David X Zhang

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc Arachidonic acid-induced dilation in human coronary arterioles: convergence of signaling mechanisms on endothelial TRPV4-mediated Ca2+ entry
    Xiaodong Zheng
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Heart Assoc 2:e000080. 2013
  2. pmc H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation
    David X Zhang
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226, USA
    Circ Res 110:471-80. 2012
  3. pmc Transient receptor potential channel activation and endothelium-dependent dilation in the systemic circulation
    David X Zhang
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 57:133-9. 2011
  4. ncbi request reprint Mitochondrial reactive oxygen species-mediated signaling in endothelial cells
    David X Zhang
    Department of Internal Medicine and Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 292:H2023-31. 2007
  5. pmc Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo
    David X Zhang
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 53:532-8. 2009
  6. pmc TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress
    Suelhem A Mendoza
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 298:H466-76. 2010
  7. pmc Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs
    Phillip G Kopf
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 57:323-9. 2011
  8. ncbi request reprint Cyclic ADP-ribose contributes to contraction and Ca2+ release by M1 muscarinic receptor activation in coronary arterial smooth muscle
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Vasc Res 40:28-36. 2003
  9. pmc Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling
    Aaron H Bubolz
    Dept of Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 302:H634-42. 2012
  10. pmc Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 52:150-5. 2008

