Zheng Xiong Xi

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 300:162-71. 2002
  2. ncbi request reprint The origin and neuronal function of in vivo nonsynaptic glutamate
    David A Baker
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 22:9134-41. 2002
  3. ncbi request reprint Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29464, USA
    J Pharmacol Exp Ther 303:608-15. 2002
  4. ncbi request reprint Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC, USA
    J Neurochem 87:1204-12. 2003
  5. ncbi request reprint GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 23:3498-505. 2003
  6. ncbi request reprint Glutamate transmission and addiction to cocaine
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29464, USA
    Ann N Y Acad Sci 1003:169-75. 2003
  7. ncbi request reprint GABAergic mechanisms of opiate reinforcement
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Alcohol Alcohol 37:485-94. 2002
  8. pmc Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats
    Zheng Xiong Xi
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropharmacology 53:771-82. 2007
  9. ncbi request reprint Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 26:8531-6. 2006
  10. pmc The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropharmacology 54:542-51. 2008

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 300:162-71. 2002
    ....
  2. ncbi request reprint The origin and neuronal function of in vivo nonsynaptic glutamate
    David A Baker
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 22:9134-41. 2002
    ..These results suggest that nonvesicular release from the cystine-glutamate antiporter is the primary source of in vivo extracellular glutamate and that this glutamate can modulate both glutamate and dopamine transmission...
  3. ncbi request reprint Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29464, USA
    J Pharmacol Exp Ther 303:608-15. 2002
    ..Together, these data demonstrate that repeated cocaine produces an enduring reduction in mGluR2/3 function in the nucleus accumbens...
  4. ncbi request reprint Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC, USA
    J Neurochem 87:1204-12. 2003
    ..Together, these data indicate that group III mGluRs regulate in vivo extracellular glutamate in the nucleus accumbens by inhibiting non-vesicular glutamate release...
  5. ncbi request reprint GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 23:3498-505. 2003
    ..The increase may be mediated in part by functional desensitization of GABA(B) receptors, likely the result of diminished Ser phosphorylation of the GABA(B2) receptor...
  6. ncbi request reprint Glutamate transmission and addiction to cocaine
    Peter W Kalivas
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29464, USA
    Ann N Y Acad Sci 1003:169-75. 2003
    ..These adaptations are hypothesized to facilitate glutamate release in response to a cocaine injection or acute stress and lead to the reinstatement of drug-seeking behavior...
  7. ncbi request reprint GABAergic mechanisms of opiate reinforcement
    Zheng Xiong Xi
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Alcohol Alcohol 37:485-94. 2002
    ....
  8. pmc Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats
    Zheng Xiong Xi
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropharmacology 53:771-82. 2007
    ..Together, the present data, combined with previous findings, support the potential use of l-THP for treatment of cocaine addiction...
  9. ncbi request reprint Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 26:8531-6. 2006
    ....
  10. pmc The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropharmacology 54:542-51. 2008
    ..In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release...
  11. pmc Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 176:57-65. 2004
    ..We have previously shown that selective D3 receptor blockade by the novel D3 antagonist SB-277011A inhibits cocaine's reinforcing action and cocaine-induced reinstatement of cocaine-seeking behavior...
  12. ncbi request reprint Agents in development for the management of cocaine abuse
    David A Gorelick
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Drugs 64:1547-73. 2004
    ..A recent phase I trial of a "cocaine vaccine" found it to be well tolerated and producing detectable levels of anti-cocaine antibodies for up to 9 months after immunisation...
  13. pmc Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors
    Jeremy G Gilbert
    Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
    Synapse 57:17-28. 2005
    ....
  14. pmc Selective dopamine D3 receptor antagonism by SB-277011A attenuates cocaine reinforcement as assessed by progressive-ratio and variable-cost-variable-payoff fixed-ratio cocaine self-administration in rats
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 21:3427-38. 2005
    ..If these results extrapolate to humans, SB-277011A or similar selective DA D(3) receptor antagonists may be useful in the treatment of cocaine addiction...
  15. ncbi request reprint The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:1393-405. 2006
    ..Owing to these properties and to its lack of rewarding effects (as assessed by BSR and by substitution during drug self-administration), NGB 2904 merits further investigation as a potential agent for treatment of cocaine addiction...
  16. pmc Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI)
    Hanbing Lu
    Neuroimaging Research Branch, National Institute on Drug Abuse NIDA, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 104:2489-94. 2007
    ..These data suggest that MEMRI may serve as a tool for investigating the effects of pharmacological agents and opens an application of MRI to study CNS drug effects at a systems level...
  17. ncbi request reprint Blockade of ionotropic glutamatergic transmission in the ventral tegmental area reduces heroin reinforcement in rat
    Zheng Xiong Xi
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Psychopharmacology (Berl) 164:144-50. 2002
    ....
  18. ncbi request reprint Attenuation of brain response to heroin correlates with the reinstatement of heroin-seeking in rats by fMRI
    Feng Luo
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Neuroimage 22:1328-35. 2004
    ....