Zijian Xie

Summary

Affiliation: Medical College of Ohio
Country: USA

Publications

  1. ncbi The Na/K-ATPase-mediated signal transduction as a target for new drug development
    Zijian Xie
    Department of Pharmacology and Medicine, Medical College of Ohio, Toledo, OH 43614, USA
    Front Biosci 10:3100-9. 2005
  2. ncbi Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes
    Z Xie
    Departments of Pharmacology and Medicine, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 274:19323-8. 1999
  3. ncbi Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function
    Zijian Xie
    Department of Pharmacology, Medical College of Ohio, Toledo, OH 43614, USA
    Mol Interv 3:157-68. 2003
  4. ncbi Molecular mechanisms of Na/K-ATPase-mediated signal transduction
    Zijian Xie
    Department of Pharmacology and Medicine, Medical College of Ohio, Toledo 43614, USA
    Ann N Y Acad Sci 986:497-503. 2003
  5. ncbi Ouabain interaction with cardiac Na/K-ATPase reveals that the enzyme can act as a pump and as a signal transducer
    Z Xie
    Department of Pharmacology, Medical College of Ohio, Toledo 43614 5804, USA
    Cell Mol Biol (Noisy-le-grand) 47:383-90. 2001
  6. ncbi Metabolic regulation of Na(+)/P(i)-cotransporter-1 gene expression in H4IIE cells
    Z Xie
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614 5804, USA
    Am J Physiol Endocrinol Metab 278:E648-55. 2000
  7. pmc Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy
    Jihad Elkareh
    Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA
    Am J Physiol Renal Physiol 296:F1219-26. 2009
  8. pmc Partial nephrectomy as a model for uremic cardiomyopathy in the mouse
    David J Kennedy
    Department of Medicine, University of Toledo College of Medicine, Toledo, OH 43614 5809, USA
    Am J Physiol Renal Physiol 294:F450-4. 2008
  9. pmc Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin
    Jiang Tian
    Department of Medicine, University of Toledo College of Medicine, Toledo, OH 43614 2598, USA
    Hypertension 54:1313-20. 2009
  10. ncbi Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat
    Snigdha Priyadarshi
    The Department of Medicine, Medical College of Ohio, Toledo, Ohio 43614, USA
    Kidney Int 63:1785-90. 2003

Collaborators

Detail Information

Publications46

  1. ncbi The Na/K-ATPase-mediated signal transduction as a target for new drug development
    Zijian Xie
    Department of Pharmacology and Medicine, Medical College of Ohio, Toledo, OH 43614, USA
    Front Biosci 10:3100-9. 2005
    ....
  2. ncbi Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes
    Z Xie
    Departments of Pharmacology and Medicine, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 274:19323-8. 1999
    ....
  3. ncbi Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function
    Zijian Xie
    Department of Pharmacology, Medical College of Ohio, Toledo, OH 43614, USA
    Mol Interv 3:157-68. 2003
    ..Finally, the signaling function of the enzyme is also pivotal to ouabain-induced nongenomic effects on cardiac myocytes...
  4. ncbi Molecular mechanisms of Na/K-ATPase-mediated signal transduction
    Zijian Xie
    Department of Pharmacology and Medicine, Medical College of Ohio, Toledo 43614, USA
    Ann N Y Acad Sci 986:497-503. 2003
    ..In addition, caveolin-1 can be co-immunoprecipitated with Na/K-ATPase. Finally, we have shown that the signaling function of the enzyme is also pivotal to ouabain-induced nongenomic effects on cardiac myocytes...
  5. ncbi Ouabain interaction with cardiac Na/K-ATPase reveals that the enzyme can act as a pump and as a signal transducer
    Z Xie
    Department of Pharmacology, Medical College of Ohio, Toledo 43614 5804, USA
    Cell Mol Biol (Noisy-le-grand) 47:383-90. 2001
    ....
