Michael Zile

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Randomized, double-blind, placebo-controlled study of sitaxsentan to improve impaired exercise tolerance in patients with heart failure and a preserved ejection fraction
    Michael R Zile
    Division of Cardiology, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina Electronic address
    JACC Heart Fail 2:123-30. 2014
  2. doi request reprint Biomarkers of diastolic dysfunction and myocardial fibrosis: application to heart failure with a preserved ejection fraction
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina and Ralph H Johnson, Ashley River Towers, 25 Courtenay Drive, Charleston, SC 29425, USA
    J Cardiovasc Transl Res 6:501-15. 2013
  3. doi request reprint Effects of exercise on left ventricular systolic and diastolic properties in patients with heart failure and a preserved ejection fraction versus heart failure and a reduced ejection fraction
    Michael R Zile
    Division of Cardiology, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    Circ Heart Fail 6:508-16. 2013
  4. pmc Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosis
    Michael R Zile
    Divisions of Cardiology, Department of Medicine, Medical University of South Carolina, 29425, USA
    Am J Physiol Heart Circ Physiol 302:H1429-37. 2012
  5. pmc Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarction
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina and Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
    Circ Cardiovasc Genet 4:614-9. 2011
  6. doi request reprint Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressures
    Michael R Zile
    Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Circulation 118:1433-41. 2008
  7. ncbi request reprint Diastolic heart failure: definitions and terminology
    Michael R Zile
    Division of Cardiology, Department of Medicine, the Gazes Cardiac Research Institute, The Medical University of South Carolina, Charleston, SC 29425, USA
    Prog Cardiovasc Dis 47:307-13. 2005
  8. ncbi request reprint Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial
    Michael R Zile
    RHJ Department of Veterans Affairs Medical Center and Medical University of South Carolina, Division of Cardiology, Department of Medicine, Charleston, SC 29425, USA
    Circulation 121:1393-405. 2010
  9. doi request reprint Application of implantable hemodynamic monitoring in the management of patients with diastolic heart failure: a subgroup analysis of the COMPASS-HF trial
    Michael R Zile
    Division of Cardiology, Departmentof Medicine, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    J Card Fail 14:816-23. 2008
  10. doi request reprint Progressive improvement in cardiac performance with continuous aortic flow augmentation (aortic flow therapy) in patients hospitalized with severe heart failure: results of the Multicenter Trial of the Orqis Medical Cancion System for the Enhanced Treatme
    Michael R Zile
    RHJ Department of Veterans Affairs Medical Center Charleston, Medical University of South Carolina, South Carolina 29425, USA
    J Heart Lung Transplant 29:86-92. 2010

Research Grants

  1. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001

Detail Information

Publications75

  1. ncbi request reprint Randomized, double-blind, placebo-controlled study of sitaxsentan to improve impaired exercise tolerance in patients with heart failure and a preserved ejection fraction
    Michael R Zile
    Division of Cardiology, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina Electronic address
    JACC Heart Fail 2:123-30. 2014
    ..The purpose of this study was to evaluate the efficacy and safety of the selective endothelin type A (ETA) receptor antagonist sitaxsentan in patients who have heart failure with preserved ejection fraction (HFpEF)...
  2. doi request reprint Biomarkers of diastolic dysfunction and myocardial fibrosis: application to heart failure with a preserved ejection fraction
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina and Ralph H Johnson, Ashley River Towers, 25 Courtenay Drive, Charleston, SC 29425, USA
    J Cardiovasc Transl Res 6:501-15. 2013
    ..The purpose of this review is to describe current and future applications of biomarkers in the management of patients with HFpEF. ..
  3. doi request reprint Effects of exercise on left ventricular systolic and diastolic properties in patients with heart failure and a preserved ejection fraction versus heart failure and a reduced ejection fraction
    Michael R Zile
    Division of Cardiology, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    Circ Heart Fail 6:508-16. 2013
    ....
