Peter W F Wilson

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study
    Peter W F Wilson
    General Clinical Research Center, Medical University of South Carolina, Charleston 29425, USA
    Arch Intern Med 165:2473-8. 2005
  2. ncbi Estimating cardiovascular disease risk and the metabolic syndrome: a Framingham view
    Peter W F Wilson
    Department of Endocrinology, Medical University of South Carolina, Charleston, SC 29425, USA
    Endocrinol Metab Clin North Am 33:467-81, v. 2004
  3. ncbi Assessing coronary heart disease risk with traditional and novel risk factors
    Peter W F Wilson
    Department of Endocrinology, Diabetes, and Medical Geriatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Clin Cardiol 27:III7-11. 2004
  4. ncbi Estimating the risk for atherothrombosis: are current approaches sufficient?
    Peter W F Wilson
    General Clinical Research Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Eur J Cardiovasc Prev Rehabil 12:427-32. 2005
  5. ncbi Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    Peter W F Wilson
    The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 112:3066-72. 2005
  6. ncbi Autoantibodies to oxidized LDL and cardiovascular risk: the Framingham Offspring Study
    Peter W F Wilson
    Medical University of South Carolina, 96 Jonathan Lucas St, Suite 815, P O Box 250609, Charleston, SC 29425, USA
    Atherosclerosis 189:364-8. 2006
  7. ncbi Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
  8. ncbi Relative importance of borderline and elevated levels of coronary heart disease risk factors
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 142:393-402. 2005
  9. pmc C-reactive protein, inflammatory conditions, and cardiovascular disease risk
    Ravi Dhingra
    National Heart Lung and Blood Institute s NHBLI Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Am J Med 120:1054-62. 2007
  10. ncbi Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study
    Johan Sundstrom
    The Framingham Heart Study, Framingham, MA, USA
    Eur Heart J 25:523-30. 2004

Collaborators

Detail Information

Publications93

  1. ncbi C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study
    Peter W F Wilson
    General Clinical Research Center, Medical University of South Carolina, Charleston 29425, USA
    Arch Intern Med 165:2473-8. 2005
    ..Determination of C-reactive protein (CRP) level has been suggested to improve cardiovascular disease (CVD) risk assessment. This study examines the utility of CRP levels to assess CVD risk in a community setting...
  2. ncbi Estimating cardiovascular disease risk and the metabolic syndrome: a Framingham view
    Peter W F Wilson
    Department of Endocrinology, Medical University of South Carolina, Charleston, SC 29425, USA
    Endocrinol Metab Clin North Am 33:467-81, v. 2004
    ....
  3. ncbi Assessing coronary heart disease risk with traditional and novel risk factors
    Peter W F Wilson
    Department of Endocrinology, Diabetes, and Medical Geriatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Clin Cardiol 27:III7-11. 2004
    ..Assessment of global risk is particularly important in lipid management, as the LDL-C target goals are determined by risk category...
  4. ncbi Estimating the risk for atherothrombosis: are current approaches sufficient?
    Peter W F Wilson
    General Clinical Research Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Eur J Cardiovasc Prev Rehabil 12:427-32. 2005
    ....
  5. ncbi Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    Peter W F Wilson
    The NHLBI s Framingham Heart Study, Framingham, Massachusetts, USA
    Circulation 112:3066-72. 2005
    ..The objective was to investigate risk for CVD, CHD, and T2DM according to metabolic syndrome traits...
  6. ncbi Autoantibodies to oxidized LDL and cardiovascular risk: the Framingham Offspring Study
    Peter W F Wilson
    Medical University of South Carolina, 96 Jonathan Lucas St, Suite 815, P O Box 250609, Charleston, SC 29425, USA
    Atherosclerosis 189:364-8. 2006
    ..The relation between measures of oxidation of lipid particles and cardiovascular disease has not been extensively investigated prospectively on a population basis...
  7. ncbi Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level
    Sekar Kathiresan
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:1415-23. 2006
    ..Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP...
