Margaret T T Wong Riley
Affiliation: Medical College of Wisconsin
Wong Riley M, Liu Q, Gao X. Mechanisms underlying a critical period of respiratory development in the rat. Respir Physiol Neurobiol. 2019;: pubmed publisher
..Carotid body denervation during this time or perinatal hyperoxia merely delays and sometimes prolongs, but not eliminate the critical period. The rationale for the necessity of the critical period in postnatal development is discussed. ..
Liu Q, Wong Riley M. Pituitary adenylate cyclase-activating polypeptide: Postnatal development in multiple brain stem respiratory-related nuclei in the rat. Respir Physiol Neurobiol. 2019;259:149-155 pubmed publisher
..Results imply that the down-regulation of PACAP during normal postnatal development may contribute to the critical period of vulnerability, when the animals' response to hypoxia is at its weakest. ..
Wong Riley M. Bigenomic regulation of cytochrome c oxidase in neurons and the tight coupling between neuronal activity and energy metabolism. Adv Exp Med Biol. 2012;748:283-304 pubmed publisher
..NRF-1, in addition, also regulates critical neurochemicals of glutamatergic synaptic transmission, thereby ensuring the tight coupling of energy metabolism and neuronal activity at the molecular level in neurons. ..
Wong Riley M, Liang H, Eells J, Chance B, Henry M, Buchmann E, et al
. Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase. J Biol Chem. 2005;280:4761-71 pubmed
..The results are consistent with our hypothesis that the mechanism of photobiomodulation involves the up-regulation of cytochrome c oxidase, leading to increased energy metabolism in neurons functionally inactivated by toxins. ..
Priya A, Johar K, Nair B, Wong Riley M. Nuclear respiratory factor 2 regulates the transcription of AMPA receptor subunit GluA2 (Gria2). Biochim Biophys Acta. 2014;1843:3018-28 pubmed publisher
..By regulating the GluA2 subunit of the AMPA receptor, NRF-2 couples energy metabolism and neuronal activity at the transcriptional level through a concurrent and parallel mechanism with NRF-1 and Sp4. ..
Gao X, Zhang H, Wong Riley M. Role of brain-derived neurotrophic factor in the excitatory-inhibitory imbalance during the critical period of postnatal respiratory development in the rat. Physiol Rep. 2015;3: pubmed publisher
..Thus, our findings are consistent with and strengthen our hypothesis that BDNF and TrkB play a significant role in inducing a synaptic imbalance during the critical period of respiratory development in the rat. ..
Nair B, Wong Riley M. Transcriptional Regulation of Brain-derived Neurotrophic Factor Coding Exon IX: ROLE OF NUCLEAR RESPIRATORY FACTOR 2. J Biol Chem. 2016;291:22583-22593 pubmed
Wong Riley M, Guo A, Bachman N, Lomax M. Human COX6A1 gene: promoter analysis, cDNA isolation and expression in the monkey brain. Gene. 2000;247:63-75 pubmed
..Monocular impulse blockade in adult monkeys induced a downregulation of COX6A1 expression in deprived visual neurons, suggesting that this subunit gene is regulated by neuronal activity. ..
Priya A, Johar K, Wong Riley M. Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B. Biochim Biophys Acta. 2013;1833:2745-2756 pubmed publisher
..Our data suggest that Sp4 operates in a complementary and concurrent/parallel manner with NRF-1 and NRF-2 to mediate the tight coupling between energy metabolism and neuronal activity at the molecular level. ..