  4. pmc Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosis
    Michael R Zile
    Divisions of Cardiology, Department of Medicine, Medical University of South Carolina, 29425, USA
    Am J Physiol Heart Circ Physiol 302:H1429-37. 2012
    ....
  5. pmc Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarction
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina and Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
    Circ Cardiovasc Genet 4:614-9. 2011
    ..The current pilot study tested the hypotheses that plasma miRs could be reliably measured in post-MI patients and that there is a relationship between temporal changes in specific miRs and post-MI LV structural remodeling...
  6. doi request reprint Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressures
    Michael R Zile
    Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Circulation 118:1433-41. 2008
    ..The purpose of this study was to use echocardiographic and implantable hemodynamic monitor data to examine the pathophysiology of chronic compensated and acute decompensated HF in SHF versus DHF patients...
  7. ncbi request reprint Diastolic heart failure: definitions and terminology
    Michael R Zile
    Division of Cardiology, Department of Medicine, the Gazes Cardiac Research Institute, The Medical University of South Carolina, Charleston, SC 29425, USA
    Prog Cardiovasc Dis 47:307-13. 2005
    ..The purpose of this presentation is to define the terminology used to describe these 2 broad categories of heart failure and to characterize the functional measurements that constitute their pathophysiological mechanisms...
  8. ncbi request reprint Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial
    Michael R Zile
    RHJ Department of Veterans Affairs Medical Center and Medical University of South Carolina, Division of Cardiology, Department of Medicine, Charleston, SC 29425, USA
    Circulation 121:1393-405. 2010
    ....
  9. doi request reprint Application of implantable hemodynamic monitoring in the management of patients with diastolic heart failure: a subgroup analysis of the COMPASS-HF trial
    Michael R Zile
    Division of Cardiology, Departmentof Medicine, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    J Card Fail 14:816-23. 2008
    ..However, appropriate management of DHF patients remains a difficult and uncertain challenge...
  10. doi request reprint Progressive improvement in cardiac performance with continuous aortic flow augmentation (aortic flow therapy) in patients hospitalized with severe heart failure: results of the Multicenter Trial of the Orqis Medical Cancion System for the Enhanced Treatme
    Michael R Zile
    RHJ Department of Veterans Affairs Medical Center Charleston, Medical University of South Carolina, South Carolina 29425, USA
    J Heart Lung Transplant 29:86-92. 2010
    ..This study examined whether improvement in this hemodynamic index is independent of changes in loading conditions and represents an improvement in cardiac performance...
  11. pmc Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, 29425, USA
    Circ Heart Fail 4:246-56. 2011
    ....
  12. doi request reprint Hemodynamic factors associated with acute decompensated heart failure: part 1--insights into pathophysiology
    Michael R Zile
    Division of Cardiology, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA
    J Card Fail 17:282-91. 2011
    ..The purpose of this study was to determine which pressure-based hemodynamic factor was most closely associated with the transition from chronic compensated to acute decompensated heart failure...
  13. doi request reprint Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA
    Circulation 124:2491-501. 2011
    ....
  14. ncbi request reprint Diastolic heart failure. Diagnosis, prognosis, treatment
    M R Zile
    Cardiology Division, Department of Medicine Gazes, Cardiac Research Institute, Medical University of South Carolina 29425, USA
    Minerva Cardioangiol 51:131-42. 2003
    ..The purpose of this review is to describe the criteria used to diagnose diastolic heart failure, the effects of diastolic heart failure on prognosis, and approaches to treatment...
  15. ncbi request reprint Role of microtubules in the contractile dysfunction of hypertrophied myocardium
    M R Zile
    Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Veterans Administration Medical Center, Charleston 29425 5799, USA
    J Am Coll Cardiol 33:250-60. 1999
    ..We sought to determine whether the ameliorative effects of microtubule depolymerization on cellular contractile dysfunction in pressure overload cardiac hypertrophy apply at the tissue level...
