Research Topics
Species | Michael ZileSummaryAffiliation: Medical University of South Carolina Country: USA Publications
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Publications
Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosisMichael R Zile
Divisions of Cardiology, Department of Medicine, Medical University of South Carolina, 29425, USA
Am J Physiol Heart Circ Physiol 302:H1429-37. 2012....- Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarctionMichael R Zile
Division of Cardiology, Department of Medicine, Medical University of South Carolina and Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
Circ Cardiovasc Genet 4:614-9. 2011..The current pilot study tested the hypotheses that plasma miRs could be reliably measured in post-MI patients and that there is a relationship between temporal changes in specific miRs and post-MI LV structural remodeling... 
Constitutive properties of adult mammalian cardiac muscle cellsM R Zile
Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina and the Veterans Administration Medical Center, Charleston 29425 5799, USA
Circulation 98:567-79. 1998..The purpose of this study was to determine whether changes in the constitutive properties of the cardiac muscle cell play a causative role in the development of diastolic dysfunction...
Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trialMichael R Zile
RHJ Department of Veterans Affairs Medical Center and Medical University of South Carolina, Division of Cardiology, Department of Medicine, Charleston, SC 29425, USA
Circulation 121:1393-405. 2010....- Progressive improvement in cardiac performance with continuous aortic flow augmentation (aortic flow therapy) in patients hospitalized with severe heart failure: results of the Multicenter Trial of the Orqis Medical Cancion System for the Enhanced TreatmeMichael R Zile
RHJ Department of Veterans Affairs Medical Center Charleston, Medical University of South Carolina, South Carolina 29425, USA
J Heart Lung Transplant 29:86-92. 2010..This study examined whether improvement in this hemodynamic index is independent of changes in loading conditions and represents an improvement in cardiac performance... - Diastolic heart failure. Diagnosis, prognosis, treatmentM R Zile
Cardiology Division, Department of Medicine Gazes, Cardiac Research Institute, Medical University of South Carolina 29425, USA
Minerva Cardioangiol 51:131-42. 2003..The purpose of this review is to describe the criteria used to diagnose diastolic heart failure, the effects of diastolic heart failure on prognosis, and approaches to treatment... - Application of implantable hemodynamic monitoring in the management of patients with diastolic heart failure: a subgroup analysis of the COMPASS-HF trialMichael R Zile
Division of Cardiology, Departmentof Medicine, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
J Card Fail 14:816-23. 2008..However, appropriate management of DHF patients remains a difficult and uncertain challenge... - Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressuresMichael R Zile
Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, USA
Circulation 118:1433-41. 2008..The purpose of this study was to use echocardiographic and implantable hemodynamic monitor data to examine the pathophysiology of chronic compensated and acute decompensated HF in SHF versus DHF patients... - Diastolic heart failure: definitions and terminologyMichael R Zile
Division of Cardiology, Department of Medicine, the Gazes Cardiac Research Institute, The Medical University of South Carolina, Charleston, SC 29425, USA
Prog Cardiovasc Dis 47:307-13. 2005..The purpose of this presentation is to define the terminology used to describe these 2 broad categories of heart failure and to characterize the functional measurements that constitute their pathophysiological mechanisms... - Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failureMichael R Zile
Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, 29425, USA
Circ Heart Fail 4:246-56. 2011.... - Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricleMichael R Zile
Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29425, USA
N Engl J Med 350:1953-9. 2004..It has traditionally been thought that the pathophysiological cause of heart failure in these patients is an abnormality in the diastolic properties of the left ventricle; however, this hypothesis remains largely unproven... - Role of microtubules in the contractile dysfunction of hypertrophied myocardiumM R Zile
Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Veterans Administration Medical Center, Charleston 29425 5799, USA
J Am Coll Cardiol 33:250-60. 1999..We sought to determine whether the ameliorative effects of microtubule depolymerization on cellular contractile dysfunction in pressure overload cardiac hypertrophy apply at the tissue level... - New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic functionMichael R Zile
Division of Cardiology, Department of Medicine, Medical University of South Carolina, The Gazes Cardiac Research Institute and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