  8. ncbi Relative importance of borderline and elevated levels of coronary heart disease risk factors
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 142:393-402. 2005
    ..Clinical trials indicate that a sizable proportion of adults have multiple borderline coronary risk factors and may benefit from treatment...
  9. pmc C-reactive protein, inflammatory conditions, and cardiovascular disease risk
    Ravi Dhingra
    National Heart Lung and Blood Institute s NHBLI Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Am J Med 120:1054-62. 2007
    ..It is uncertain to what extent high C-reactive protein (CRP) concentrations reflect the presence of inflammatory conditions in the community...
  10. ncbi Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study
    Johan Sundstrom
    The Framingham Heart Study, Framingham, MA, USA
    Eur Heart J 25:523-30. 2004
    ..Hyperhomocysteinaemia is a risk factor for congestive heart failure, especially in women. We investigated if homocysteine promotes left ventricular (LV) remodelling...
  11. pmc Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study
    Renate Schnabel
    The NHLBI s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Atherosclerosis 204:601-7. 2009
    ..Higher circulating Lp-PLA(2) predicts cardiovascular disease risk, but sources of inter-individual variability are incompletely understood...
  12. ncbi Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study
    Ronenn Roubenoff
    United States Department of Agriculture Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Am J Med 115:429-35. 2003
    ..We hypothesized that these factors are independently linked to mortality in community-dwelling older persons...
  13. ncbi Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Arterioscler Thromb Vasc Biol 22:1662-7. 2002
    ..The objective of this study was to examine the relationship between C-reactive protein (CRP) and carotid atherosclerosis...
  14. doi Prediction of intermittent claudication, ischemic stroke, and other cardiovascular disease by detection of abdominal aortic calcific deposits by plain lumbar radiographs
    Yamini S Levitzky
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 101:326-31. 2008
    ..AAC appears to be useful for risk stratification in patients at intermediate CHD risk...
  15. ncbi Serum aldosterone and the incidence of hypertension in nonhypertensive persons
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass 01702 5827, USA
    N Engl J Med 351:33-41. 2004
    ..Primary hyperaldosteronism is a well-recognized cause of secondary hypertension. It is unknown whether serum aldosterone levels within the physiologic range influence the risk of hypertension...
  16. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  17. ncbi Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study
    Johan Sundstrom
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Hypertension 42:1100-5. 2003
    ....
  18. pmc Differences in cardiovascular disease mortality associated with body mass between Black and White persons
    Jill E Abell
    Medical University of South Carolina, Charleston, SC 29401, USA
    Am J Public Health 98:63-6. 2008
    ..91 (95% CI=0.77, 1.05), respectively. The results suggest that obesity is an independent risk factor in White people, and additional study of body size and disease progression is necessary in the assessment of racial disparities...
  19. ncbi Impact of obesity on plasma natriuretic peptide levels
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 109:594-600. 2004
    ..The natriuretic peptides are important regulators of sodium homeostasis and neurohormonal activation, raising the possibility that obese individuals have an impaired natriuretic peptide response...
  20. ncbi Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study
    Johan Sundstrom
    The Framingham Study, Boston University School of Medicine, 73 Mt Wayte Ave Suite 2, Framingham, MA, USA
    Eur Heart J 25:1509-16. 2004
    ..We examined relations of plasma total TIMP-1 to cardiovascular risk factors and echocardiographic left ventricular (LV) structure and function in a community-based sample...
  21. ncbi Monocyte cytokine production, systemic inflammation and cardiovascular disease in very elderly men and women: the Framingham Heart Study
    Agha W Haider
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702 5827, USA
    Eur J Cardiovasc Prev Rehabil 11:214-5. 2004
    ..Further studies are warranted to examine the prognostic implications of CRP and related cytokines for CVD in the elderly...
  22. ncbi Accuracy of offspring reports of parental cardiovascular disease history: the Framingham Offspring Study
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Ann Intern Med 140:434-40. 2004
    ..Family history is used to infer the risk for heart disease; however, little is known about the accuracy of family history reports...
