Research Topics
Genomes and GenesSpecies | Xiaoling WangSummaryAffiliation: Medical College of Georgia Country: USA Publications
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Publications
Obesity related methylation changes in DNA of peripheral blood leukocytesXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA
BMC Med 8:87. 2010..Because of emerging evidence that immune responses are epigenetically regulated, we hypothesized that DNA methylation changes are involved in obesity induced immune dysfunction and aimed to identify these changes...
Genetic influences on heart rate variability at rest and during stressXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Psychophysiology 46:458-65. 2009..23 for HF. The findings suggest that, independent of ethnicity and gender, HRV regulation at rest and under stress is largely influenced by the same genes with a small but significant contribution of stress-specific genetic effects...- Genetic influence on blood pressure measured in the office, under laboratory stress and during real lifeXiaoling Wang
Department of Pediatrics, Medical College of Georgia, Georgia Prevention Institute, Augusta, GA, USA
Hypertens Res 34:239-44. 2011..However, significant genetic components specific to each BP measurement also exist. These findings suggest that partly different genes or sets of genes contribute to BP regulation in different conditions... - Heritability of insulin sensitivity and lipid profile depend on BMI: evidence for gene-obesity interactionX Wang
Georgia Prevention Institute, Medical College of Georgia, Building HS 1640, Augusta, GA 30912, USA
Diabetologia 52:2578-84. 2009..On an aggregate level, gene-obesity interactions are expected to result in different heritability estimates at different obesity levels. However, this hypothesis has never been tested... - Genetic influences on daytime and night-time blood pressure: similarities and differencesXiaoling Wang
Department of Pediatrics, Medical College of Georgia, Georgia Prevention Institute, Augusta, GA 30912, USA
J Hypertens 27:2358-64. 2009..To examine whether the genetic influences on blood pressure (BP) during night-time are different from those during daytime and the extent to which they depend on ethnicity or sex... 
Ethnic and gender differences in ambulatory blood pressure trajectories: results from a 15-year longitudinal study in youth and young adultsXiaoling Wang
Medical College of Georgia, Georgia Prevention Institute, Bldg HS 1640, Augusta, GA 30912, USA
Circulation 114:2780-7. 2006..Cross-sectional studies demonstrated ethnic and gender differences in ambulatory blood pressure patterns, but little is known about the longitudinal development of these differences...- Stress-induced sodium excretion: a new intermediate phenotype to study the early genetic etiology of hypertension?Dongliang Ge
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Hypertension 53:262-9. 2009..36 in whites and 0.39 in blacks. In summary, this study establishes Delta U(Na)V and stress U(Na)V as heritable phenotypes that may be used to study the genetic etiology of early hypertension development... - A longitudinal study of blood pressure variability in African-American and European American youthZhibin Li
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta 30912, USA
J Hypertens 28:715-22. 2010..However, little is known about blood pressure variability changes with age and its possible sociodemographic, anthropometric, and genetic moderators... - The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twinsHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Building HS 1640, Augusta, GA 30912 3715, USA
Am J Hypertens 19:61-6. 2006..The present study evaluated the impact of the GRK4 gene variants on BP levels in normotensive adolescents and young adults... - Effects of angiotensinogen and angiotensin II type I receptor genes on blood pressure and left ventricular mass trajectories in multiethnic youthXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, 30912, USA
Twin Res Hum Genet 9:393-402. 2006..A protective AGTR1 haplotype for LVM was also identified... - A longitudinal study in youth of heart rate variability at rest and in response to stressZhibin Li
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
Int J Psychophysiol 73:212-7. 2009..Few longitudinal studies have examined ethnic and sex differences, predictors and tracking stabilities of heart rate variability (HRV) at rest and in response to stress in youths and young adults... - Influence of the eNOS gene on development of blood pressure and left ventricular mass: longitudinal findings in multiethnic youthHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3710, USA
Pharmacogenet Genomics 15:669-75. 2005..To evaluate the impact of the endothelial nitric oxide synthase (eNOS) gene on longitudinal development of blood pressure (BP) and left ventricular mass (LVM) from childhood into early adulthood... - A 15-year longitudinal study on ambulatory blood pressure tracking from childhood to early adulthoodZhibin Li
Department of Pediatrics, Medical College of Georgia, Georgia Prevention Institute, Augusta, GA, USA
Hypertens Res 32:404-10. 2009..001). No significant ethnic differences were observed. The high tracking stability of 24-h ABP highlights the importance of using ambulatory BP monitoring in both research and clinical settings... - The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescentsHaidong Zhu
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912 3715, USA
Pediatr Res 60:440-2. 2006..The 65L allele of the GRK4 gene is associated with stress-induced U(Na)V reduction, suggesting impaired sodium handling in affected black youth... - Effects of dopamine receptor type 1 and Gs protein alpha subunit gene polymorphisms on blood pressure at rest and in response to stressYanhui Lu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3715, USA
Am J Hypertens 19:832-6. 2006..Therefore, we investigated whether the A-48G polymorphism of the DRD1 gene and the T393C polymorphism of the Gs protein alpha subunit (GNAS) gene influenced BP levels at rest and in response to stress... - Genetic and environmental determinants of lipid profile in black and white youth: a study of four candidate genesCatherine L Davis
