influenza vaccine virus in subjects 5-49 years of ageStan L Block
Kentucky Pediatric and Adult Research, Bardstown, KY 40004, United States
Vaccine 26:4940-6. 2008..Live attenuated influenza vaccine (LAIV) is indicated for influenza prevention in persons 2-49 years of age. This study describes the incidence and duration of vaccine virus shedding and serum immune responses after receipt of LAIV...