Research Topics
Genomes and GenesSpecies | F TreiberSummaryAffiliation: Medical College of Georgia Country: USA Publications
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Publications
Impact of stress reduction on negative school behavior in adolescentsVernon A Barnes
Georgia Institute for Prevention of Human Diseases and Accidents, Medical College of Georgia, Augusta, GA 30912, USA
Health Qual Life Outcomes 1:10. 2003..The purpose of this study was to determine the effect of stress reduction via the Transcendental Meditation program on school rule infractions in adolescents...
FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youthGaifen Liu
Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
BMC Med Genet 11:57. 2010..This study aimed to assess the influence of FTO variant rs9939609 on adiposity, insulin resistance, energy intake and physical activity in European - (EA) and African-American (AA) youth...
Plasma endothelin-1 release during acute stress: role of ethnicity and sexFrank A Treiber
Georgia Prevention Institute and the Department of Pediatrics, Medical College of Georgia, Augusta 30912 3710, USA
Psychosom Med 64:707-13. 2002..The purposes of this study were to examine possible ethnic and sex differences in plasma ET-1 levels at rest and in response to acute stress and to examine relationships between ET-1 and vasoconstrictive-mediated BP reactivity to stress...
Cardiovascular reactivity and development of preclinical and clinical disease statesFrank A Treiber
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, Georgia 30912, USA
Psychosom Med 65:46-62. 2003....
Racial differences in endothelin-1 at rest and in response to acute stress in adolescent malesF A Treiber
Georgia Prevention Institute, the Vascular Biology Center, Departments of Pediatrics and Psychiatry, and Office of Biostatistics, Medical College of Georgia, Augusta, GA 30912 3710, USA
Hypertension 35:722-5. 2000..05). These findings suggest that altered endothelial function may be involved in racial differences in hemodynamic reactivity to stress and possibly in the development of essential hypertension...
Cardiovascular (CV) responsivity and recovery to acute stress and future CV functioning in youth with family histories of CV disease: a 4-year longitudinal studyF A Treiber
Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
Int J Psychophysiol 41:65-74. 2001..The predictive value of the derived models did not decline from one annual evaluation to the next over the length of the study. CV recovery may supplement resting and responsivity in the prediction of future development of CVD..
Fasting insulin concentration is related to cardiovascular reactivity to exercise in childrenB Gutin
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta 30912 3710, USA
Pediatrics 96:1123-5. 1995..We tested this hypothesis by determining the relationship of insulin concentration and sympathetically mediated cardiovascular reactivity to exercise in children...
Weight-independent cardiovascular fitness and coronary risk factorsB Gutin
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, USA
Arch Pediatr Adolesc Med 151:462-5. 1997....
Heritabilities of lipids in young European American and African American twinsAnastasia Iliadou
Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Twin Res Hum Genet 8:492-8. 2005..In this first twin study on lipids to include AAs, no ethnic differences in heritability were found except for LDL, where AAs exhibited higher estimates...
A gene-environment interaction model of stress-induced hypertensionIkhide G Imumorin
Department of Biology, Spelman College, Atlanta, GA 30314, USA
Cardiovasc Toxicol 5:109-32. 2005....
Interactive effects of anger expression and ET-1 Lys198Asn polymorphism on vasoconstriction reactivity to behavioral stressKristen M Rabineau
Department of Psychiatry, Medical College of Georgia, Georgia Prevention Institute, Augusta 30912, USA
Ann Behav Med 30:85-9. 2005..African Americans (AAs) are at particular risk for development of EH, report greater anger difficulties, and exhibit greater vasoconstrictive reactivity than their European American (EA) counterparts...
Tobacco prevention in children and cessation in family membersMartha S Tingen
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, Georgia, USA
J Am Acad Nurse Pract 18:169-79. 2006..To examine the effects of a theory-driven tobacco prevention program in sixth-grade children with a family tobacco cessation component implemented by school nurses in conjunction with the initiation of a statewide toll-free Quit Line...
Emergence of novel genetic effects on blood pressure and hemodynamics in adolescence: the Georgia Cardiovascular Twin StudyNina Kupper
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Hypertension 47:948-54. 2006..Environmental influences become more important with age in AAs compared with EAs for both systolic and diastolic BP. Future elucidation of these environmental factors may help explain ethnic differences in hypertension risk...
Anger suppression and adiposity modulate association between ADRB2 haplotype and cardiovascular stress reactivityJoseph C Poole
Department of Pediatrics, Georgia Prevention Institute, Augusta, Georgia 30912, USA
Psychosom Med 68:207-12. 2006....
The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twinsHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Building HS 1640, Augusta, GA 30912 3715, USA
Am J Hypertens 19:61-6. 2006..The present study evaluated the impact of the GRK4 gene variants on BP levels in normotensive adolescents and young adults...