Circulation 105:1387-93. 2002 - Hemodynamic factors associated with acute decompensated heart failure: part 1--insights into pathophysiologyMichael R Zile
Division of Cardiology, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA
J Card Fail 17:282-91. 2011..The purpose of this study was to determine which pressure-based hemodynamic factor was most closely associated with the transition from chronic compensated to acute decompensated heart failure... - New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatmentMichael R Zile
Division of Cardiology, Medical University of South Carolina, The Gazes Cardiac Research Institute and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
Circulation 105:1503-8. 2002 - Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fractionMichael R Zile
Division of Cardiology, Department of Medicine, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA
Circulation 124:2491-501. 2011.... - Left ventricular systolic performance, function, and contractility in patients with diastolic heart failureCatalin F Baicu
Division of Cardiology, Department of Medicine, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
Circulation 111:2306-12. 2005..CONCLUSIONS: Patients with DHF had normal LV systolic performance, function, and contractility. The pathophysiology of DHF does not appear to be related to significant abnormalities in these systolic properties of the LV... - Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failureGerard P Aurigemma
Department of Medicine, Division of Cardiology, University of Massachusetts Medical School, Worcester, Mass 01655, USA
Am Heart J 148:E12. 2004..The purpose of this study was to compare invasive with noninvasive indices of diastolic function in a well-defined group of patients with diastolic dysfunction and a history of diastolic heart failure... - Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processingAmy D Bradshaw
Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC 29425, USA
Circulation 119:269-80. 2009..We further hypothesized that secreted protein acidic and rich in cysteine (SPARC) plays a key role in post-synthetic procollagen processing in normal and pressure-overloaded myocardium... - Changes in extracellular collagen matrix alter myocardial systolic performanceCatalin F Baicu
Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29401, USA
Am J Physiol Heart Circ Physiol 284:H122-32. 2003..These data support the hypothesis that fibrillar collagen facilitates transduction of cardiomyocyte contraction into myocardial force development and helps to maintain normal myocardial systolic performance... - Selective matrix metalloproteinase inhibition with developing heart failure: effects on left ventricular function and structureMary K King
Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
Circ Res 92:177-85. 2003..These results suggest that targeting a selective portfolio of myocardial MMP species for inhibition may provide a more rational therapeutic strategy in the setting of congestive heart failure... - Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardiumRebecca K Harston
Cardiology Division of the Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, South Caroline, USA
Am J Physiol Heart Circ Physiol 300:H1696-706. 2011..Long-term rapamycin treatment in 2-wk PO myocardium blunted hypertrophy, improved contractile function, and reduced caspase-3 and calpain activation. These data indicate potential cardioprotective benefits of rapamycin in PO hypertrophy... - Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processingAmy D Bradshaw
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
Am J Physiol Heart Circ Physiol 298:H614-22. 2010..These data support the hypothesis that SPARC plays a key role in post-synthetic procollagen processing and contributes to the increase in collagen content found in the aged myocardium... - Calpain inhibition preserves myocardial structure and function following myocardial infarctionSanthosh K Mani
Division of Cardiology, Department of Medicine, Charleston, South Carolina, USA
Am J Physiol Heart Circ Physiol 297:H1744-51. 2009..These studies indicate that calpain contributes to MI-induced alterations in myocardial structure and function and that it could be a potential therapeutic target in treating MI patients... - Cardiac-specific expression and hypertrophic upregulation of the feline Na(+)-Ca(2+) exchanger gene H1-promoter in a transgenic mouse modelJoachim G Muller
Gazes Cardiac Research Institute and Division of Cardiology, Medical University of South Carolina, Ralph H Johnson Department of Veterans Affairs, Charleston, SC 29425, USA
Circ Res 90:158-64. 2002..This work demonstrates that the NCX1H1 promoter directs cardiac-specific expression of the exchanger in both the embryo and adult and is also sufficient for the upregulation of NCX1 in response to pressure overload... - Myocardial infarct expansion and matrix metalloproteinase inhibitionRupak Mukherjee
Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
