Ming You

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. doi request reprint Chemoprevention of lung squamous cell carcinoma by ginseng
    Jing Pan
    Medical College of Wisconsin Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cancer Prev Res (Phila) 6:530-9. 2013
  2. doi request reprint Modulation of gene expression and cell-cycle signaling pathways by the EGFR inhibitor gefitinib (Iressa) in rat urinary bladder cancer
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri, USA
    Cancer Prev Res (Phila) 5:248-59. 2012
  3. pmc Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1
    Yan Liu
    Washington University, St Louis, Missouri, USA
    Cancer Res 69:7844-50. 2009
  4. ncbi request reprint Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 4:971-81. 2006
  5. ncbi request reprint Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 38:888-95. 2006
  6. ncbi request reprint p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer
    Zhongqiu Zhang
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Res 4:401-10. 2006
  7. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
  8. doi request reprint Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center and Division of Comparative Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 2:1059-64. 2009
  9. pmc A second genetic variant on chromosome 15q24-25.1 associates with lung cancer
    Pengyuan Liu
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:3128-35. 2010
  10. doi request reprint Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Ther 9:3074-82. 2010

Collaborators

  • Yian Wang
  • Ronald A Lubet
  • Yan Lu
  • Ying Yan
  • Min Wang
  • Ping Yang
  • Yan Liu
  • Jing Pan
  • Qi Zhang
  • Carl Morrison
  • Mariza de Andrade
  • Joan E Bailey-Wilson
  • John Minna
  • Ramaswamy Govindan
  • Christopher I Amos
  • Jie Li
  • Eva Szabo
  • Pengyuan Liu
  • Ruisheng Yao
  • Haris G Vikis
  • Zhongqiu Zhang
  • Michael A James
  • Joel R Garbow
  • Haris Vikis
  • Andrew E Gelman
  • Clinton J Grubbs
  • Daolong Wang
  • Donghai Xiong
  • Daniel Kreisel
  • Alexander S Krupnick
  • Jay W Tichelaar
  • Michael James
  • Marshall W Anderson
  • PETER T VEDELL
  • Yuxin Yin
  • Hui Jiang
  • Feng Ding
  • William J Lemon
  • Xing Hua
  • Alexander Sasha Krupnick
  • Weidong Wen
  • PETER VEDELL
  • Peng Cui
  • Andrew Franklin
  • Dongmei Jia
  • Peng Yuan Liu
  • Susan M Pinney
  • Ann G Schwartz
  • Elena Kupert
  • Daniela Seminara
  • Colette Gaba
  • Diptasri Mandal
  • Adi Gazdar
  • Julie Clark
  • Charles Christopher Henderson
  • Kirby I Bland
  • Dusica Cvetkovic
  • Donald D Muccio
  • John A Engelbach
  • Bin Zhang
  • Ding Ma
  • Samantha M Taffner
  • Charuhas Deshpande
  • Liang Wang
  • Kelsey A Toth
  • Haijie Xiao
  • Beatriz M Carreno
  • Howard Jacob
  • Wayne M Yokoyama
  • Mary Anne Watt
  • Ken C Lo
  • Karen Head
  • Alex A Adjei
  • Xue Lin
  • Jihong Zhu
  • Vanessa K Tidwell
  • J Michael White
  • John D Ebben
  • Hongbo Liu
  • Rebecca Selzer
  • Kevin R Coombes
  • Amy Rymaszewski
  • Ryuji Higashikubo
  • Xiaomian Li
  • Luc Girard
  • Michael R Tschannen
  • Arye Nehorai
  • John V Heymach
  • Ze Zhu
  • Francoise Van den Bergh

Detail Information

Publications65

  1. doi request reprint Chemoprevention of lung squamous cell carcinoma by ginseng
    Jing Pan
    Medical College of Wisconsin Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Cancer Prev Res (Phila) 6:530-9. 2013
    ..These results suggest that KWG could be a potential chemopreventive agent for lung SCC...