  23. ncbi A likely explanation for the J-curve of blood pressure cardiovascular risk
    William B Kannel
    Boston University School of Medicine Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Am J Cardiol 94:380-4. 2004
    ..Patients with this condition of isolated systolic hypertension have been shown to benefit from antihypertensive treatment...
  24. ncbi Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 139:642-8. 2003
    ..It is unclear whether low serum IGF-I is a risk factor for heart failure...
  25. ncbi Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: the Framingham Heart Study
    Craig R Walsh
    Framingham Heart Study, Framingham, Mass 01702, USA
    Am Heart J 144:733-9. 2002
    ..We sought to determine the association of aortic atherosclerosis, detected by calcific deposits in the abdominal aorta seen on lateral lumbar radiographs, with risk for congestive heart failure (CHF)...
  26. ncbi Relations of plasma matrix metalloproteinase-9 to clinical cardiovascular risk factors and echocardiographic left ventricular measures: the Framingham Heart Study
    Johan Sundstrom
    The Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Circulation 109:2850-6. 2004
    ..We investigated cross-sectional relations of plasma MMP-9 to vascular risk factors and echocardiographic left ventricular (LV) measurements...
  27. ncbi Plasma brain natriuretic peptide levels and blood pressure tracking in the Framingham Heart Study
    Michael H Freitag
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Hypertension 41:978-83. 2003
    ..Additional investigations are warranted to confirm these findings and elucidate the basis for these gender-related differences...
  28. ncbi Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study
    Sekar Kathiresan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circulation 113:20-9. 2006
    ..However, the atherogenic potential of LDL may depend on the number and size of LDL particles in addition to the cholesterol content of LDL...
  29. ncbi Risk stratification of obesity as a coronary risk factor
    William B Kannel
    Framingham Study, Boston University School of Medicine, Framingham, Massachusetts, USA
    Am J Cardiol 90:697-701. 2002
    ..Global risk assessment can identify high-risk overweight candidates for CHD who most urgently need correction of associated risk factors, as well as sustained weight reduction...
  30. ncbi Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Circulation 107:1486-91. 2003
    ..It is unclear whether cytokine levels can predict the incidence of CHF in asymptomatic individuals...
  31. ncbi Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Site 2, Framingham, MA 01702 5803, USA
    JAMA 289:1251-7. 2003
    ..Elevated plasma homocysteine levels are associated with increased risk of vascular disease. It is unclear whether elevated homocysteine levels are a risk factor for congestive heart failure (CHF)...
  32. pmc Long-term C-reactive protein variability and prediction of metabolic risk
    Ting Hsu Chen
    The Framingham Heart Study and Boston University School of Medicine, Framingham, Mass, USA
    Am J Med 122:53-61. 2009
    ....
  33. ncbi The ankle-brachial index in the elderly and risk of stroke, coronary disease, and death: the Framingham Study
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Framingham, MA 01702 5827, USA
    Arch Intern Med 163:1939-42. 2003
    ..Limited data exist regarding the relation between a low ABI and stroke. We sought to examine the relation between a low ABI and stroke, coronary heart disease, and death in the elderly...
  34. ncbi Temporal trends in the incidence of intermittent claudication from 1950 to 1999
    Joanne M Murabito
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702 5827, USA
    Am J Epidemiol 162:430-7. 2005
    ..IC incidence has declined since 1950, but mortality has remained high and unchanged. Factors contributing to the declining incidence of IC need clarification...
  35. ncbi Genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Kidney Int 67:70-4. 2005
    ..Microalbuminuria is a powerful risk factor for cardiovascular disease. It is not known whether genetic factors play a role in the expression of microalbuminuria in population-based samples...
  36. ncbi Glycemic status and development of kidney disease: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave Suite 2, Framingham, Massachusetts 01702, USA
    Diabetes Care 28:2436-40. 2005
    ..Diabetes is a major risk factor for the development of kidney disease and is the leading cause of end-stage renal disease in the U.S. Whether pre-diabetes is associated with the development of kidney disease is unclear...