Circulation 107:618-25. 2003..CONCLUSIONS: MMPi attenuated the degree of post-MI LV dilation and expansion of the infarct during the late phase of MI healing. In addition, exogenous MMPi caused region-specific modulation of certain MMP and TIMP species... - Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs)D Dirk Bonnema
Division of Cardiology, Department of Medicine, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina 29425, USA
J Card Fail 13:530-40. 2007..However, whether these determinants of extracellular matrix (ECM) composition change as a function of age has not been examined in an aging population free of clinically significant cardiovascular disease... - Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulationLin Xu
Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 281:34430-40. 2006..This work is the first in vivo study that demonstrates which cis elements are important for Ncx1 regulation... - New York Heart Association functional class predicts exercise parameters in the current eraStuart D Russell
Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Am Heart J 158:S24-30. 2009..Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship... - A phase II, double-blind, randomized, placebo-controlled, dose comparative study of the efficacy, tolerability, and safety of MCC-135 in subjects with chronic heart failure, NYHA class II/III (MCC-135-GO1 study): rationale and designMichael Zile
Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, and the Ralph H. Johnson, Department of Veterans Affairs Medical Center, Charleston, 29425, USA
J Card Fail 10:193-9. 2004..CONCLUSION: Patient recruitment was completed in September 2002. Patient follow-up was completed by February 2003; the results will be available for release in 2004... - Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibitionJohn S Ikonomidis
Division of Cardiothoracic Surgery, Medical University of South Carolina, 114 Doughty St, Charleston, SC 29425, USA
Am J Physiol Heart Circ Physiol 288:H149-58. 2005..These results define the importance of local endogenous control of MMP activity with respect to regulating LV structure and function after MI... - Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic functionGerard P Aurigemma
Division of Cardiology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Circulation 113:296-304. 2006 - A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heartGuangmao Cheng
Cardiology Division, Gazes Cardiac Research Institute, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29403, USA
Am J Physiol Heart Circ Physiol 294:H2231-41. 2008.... - Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4 after alcohol septal ablation in hypertrophic obstructive cardiomyopathyRobert E Stroud
Division of Cardiothoracic Surgery Medical University of South Carolina, Charleston, South Carolina 29403, USA
J Card Fail 11:124-30. 2005.... - Beta3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophyRebecca K Johnston
Cardiology Division of the Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425 2221, USA
FASEB J 23:2759-71. 2009..This is the first study to show that a beta(3) integrin/Ub/NF-kappaB pathway contributes to compensatory hypertrophic growth... - Severe left ventricular hypertrophy 1 year after transplant predicts mortality in cardiac transplant recipientsRandy Goodroe
Division of Cardiology, Department of Medicine, Medical University of South Carolina and Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina 29425, USA
J Heart Lung Transplant 26:145-51. 2007..Left ventricular hypertrophy (LVH) is a known predictor of morbidity and mortality in patients with essential hypertension. The prevalence and significance of LVH in heart transplant recipients is unknown... - In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardiumSanthosh K Mani
Gazes Cardiac Research Institute, Charleston, SC 29425 2221, USA
Am J Physiol Heart Circ Physiol 295:H314-26. 2008.... - Selective translation of mRNAs in the left ventricular myocardium of the mouse in response to acute pressure overloadLaura S Spruill
Gazes Cardiac Research Institute, Department of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
J Mol Cell Cardiol 44:69-75. 2008..These studies demonstrate that acute pressure overload alters cardiac gene expression by mechanisms that selectively regulate translational activity of specific mRNAs... - Quantification of protein expression changes in the aging left ventricle of Rattus norvegicusJennifer E Grant
The Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Division of Cardiology, Medical University of South Carolina, Charleston, SC 28425, USA
J Proteome Res 8:4252-63. 2009..This work serves as the basis for making future comparisons of the aged left ventricle proteome to that of left ventricles obtained from other models of disease and heart failure... - Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart diseaseS Hinan Ahmed
Department of Medicine, Medical University of South Carolina, RHJ Department of Veterans Affairs Medical Center, Charleston, SC, USA
Circulation 113:2089-96. 2006.... - Cardiopulmonary exercise variables in diastolic versus systolic heart failureMary Jane Farr