  16. ncbi request reprint New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, The Gazes Cardiac Research Institute and the Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    Circulation 105:1387-93. 2002
  17. ncbi request reprint Constitutive properties of adult mammalian cardiac muscle cells
    M R Zile
    Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina and the Veterans Administration Medical Center, Charleston 29425 5799, USA
    Circulation 98:567-79. 1998
    ..The purpose of this study was to determine whether changes in the constitutive properties of the cardiac muscle cell play a causative role in the development of diastolic dysfunction...
  18. ncbi request reprint Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 350:1953-9. 2004
    ..It has traditionally been thought that the pathophysiological cause of heart failure in these patients is an abnormality in the diastolic properties of the left ventricle; however, this hypothesis remains largely unproven...
  19. ncbi request reprint New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment
    Michael R Zile
    Division of Cardiology, Medical University of South Carolina, The Gazes Cardiac Research Institute and the Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    Circulation 105:1503-8. 2002
  20. ncbi request reprint Left ventricular systolic performance, function, and contractility in patients with diastolic heart failure
    Catalin F Baicu
    Division of Cardiology, Department of Medicine, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    Circulation 111:2306-12. 2005
    ..Whether and to what extent these abnormalities in diastolic function occur in association with abnormalities in LV systolic performance, function, and contractility has not been investigated thoroughly...
  21. ncbi request reprint Selective matrix metalloproteinase inhibition with developing heart failure: effects on left ventricular function and structure
    Mary K King
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Circ Res 92:177-85. 2003
    ..These results suggest that targeting a selective portfolio of myocardial MMP species for inhibition may provide a more rational therapeutic strategy in the setting of congestive heart failure...
  22. pmc Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing
    Amy D Bradshaw
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Heart Circ Physiol 298:H614-22. 2010
    ..These data support the hypothesis that SPARC plays a key role in post-synthetic procollagen processing and contributes to the increase in collagen content found in the aged myocardium...
  23. pmc Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing
    Amy D Bradshaw
    Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Circulation 119:269-80. 2009
    ..We further hypothesized that secreted protein acidic and rich in cysteine (SPARC) plays a key role in post-synthetic procollagen processing in normal and pressure-overloaded myocardium...
  24. pmc Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium
    Rebecca K Harston
    Cardiology Division of the Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, South Caroline, USA
    Am J Physiol Heart Circ Physiol 300:H1696-706. 2011
    ..Long-term rapamycin treatment in 2-wk PO myocardium blunted hypertrophy, improved contractile function, and reduced caspase-3 and calpain activation. These data indicate potential cardioprotective benefits of rapamycin in PO hypertrophy...
  25. ncbi request reprint Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure
    Gerard P Aurigemma
    Department of Medicine, Division of Cardiology, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Am Heart J 148:E12. 2004
    ..The purpose of this study was to compare invasive with noninvasive indices of diastolic function in a well-defined group of patients with diastolic dysfunction and a history of diastolic heart failure...
  26. ncbi request reprint Changes in extracellular collagen matrix alter myocardial systolic performance
    Catalin F Baicu
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29401, USA
    Am J Physiol Heart Circ Physiol 284:H122-32. 2003
    ..These data support the hypothesis that fibrillar collagen facilitates transduction of cardiomyocyte contraction into myocardial force development and helps to maintain normal myocardial systolic performance...
  27. pmc Calpain inhibition preserves myocardial structure and function following myocardial infarction
    Santhosh K Mani
    Division of Cardiology, Department of Medicine, Charleston, South Carolina, USA
    Am J Physiol Heart Circ Physiol 297:H1744-51. 2009
    ..These studies indicate that calpain contributes to MI-induced alterations in myocardial structure and function and that it could be a potential therapeutic target in treating MI patients...
  28. pmc New York Heart Association functional class predicts exercise parameters in the current era
    Stuart D Russell
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 158:S24-30. 2009
    ..Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship...
  29. pmc Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation
    Lin Xu
    Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:34430-40. 2006
    ..This work is the first in vivo study that demonstrates which cis elements are important for Ncx1 regulation...
