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Genomes and Genes | Li WuSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Publications
Intercellular adhesion molecule 1 (ICAM-1), but not ICAM-2 and -3, is important for dendritic cell-mediated human immunodeficiency virus type 1 transmissionJian Hua Wang
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Virol 83:4195-204. 2009..Taken together, our data clarified the role of ICAMs in DC-mediated HIV-1 transmission to CD4(+) T cells...- Dendritic-cell interactions with HIV: infection and viral disseminationLi Wu
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
Nat Rev Immunol 6:859-68. 2006..This Review highlights the latest advances in our understanding of the interactions between DCs and HIV, focusing on the mechanisms of DC-mediated viral dissemination... - CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1Jian Hua Wang
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, BSB 203, Milwaukee, WI 53226, USA
J Virol 81:2497-507. 2007..These results suggest that CD4, which is present at various levels in DC-SIGN-positive primary cells, is a key regulator of HIV-1 transmission... - Characterization of human immunodeficiency virus type 1 replication in immature and mature dendritic cells reveals dissociable cis- and trans-infectionChunsheng Dong
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
J Virol 81:11352-62. 2007..Our results suggest that various DC subsets in vivo may differentially contribute to HIV-1 dissemination via dissociable cis- and trans-infections... - Productive infection of human immunodeficiency virus type 1 in dendritic cells requires fusion-mediated viral entryAlicia M Janas
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Virology 375:442-51. 2008..Together, these results provide functional evidence in understanding HIV-1 cis-infection of DCs, suggesting that different pathways of HIV-1 entry into DCs determine the outcome of viral infection... - Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cellsJian Hua Wang
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
J Virol 81:8933-43. 2007..Our results provide new insights into the mechanisms underlying DC-mediated HIV-1 transmission, suggesting that HIV-1 exploits mDCs to facilitate its dissemination within lymphoid tissues... - Macropinocytosis and cytoskeleton contribute to dendritic cell-mediated HIV-1 transmission to CD4+ T cellsJian Hua Wang
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Virology 381:143-54. 2008..Our results provide new insights into the mechanisms underlying DC-mediated HIV-1 transmission to CD4+ T cells via the cytoskeletal network... - HIV interactions with monocytes and dendritic cells: viral latency and reservoirsChristopher M Coleman
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Retrovirology 6:51. 2009.... - HIV-1 interactions with cells: from viral binding to cell-cell transmissionAlicia M Janas
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Curr Protoc Cell Biol . 2009..These functional assays provide useful tools to quantitatively study HIV-1 infection and viral transmission... - Transcriptional restriction of human immunodeficiency virus type 1 gene expression in undifferentiated primary monocytesChunsheng Dong
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
J Virol 83:3518-27. 2009..Our results provide new insights into HIV-1 infection and regulation in primary monocytes and viral pathogenesis... - Biology of HIV Mucosal TransmissionLi Wu
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Curr Opin HIV AIDS 3:534-40. 2008..Functional studies of HIV-1 interactions with host cells can provide new insights into the design of more effective approaches to combat HIV-1 infection and AIDS... - The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancementIrina Caminschi
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Blood 112:3264-73. 2008..Furthermore, targeting Ags to DCs with antibodies to Clec9A is a promising strategy to enhance the efficiency of vaccines, even in the absence of adjuvants... 
Role of DC-SIGN in the activation of dendritic cells by HPV-16 L1 virus-like particle vaccineAlfonso J Garcia-Pineres
SAIC Frederick NCI Frederick, Frederick, MD, USA
Eur J Immunol 36:437-45. 2006..These results suggest that DC-SIGN has a functional role in DC activation induced by HPV-16 L1-VLP, and thus highlight new aspects of DC interactions with HPV VLP...- Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmissionLi Wu
Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
Retrovirology 1:14. 2004..We thus examined whether K562 erythroleukemic cells could recapitulate efficient DC-SIGN-mediated HIV-1 transmission (DMHT)... - Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmissionLi Wu
HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
J Virol 76:5905-14. 2002..While these findings do not discount the role of intercellular contact in facilitating HIV-1 transmission, our in vitro data indicate that DC-SIGN interactions with ICAM-3 do not promote DC-SIGN-mediated virus transmission... - Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmissionLi Wu
Model Development Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA
Virology 318:17-23. 2004..These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission... - Novel member of the CD209 (DC-SIGN) gene family in primatesArman A Bashirova
Science Application International Corporation at Frederick, Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Maryland 21702, USA
J Virol 77:217-27. 2003.... - Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivoShalin H Naik
The Walter and Eliza Hall Institute, Parkville, Victoria 3050, Australia
Nat Immunol 8:1217-26. 2007..Thus, commitment to particular DC subtypes begins mainly at this pro-DC stage... - Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subsetMing Lee Lin
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3050, Australia
Proc Natl Acad Sci U S A 105:3029-34. 2008..Our model opens an avenue to specifically target cross-presenting DCs in vivo for manipulating cytotoxic T lymphocyte responses toward infections, tumors, and transplants... - The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3Angela D'Amico