Division of Cardiology, Columbia University, New York, New York, USA
Am J Cardiol 102:203-6. 2008..3, diastolic HF vs systolic HF). In conclusion, the CPX response in patients with diastolic HF and systolic HF is markedly abnormal and indistinguishable with regard to peak VO(2) and ventilation despite marked differences in the LV EF... - Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytesYuji Ishibashi
Gazes Cardiac Research Institute, Cardiology Division, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29403, USA
Am J Physiol Heart Circ Physiol 285:H1270-85. 2003.... - STAT3 activation in pressure-overloaded feline myocardium: role for integrins and the tyrosine kinase BMXChristopher D Willey
Cardiology Division of the Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, SC 29425 2221, USA
Int J Biol Sci 4:184-99. 2008..Therefore, these studies indicate a novel mechanism of BMX-mediated STAT3 activation within a PO model of cardiac hypertrophy that might contribute to cardiomyocyte growth and survival... - Structural components of cardiomyocyte remodeling: summationMichael R Zile
Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Card Fail 8:S311-3. 2002 - Heart failure in aortic stenosis - improving diagnosis and treatmentMichael R Zile
Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, USA
N Engl J Med 348:1735-6. 2003 - Comparison of variability associated with sample preparation in two-dimensional gel electrophoresis of cardiac tissueAlison M Bland
Medical University of South Carolina, Charleston, USA
J Biomol Tech 17:195-9. 2006..Sample preparation should be optimized to minimize variability as well as to maximize the number of spots seen... - Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodelingCarson S Webb
Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
Circulation 114:1020-7. 2006..These findings suggest that a specific MMP/TIMP plasma profile occurs after MI and holds both prognostic and diagnostic significance... - Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: an 8-year retrospective cohort studyLeslie L Clark
Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29403, USA
J Thorac Cardiovasc Surg 131:679-85. 2006..96% vs 7.5%). CONCLUSIONS: These findings indicate that statin pretreatment before cardiac surgery confers a protective effect with respect to postoperative outcomes... - A multidimensional proteomic approach to identify hypertrophy-associated proteinsMerry L Lindsey
Division of Cardiothoracic Surgery Research, Department of Surgery, Medical University of South Carolina, Charleston, SC, USA
Proteomics 6:2225-35. 2006..We also discuss common pitfalls and strategies to overcome the limitations of current proteomic technologies. Together, the multidimensional approach provides insight into the proteomic changes that occur in the LV during hypertrophy... - Effects of conversion from cyclosporine to tacrolimus on left ventricular structure in cardiac allograft recipientsJennifer L Peura
Division of Cardiology, Department of Internal Medicine, Medical University of South Carolina, Gazes Cardiac Research Institute, Charleston 29425, USA
J Heart Lung Transplant 24:1969-72. 2005..Left ventricular mass decreased by 24% and left ventricular geometry returned toward normal at 6 months after conversion, without significant changes in blood pressure... - Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunctionWilliam C Little
Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Am J Cardiol 98:383-5. 2006..In conclusion, in patients with diastolic dysfunction and hypertensive responses to exercise, 6 months of losartan and HCTZ blunted systolic BP during exercise. Only losartan increased exercise tolerance and improved quality of life... - Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: the COMPASS-HF studyRobert C Bourge
Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Am Coll Cardiol 51:1073-9. 2008..The purpose of this study was to determine whether a heart failure (HF) management strategy using continuous intracardiac pressure monitoring could decrease HF morbidity... - Chronic heart failure: a report from the Dartmouth Diastole DiscoursesMiguel A Quinones
Department of Cardiology, The Methodist Hospita, Methodist DeBakey Heart Center, Houston, TX 77030, USA
Congest Heart Fail 12:162-5. 2006..Despite a wide diversity of expressed opinions, several areas of discussion ultimately led to the consensus expressed in this document... - Left ventricular diastolic dysfunction and diastolic heart failureWilliam H Gaasch
Department of Cardiovascular Medicine, Lahey Clinic, Burlington, Massachusetts 01805, USA
Annu Rev Med 55:373-94. 2004..g., venous congestion), and the second is to eliminate or reduce the factors responsible for diastolic dysfunction (e.g., myocardial hypertrophy, fibrosis, and ischemia)... - Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trialAli Ahmed
University of Alabama at Birmingham, 1530 3rd Ave S, CH 19, Suite 219, Birmingham AL 35294 2041, USA