  37. pmc A coronary heart disease risk score based on patient-reported information
    Arch G Mainous
    Department of Family Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Cardiol 99:1236-41. 2007
    ..69, p = 0.01). In conclusion, the Personal HEART score identifies 10-year risk for CHD based on self-report data, is similar in predictive ability to the FRS and European SCORE, and has the potential for easy self-assessment...
  38. ncbi The significant effect of diabetes duration on coronary heart disease mortality: the Framingham Heart Study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    Diabetes Care 27:704-8. 2004
    ..We hypothesized that duration of diabetes is an important predictor of incident CHD among people with diabetes...
  39. ncbi Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study
    Hélène Payette
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, Massachusetts, USA
    J Am Geriatr Soc 51:1237-43. 2003
    ..To assess the prognostic role of the inflammatory cytokine, interleukin 6 (IL-6), and insulin-like growth factor-1 (IGF-1) in predicting 2-year changes in fat-free mass (FFM) while controlling for potential confounders...
  40. ncbi Trends in cardiovascular complications of diabetes
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 292:2495-9. 2004
    ..Despite reductions in cardiovascular disease (CVD) mortality over the past few decades, it is unclear whether adults with and without diabetes have experienced similar declines in CVD risk...
  41. ncbi Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    JAMA 294:3117-23. 2005
    ..While parental cardiovascular disease (CVD) doubles the risk for CVD in offspring, the extent of increased risk associated with sibling CVD is unclear...
  42. ncbi C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 106:1189-91. 2002
    ..It has not been established whether elevated CRP reflects an increased burden of subclinical coronary atherosclerosis...
  43. pmc Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 31:1582-4. 2008
    ..We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes...
  44. ncbi Concept and usefulness of cardiovascular risk profiles
    William B Kannel
    National Heart, Lung, and Blood Institute s Framingham Study, National Institutes of Health, Boston University School of Medicine, Framingham, Mass 01702, USA
    Am Heart J 148:16-26. 2004
    ..Multivariable risk stratification is now recognized as essential in efficiently identifying likely candidates for CVD and quantifying the hazard...
  45. ncbi Genomewide linkage analysis to serum creatinine, GFR, and creatinine clearance in a community-based population: the Framingham Heart Study
    Caroline S Fox
    NHLBI, NIH, Framingham Heart Study, Framingham, MA 01702, USA
    J Am Soc Nephrol 15:2457-61. 2004
    ..Further research is necessary to identify the genes involved in the development of kidney disease and to understand their roles in this complex process...
  46. ncbi Heritability of age at natural menopause in the Framingham Heart Study
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Avenue, Suite 2, Framingham, Massachusetts 01702 5827, USA
    J Clin Endocrinol Metab 90:3427-30. 2005
    ..We sought to estimate heritability of age at natural menopause in women participating in the multigenerational Framingham Heart Study, a community-based epidemiological study...
  47. ncbi Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    JAMA 288:1252-9. 2002
    ..Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women...
  48. ncbi Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart Study
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Am J Hypertens 18:657-65. 2005
    ..We investigated the environmental and genetic sources of interindividual variability in serum aldosterone level in a large, community-based sample...
  49. pmc Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification
    Christopher J O'Donnell
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    Arterioscler Thromb Vasc Biol 26:2769-74. 2006
    ..Matrix Gla protein (MGP) is an inhibitor of calcification in vivo. However, little is known regarding the distribution of circulating MGP and its associations with CHD risk factors or with CAC in humans...
  50. ncbi Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies
    James B Meigs
    Department of Medicine, General Medicine Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 52:2160-7. 2003
    ..S. By any criteria, subjects with the metabolic syndrome are more insulin resistant and at increased predicted risk for CHD versus those without the metabolic syndrome...
  51. ncbi The association of seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus with risk of cardiovascular disease: a prospective study
    Agha W Haider
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702, USA
    J Am Coll Cardiol 40:1408-13. 2002
    ..We sought to determine whether seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus (CMV) is an independent predictor of incident cardiovascular disease...