  6. ncbi Metabolic regulation of Na(+)/P(i)-cotransporter-1 gene expression in H4IIE cells
    Z Xie
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614 5804, USA
    Am J Physiol Endocrinol Metab 278:E648-55. 2000
    ..Thus we herein propose that metabolic regulation of RNaPi-1 expression by insulin is mediated through the phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase pathways, but not the Ras/MAPK pathway...
  7. pmc Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy
    Jihad Elkareh
    Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio, USA
    Am J Physiol Renal Physiol 296:F1219-26. 2009
    ..Should these findings be confirmed, we speculate that this pathway may represent a therapeutic target for uremic cardiomyopathy as well as other conditions associated with excessive fibrosis...
  8. pmc Partial nephrectomy as a model for uremic cardiomyopathy in the mouse
    David J Kennedy
    Department of Medicine, University of Toledo College of Medicine, Toledo, OH 43614 5809, USA
    Am J Physiol Renal Physiol 294:F450-4. 2008
    ..Our results suggest that partial nephrectomy in the mouse establishes a model of uremic cardiomyopathy which shares phenotypical features with the rat model as well as patients with chronic renal failure...
  9. pmc Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin
    Jiang Tian
    Department of Medicine, University of Toledo College of Medicine, Toledo, OH 43614 2598, USA
    Hypertension 54:1313-20. 2009
    ..Our data suggest that some of the antifibrotic effects of spironolactone may be attributed to antagonism of marinobufagenin signaling through the sodium-potassium-ATPase...
  10. ncbi Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat
    Snigdha Priyadarshi
    The Department of Medicine, Medical College of Ohio, Toledo, Ohio 43614, USA
    Kidney Int 63:1785-90. 2003
    ..We, therefore, studied whether green tea supplementation could attenuate the development of left ventricular hypertrophy in an animal model of chronic renal failure...
  11. ncbi Ouabain-induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells requires caveolin-1
    Jiang Liu
    Department of Medicine, Medical College of Ohio, Toledo, Ohio 43614 5089, USA
    Kidney Int 67:1844-54. 2005
    ..Our data also suggest a role of endocytosis in both ouabain-induced signal transduction and proximal tubule sodium handling. The present study addresses the molecular mechanisms involved in this process...
  12. pmc Effects of cardiotonic steroids on dermal collagen synthesis and wound healing
    Nasser El-Okdi
    Department of Medicine, University of Toledo College of Medicine, 3000 Arlington Ave, Mail Stop 1186, Toledo, OH 43614 2598, USA
    J Appl Physiol (1985) 105:30-6. 2008
    ..01). The data suggest that cardiotonic steroids induce increases in collagen synthesis by dermal fibroblasts, as could potentially be exploited to accelerate wound healing...
  13. ncbi Identification of a PKCepsilon-dependent regulation of myocardial contraction by epicatechin-3-gallate
    Daxiang Li
    Department of Physiology and Pharmacology, Health Science Campus, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614 2598, USA
    Am J Physiol Heart Circ Physiol 294:H345-53. 2008
    ..Together, these findings indicate that ECG can regulate myocardial contractility via a novel PKCepsilon-dependent signaling pathway...
  14. ncbi Regulation of apical NHE3 trafficking by ouabain-induced activation of the basolateral Na+-K+-ATPase receptor complex
    Haiping Cai
    Department of Medicine, University of Toledo College of Medicine, 3120 Glendale Ave, Toledo, OH 43614 5089, USA
    Am J Physiol Cell Physiol 294:C555-63. 2008
    ..This mechanism may be relevant to proximal tubular Na(+) handling during conditions associated with increases in circulating endogenous cardiotonic steroids...
  15. pmc Changes in sodium pump expression dictate the effects of ouabain on cell growth
    Jiang Tian
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    J Biol Chem 284:14921-9. 2009
    ..Taken together, we conclude that changes in the expression of Na/K-ATPase dictate the growth regulatory effects of ouabain on cells...