Circulation 114:397-403. 2006..Although digoxin was tested in an appreciable number of diastolic heart failure patients in the Digitalis Investigation Group ancillary trial, detailed findings from this important study have not previously been published... - Patterns of structural and functional remodeling of the left ventricle in chronic heart failureWilliam H Gaasch
Department of Cardiovascular Medicine, Lahey Clinic, Burlington, Massachusetts, USA
Am J Cardiol 102:459-62. 2008..In conclusion, these patterns of remodeling encompass a wide spectrum of geometric changes with different clinical and pathophysiologic features and possibly different management strategies... - Hospitalizations due to unstable angina pectoris in diastolic and systolic heart failureAli Ahmed
University of Alabama at Birmingham, Alabama, USA
Am J Cardiol 99:460-4. 2007..As in patients with systolic HF, those with diastolic HF should be routinely evaluated for myocardial ischemia and managed accordingly... - New molecular mechanism in diastolic heart failureArnold M Katz
Circulation 113:1922-5. 2006 - The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failureWilliam C Little
Department of Internal Medicine, Cardiology Section, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA
J Card Fail 11:191-5. 2005..CONCLUSION: Sixteen weeks of treatment with the glucose crosslink breaker, alagebrium, resulted in a decrease in left ventricular mass and improvements in left ventricular diastolic filling and quality of life in patient with DHF... - Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: a randomised trialScott D Solomon
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Lancet 369:2079-87. 2007.... - Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched studyAli Ahmed
University of Alabama at Birmingham, Birmingham, Alabama, USA
Am J Cardiol 99:393-8. 2007..Patients with diastolic HF should be evaluated for CKD, and the role of inhibitors of the renin-angiotensin system in these patients needs to be investigated... - Left ventricular end-diastolic volume is normal in patients with heart failure and a normal ejection fraction: a renewed consensus in diastolic heart failureMichael R Zile
J Am Coll Cardiol 49:982-5. 2007 - Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatmentJason D Stroud
Med U SC, Charleston
Am J Physiol Heart Circ Physiol 282:H2324-35. 2002..Thus, whereas many mechanisms may contribute to the abnormalities in myocardial viscoelasticity in the POH myocardium, changes in fibrillar collagen appear to play a predominant role... - Constitutive properties of hypertrophied myocardium: cellular contribution to changes in myocardial stiffnessTodd S Harris
Med U SC, Charleston
Am J Physiol Heart Circ Physiol 282:H2173-82. 2002..Changes in the constitutive properties of the cardiocytes themselves contribute to the abnormalities in myocardial stiffness and viscosity that develop during POH... - Randomized trial comparing partial versus complete chordal-sparing mitral valve replacement: effects on left ventricular volume and functionKwok L Yun
Department of Cardiac Surgery, Kaiser Permanente Medical Center, Los Angeles, CA 90027, USA
J Thorac Cardiovasc Surg 123:707-14. 2002..In this report we analyzed the early and late effects of complete versus partial chordal preservation on left ventricular mechanics... - A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: rationale and design of the evaluation of MCC-Ik Kyung Jang
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Thromb Thrombolysis 20:147-53. 2005..The rationale, design, and methods of the EVOLVE study, along with two sub-studies, are described in this paper... - Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in miceEsther E J M Creemers
Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
Am J Physiol Heart Circ Physiol 284:H364-71. 2003..These findings demonstrate that TIMP-1 deficiency amplifies adverse LV remodeling after MI in mice and emphasizes the importance of local endogenous control of cardiac MMP activity by TIMP-1... - Treating diastolic heart failure with statins: "phat" chance for pleiotropic benefitsMichael R Zile
Circulation 112:300-3. 2005 - Heart failure with preserved ejection fraction: is this diastolic heart failure?Michael R Zile
J Am Coll Cardiol 41:1519-22. 2003 - A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular salIk Kyung Jang
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am Heart J 155:113.e1-8. 2008.... - Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trialJohn J V McMurray
Department of Cardiology, Western Infirmary, Glasgow, and Faculty of Medicine, University of Glasgow, Scotland, UK
Eur J Heart Fail 10:149-56. 2008.... - Continuous aortic flow augmentation: a pilot study of hemodynamic and renal responses to a novel percutaneous intervention in decompensated heart failureMarvin A Konstam
Tufts New England Medical Center, Tufts University, Boston, MA, USA
Circulation 112:3107-14. 2005....
Research Grants
- HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEMMichael Zile; Fiscal Year: 2001..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..