  52. ncbi Lifetime risk of coronary heart disease by cholesterol levels at selected ages
    Donald M Lloyd-Jones
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    Arch Intern Med 163:1966-72. 2003
    ..We sought to assess how cholesterol levels at different ages modify the remaining lifetime risk of coronary heart disease (CHD)...
  53. ncbi Obesity and the risk of heart failure
    Satish Kenchaiah
    Framingham Heart Study, Framingham, Mass 01702, USA
    N Engl J Med 347:305-13. 2002
    ..Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk...
  54. ncbi Predictors of new-onset kidney disease in a community-based population
    Caroline S Fox
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    JAMA 291:844-50. 2004
    ..Kidney disease is associated with an increased risk for the development of cardiovascular disease and end-stage renal disease; however, risk factors for kidney disease have not been well studied...
  55. pmc Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes
    Ayad A Jaffa
    Department of Medicine, Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA
    J Clin Endocrinol Metab 93:1893-900. 2008
    ..We explored the relevance and significance of connective tissue growth factor (CTGF) as a determinant of renal and vascular complications among type 1 diabetic patients...
  56. pmc Age and race impact the association between BMI and CVD mortality in women
    Jill E Abell
    Medical University of South Carolina, Charleston, SC, USA
    Public Health Rep 122:507-12. 2007
    ..This study examines the effect of age on the association of BMI to CVD in black and white women...
  57. ncbi Evidence for heritability of abdominal aortic calcific deposits in the Framingham Heart Study
    Christopher J O'Donnell
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 106:337-41. 2002
    ..Little is known about the heritability of aortic calcification...
  58. ncbi Prevalence and clinical correlates of peripheral arterial disease in the Framingham Offspring Study
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Am Heart J 143:961-5. 2002
    ..Peripheral arterial disease (PAD) is associated with an increased risk for mortality. We sought to assess the prevalence of PAD and its risk factors in a population-based sample...
  59. ncbi Framingham and European risk algorithms: implications for African Americans
    Peter W F Wilson
    General Clinical Research Center, Medical University of South Carolina, Charleston, South Carolina, USA
    Rev Cardiovasc Med 5:S34-41. 2004
    ..Estimation of risk for cardiovascular events is a dynamic field, and current approaches will likely be modified as newer information is obtained...
  60. ncbi Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 105:48-53. 2002
    ..It is unclear whether time-averaged past BP measures incrementally improve CVD risk assessment...
  61. ncbi Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study
    Ernst J Schaefer
    Lipid Research Laboratory, Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Diabetes Care 25:989-94. 2002
    ..We hypothesized that diabetic patients would have higher remnant levels than nondiabetic patients...
  62. ncbi Overweight and obesity as determinants of cardiovascular risk: the Framingham experience
    Peter W F Wilson
    Boston University School of Medicine, 715 Albany St, Evans 204, Boston, MA 02118, USA
    Arch Intern Med 162:1867-72. 2002
    ..To our knowledge, no single investigation concerning the long-term effects of overweight status on the risk for hypertension, hypercholesterolemia, diabetes mellitus, and cardiovascular sequelae has been reported...
  63. ncbi Sex and age differences in lipoprotein subclasses measured by nuclear magnetic resonance spectroscopy: the Framingham Study
    David S Freedman
    Division of Nutrition and Physical Activity, CDC, Atlanta, GA, USA
    Clin Chem 50:1189-200. 2004
    ..We examined whether this differential CHD risk might, in part, be attributable to the sizes of lipoprotein particles or concentrations of lipoprotein subclasses...
  64. ncbi One-year cardiovascular event rates in outpatients with atherothrombosis
    Ph Gabriel Steg
    Departement de Cardiologie, Hopital Bichat Claude Bernard, Paris, France
    JAMA 297:1197-206. 2007
    ....