  30. pmc Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs)
    D Dirk Bonnema
    Division of Cardiology, Department of Medicine, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, South Carolina 29425, USA
    J Card Fail 13:530-40. 2007
    ..However, whether these determinants of extracellular matrix (ECM) composition change as a function of age has not been examined in an aging population free of clinically significant cardiovascular disease...
  31. ncbi request reprint Cardiac-specific expression and hypertrophic upregulation of the feline Na(+)-Ca(2+) exchanger gene H1-promoter in a transgenic mouse model
    Joachim G Muller
    Gazes Cardiac Research Institute and Division of Cardiology, Medical University of South Carolina, Ralph H Johnson Department of Veterans Affairs, Charleston, SC 29425, USA
    Circ Res 90:158-64. 2002
    ..This work demonstrates that the NCX1H1 promoter directs cardiac-specific expression of the exchanger in both the embryo and adult and is also sufficient for the upregulation of NCX1 in response to pressure overload...
  32. ncbi request reprint Myocardial infarct expansion and matrix metalloproteinase inhibition
    Rupak Mukherjee
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Circulation 107:618-25. 2003
    ..This study examined the effects of MMP inhibition (MMPi) on regional LV geometry and MMP levels after MI...
  33. ncbi request reprint A phase II, double-blind, randomized, placebo-controlled, dose comparative study of the efficacy, tolerability, and safety of MCC-135 in subjects with chronic heart failure, NYHA class II/III (MCC-135-GO1 study): rationale and design
    Michael Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, and the Ralph H Johnson, Department of Veterans Affairs Medical Center, Charleston, 29425, USA
    J Card Fail 10:193-9. 2004
    ..The purpose of this study was to test the safety, tolerability, and efficacy of MCC-135 in patients with mild to moderate heart failure...
  34. pmc Beta3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy
    Rebecca K Johnston
    Cardiology Division of the Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425 2221, USA
    FASEB J 23:2759-71. 2009
    ..This is the first study to show that a beta(3) integrin/Ub/NF-kappaB pathway contributes to compensatory hypertrophic growth...
  35. ncbi request reprint Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition
    John S Ikonomidis
    Division of Cardiothoracic Surgery, Medical University of South Carolina, 114 Doughty St, Charleston, SC 29425, USA
    Am J Physiol Heart Circ Physiol 288:H149-58. 2005
    ..These results define the importance of local endogenous control of MMP activity with respect to regulating LV structure and function after MI...
  36. ncbi request reprint A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart
    Guangmao Cheng
    Cardiology Division, Gazes Cardiac Research Institute, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29403, USA
    Am J Physiol Heart Circ Physiol 294:H2231-41. 2008
    ....
  37. ncbi request reprint Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function
    Gerard P Aurigemma
    Division of Cardiology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Circulation 113:296-304. 2006
  38. ncbi request reprint Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4 after alcohol septal ablation in hypertrophic obstructive cardiomyopathy
    Robert E Stroud
    Division of Cardiothoracic Surgery Medical University of South Carolina, Charleston, South Carolina 29403, USA
    J Card Fail 11:124-30. 2005
    ..Recent clinical studies have measured changes in TIMP-4 levels; however, these studies have been limited to measuring this protein from myocardial tissue samples. To date, no studies have monitored TIMP-4 levels in plasma samples...
  39. pmc Quantification of protein expression changes in the aging left ventricle of Rattus norvegicus
    Jennifer E Grant
    The Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Division of Cardiology, Medical University of South Carolina, Charleston, SC 28425, USA
    J Proteome Res 8:4252-63. 2009
    ..This work serves as the basis for making future comparisons of the aged left ventricle proteome to that of left ventricles obtained from other models of disease and heart failure...
  40. ncbi request reprint Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease
    S Hinan Ahmed
    Department of Medicine, Medical University of South Carolina, RHJ Department of Veterans Affairs Medical Center, Charleston, SC, USA
    Circulation 113:2089-96. 2006
    ..However, whether the determinants of ECM composition, such as the balance between ECM proteases (matrix metalloproteinases [MMPs]) and their tissue inhibitors [TIMPs]), are altered in hypertensive heart disease is unknown...