  16. pmc NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-activated signal transduction in cultured cells
    Zhichuan Li
    Departments of Physiology and Pharmacology, University of Toledo, Toledo, Ohio 43614, USA
    J Biol Chem 284:21066-76. 2009
    ..Taken together, we suggest that pNaKtide may be used as a novel antagonist of ouabain for probing the physiological and pathological significance of the newly appreciated signaling function of Na/K-ATPase and cardiotonic steroids...
  17. ncbi Ouabain decreases sarco(endo)plasmic reticulum calcium ATPase activity in rat hearts by a process involving protein oxidation
    David J Kennedy
    Dept of Medicine, Medical University of Ohio, Toledo, Ohio 43614 5089, USA
    Am J Physiol Heart Circ Physiol 291:H3003-11. 2006
    ..These data suggest that ouabain induces oxidative changes of the sarcoplasmic reticulum Ca(2+)-ATPase structure and function that may, in turn, produce some of the associated changes in Ca(2+) cycling and physiological function...
  18. pmc Ouabain-stimulated trafficking regulation of the Na/K-ATPase and NHE3 in renal proximal tubule cells
    Yanling Yan
    Department of Medicine, University of Toledo College of Medicine, Toledo, OH 43614 2598, USA
    Mol Cell Biochem 367:175-83. 2012
    ..These data indicated that the ouabain-induced redistribution of the α1 subunit and NHE3 is not a species-specific phenomenon, and ouabain-activated Na/K-ATPase signaling influences NHE3 regulation...
  19. pmc Ouabain and insulin induce sodium pump endocytosis in renal epithelium
    Shalini Gupta
    Department of Medicine, University of Toledo College of Medicine, Toledo, OH 43614 2598, USA
    Hypertension 59:665-72. 2012
    ....
  20. ncbi Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase
    Haojie Wang
    Department of Pharmacology and Medicine, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 279:17250-9. 2004
    ..Clearly, the caveolar Na(+)/K(+)-ATPase represents the signaling pool of the pump that interacts with Src and transmits the ouabain signals...
  21. pmc Regulation of intracellular cholesterol distribution by Na/K-ATPase
    Yiliang Chen
    Department of Physiology and Pharmacology, College of Medicine, University of Toledo, Toledo, Ohio 43614 2598, USA
    J Biol Chem 284:14881-90. 2009
    ..Moreover, the data also suggest that the plasma membrane Na/K-ATPase-caveolin-1 interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein pathway...
  22. ncbi Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy
    David J Kennedy
    Department of Medicine, Medical University of Ohio, Toledo, OH 43614 5809, USA
    Hypertension 47:488-95. 2006
    ..These data suggest that the increased concentrations of MBG are important in the cardiac disease and oxidant stress state seen with renal failure...
  23. ncbi Role of caveolae in signal-transducing function of cardiac Na+/K+-ATPase
    Lijun Liu
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Am J Physiol Cell Physiol 284:C1550-60. 2003
    ..They also suggest that ouabain-induced recruitments of Src and alpha(2)-isoform to caveolae are involved in the manifestation of the positive inotropic effect of ouabain...
  24. ncbi Positive inotropic effect of ouabain on isolated heart is accompanied by activation of signal pathways that link Na+/K+-ATPase to ERK1/2
    Kamiar Mohammadi
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio, 43614 5804, USA
    J Cardiovasc Pharmacol 41:609-14. 2003
    ..They also suggest that treatment with positive inotropic doses of cardiac glycosides is likely to be associated with changes in the cardiac phenotype...
  25. ncbi Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism
    Jiang Liu
    The Department of Medicine, Medical College of Ohio, Toledo, Ohio, USA
    Kidney Int 66:227-41. 2004
    ..We have demonstrated that ouabain causes dose- and time-dependent decreases in (86)Rb uptake in porcine proximal tubular (LLC-PK1) cells. The present study addresses the molecular mechanisms involved in this process...