  65. ncbi Impact of insulin resistance on risk of type 2 diabetes and cardiovascular disease in people with metabolic syndrome
    James B Meigs
    Harvard Medical School and the General Medicine Division, Massachusetts General Hospital, 50 Staniford St, 9th Floor, Boston, MA 02114, USA
    Diabetes Care 30:1219-25. 2007
    ..Metabolic syndrome increases the risk for type 2 diabetes and cardiovascular disease (CVD) and may be associated with insulin resistance...
  66. ncbi Atherosclerotic Vascular Disease Conference: Writing Group II: risk factors
    Sidney C Smith
    Circulation 109:2613-6. 2004
  67. ncbi American College of Endocrinology position statement on the insulin resistance syndrome
    Daniel Einhorn
    American College of Endocrinology
    Endocr Pract 9:237-52. 2003
  68. ncbi Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group III: risk assessment in persons with diabetes
    Rita F Redberg
    Circulation 105:e144-52. 2002
  69. ncbi Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
    ..Studies of newly diagnosed dementia are required in order to establish whether the elevated homocysteine levels precede the onset of dementia or result from dementia-related nutritional and vitamin deficiencies...
  70. ncbi Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S.women: the Framingham study
    Miriam J J de Kleijn
    Julius Center for General Practice and Patient Oriented Research, University Medical Center, Utrecht, The Netherlands
    J Nutr 132:276-82. 2002
    ..55 points (95% CI, -0.82 to -0.28). In conclusion, high intake of phytoestrogens in postmenopausal women appears to be associated with a favorable metabolic cardiovascular risk profile...
  71. ncbi Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort
    Nicola M McKeown
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Diabetes Care 27:538-46. 2004
    ..The aim of this study was to examine the relation between carbohydrate-related dietary factors, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort...
  72. doi Risk factor profile and management of cerebrovascular patients in the REACH Registry
    Joachim Rother
    Department of Neurology, Klinikum Minden, Hannover Medical School, Minden, Germany
    Cerebrovasc Dis 25:366-74. 2008
    ..We assessed these factors in 18,992 CVD patients within a worldwide registry of stable outpatients...
  73. doi Prediction of first events of coronary heart disease and stroke with consideration of adiposity
    Peter W F Wilson
    EPICORE, Emory University School of Medicine, Atlanta, GA 30306, USA
    Circulation 118:124-30. 2008
    ..Previous reports have focused on traditional cardiovascular risk factors; less information has been available on the role of overweight and obesity...
  74. doi Low-cost strategies to predict cardiovascular disease
    Peter W F Wilson
    Emory University, Atlanta, GA 30306, USA
    Nat Clin Pract Cardiovasc Med 5:518-9. 2008
    ..Strategies such as these might enhance screening and prevention programs but require validation. Testing the usefulness of low-cost prediction models in developing regions is the next logical step in carrying this concept forward...
  75. ncbi PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Obesity (Silver Spring) 14:753-8. 2006
    ..Elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels...
  76. ncbi Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease
    James B Meigs
    General Medicine Division, Massachusetts General Hospital, 50 Staniford Street, 9th Floor, Boston, MA 02114, USA
    J Clin Endocrinol Metab 91:2906-12. 2006
    ..Metabolic risk conferred by adiposity may be due to associated risk factor clustering...
  77. ncbi Heart disease risk determines menopausal age rather than the reverse
    Helen S Kok
    Julius Center for Health Sciences and Primary Care, Utrecht University, Utrecht, The Netherlands
    J Am Coll Cardiol 47:1976-83. 2006
    ..The purpose of this study was to investigate whether a harmful cardiovascular risk profile accelerates menopause...
  78. ncbi CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: ability of inflammatory markers to predict disease in asymptomatic patients: a background paper
    Peter W F Wilson
    Circulation 110:e568-71. 2004
    ....
  79. ncbi Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study
    Zaldy Sy Tan
    Division on Aging, Harvard Medical School, Boston, MA, USA
    Arch Intern Med 163:1053-7. 2003
    ..We examined the impact of baseline and lifetime plasma total cholesterol levels averaged across many years on the risk for AD in a large, population-based cohort...