  41. pmc Selective translation of mRNAs in the left ventricular myocardium of the mouse in response to acute pressure overload
    Laura S Spruill
    Gazes Cardiac Research Institute, Department of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
    J Mol Cell Cardiol 44:69-75. 2008
    ..These studies demonstrate that acute pressure overload alters cardiac gene expression by mechanisms that selectively regulate translational activity of specific mRNAs...
  42. ncbi request reprint Severe left ventricular hypertrophy 1 year after transplant predicts mortality in cardiac transplant recipients
    Randy Goodroe
    Division of Cardiology, Department of Medicine, Medical University of South Carolina and Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina 29425, USA
    J Heart Lung Transplant 26:145-51. 2007
    ..Left ventricular hypertrophy (LVH) is a known predictor of morbidity and mortality in patients with essential hypertension. The prevalence and significance of LVH in heart transplant recipients is unknown...
  43. pmc In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium
    Santhosh K Mani
    Gazes Cardiac Research Institute, Charleston, SC 29425 2221, USA
    Am J Physiol Heart Circ Physiol 295:H314-26. 2008
    ....
  44. doi request reprint Cardiopulmonary exercise variables in diastolic versus systolic heart failure
    Mary Jane Farr
    Division of Cardiology, Columbia University, New York, New York, USA
    Am J Cardiol 102:203-6. 2008
    ..3, diastolic HF vs systolic HF). In conclusion, the CPX response in patients with diastolic HF and systolic HF is markedly abnormal and indistinguishable with regard to peak VO(2) and ventilation despite marked differences in the LV EF...
  45. ncbi request reprint Role of microtubules versus myosin heavy chain isoforms in contractile dysfunction of hypertrophied murine cardiocytes
    Yuji Ishibashi
    Gazes Cardiac Research Institute, Cardiology Division, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29403, USA
    Am J Physiol Heart Circ Physiol 285:H1270-85. 2003
    ....
  46. pmc STAT3 activation in pressure-overloaded feline myocardium: role for integrins and the tyrosine kinase BMX
    Christopher D Willey
    Cardiology Division of the Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, SC 29425 2221, USA
    Int J Biol Sci 4:184-99. 2008
    ..Therefore, these studies indicate a novel mechanism of BMX-mediated STAT3 activation within a PO model of cardiac hypertrophy that might contribute to cardiomyocyte growth and survival...
  47. ncbi request reprint A multidimensional proteomic approach to identify hypertrophy-associated proteins
    Merry L Lindsey
    Division of Cardiothoracic Surgery Research, Department of Surgery, Medical University of South Carolina, Charleston, SC, USA
    Proteomics 6:2225-35. 2006
    ..We also discuss common pitfalls and strategies to overcome the limitations of current proteomic technologies. Together, the multidimensional approach provides insight into the proteomic changes that occur in the LV during hypertrophy...
  48. ncbi request reprint Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: an 8-year retrospective cohort study
    Leslie L Clark
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29403, USA
    J Thorac Cardiovasc Surg 131:679-85. 2006
    ..Accordingly, this study tested the central hypothesis that pretreatment with statins before cardiac surgery would reduce adverse postoperative surgical outcomes...
  49. ncbi request reprint Effects of conversion from cyclosporine to tacrolimus on left ventricular structure in cardiac allograft recipients
    Jennifer L Peura
    Division of Cardiology, Department of Internal Medicine, Medical University of South Carolina, Gazes Cardiac Research Institute, Charleston 29425, USA
    J Heart Lung Transplant 24:1969-72. 2005
    ..Left ventricular mass decreased by 24% and left ventricular geometry returned toward normal at 6 months after conversion, without significant changes in blood pressure...