  2. doi request reprint Modulation of gene expression and cell-cycle signaling pathways by the EGFR inhibitor gefitinib (Iressa) in rat urinary bladder cancer
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri, USA
    Cancer Prev Res (Phila) 5:248-59. 2012
    ..The identified hub genes may also serve as pharmacodynamic or efficacy biomarkers in clinical trials of chemoprevention in human bladder cancer...
  3. pmc Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1
    Yan Liu
    Washington University, St Louis, Missouri, USA
    Cancer Res 69:7844-50. 2009
    ..We concluded that PSMA4 is a strong candidate mediator of lung cancer cell growth, and may directly affect lung cancer susceptibility through its modulation of cell proliferation and apoptosis...
  4. ncbi request reprint Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 4:971-81. 2006
    ..Thus, gefitinib showed highly promising chemopreventive and chemotherapeutic activity in this mouse model of lung carcinogenesis...
  5. ncbi request reprint Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 38:888-95. 2006
    ..Our findings demonstrate the prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and identify genetic determinants of complex traits...
  6. ncbi request reprint p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer
    Zhongqiu Zhang
    Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Res 4:401-10. 2006
    ....
  7. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
    ..Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer...
  8. doi request reprint Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center and Division of Comparative Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 2:1059-64. 2009
    ..Our results indicate that the retinoid X receptor agonist bexarotene may be a potent chemopreventive agent in this cancer type...
  9. pmc A second genetic variant on chromosome 15q24-25.1 associates with lung cancer
    Pengyuan Liu
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:3128-35. 2010
    ..42 x 10(-11); OR, 1.60; 95% CI, 1.46-1.74; rs481134: P = 7.01 x 10(-4); OR, 0.81; 95% CI, 0.72-0.92). The second variant on 15q24-25.1, marked by rs481134, explains an additional 13.2% of population attributable risk for lung cancer...
  10. doi request reprint Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Ther 9:3074-82. 2010
    ..05) decrease in lung SCC. Induction of apoptosis occurred in both model systems. These data show that pioglitazone significantly inhibited progression of both adenocarcinoma and SCC in the two mouse model systems...
  11. ncbi request reprint Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice
    Ying Yan
    Department of Surgery, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Inhal Toxicol 19:183-7. 2007
    ..These results indicate that a p53 mutation or loss of a Kras2 allele increases susceptibility to MS-induced lung tumor development...
  12. doi request reprint Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus
    Peng Yuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:6290-8. 2009
    ..Deletion of LAS2 was observed in approximately 40% of human lung adenocarcinomas, implying that loss of function of LAS2 may be a key step for lung tumorigenesis...
  13. pmc Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 8:52-8. 2006
    ..The results of these investigations demonstrate that polyphenon E, red ginseng, and rapamycin significantly inhibit pulmonary adenoma formation and growth in A/J mice...
  14. doi request reprint Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 2:634-40. 2009
    ..We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs...
  15. ncbi request reprint A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 66:1956-63. 2006
    ..These experiments identified patterns of gene expressions that both offer clues for green tea's potential mechanisms of action and provide a molecular signature specific for green tea exposure...
  16. ncbi request reprint Fine mapping and candidate gene analyses of pulmonary adenoma resistance 1, a major genetic determinant of mouse lung adenoma resistance
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:2508-16. 2007
    ..Our findings have narrowed the Par1 QTL region and will greatly facilitate the identification of the major genetic determinant of mouse lung adenoma resistance...
  17. ncbi request reprint Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 Euclid Avenue, Box 8109, St Louis, Missouri 63110, USA
    Mol Cancer Res 3:563-74. 2005
    ..The present study provides the first in vivo evidence that a germ line p53 mutation and activated H-ras act synergistically to profoundly enhance tumor progression...
  18. doi request reprint Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in mice
    Qi Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 4:270-6. 2011
    ..These results indicate that aerosolization may be a safe and effective route of administering bexarotene for chemoprevention of lung cancer...
