Barbara C Tilley

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Screening potential therapies: lessons learned from new paradigms used in Parkinson disease
    Barbara C Tilley
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425
    Stroke 38:800-3. 2007
  2. ncbi request reprint Optimizing the ongoing search for new treatments for Parkinson disease: using futility designs
    B C Tilley
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, P O Box 250835, Charleston, SC 29425, USA
    Neurology 66:628-33. 2006
  3. ncbi request reprint Non-linearity of Parkinson's disease progression: implications for sample size calculations in clinical trials
    Paulo Guimaraes
    Dept of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon St Suite 303, Charleston, SC 29425, USA
    Clin Trials 2:509-18. 2005
  4. ncbi request reprint Applying a phase II futility study design to therapeutic stroke trials
    Yuko Y Palesch
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, P O Box 250835, Charleston, SC 29425, USA
    Stroke 36:2410-4. 2005
  5. pmc Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale
    Sydney E Seidel
    Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Parkinsonism Relat Disord 18:230-3. 2012
  6. ncbi request reprint Self-reported adherence versus pill count in Parkinson's disease: the NET-PD experience
    Jordan J Elm
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
    Mov Disord 22:822-7. 2007
  7. ncbi request reprint Unequal burden of disease, unequal participation in clinical trials: solutions from African American and Latino community members
    Marvella E Ford
    College of Medicine, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Health Soc Work 38:29-38. 2013
  8. pmc Factors influencing physician referrals of patients to clinical trials
    Arch G Mainous
    Departments of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Natl Med Assoc 100:1298-303. 2008
  9. pmc Acculturation and diabetes among Hispanics: evidence from the 1999-2002 National Health and Nutrition Examination Survey
    Arch G Mainous
    Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Public Health Rep 121:60-6. 2006
  10. ncbi request reprint Racial variation in clinical and immunological manifestations of systemic sclerosis
    Paul J Nietert
    Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, 29425, USA
    J Rheumatol 33:263-8. 2006