  50. ncbi request reprint Structural components of cardiomyocyte remodeling: summation
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Card Fail 8:S311-3. 2002
  51. ncbi request reprint Heart failure in aortic stenosis - improving diagnosis and treatment
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston, USA
    N Engl J Med 348:1735-6. 2003
  52. ncbi request reprint Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling
    Carson S Webb
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Circulation 114:1020-7. 2006
    ..We tested the hypothesis that a specific plasma MMP/TIMP profile would emerge after MI and be associated with the degree of LV dilation...
  53. pmc Comparison of variability associated with sample preparation in two-dimensional gel electrophoresis of cardiac tissue
    Alison M Bland
    Medical University of South Carolina, Charleston, USA
    J Biomol Tech 17:195-9. 2006
    ..Sample preparation should be optimized to minimize variability as well as to maximize the number of spots seen...
  54. ncbi request reprint The effect of alagebrium chloride (ALT-711), a novel glucose cross-link breaker, in the treatment of elderly patients with diastolic heart failure
    William C Little
    Department of Internal Medicine, Cardiology Section, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Card Fail 11:191-5. 2005
    ..Despite its high prevalence, optimal therapy for diastolic heart failure (DHF) has not been determined. Alagebrium chloride (ALT-711) is a novel compound that breaks glucose crosslinks and may improve ventricular and arterial compliance...
  55. ncbi request reprint Left ventricular diastolic dysfunction and diastolic heart failure
    William H Gaasch
    Department of Cardiovascular Medicine, Lahey Clinic, Burlington, Massachusetts 01805, USA
    Annu Rev Med 55:373-94. 2004
    ..g., venous congestion), and the second is to eliminate or reduce the factors responsible for diastolic dysfunction (e.g., myocardial hypertrophy, fibrosis, and ischemia)...
  56. pmc Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial
    Ali Ahmed
    University of Alabama at Birmingham, 1530 3rd Ave S, CH 19, Suite 219, Birmingham AL 35294 2041, USA
    Circulation 114:397-403. 2006
    ..Although digoxin was tested in an appreciable number of diastolic heart failure patients in the Digitalis Investigation Group ancillary trial, detailed findings from this important study have not previously been published...
  57. ncbi request reprint Patterns of structural and functional remodeling of the left ventricle in chronic heart failure
    William H Gaasch
    Department of Cardiovascular Medicine, Lahey Clinic, Burlington, Massachusetts, USA
    Am J Cardiol 102:459-62. 2008
    ..In conclusion, these patterns of remodeling encompass a wide spectrum of geometric changes with different clinical and pathophysiologic features and possibly different management strategies...
  58. ncbi request reprint Chronic heart failure: a report from the Dartmouth Diastole Discourses
    Miguel A Quinones
    Department of Cardiology, The Methodist Hospita, Methodist DeBakey Heart Center, Houston, TX 77030, USA
    Congest Heart Fail 12:162-5. 2006
    ..Despite a wide diversity of expressed opinions, several areas of discussion ultimately led to the consensus expressed in this document...
  59. ncbi request reprint New molecular mechanism in diastolic heart failure
    Arnold M Katz
    Circulation 113:1922-5. 2006
  60. pmc Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched study
    Ali Ahmed
    University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Cardiol 99:393-8. 2007
    ..Patients with diastolic HF should be evaluated for CKD, and the role of inhibitors of the renin-angiotensin system in these patients needs to be investigated...
  61. pmc Hospitalizations due to unstable angina pectoris in diastolic and systolic heart failure
    Ali Ahmed
    University of Alabama at Birmingham, Alabama, USA
    Am J Cardiol 99:460-4. 2007
    ..As in patients with systolic HF, those with diastolic HF should be routinely evaluated for myocardial ischemia and managed accordingly...
  62. ncbi request reprint Effect of angiotensin receptor blockade and antihypertensive drugs on diastolic function in patients with hypertension and diastolic dysfunction: a randomised trial
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet 369:2079-87. 2007
    ....
  63. ncbi request reprint Effect of losartan and hydrochlorothiazide on exercise tolerance in exertional hypertension and left ventricular diastolic dysfunction
    William C Little
    Cardiology Section, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 98:383-5. 2006
    ..In conclusion, in patients with diastolic dysfunction and hypertensive responses to exercise, 6 months of losartan and HCTZ blunted systolic BP during exercise. Only losartan increased exercise tolerance and improved quality of life...