Sympathetic nervous system, genes and human essential hypertensionHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, 30912-3715, USA
Curr Neurovasc Res 2:303-17. 2005....
Genetic and environmental determinants of lipid profile in black and white youth: a study of four candidate genesCatherine L Davis
Georgia Prevention Institute, Medical College of Georgia, Augusta, Georgia 30912, USA
Ethn Dis 15:568-77. 2005..To identify genotypes and gene-environment interactions, which may explain ethnic differences on lipid profile in Black and White youth...
Effects of dopamine receptor type 1 and Gs protein alpha subunit gene polymorphisms on blood pressure at rest and in response to stressYanhui Lu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3715, USA
Am J Hypertens 19:832-6. 2006..Therefore, we investigated whether the A-48G polymorphism of the DRD1 gene and the T393C polymorphism of the Gs protein alpha subunit (GNAS) gene influenced BP levels at rest and in response to stress...
The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescentsHaidong Zhu
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912 3715, USA
Pediatr Res 60:440-2. 2006..The 65L allele of the GRK4 gene is associated with stress-induced U(Na)V reduction, suggesting impaired sodium handling in affected black youth...
Effects of angiotensinogen and angiotensin II type I receptor genes on blood pressure and left ventricular mass trajectories in multiethnic youthXiaoling Wang
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, 30912, USA
Twin Res Hum Genet 9:393-402. 2006..A protective AGTR1 haplotype for LVM was also identified...
Impact of breathing awareness meditation on ambulatory blood pressure and sodium handling in prehypertensive African American adolescentsVernon A Barnes
Georgia Institute for Prevention of Human Diseases and Accidents, Medical College of Georgia, Augusta 30912, USA
Ethn Dis 18:1-5. 2008..This study evaluated the impact of a breathing awareness meditation (BAM) program on ambulatory blood pressure and sodium handling in African American adolescents with high-normal systolic blood pressure (SBP) levels...
Change of genetic determinants of left ventricular structure in adolescence: longitudinal evidence from the Georgia cardiovascular twin studyGaston K Kapuku
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Am J Hypertens 21:799-805. 2008..Background: Genetic contribution to left ventricular (LV) structure is generally recognized, but whether and how this influence varies by ethnicity or with age is unknown...
Relationships of cardiovascular phenotypes with healthy weight, at risk of overweight, and overweight in US youthsHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3715, USA
Pediatrics 121:115-22. 2008..This study aimed to evaluate comprehensively the cardiovascular phenotypes of cardiovascular disease-free youths at risk of overweight, in comparison with healthy weight and overweight...
Ethnic differences in the association of birth weight and blood pressure: the Georgia cardiovascular twin studySara Oberg
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
Am J Hypertens 20:1235-41. 2007..However, most previous studies in biethnic samples have not found a significant inverse association between birth weight and blood pressure in AAs...
Heritability of arterial stiffness in black and white American youth and young adultsDongliang Ge
Georgia Prevention Institute, Department of Pediatrics, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
Am J Hypertens 20:1065-72. 2007..Our objectives were to examine the heritability of arterial stiffness measured as pulse-wave velocity (PWV), and its dependence on ethnicity, gender, and blood pressure (BP)...
Cardiovascular characteristics in American youth with prehypertensionHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3715, USA
Am J Hypertens 20:1051-7. 2007..Cardiovascular structure and function in youth with prehypertension have been incompletely investigated...
Perceived stress, heart rate, and blood pressure among adolescents with family members deployed in Operation Iraqi FreedomVernon A Barnes
Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
Mil Med 172:40-3. 2007..02). Military dependent European Americans exhibited higher systolic BP compared to the other groups on the second evaluation (p < 0.03)...
The Georgia Cardiovascular Twin Study: influence of genetic predisposition and chronic stress on risk for cardiovascular disease and type 2 diabetesDongliang Ge
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta, GA 30912, USA
Twin Res Hum Genet 9:965-70. 2006....
Ethnic and gender differences in ambulatory blood pressure trajectories: results from a 15-year longitudinal study in youth and young adultsXiaoling Wang
Medical College of Georgia, Georgia Prevention Institute, Bldg HS 1640, Augusta, GA 30912, USA
Circulation 114:2780-7. 2006..Cross-sectional studies demonstrated ethnic and gender differences in ambulatory blood pressure patterns, but little is known about the longitudinal development of these differences...
Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjectsDongliang Ge
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta 30912 3715, USA
Hypertension 49:107-12. 2007..We proposed a viable approach to test for the multiple genetic contributions to BP and hypertension...
Early markers of cardiovascular diseaseGaston K Kapuku
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 4534, USA
Vascul Pharmacol 45:277-80. 2006..In addition, we highlight the necessity of targeting the pediatric population in studies aimed at preventing and treating cardiovascular disease...