  80. ncbi Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring
    Donald M Lloyd-Jones
    Department of Preventive Medicine and Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    JAMA 291:2204-11. 2004
    ..Whether parental cardiovascular disease confers increased risk independent of other risk factors remains controversial. Prior studies relied on offspring report, without complete validation of parental events...
  81. ncbi C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring Study
    Martin K Rutter
    Countess of Chester Hospital, Chester, UK
    Circulation 110:380-5. 2004
    ..Inflammation (assessed by C-reactive protein [CRP]) and the metabolic syndrome (MetS) are associated with cardiovascular disease (CVD), but population-based data are limited...
  82. ncbi Determinants of plasma dihydrophylloquinone in men and women
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Br J Nutr 93:701-8. 2005
    ..Despite this caveat, higher plasma dihydrophylloquinone was associated with higher dihydrophylloquinone intake and higher trans fatty acid intake...
  83. ncbi Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study)
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University, Boston, MA, USA
    Am J Cardiol 96:227-32. 2005
    ..The interaction does not appear to be mediated through effects on high-density lipoprotein cholesterol...
  84. ncbi Association between increased homocysteine levels and impaired fibrinolytic potential: potential mechanism for cardiovascular risk
    Geoffrey H Tofler
    Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Thromb Haemost 88:799-804. 2002
    ..Since thrombosis plays an important role in plaque development and acute coronary syndromes, hyperhomocysteinemia may increase risk by increasing the thrombotic potential...
  85. ncbi The metabolic syndrome: practical guide to origins and treatment: Part I
    Peter W F Wilson
    Framingham Heart Study of the National Heart, Blood, and Lung Institute, Boston, Mass, USA
    Circulation 108:1422-4. 2003
  86. ncbi Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort
    Giuseppina T Russo
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3416-21. 2003
    ..001). Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations...
  87. ncbi Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study
    John F Keaney
    Evans Memorial Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    J Am Coll Cardiol 44:168-73. 2004
    ..We sought to determine the clinical factors and heritability associated with inflammation measured as circulating levels of soluble-intercellular adhesion molecule-1 (sICAM-1) in a community-based cohort...
  88. ncbi Anticardiolipin antibodies and risk of ischemic stroke and transient ischemic attack: the Framingham cohort and offspring study
    Vallabh Janardhan
    Department of Neurology, Boston University, Boston, Mass, USA
    Stroke 35:736-41. 2004
    ..Prior cohort studies included only selected subjects, mostly men. We related serum concentrations of aCLs to incident first ischemic stroke/TIA among men and women in the Framingham Heart Study cohort and offspring...
  89. ncbi Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study
    Nicola M McKeown
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:390-8. 2002
    ..The influence of whole grains on cardiovascular disease risk may be mediated through multiple pathways, eg, a reduction in blood lipids and blood pressure, an enhancement of insulin sensitivity, and an improvement in blood glucose control...
  90. ncbi Impact of age and sex on plasma natriuretic peptide levels in healthy adults
    Thomas J Wang
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Massachusetts 01702, USA
    Am J Cardiol 90:254-8. 2002
    ..The reference limits derived from this large, healthy community-based sample will aid in the identification of elevated natriuretic peptide levels in clinical practice...
  91. ncbi Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke: the Framingham Offspring Study
    Robert M Najarian
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    Arch Intern Med 166:106-11. 2006
    ..Metabolic syndrome (MetS) has been recognized as a prediabetic constellation of symptoms and an independent risk factor for cardiovascular disease...
  92. ncbi Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk?
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research, Boston, Mass, USA
    Circulation 109:2818-25. 2004
    ..Toward this end, we believe experts in the fields of epidemiology, prevention, vascular biology, and clinical cardiology should be convened to begin discussing the merits of this proposal...
  93. ncbi Dietary and nondietary determinants of vitamin K biochemical measures in men and women
    Nicola M McKeown
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:1329-34. 2002
    ..Despite these caveats, these findings support the use of a FFQ for a relative assessment of vitamin K status in population-based studies...