Genomes and Genes


Ming You


Affiliation: Medical College of Wisconsin
Country: USA


  1. Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, et al. Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. iScience. 2018;3:192-207 pubmed publisher
    ..Its pronounced anti-invasive and anti-metastatic effects in the brain are particularly intriguing given the paucity of treatment options for such patients either alone or in combination with standard chemotherapeutics. ..
  2. Xiong D, Wang Y, Singavi A, MacKinnon A, George B, You M. Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer. iScience. 2018;9:258-277 pubmed publisher
    ..In summary, we identified the genomics and immune features associated with HPD, which may help identify patients at risk of adverse clinical outcome after anti-PD-1 immunotherapy. ..
  3. Pan J, Zhang Q, Liu Q, Komas S, Kalyanaraman B, Lubet R, et al. Honokiol inhibits lung tumorigenesis through inhibition of mitochondrial function. Cancer Prev Res (Phila). 2014;7:1149-59 pubmed publisher
    ..This novel mechanism of targeting mitochondrial suggests honokiol as a potential lung SCC chemopreventive agent. ..
  4. Xiong D, Wang Y, Kupert E, Simpson C, Pinney S, Gaba C, et al. A recurrent mutation in PARK2 is associated with familial lung cancer. Am J Hum Genet. 2015;96:301-8 pubmed publisher
  5. Ebben J, Lubet R, Gad E, Disis M, You M. Epidermal growth factor receptor derived peptide vaccination to prevent lung adenocarcinoma formation: An in vivo study in a murine model of EGFR mutant lung cancer. Mol Carcinog. 2016;55:1517-1525 pubmed publisher
    ..2015 Wiley Periodicals, Inc. ..
  6. Pan J, Xiong D, Zhang Q, Szabo E, Miller M, Lubet R, et al. Airway brushing as a new experimental methodology to detect airway gene expression signatures in mouse lung squamous cell carcinoma. Sci Rep. 2018;8:8895 pubmed publisher
    ..Prolonged exposure to NTCU also induced activation of NF-kappaB (NF?B), the downstream pathway of PI3K; this NTCU-induced lung SCC progression can be reversed by blocking the NF?B pathway. ..
  7. Zhang Q, Pan J, Lubet R, Komas S, Kalyanaraman B, Wang Y, et al. Enhanced antitumor activity of 3-bromopyruvate in combination with rapamycin in vivo and in vitro. Cancer Prev Res (Phila). 2015;8:318-26 pubmed publisher
    ..Our results demonstrate that rapamycin enhanced the antitumor efficacy of 3-BrPA, and that dual inhibition of mTOR signaling and glycolysis may be an effective therapeutic strategy for lung cancer chemoprevention. ..
  8. Pan J, Lee Y, Zhang Q, Xiong D, Wan T, Wang Y, et al. Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway. Cancer Prev Res (Phila). 2017;10:133-141 pubmed publisher
    ..These observations suggest that HNK could provide novel chemopreventive or therapeutic options for preventing both lung tumor progression and lung cancer metastasis. Cancer Prev Res; 10(2); 133-41. ©2016 AACR. ..
  9. Ebben J, You M. Brain metastasis in lung cancer: Building a molecular and systems-level understanding to improve outcomes. Int J Biochem Cell Biol. 2016;78:288-296 pubmed publisher
    ..From this clinical starting point, we will investigate the literature surrounding the molecular underpinnings of lung tumor metastasis and seek to understand the process from a biological perspective to generate new hypotheses. ..

More Information


  1. Musolf A, Simpson C, de Andrade M, Mandal D, Gaba C, Yang P, et al. Familial Lung Cancer: A Brief History from the Earliest Work to the Most Recent Studies. Genes (Basel). 2017;8: pubmed publisher
    ..Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease. ..