Influence of the eNOS gene on development of blood pressure and left ventricular mass: longitudinal findings in multiethnic youthHaidong Zhu
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912 3710, USA
Pharmacogenet Genomics 15:669-75. 2005..To evaluate the impact of the endothelial nitric oxide synthase (eNOS) gene on longitudinal development of blood pressure (BP) and left ventricular mass (LVM) from childhood into early adulthood...
African-American adolescents' stress responses after the 9/11/01 terrorist attacksVernon A Barnes
Department of Pediatrics, Georgia Institute for Prevention of Human Diseases and Accidents, Medical College of Georgia, Augusta, GA, USA
J Adolesc Health 36:201-7. 2005..To examine the impact of indirect exposure to the 9/11/01 attacks upon physical and emotional stress-related responses in a community sample of African-American (AA) adolescents...
Physical activity buffers the effects of chronic stress on adiposity in youthZenong Yin
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, USA
Ann Behav Med 29:29-36. 2005..The moderating effect of physical activity (PA) on relations between chronic stress and adiposity is unknown in youth...
Beta2-adrenergic receptor gene and resting hemodynamics in European and African American youthHarold Snieder
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Building HS 1640, Augusta, GA 30912, USA
Am J Hypertens 15:973-9. 2002..The purpose of this study was to investigate the relationship between these polymorphisms and resting hemodynamic function in African American (AA) and European American (EA) youths...
Relationships among socioeconomic status, stress induced changes in cortisol, and blood pressure in African American malesGaston L Kapuku
Medical College of Georgia, Augusta 30912-3710, USA
Ann Behav Med 24:320-5. 2002..44, p < .05). These results suggest that SES may be linked to CVD via BP and cortisol reactivity to stress, but prospective studies are needed to clarify whether such is the case...
A comparison of ambulatory blood pressure patterns across populationsGregory A Harshfield
Department of Pediatrics and Georgia Prevention Institute, Medical College of Georgia, Augusta, 30912 4534, USA
Blood Press Monit 7:265-9. 2002..e. dipping) in blood pressure compared with whites. The resulting increase in cardiovascular load has been hypothesized to contribute to ethnic differences in hypertension and its sequelae...
Dissecting the genetic architecture of the cardiovascular and renal stress responseHarold Snieder
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Building HS 1640, Augusta, GA 30912, USA
Biol Psychol 61:73-95. 2002..Finally, by describing the underlying physiological systems of our model and their genetic underpinning we emphasize the importance of inclusion of genetic measurements in any future studies testing the reactivity hypothesis...
Impaired stress-induced pressure natriuresis increases cardiovascularload in African American youthsGregory A Harshfield
Georgia Prevention Institute, Augusta, USA
Am J Hypertens 15:903-6. 2002..We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load...
Adiposity changes in youth with a family history of cardiovascular disease: impact of ethnicity, gender and socioeconomic statusDonna B Moore
Department of Pediatrics, BG 2120, Medical College of Georgia, Augusta, GA 30912 3770, USA
J Assoc Acad Minor Phys 13:76-83. 2002....
Insulin resistance syndrome and left ventricular mass in healthy young peopleCatherine L Davis
Medical College of Georgia, Georgia Prevention Institute, Augusta 30912, USA
Am J Med Sci 324:72-5. 2002..Left ventricular hypertrophy has been linked to hypertension, obesity, and insulin resistance...
A longitudinal study of ethnic differences in ambulatory blood pressure patterns in youthGregory A Harshfield
Department of Pediatrics, Georgia Prevention Institute, Medical College of Georgia, Augusta 30912 4534, USA
Am J Hypertens 15:525-30. 2002..We examined: 1) the stability of this difference; 2) demographic and anthropometric characteristics that predict the difference over 2 years; and 3) the clinical significance of the difference...
Growth of left ventricular mass in African American and European American youthCaroline Dekkers
Georgia Prevention Institute, Medical College of Georgia, Augusta
Hypertension 39:943-51. 2002..Apart from these ethnicity and gender effects, individual differences in cardiac growth can mainly be explained by body growth and increases in general adiposity...
Impaired stress-induced pressure natriuresis is related to left ventricle structure in blacksGregory A Harshfield
Georgia Prevention Institute in the Department of Pediatrics, Medical College of Georgia, Augusta 30912 4534, USA
Hypertension 39:844-7. 2002..31+/-0.04 versus 0.29+/-0.03, P<0.002). In conclusion, impaired stress-induced pressure natriuresis in blacks may contribute to racial differences in essential hypertension and its sequelae...
Moderators of blood pressure development from childhood to adulthood: a 10-year longitudinal studyJ Caroline Dekkers
Georgia Prevention Institute, Medical College of Georgia, Augusta 30912, USA
J Pediatr 141:770-9. 2002..The ethnic differences cannot be entirely explained by individual differences in SES, growth, or adiposity. Identification of mechanisms responsible for increase of BP in childhood will improve prevention of hypertension in adulthood...