Georgia Prevention Institute, Medical College of Georgia, Augusta, Georgia 30912, USA
Ethn Dis 15:568-77. 2005..To identify genotypes and gene-environment interactions, which may explain ethnic differences on lipid profile in Black and White youth... - Endothelin-1 gene and progression of blood pressure and left ventricular mass: longitudinal findings in youthYanbin Dong
Georgia Prevention Institute Department of Pediatrics, Medical College of Georgia, Augusta 30912 3710, USA
Hypertension 44:884-90. 2004..In summary, our results uncover a sex-specific protective effect of variation in the ET-1 gene on the progression of hypertension risk, and a SES-specific effect on risk of developing left ventricular hypertrophy in multiethnic youth... - Heritability of arterial stiffness in black and white American youth and young adultsDongliang Ge
Georgia Prevention Institute, Department of Pediatrics, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Am J Hypertens 20:1065-72. 2007..Our objectives were to examine the heritability of arterial stiffness measured as pulse-wave velocity (PWV), and its dependence on ethnicity, gender, and blood pressure (BP)... - The Georgia Cardiovascular Twin Study: influence of genetic predisposition and chronic stress on risk for cardiovascular disease and type 2 diabetesDongliang Ge
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
Twin Res Hum Genet 9:965-70. 2006.... - Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with race, sex, adiposity, adipokines, and physical activityHaidong Zhu
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912 3715, USA
J Pediatr 158:215-20. 2011..To examine the relationships of race, sex, adiposity, adipokines, and physical activity to telomere length in adolescents... - Update on G-protein polymorphisms in hypertensionHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, 1120 15th Street, HS 1640, Augusta, GA 30912 3715, USA
Curr Hypertens Rep 8:23-9. 2006..In this review, in conjunction with our own research, we bring readers up to date on the latest developments of GNB3 polymorphisms in the field of hypertension... - Prostasin: a possible candidate gene for human hypertensionHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Am J Hypertens 21:1028-33. 2008..This study aimed to evaluate whether the human prostasin gene is a novel candidate gene underlying blood pressure (BP) elevation... - Genetic and environmental influences on anger expression, John Henryism, and stressful life events: the Georgia Cardiovascular Twin StudyXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
Psychosom Med 67:16-23. 2005..The association between anger expression and life events is largely the result of common genes... - Ethnic differences and heritability of heart rate variability in African- and European American youthXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Am J Cardiol 96:1166-72. 2005..High heritability estimates for HRV measures were observed, and no differences in HRV heritability estimates were noted for ethnicity or gender... - A Genome-Wide Methylation Study of Severe Vitamin D Deficiency in African American AdolescentsHaidong Zhu
Department of Pediatrics, Georgia Prevention Institute, Georgia Health Sciences University, Augusta, GA Electronic address
J Pediatr 162:1004-1009.e1. 2013..To test the hypothesis that changes in DNA methylation are involved in vitamin D deficiency-related immune cell regulation using an unbiased genome-wide approach combined with a genomic and epigenomic integrative approach... - Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: a study of female dizygotic twinsYanbin Dong
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Pharmacogenetics 14:419-27. 2004.... - A genome-wide methylation study on essential hypertension in young African American malesXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences University, Augusta, Georgia, United States of America
PLoS ONE 8:e53938. 2013..Based on the recent studies that highlight the involvement of inflammation in the development of hypertension, we hypothesize that changes in DNA methylation of leukocytes are involved in the pathogenesis of hypertension... - Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertensionXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA
Curr Hypertens Rep 13:442-51. 2011.... - Genetic and environmental influences on blood pressure variability: a study in twinsXiaojing Xu
Department of Pediatrics, Georgia Prevention Institute, Georgia Health Sciences University, Augusta, Georgia 30912, USA
J Hypertens 31:690-7. 2013..In this study, we examined the relative influence of genetic and environmental sources of variance of BPV and the extent to which it may depend on race or sex in young twins... - A method to detect differentially methylated Loci with next-generation sequencingHongyan Xu
Department of Biostatistics and Epidemiology, Georgia Health Sciences University, Augusta, Georgia
Genet Epidemiol 37:377-82. 2013..It has good power and is computationally efficient. Finally, we apply the test to our NGS data on chronic lymphocytic leukemia. The results indicate that it is a promising and practical test... - Waist-to-height ratio and BMI predict different cardiovascular risk factors in Chinese childrenWeili Yan
Diabetes Care 29:2760-1. 2006 - Plasminogen activator inhibitor-1 gene: selection of tagging single nucleotide polymorphisms and association with coronary heart diseaseShaoyong Su
Division of Population Genetics and Prevention, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Arterioscler Thromb Vasc Biol 26:948-54. 2006..To explore the effect of plasminogen activator inhibitor-1 (PAI-1) gene variations on the risk of coronary heart disease (CHD) in Chinese Han population... - Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female populationNicola J Spencer-Jones
Department of Clinical Developmental Sciences, St George s, University of London, London, UK