  19. ncbi request reprint Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression
    Yan Liu
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 67:10207-13. 2007
    ..The differential degradation of Las1-A/J and Las-B6 has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis...
  20. pmc Common human cancer genes discovered by integrated gene-expression analysis
    Yan Lu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 2:e1149. 2007
    ..Discovery of genes commonly regulated in cancer may have an important implication in understanding the common molecular mechanism of cancer...
  21. ncbi request reprint Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 22:6257-65. 2003
    ..In fact, L-778,123 is more effective in inhibiting primary lung progression in mice with a p53 mutation and/or an Ink4a/Arf deletion than in wild-type animals...
  22. doi request reprint Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis
    Yian Wang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Carcinog 52:49-56. 2013
    ..There was no significant body weight loss and there was no other obvious sign of toxicity in Antitumor B-treated mice. These results suggest that Antitumor B is a promising agent for human oral cancer chemoprevention...
  23. doi request reprint Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging
    Joel R Garbow
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:1363-7. 2008
    ..The goal of this work was to monitor quantitatively the development and progression of adenocarcinoma in a time course study of mice treated with the carcinogen urethane using in vivo small-animal magnetic resonance imaging (MRI)...
  24. ncbi request reprint Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Carcinogenesis 27:1420-31. 2006
    ..Elucidation of gene expression changes in FTI-treated or control rat mammary adenocarcinomas will help in identifying potential pharmacodynamic markers of FTI treatment as well as potential molecular targets of R115777 and other FTIs...
  25. pmc Gene expression profiling of chemically induced rat bladder tumors
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neoplasia 9:207-21. 2007
    ..These results suggest that multiple pathways are involved in rat bladder tumorigenesis, and a common molecular mechanism was found in both rat and mouse bladder tumors...
  26. pmc MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer
    Yan Lu
    Department of Physiology and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Carcinogenesis 33:1046-54. 2012
    ..The identified miRNAs hold great potential as targets for histology-specific treatment or prevention and treatment of recurrent disease...
  27. pmc Large-scale in silico mapping of complex quantitative traits in inbred mice
    Pengyuan Liu
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 2:e651. 2007
    ..These high-resolution QTL data can serve as a primary resource for positional cloning and gene identification in the research community...
  28. doi request reprint Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice
    Pengyuan Liu
    Department of Physiology and the Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mol Cancer Res 10:66-74. 2012
    ....
  29. pmc Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis
    Haris G Vikis
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Carcinog 51:993-1002. 2012
    ..These data demonstrate that neutrophils are essential to promote tumor growth in the MCA/BHT two-step lung carcinogenesis model...
  30. ncbi request reprint Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide
    Yian Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South, Euclid Avenue, St Louis, MO 63110, USA
    Mol Cancer Ther 5:1060-72. 2006
    ..These expression signatures could provide useful pharmacodynamic biomarkers for retinoid treatment and chemoprevention...
  31. pmc Altered gene expression profile in mouse bladder cancers induced by hydroxybutyl(butyl)nitrosamine
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, St Louis, MO 63110, USA
    Neoplasia 6:569-77. 2004
    ....
  32. pmc A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice
    Jay W Tichelaar
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 3:1148-56. 2010
    ..Our results support the concept that AP-1 is a key regulator of mouse lung tumorigenesis, and identify AP-1-dependent transcription as a potential target to prevent lung tumor progression...
  33. ncbi request reprint K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Exp Lung Res 31:271-81. 2005
    ..These results suggest that tobacco smoke enhances lung tumorigenesis primarily through promoting spontaneously occurring K-ras mutations...
  34. ncbi request reprint Analysis of the Par2 modifier of pulmonary adenoma formation in mice
    Min Wang
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Exp Lung Res 31:193-204. 2005
    ..The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates...
  35. pmc Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:12642-7. 2003
    ..Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity...