Reproducibility of ambulatory blood pressure measures in African-American adolescentsVernon A Barnes
Georgia Institute for Prevention of Human Diseases and Accidents, Medical College of Georgia, Augusta, Georgia 30912, USA
Ethn Dis 12:S3-101-6. 2002..The primary purpose of this study was to evaluate the reproducibility of ambulatory blood pressure (BP) measures in African-American (AA) adolescents...
The Georgia Cardiovascular Twin StudyHarold Snieder
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
Twin Res 5:497-8. 2002..Future work will explore the influence of polymorphic variation in candidate genes and their potential interaction with the environment on these risk factors...
Impact of meditation on resting and ambulatory blood pressure and heart rate in youthVernon A Barnes
Georgia Institute for Prevention of Human Diseases and Accidents, Augusta, GA 30912, USA
Psychosom Med 66:909-14. 2004..3 vs. 0.3 bpm).CONCLUSION: These findings demonstrate the potential beneficial impact of meditation on blood pressure and heart rate in the natural environment in healthy normotensive youth...
Endothelin-1 gene and progression of blood pressure and left ventricular mass: longitudinal findings in youthYanbin Dong
Georgia Prevention Institute Department of Pediatrics, Medical College of Georgia, Augusta 30912 3710, USA
Hypertension 44:884-90. 2004..In summary, our results uncover a sex-specific protective effect of variation in the ET-1 gene on the progression of hypertension risk, and a SES-specific effect on risk of developing left ventricular hypertrophy in multiethnic youth...
Temporal stability of twenty-four-hour ambulatory hemodynamic bioimpedance measures in African American adolescentsVernon A Barnes
Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
Blood Press Monit 9:173-7. 2004..The reliability of ambulatory impedance cardiography has not been evaluated...
Gender influences endothelial-dependent arterial dilatation via arterial size in youthGaston K Kapuku
Pediatrics Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912 4534, USA
Am J Med Sci 327:305-9. 2004..It is unclear, however, whether gender plays a mediating or a moderating role in these relationships. The aim of this study was to evaluate the influence of gender on EDAD in youth at risk for CVD...
Impact of transcendental meditation on ambulatory blood pressure in African-American adolescentsVernon A Barnes
Georgia Institute for Prevention of Human Diseases and Accidents, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
Am J Hypertens 17:366-9. 2004..04) and diastolic BP (P < .06) in the TM group compared with the control group across the visits demonstrate a beneficial impact of the TM program in youth at risk for the development of hypertension...
Development of general and central obesity from childhood into early adulthood in African American and European American males and females with a family history of cardiovascular diseaseJ Caroline Dekkers
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta 30912-3710, USA
Am J Clin Nutr 79:661-8. 2004..However, race, sex, and SES had joint effects on adiposity levels. The development of obesity can begin to be distinguished in midchildhood, but the age at which this distinction becomes apparent depends on race...
Endothelin-1 gene Lys198Asn polymorphism and blood pressure reactivityFrank A Treiber
Medical College of Georgia, Georgia Prevention Institute, Building HS 1640, Augusta, GA 30912, USA
Hypertension 42:494-9. 2003..05). In conclusion, the findings point out the importance of examining the impact of genetic polymorphisms on blood pressure control phenotypes within the context of potentiating environmental factors...
A tyrosine hydroxylase microsatellite and hemodynamic response to stress in a multi-ethnic sample of youthPaule Barbeau
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
Ethn Dis 13:186-92. 2003..The aim of this study was to determine whether a relationship exists between a tyrosine hydroxylase microsatellite and resting hemodynamic function, and/or hemodynamic responsivity to laboratory stress...
Differential influence of family history of hypertension and premature myocardial infarction on systolic blood pressure and left ventricular mass trajectories in youthJ Caroline Dekkers
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912-3710, USA
Pediatrics 111:1387-93. 2003..Genetic markers of EH may improve the understanding of individual differences in susceptibility to develop hypertension and LV hypertrophy...
Heritability of blood pressure and hemodynamics in African- and European-American youthHarold Snieder
Georgia Prevention Institute, Medical College of Georgia, Bldg HS 1640, Augusta, GA 30912, USA
Hypertension 41:1196-201. 2003..In summary, relative influences of genetic and environmental factors on blood pressure and hemodynamics in AA and EA youth are similar and independent of (genes for) obesity...
Changes in overweight in youth over a period of 7 years: impact of ethnicity, gender and socioeconomic statusDonna B Moore
Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA
Ethn Dis 12:S1-83-6. 2002..To examine changes in overweight in youth over a period of 7 years, within the context of ethnicity, gender, and socioeconomic status (SES)...