  64. ncbi request reprint Left ventricular end-diastolic volume is normal in patients with heart failure and a normal ejection fraction: a renewed consensus in diastolic heart failure
    Michael R Zile
    J Am Coll Cardiol 49:982-5. 2007
  65. doi request reprint Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: the COMPASS-HF study
    Robert C Bourge
    Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Am Coll Cardiol 51:1073-9. 2008
    ..The purpose of this study was to determine whether a heart failure (HF) management strategy using continuous intracardiac pressure monitoring could decrease HF morbidity...
  66. ncbi request reprint Treating diastolic heart failure with statins: "phat" chance for pleiotropic benefits
    Michael R Zile
    Circulation 112:300-3. 2005
  67. doi request reprint Heart failure with preserved ejection fraction: clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial
    John J V McMurray
    Department of Cardiology, Western Infirmary, Glasgow, and Faculty of Medicine, University of Glasgow, Scotland, UK
    Eur J Heart Fail 10:149-56. 2008
    ....
  68. ncbi request reprint A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: Evaluation of MCC-135 for left ventricular sal
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 155:113.e1-8. 2008
    ....
  69. ncbi request reprint Randomized trial comparing partial versus complete chordal-sparing mitral valve replacement: effects on left ventricular volume and function
    Kwok L Yun
    Department of Cardiac Surgery, Kaiser Permanente Medical Center, Los Angeles, CA 90027, USA
    J Thorac Cardiovasc Surg 123:707-14. 2002
    ..In this report we analyzed the early and late effects of complete versus partial chordal preservation on left ventricular mechanics...
  70. ncbi request reprint Constitutive properties of hypertrophied myocardium: cellular contribution to changes in myocardial stiffness
    Todd S Harris
    Cardiology Section, Department of Medicine, and Gazes Cardiac Research Institute, Medical University of South Carolina and Veterans Administration Medical Center, Charleston, South Carolina 29401, USA
    Am J Physiol Heart Circ Physiol 282:H2173-82. 2002
    ..Changes in the constitutive properties of the cardiocytes themselves contribute to the abnormalities in myocardial stiffness and viscosity that develop during POH...
  71. ncbi request reprint Heart failure with preserved ejection fraction: is this diastolic heart failure?
    Michael R Zile
    J Am Coll Cardiol 41:1519-22. 2003
  72. ncbi request reprint Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment
    Jason D Stroud
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina and the Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina 29401, USA
    Am J Physiol Heart Circ Physiol 282:H2324-35. 2002
    ..Thus, whereas many mechanisms may contribute to the abnormalities in myocardial viscoelasticity in the POH myocardium, changes in fibrillar collagen appear to play a predominant role...
  73. ncbi request reprint A randomized, double-blind, placebo-controlled study of the safety and efficacy of intravenous MCC-135 as an adjunct to primary percutaneous coronary intervention in patients with acute myocardial infarction: rationale and design of the evaluation of MCC-
    Ik Kyung Jang
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Thromb Thrombolysis 20:147-53. 2005
    ..The rationale, design, and methods of the EVOLVE study, along with two sub-studies, are described in this paper...
  74. ncbi request reprint Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice
    Esther E J M Creemers
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Am J Physiol Heart Circ Physiol 284:H364-71. 2003
    ..These findings demonstrate that TIMP-1 deficiency amplifies adverse LV remodeling after MI in mice and emphasizes the importance of local endogenous control of cardiac MMP activity by TIMP-1...
  75. ncbi request reprint Continuous aortic flow augmentation: a pilot study of hemodynamic and renal responses to a novel percutaneous intervention in decompensated heart failure
    Marvin A Konstam
    Tufts New England Medical Center, Tufts University, Boston, MA, USA
    Circulation 112:3107-14. 2005
    ....

Research Grants1

  1. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..