Diabetes 54:3296-304. 2005..PTPN1 variants appear to contribute to central fat and metabolic syndrome traits, secondary to their effect on insulin sensitivity... - Heritabilities of lipids in young European American and African American twinsAnastasia Iliadou
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Twin Res Hum Genet 8:492-8. 2005..In this first twin study on lipids to include AAs, no ethnic differences in heritability were found except for LDL, where AAs exhibited higher estimates... - Angiotensin II type I receptor gene and myocardial infarction: tagging SNPs and haplotype based association study. The Beijing atherosclerosis studyShaoyong Su
The Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China
Pharmacogenetics 14:673-81. 2004..The present study aimed to assess the effect of haplotype variation in angiotensin II type I receptor (AGTR1) gene on the risk of myocardial infarction (MI) in Chinese males... - Linkage analysis of 2q14-q23 and 5q32 with blood pressure quantitative traits in Chinese sib pairsDongliang Ge
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
J Hypertens 21:305-10. 2003..The current study aimed to examine the linkage of qualitative and blood pressure quantitative traits in essential hypertension with these genomic regions in a large sample of Chinese hypertensive families... - Extensive association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese Han populationXiaoling Wang
Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
Arterioscler Thromb Vasc Biol 23:328-34. 2003..An extensive association analysis of PON gene cluster (PONs) with coronary heart disease (CHD) was performed in Chinese Han population... - Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han populationXiaoyang Zhou
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 BeiLiShi Rd, Beijing 100037, People s Republic of China
Clin Sci (Lond) 106:495-500. 2004..Additional investigations should be performed in populations at different risk of coronary events in order to elucidate further the possible contribution of this polymorphism to cardiovascular disease... - Genetic and environmental factors associated with plasma paraoxonase activity in healthy ChineseXiaoling Wang
Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
Int J Mol Med 13:445-50. 2004..The results illustrate the complexity of polymorphism-phenotype associations. The observed interactions constitute concrete examples of gene-environment and environment-environment interactions... - A genetic variation map for chicken with 2.8 million single-nucleotide polymorphismsGane Ka-Shu Wong
Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China
Nature 432:717-22. 2004..In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases... - Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female populationYuanneng Chen
Department of Clinical Developmental Sciences, St George s Hospital Medical School, London, UK
Eur J Hum Genet 13:772-80. 2005..78 (P<0.0001)). Associations of BMI, weight and total fat with SNPs in regions flanking the POMC gene in this powerful study suggest that regulation of POMC expression may be influential in determining body weight... - Waist circumference cutoff points in school-aged Chinese Han and Uygur childrenWeili Yan
Division of Epidemiology and Biostatistics, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China
Obesity (Silver Spring) 16:1687-92. 2008..To examine the distribution of age- and gender-specific waist circumference (WC) and to identify optimal cutoffs for predicting cardiovascular (CV) risk factors in Chinese Han and Uygur children... - Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activityTheodosios Kyriakou
Nutritional Sciences Division, King s College London, Franklin Wilkins Building, London, SE1 9NH, UK
J Hum Genet 53:718-27. 2008..2 kb of the ADIPOQ promoter region was cloned in a luciferase reporter plasmid, and the four haplotypes were transfected in differentiated 3T3-L1 adipocytes. No significant allelic effects on promoter activity were found... - STAT5a/PPARgamma pathway regulates involucrin expression in keratinocyte differentiationXiuju Dai
Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
J Invest Dermatol 127:1728-35. 2007..This report provides early evidence of a major role for STAT5a in the differentiation of keratinocytes, where it contributes to involucrin expression by activating the PPARgamma signal... - Thoc1/Hpr1/p84 is essential for early embryonic development in the mouseXiaoling Wang
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Mol Cell Biol 26:4362-7. 2006..While Hpr1p is not essential for the viability of unicellular yeasts, the orthologous Thoc1 protein is required for viability of the early mouse embryo... - An allelic series for studying the mouse Thoc1 geneXiaoling Wang
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Genesis 45:32-7. 2007..However, these mice express less pThoc1 than wild type mice and exhibit a dwarf phenotype. The dwarf phenotype can be detected in mid-gestation embryos, suggesting that Thoc1 is also required later in embryonic and postnatal development... - Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese populationYanhui Lu
Division of Cardio Pulmonary Circulation, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037, Beijing, People s Republic of China
Thromb Res 106:7-12. 2002.... - Common STAT3 variants are not associated with obesity or insulin resistance in female twinsYalda Jamshidi
Nutrition Food and Health Research Centre, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom
Obesity (Silver Spring) 15:1634-9. 2007..Although defective STAT3 action results in obesity and insulin resistance in animal models, we failed to establish any indicative associations with common SNPs in this human study... - Ethnic differences in heart rate variability: does ultralow-frequency heart rate variability really measure autonomic tone?Julian F Thayer
Am Heart J 152:e27. 2006
Research Grants
- Identifying genes related to heart rate variability at rest and during stressXiaoling Wang; Fiscal Year: 2007..Low HRV increases the risk of cardiovascular disease. We will look for variants in the genes involved in the regulation of HRV to see if they explain individual differences in HRV observed in the population. ..