  36. doi request reprint Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity
    Qi Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Prev Res (Phila) 5:717-25. 2012
    ..The ability of 3-bromopyruvate to inhibit mouse lung tumorigenesis, in part through induction of apoptosis, merits further investigation of this compound as a chemopreventive agent for human lung cancer...
  37. pmc A gene expression signature predicts survival of patients with stage I non-small cell lung cancer
    Yan Lu
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Med 3:e467. 2006
    ..As a consequence, it is not possible to select those high-risk patients for more aggressive therapies and assign less aggressive treatments to patients at low risk for recurrence...
  38. ncbi request reprint Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Exp Lung Res 31:165-77. 2005
    ....
  39. pmc Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing
    Pengyuan Liu
    Department of Physiology and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Carcinogenesis 33:1270-6. 2012
    ..Of potential immediate clinical relevance, several highly mutated genes identified in our study are promising druggable targets in cancer therapy including ALK, CTNNA3, DCC, MLL3, PCDHIIX, PIK3C2B, PIK3CG and ROCK2...
  40. pmc Gene-expression signature predicts postoperative recurrence in stage I non-small cell lung cancer patients
    Yan Lu
    Department of Physiology and the Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e30880. 2012
    ..The gene signature is highly predictive of recurrence in stage I NSCLC patients, which has important prognostic and therapeutic implications for the future management of these patients...
  41. pmc Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer
    Daniel Kreisel
    Departments of Surgery, Pathology and Immunology, and Internal Medicine, The Alvin Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 72:4311-7. 2012
    ....
  42. pmc Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus
    Michael A James
    MCW Cancer Center, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e36116. 2012
    ..Thus, this study implicates anti-apoptotic CLPTM1L function as a potential mechanism of susceptibility to lung tumorigenesis and resistance to chemotherapy...
  43. pmc Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients
    Donghai Xiong
    Department of Pharmacology and Toxicology and Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Carcinogenesis 33:1797-805. 2012
    ..These findings, together with the results from pathway analysis, strongly indicate that altered extracellular matrix-remodeling may be involved in the etiology of NSCLC...
  44. doi request reprint Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice
    Haris G Vikis
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:4859-67. 2010
    ..One possible mechanism of resistance to pulmonary metastasis in BTBRT+tf/J mice may require T-cell function. Our experiments present a new mouse model for further characterization of the genetics and mechanisms of pulmonary metastasis...
  45. pmc Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 7:1053-7. 2005
    ..Thus, deguelin appears to be a promising new preventive agent for lung cancer and may be considered for further studies in other animal models and in clinical trials...
  46. ncbi request reprint Budesonide exerts its chemopreventive efficacy during mouse lung tumorigenesis by modulating gene expressions
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 23:7746-52. 2004
    ..Our results indicate that the chemopreventive effects of budesonide in the mouse lung tumorigenesis assay involved increase and decrease expression of a wide variety of genes in multiple signaling pathways...
  47. pmc RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway
    Michael A James
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:2108-16. 2009
    ..The prevalence of the induction of RGS17 in tumor tissues of various types further implicates its importance in the maintenance of tumor growth...
  48. doi request reprint Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis
    Michael A James
    Department of Surgery, Campus Box 8109, The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Carcinog 50:1-7. 2011
    ....
  49. ncbi request reprint Pas1c1 is a candidate for the mouse pulmonary adenoma susceptibility 1 locus
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
    Oncogene 24:1958-63. 2005
    ..These results support that Pas1c1 as a candidate for the Pas1 locus and the strain-specific isoforms may have differential effects on cell proliferation...
  50. ncbi request reprint A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility
    Yian Wang
    Department of Surgery and the Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 64:1647-54. 2004
    ..Furthermore, this model can be used in determining genetic modifiers that contribute to susceptibility or resistance to lung SCC development...
  51. pmc Chemopreventive effect of aerosolized polyphenon E on lung tumorigenesis in A/J mice
    Ying Yan
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Neoplasia 9:401-5. 2007
    ..These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer...