  26. ncbi Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy
    Jihad Elkareh
    Department of Medicine, University of Toledo College of Medicine, 3120 Glendale Ave, Toledo, OH 43614 5809, USA
    Hypertension 49:215-24. 2007
    ..Based on these findings, we propose that MBG directly induces increases in collagen expression by fibroblasts, and we suggest that this may be important in the cardiac fibrosis seen with experimental renal failure...
  27. ncbi The Na,K-ATPase receptor complex: its organization and membership
    Sandrine V Pierre
    Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, Medical University of Ohio, Toledo, OH 43614, USA
    Cell Biochem Biophys 46:303-16. 2006
    ..This article reviews these new developments and provides a comparison of Na,K-ATPase-mediated signal transduction with other receptors and ion transporters...
  28. pmc Regulation of alpha1 Na/K-ATPase expression by cholesterol
    Yiliang Chen
    Department of Physiology and Pharmacology, College of Medicine, University of Toledo, Toledo, Ohio 43614 2598, USA
    J Biol Chem 286:15517-24. 2011
    ....
  29. ncbi Involvement of mitogen-activated protein kinases and reactive oxygen species in the inotropic action of ouabain on cardiac myocytes. A potential role for mitochondrial K(ATP) channels
    Jiang Tian
    Department of Pharmacology, Medical College of Ohio, Toledo, OH 43614 5804, USA
    Mol Cell Biochem 242:181-7. 2003
    ..While activation of MAPKs leads to increases in [Ca2+]i, opening of mitochondrial K(ATP) channel relays the ouabain signal to increased ROS production in cardiac myocytes...
  30. pmc Ouabain triggers preconditioning through activation of the Na+,K+-ATPase signaling cascade in rat hearts
    Sandrine V Pierre
    Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, Medical University of Ohio, 3035 Arlington Avenue, Toledo, OH 43614 5804, USA
    Cardiovasc Res 73:488-96. 2007
    ....
  31. pmc Identification of a mutant α1 Na/K-ATPase that pumps but is defective in signal transduction
    Fangfang Lai
    Department of Physiology, Pharmacology, and Medicine, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    J Biol Chem 288:13295-304. 2013
    ..It has not been possible to study the pumping and signaling functions of Na/K-ATPase independently in live cells...
  32. ncbi Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells
    Sankaridrug M Periyasamy
    Department of Medicine, Medical College of Ohio, Toledo, Ohio 43614 5089, USA
    Kidney Int 67:1868-77. 2005
    ..The current report addresses the potential relevance of plasmalemmal Na/K-ATPase redistribution to in vivo salt handling...
  33. pmc Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex
    Zhaokan Yuan
    Department of Pharmacology, Medical College of Ohio, Toledo, OH 43614, USA
    Mol Biol Cell 16:4034-45. 2005
    ..This effect required the ouabain-induced activation of PLC-gamma1. Inhibition of Src or depletion of cholesterol also abolished the effect of ouabain on intracellular Ca(2+)...
  34. ncbi Involvement of Na+/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes
    Lijun Liu
    Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, Medical University of Ohio, Toledo, OH 43614, USA
    Free Radic Biol Med 41:1548-56. 2006
    ..These results, taken together with our prior observations, suggest that ROS may cross talk with Na+/K+-ATPase, leading to the activation of hypertrophic pathways in cardiac myocytes...
  35. pmc Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells
    Zhichuan Li
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    J Biol Chem 286:32394-403. 2011
    ..Thus, the new findings demonstrate the in vivo effectiveness of pNaKtide and suggest that the defect in Na/K-ATPase-mediated signal transduction may be targeted for developing new anticancer therapeutics...
  36. pmc Identification of a potential receptor that couples ion transport to protein kinase activity
    Qiqi Ye
    Department of Physiology, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    J Biol Chem 286:6225-32. 2011
    ..Together, the data suggest that the Src-coupled α1 Na/K-ATPase may act as a Na(+)/K(+) receptor, allowing salt to regulate cellular function through Src and Src effectors...