Collaborators

Detail Information

Publications29

  1. pmc Arachidonic acid-induced dilation in human coronary arterioles: convergence of signaling mechanisms on endothelial TRPV4-mediated Ca2+ entry
    Xiaodong Zheng
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Heart Assoc 2:e000080. 2013
    ..In this study, we investigated the role of the transient receptor potential vanilloid 4 (TRPV4) channel in AA-induced endothelial Ca(2+) response and dilation of HCAs...
  2. pmc H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation
    David X Zhang
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226, USA
    Circ Res 110:471-80. 2012
    ..An important mode of action of H(2)O(2) involves the oxidation of cysteine residues in its target proteins, including protein kinase G (PKG)-Iα, thereby modulating their activities...
  3. pmc Transient receptor potential channel activation and endothelium-dependent dilation in the systemic circulation
    David X Zhang
    Department of Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 57:133-9. 2011
    ....
  4. ncbi request reprint Mitochondrial reactive oxygen species-mediated signaling in endothelial cells
    David X Zhang
    Department of Internal Medicine and Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 292:H2023-31. 2007
    ....
  5. pmc Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo
    David X Zhang
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 53:532-8. 2009
    ..These findings may provide novel insight into mechanisms of Ca2+ entry evoked by chemical agonists in endothelial cells...
  6. pmc TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress
    Suelhem A Mendoza
    Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 298:H466-76. 2010
    ....
  7. pmc Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs
    Phillip G Kopf
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 57:323-9. 2011
    ..This provides a mechanism by which Ang II concurrently increases adrenal blood flow and steroidogenesis...
  8. ncbi request reprint Cyclic ADP-ribose contributes to contraction and Ca2+ release by M1 muscarinic receptor activation in coronary arterial smooth muscle
    Zhi Dong Ge
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Vasc Res 40:28-36. 2003
    ..These results suggest that the cADPR signaling pathway participates in the contraction of small coronary arterial smooth muscle and Ca(2+) release induced by activation of M(1) muscarinic receptors...
  9. pmc Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling
    Aaron H Bubolz
    Dept of Medicine, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 302:H634-42. 2012
    ..Elucidation of this novel TRPV4-ROS pathway may improve our understanding of the pathogenesis of coronary artery disease and/or other cardiovascular disorders...
  10. pmc Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 52:150-5. 2008
    ....
  11. ncbi request reprint Urotensin II is a nitric oxide-dependent vasodilator and natriuretic peptide in the rat kidney
    Andrew Y Zhang
    Deptartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Renal Physiol 285:F792-8. 2003
    ..These results indicate that UII produces vasodilator and natriuretic effects in the kidney and that UII-induced vasodilation is associated with increased endothelial NO in the RA...
  12. pmc Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries
    Debebe Gebremedhin
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    PLoS ONE 8:e68498. 2013
    ....
  13. pmc H2O2 is the transferrable factor mediating flow-induced dilation in human coronary arterioles
    Yanping Liu
    Office of Research, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Circ Res 108:566-73. 2011
    ..However, H(2)O(2) has never been shown to be the endothelium-dependent transferrable hyperpolarization factor (EDHF) in response to shear stress...
  14. ncbi request reprint Angiotensin II dilates bovine adrenal cortical arterioles: role of endothelial nitric oxide
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Endocrinology 146:3319-24. 2005
    ..Our results demonstrate that AII stimulates adrenal cortical arterial dilation through endothelial cell AT2 receptor activation and NO release and AT1 receptor-dependent constriction...
  15. pmc Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors
    Phillip G Kopf
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Hypertension 55:547-54. 2010
    ..Thus, adrenic acid metabolites could function as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors in the adrenal cortex and contribute to the regulation of adrenal blood flow...
  16. ncbi request reprint Acetylcholine-induced relaxation and hyperpolarization in small bovine adrenal cortical arteries: role of cytochrome P450 metabolites
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Endocrinology 145:4532-9. 2004
    ..The acetylcholine-induced relaxation is largely mediated by an endothelium-dependent hyperpolarization mechanism, presumably through cytochrome P450 metabolites of arachidonic acid...
  17. ncbi request reprint ACh-induced relaxations of rabbit small mesenteric arteries: role of arachidonic acid metabolites and K+
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 293:H152-9. 2007
    ....
  18. ncbi request reprint Steroid-producing cells regulate arterial tone of adrenal cortical arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Endocrinology 148:3569-76. 2007
    ..We conclude that ZG cells release EETs and this release is stimulated by ACTH. Interaction of endocrine and vascular cells represents a mechanism for regulating adrenal blood flow and couples steroidogenesis to increased blood flow...
  19. ncbi request reprint Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 283:H1785-94. 2002
    ..We conclude that TNF-alpha inhibits NO-mediated endothelium-dependent vasorelaxation in small coronary arteries via sphingomyelinase activation and consequent superoxide production in endothelial cells...
  20. ncbi request reprint Characterization of vasoconstrictor responses in small bovine adrenal cortical arteries in vitro
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Endocrinology 145:1571-8. 2004
    ..The forceful contractile responses of these arterioles are consistent with their potential role in the regulation of adrenal blood flow...
  21. ncbi request reprint Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226, USA
    Am J Physiol Heart Circ Physiol 284:H605-12. 2003
    ..We conclude that NADPH oxidase-mediated superoxide production and subsequent peroxynitrite formation mediate ceramide-induced endothelial dysfunction in small coronary arteries...
  22. ncbi request reprint Mechanisms of histamine-induced relaxation in bovine small adrenal cortical arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Endocrinol Metab 289:E1058-63. 2005
    ..The potential role of histamine in linking adrenal vascular events and steroid secretion requires further investigation...
  23. ncbi request reprint Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells
    Pin Lan Li
    Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 282:H1229-36. 2002
    ....
  24. ncbi request reprint Calcium-induced calcium release and cyclic ADP-ribose-mediated signaling in the myocytes from small coronary arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, 53226, USA
    Microvasc Res 64:339-48. 2002
  25. ncbi request reprint Cyclooxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries
    David X Zhang
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 288:H302-9. 2005
    ..These findings provide functional and biochemical evidence that AA-induced relaxation in rabbit small mesenteric arteries is mediated through both COX and lipoxygenase pathways...
  26. ncbi request reprint Effects of homocysteine on intracellular nitric oxide and superoxide levels in the renal arterial endothelium
    Ningjun Li
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 283:H1237-43. 2002
    ..These results indicate that L-Hcys inhibits the agonist-induced NO increase but stimulates O. production within endothelial cells. These effects of L-Hcys on [NO](i) and [O.] may contribute to endothelial injury associated with hHcys...
  27. ncbi request reprint Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure
    Sribalaji Lakshmikanthan
    From the Blood Research Institute, BloodCenter of Wisconsin, Milwaukee S L, M C W Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville B J Z, K M, M V A, A V S and Department of Pharmacology and Toxicology Z D G, J A A, Cardiovascular Center Z D G, X Z, J E M, D X Z, J A A, Department of Medicine X Z, J E M, D X Z, Department of Physiology H L, D L M, and Division of Biostatistics A S, Medical College of Wisconsin, Milwaukee
    Arterioscler Thromb Vasc Biol 34:1486-94. 2014
    ..We found that Rap1b(-/-) mice develop cardiac hypertrophy and hypertension. Therefore, we examined the function of Rap1b in regulation of blood pressure...
  28. pmc Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles
    Yanping Liu
    The National Center for Research Resources, National Institutes of Health, Bethesda, MD, USA
    Med Biol Eng Comput 46:469-78. 2008
    ..58 +/- 7%). These results suggest that cytoskeletal elements are a critical component of the signaling mechanism linking endothelial shear stress and mitochondrial release of ROS in the human coronary microcirculation...
  29. ncbi request reprint Epoxyeicosatrienoic acids, TRP channels, and intracellular Ca2+ in the vasculature: an endothelium-derived endothelium-hyperpolarizing factor?
    Brandon T Larsen
    Arterioscler Thromb Vasc Biol 27:2496-8. 2007