  52. doi request reprint Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis
    Qi Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri
    Mol Carcinog 52:686-91. 2013
    ..Our data show that betanin significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer. © 2012 Wiley Periodicals, Inc. ..
  53. pmc 26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro
    Jing Pan
    Department of Surgery, Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e13298. 2010
    ....
  54. doi request reprint Animal models of lung cancer characterization and use for chemoprevention research
    Yian Wang
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Prog Mol Biol Transl Sci 105:211-26. 2012
    ....
  55. doi request reprint Quantitative monitoring of mouse lung tumors by magnetic resonance imaging
    Alexander Sasha Krupnick
    Department of Surgery, Washington University in St Louis, Missouri, USA
    Nat Protoc 7:128-42. 2012
    ....
  56. ncbi request reprint Five loci, SLT1 to SLT5, controlling the susceptibility to spontaneously occurring lung cancer in mice
    Daolong Wang
    Department of Surgery and the Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 65:8158-65. 2005
    ..Our results provide, for the first time, an insight into the genetic control of spontaneously occurring lung tumorigenesis...
  57. pmc RASSF1A promoter methylation and Kras2 mutations in non small cell lung cancer
    Jie Li
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Neoplasia 5:362-6. 2003
    ..Our results indicate a trend of inverse relationship between Kras2 activation and RASSF1A promoter methylation in the majority of human lung adenocarcinomas and large cell carcinomas...
  58. ncbi request reprint A moderate reduction of Bcl-x(L) expression protects against tumorigenesis; however, it also increases susceptibility to tissue injury
    Charles Christopher Henderson
    Division of Urology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Oncogene 24:7120-4. 2005
    ..Additionally, they indicate that the potential for increased susceptibility to tissue injury must be considered in the design of chemopreventative and antineoplastic strategies that involve inhibition of Bcl-x(L) activity...
  59. ncbi request reprint Detection of primary lung tumors in rodents by magnetic resonance imaging
    Joel R Garbow
    Department of Chemistry, Washington University, St Louis, Missouri, USA
    Cancer Res 64:2740-2. 2004
    ....
  60. ncbi request reprint Chemoprevention of lung cancer by tea
    Julie Clark
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Nutr Food Res 50:144-51. 2006
    ..Future studies are needed to determine how green tea affects the genes associated with cell cycle regulation and apoptosis during the mouse lung carcinogenesis process...
  61. pmc Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4-methyl-UAB30, and Targretin (Bexarotene)
    PETER T VEDELL
    Medical College of Wisconsin, Cancer Center, Department of Pharmacology Toxicology, Milwaukee, Wisconsin, USA
    Mol Pharmacol 83:698-708. 2013
    ..Different patterns of gene expression among the agonists provided insight into molecular differences and allowed one to predict certain physiologic consequences of agonist treatment...
  62. ncbi request reprint Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models
    Zhongqiu Zhang
    Department of Surgery and The Alvin J Siteman Cancer Center, Campus Box 8109, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Oncogene 23:3841-50. 2004
    ..Furthermore, ATB exhibited an enhanced inhibitory effect in animals harboring genetic alterations (Kras2, p53, and Ink4a/Arf), which are often seen in human lung adenocarcinomas...
  63. pmc Genomic landscape of non-small cell lung cancer in smokers and never-smokers
    Ramaswamy Govindan
    Department of Internal Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell 150:1121-34. 2012
    ..Cell-cycle and JAK-STAT pathways are significantly altered in lung cancer, along with perturbations in 54 genes that are potentially targetable with currently available drugs...
  64. ncbi request reprint Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia
    Min Wang
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 64:1924-31. 2004
    ..Thus, our data support the Pol iota gene as a modifier of lung tumorigenesis by altering DNA polymerase activity...
  65. doi request reprint Mouse models of lung squamous cell carcinomas
    Michael S You
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Metastasis Rev 32:77-82. 2013
    ..Here, we review the application of mouse lung squamous cell carcinoma models with different stages of squamous lesions and squamous cell carcinomas to cancer development and chemoprevention studies...