The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
J Exp Med 198:293-303. 2003..These findings demonstrate that the early precursors for all DC subtypes are within the BM Flt3+ precursor populations, regardless of their lymphoid or myeloid lineage orientation... - The lymphoid past of mouse plasmacytoid cells and thymic dendritic cellsLynn Corcoran
The Walter and Eliza Hall Institute, Melbourne, Australia
J Immunol 170:4926-32. 2003..Therefore, many plasmacytoid pre-DC and thymic CD8(+) DC have shared early steps of development with the lymphoid lineages, and differ in origin from conventional peripheral DC... - Differential production of inflammatory chemokines by murine dendritic cell subsetsAnna I Proietto
The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Vic. 3050, Australia
Immunobiology 209:163-72. 2004..Thus, we report a new functional difference between the murine splenic cDC subsets, with the CD4+ cDC demonstrating the most efficient production of the inflammatory chemokines Mip-1alpha, Mip-1beta and Rantes... - Recruitment of HIV and its receptors to dendritic cell-T cell junctionsDavid McDonald
Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA
Science 300:1295-7. 2003..We propose that contact between dendritic cells and T cells facilitates transmission of HIV by locally concentrating virus, receptor, and coreceptor during the formation of an infectious synapse... - CD8alpha+ mouse spleen dendritic cells do not originate from the CD8alpha- dendritic cell subsetShalin Naik
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Blood 102:601-4. 2003..Most of the immediate precursors of CD8alpha+ DCs are cells that lack the phenotype of a recognizable DC. CD8alpha- DCs and CD8alpha+ DCs are not precursor-product related, though these sublineages may be connected further upstream... - Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulusMeredith O'Keeffe
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
J Exp Med 196:1307-19. 2002..Hence as well as activating preexistant DCs, microbial infection induces a wave of production of a new DC subtype. The functional implications of this shift in the DC network remain to be determined... - Hemopoietic precursors and development of dendritic cell populationsAleksandar Dakic
The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Vic. 3050, Australia
Leuk Lymphoma 44:1469-75. 2003..The downstream points where the DC sub-lineages branch off from the conventional myeloid and lymphoid precursors, and the cytokines and environmental factors required for inducing their specialised functions are yet to be determined... - Development of dendritic-cell lineagesLi Wu
Immunology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
Immunity 26:741-50. 2007..The development of different populations of DCs is differentially regulated by various transcription factors and cytokines. This review summarizes the recent advances made in the field of DC development... - Development of the dendritic cell system during mouse ontogenyAleksandar Dakic
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
J Immunol 172:1018-27. 2004..These results suggest that the neonatal DC system is not fully developed, and innate immunity is the dominant form of response. The complete DC system required for adaptive immunity in the mouse is not fully developed until 5 wk of age... - Are dendritic cells end cells?Ken Shortman
Nat Immunol 5:1105-6. 2004 - Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow culturesShalin H Naik
Immunology Division and the Cooperative Research Centre for Vaccine Technology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
J Immunol 174:6592-7. 2005..This culture system allows access to bona fide counterparts of the splenic DC subsets... - Heterogeneity of thymic dendritic cellsLi Wu
The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, VIC 3050, Australia
Semin Immunol 17:304-12. 2005..Thymic pDC can produce type-I interferon upon appropriate activation. However, their role in a steady state thymus is currently unclear... - Development of murine plasmacytoid dendritic cell subsetsShalin H Naik
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Melbourne, Victoria, Australia
Immunol Cell Biol 83:563-70. 2005.... - Development of dendritic cell systemLi Wu
The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
Cell Mol Immunol 1:112-8. 2004..These findings suggest an early developmental flexibility of precursors for DCs and pDCs. This review summarizes some recent observations on the development of DC system in both human and mouse... - Nortriterpenoids from Schisandra lancifoliaWei-Lie Xiao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China
J Nat Prod 69:650-3. 2006..In addition, all new compounds were tested for anti-HIV-1 activity... - Intrasplenic steady-state dendritic cell precursors that are distinct from monocytesShalin H Naik
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Vaccine Technology, Parkville, Victoria 3050, Australia
Nat Immunol 7:663-71. 2006..Thus, the inflammatory status of the host influences the developmental origin and type of DC present in lymphoid tissues... - Signal regulatory protein molecules are differentially expressed by CD8- dendritic cellsMireille H Lahoud
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
J Immunol 177:372-82. 2006..Thus, we postulate that the differential expression of these molecules may confer the ability to regulate the phagocytosis of particular ligands to CD8(-) cDC... - The thymic stromal cell line MTSC4 induced thymocyte apoptosis in a non-MHC-restricted mannerXue Ying He
Department of Immunology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, China
Cell Res 14:125-33. 2004..Our study has also shown that the interaction of MTSC4 stromal cells and thymocytes is required for the induction of thymocyte apoptosis... - Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGNLi Wu
HIV Drug Resistance Program, Laboratory of Genomic Diversity, and Basic Research Program, Science Applications International Corporation Frederick, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 99:1568-73. 2002....