  37. ncbi Effect of chronic renal failure on cardiac contractile function, calcium cycling, and gene expression of proteins important for calcium homeostasis in the rat
    David Kennedy
    Departments of Medicine and Pharmacology, Medical College of Ohio, Toledo, Ohio 43614 5089, USA
    J Am Soc Nephrol 14:90-7. 2003
    ..In conclusion, chronic renal failure leads to alterations in cardiac gene expression, which produces alterations in cardiac calcium cycling and contractile function. These changes cannot be explained only by the observed increases in BP...
  38. ncbi Cardiac glycoside downregulates NHE3 activity and expression in LLC-PK1 cells
    Shadi Oweis
    Dept of Medicine, Medical Univ of Ohio, 3120 Glendale Ave, Toledo, OH 43614 5089, USA
    Am J Physiol Renal Physiol 290:F997-1008. 2006
    ..These novel findings may represent the underlying mechanism of cardiotonic steroid-mediated renal compensatory response to volume expansion and/or hypertension...
  39. ncbi Regulation of inositol 1,4,5-trisphosphate receptor-mediated calcium release by the Na/K-ATPase in cultured renal epithelial cells
    Ying Chen
    Department of Physiology and Pharmacology, University of Toledo, College of Medicine, Toledo, Ohio 43614, USA
    J Biol Chem 283:1128-36. 2008
    ..Finally, we observed that the alpha1 knockdown was also effective in attenuating ER Ca(2+) release provoked by angiotensin II and epidermal growth factor...
  40. ncbi Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells
    Jiang Liu
    Department of Medicine, Medical College of Ohio, Toledo, Ohio 43614, USA
    Kidney Int 62:2118-25. 2002
    ..However, the circulating concentrations of DLS do not acutely inhibit the sodium pump to a degree consistent with the observed changes in proximal tubule sodium reabsorption...
  41. pmc Impairment of Na/K-ATPase signaling in renal proximal tubule contributes to Dahl salt-sensitive hypertension
    Jiang Liu
    Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    J Biol Chem 286:22806-13. 2011
    ..Our data suggested that impairment of Na/K-ATPase signaling and consequent regulation of Na/K-ATPase and NHE3 in renal proximal tubule may contribute to salt-induced hypertension in the Dahl S rat...
  42. ncbi Na(+)/K(+)-ATPase as a signal transducer
    Zijian Xie
    Department of Pharmacology, Medical College of Ohio, Toledo, USA
    Eur J Biochem 269:2434-9. 2002
    ..The likely extracellular physiological stimuli for the signal transducing function of Na+/K+-ATPase are the endogenous ouabain-like hormones, and changes in extracellular K+ concentration...
  43. ncbi Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases
    Michael Haas
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 277:18694-702. 2002
    ..Taken together, these new findings suggest that Src mediates the inter-receptor cross-talk between Na(+)/K(+)-ATPase and the EGFR to transduce the signals from ouabain to the Ras/MAPK cascade...
  44. doi The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades
    Zhichuan Li
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, Mail Stop 1008, 3000 Arlington Avenue, Toledo, OH 43614 2598, USA
    Pflugers Arch 457:635-44. 2009
    ....
  45. pmc Effects of Na/K-ATPase and its ligands on bone marrow stromal cell differentiation
    Moustafa Sayed
    Department of Medicine, University of Toledo, Toledo, OH, USA
    Stem Cell Res 13:12-23. 2014
    ..MBG also potentiated rosiglitazone-induced adipogenesis in 3T3-L1 cells and in mouse BMSCs. These results suggest that Na/K-ATPase and its signaling functions are involved in the regulation of BMSCs differentiation. ..
  46. ncbi Regulation of renal function and structure by the signaling Na/K-ATPase
    Jeffrey X Xie
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA
    IUBMB Life 65:991-8. 2013
    ..J. Physiol. Renal Physiol. 305, F797-F812). This article will focus on the molecular mechanism of Na/K-ATPase-mediated signal transduction and its potential regulatory role in renal physiology and diseases...