Research Grants

Detail Information

Publications39

  1. ncbi request reprint Screening potential therapies: lessons learned from new paradigms used in Parkinson disease
    Barbara C Tilley
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425
    Stroke 38:800-3. 2007
    ..The CINAPS process, and lessons learned from NET-PD futility studies, particularly with respect to calibration controls and assessment of outcome measures, could enhance the choice and testing of new agents for stroke treatment...
  2. ncbi request reprint Optimizing the ongoing search for new treatments for Parkinson disease: using futility designs
    B C Tilley
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, P O Box 250835, Charleston, SC 29425, USA
    Neurology 66:628-33. 2006
    ..Futility studies may decrease the time to identify treatments unworthy of further pursuit and reduce subjects' exposure to futile treatments...
  3. ncbi request reprint Non-linearity of Parkinson's disease progression: implications for sample size calculations in clinical trials
    Paulo Guimaraes
    Dept of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon St Suite 303, Charleston, SC 29425, USA
    Clin Trials 2:509-18. 2005
    ..Models can help better understand behavior of the UPDRS after initiation of symptomatic therapy when scores will improve and eventually start deteriorating again...
  4. ncbi request reprint Applying a phase II futility study design to therapeutic stroke trials
    Yuko Y Palesch
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, P O Box 250835, Charleston, SC 29425, USA
    Stroke 36:2410-4. 2005
    ..We determined whether some phase III studies could have been avoided if preceded by smaller single-arm phase II studies to evaluate the futility of proceeding to phase III...
  5. pmc Subject-investigator reproducibility of the Unified Parkinson's Disease Rating Scale
    Sydney E Seidel
    Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Parkinsonism Relat Disord 18:230-3. 2012
    ..To evaluate the subject-investigator agreement on the Unified Parkinson's Disease Rating Scale (UPDRS) subsections I and II...
  6. ncbi request reprint Self-reported adherence versus pill count in Parkinson's disease: the NET-PD experience
    Jordan J Elm
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
    Mov Disord 22:822-7. 2007
    ..The most common approach to assessment is to do a pill count at each visit. The simple, 4-question Morisky medication adherence questionnaire may provide an alternative approach to monitoring treatment adherence in PD...
  7. ncbi request reprint Unequal burden of disease, unequal participation in clinical trials: solutions from African American and Latino community members
    Marvella E Ford
    College of Medicine, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Health Soc Work 38:29-38. 2013
    ..The results suggest the importance of developing a tailored, barriers-focused navigation intervention to improve participation among diverse racial and ethnic populations...
  8. pmc Factors influencing physician referrals of patients to clinical trials
    Arch G Mainous
    Departments of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    J Natl Med Assoc 100:1298-303. 2008
    ..Our purpose was to assess physicians' attitudes and beliefs about patient recruitment, particularly minorities, into clinical trials...
  9. pmc Acculturation and diabetes among Hispanics: evidence from the 1999-2002 National Health and Nutrition Examination Survey
    Arch G Mainous
    Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Public Health Rep 121:60-6. 2006
    ..The purpose of our research was to examine acculturation among Hispanic Americans with respect to prevalence and control of diabetes...
  10. ncbi request reprint Racial variation in clinical and immunological manifestations of systemic sclerosis
    Paul J Nietert
    Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, 29425, USA
    J Rheumatol 33:263-8. 2006
    ..To clarify which racial differences in disease manifestations can be attributed to differences in other factors such as gender, education, disease classification, and disease duration...
  11. pmc English language skills and diabetes and hypertension among foreign-born South Asian adults in England
    Arch G Mainous
    Department of Family Medicine, Medical University of South Carolina, Charleston 29425, USA
    Public Health Rep 121:331-6. 2006
  12. ncbi request reprint A study of lower extremity amputation rates in older diabetic South Carolinians
    Wanda C Gonsalves
    MUSC, Dept of Family Medicine, 295 Calhoun St, Charleston SC 29425, USA
    J S C Med Assoc 103:4-7. 2007
    ..Fortunately, the decrease in LEA rates over time as shown in our study is a step in the right direction. However, the decrease is not consistent across all counties in South Carolina...
  13. pmc Retention of under-represented minorities in drug abuse treatment studies
    Kathryn M Magruder
    Mental Health Service, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, USA
    Clin Trials 6:252-60. 2009
    ..This is especially important in drug abuse treatment studies, as minorities are over-represented in substance abuse clinical treatment programs...
  14. ncbi request reprint Demographic and clinical factors associated with in-hospital death among patients with systemic sclerosis
    Paul J Nietert
    Department of Biostatistics, Bioinformatics, and Epidemiology, Division of Rheumatology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Rheumatol 32:1888-92. 2005
    ..To examine demographic and clinical predictors of in-hospital death of patients with systemic sclerosis (SSc) and determine to what extent apparent racial differences may be attributed to socioeconomic factors...
  15. ncbi request reprint An assessment of racial differences in clinical practices for hypertension at primary care sites for medically underserved patients
    Daniel T Lackland
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Hypertens (Greenwich) 6:26-31; quiz 32-3. 2004
    ..Based on the sites examined, ethnic variations in important process and treatment indicators do not explain racial differences in cardiovascular and renal outcomes...
  16. pmc Nonprescribed antimicrobial drugs in Latino community, South Carolina
    Arch G Mainous
    Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Emerg Infect Dis 11:883-8. 2005
    ..Many persons within the Latino community self-medicate with antimicrobial drugs obtained without a prescription both inside and outside the United States, which adds to the reservoir of antimicrobial drugs in the United States...
  17. ncbi request reprint Quasi-likelihood estimation for relative risk regression models
    Rickey E Carter
    Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Biostatistics 6:39-44. 2005
    ..We apply these methods to a double-blinded randomized trial in primary biliary cirrhosis of the liver (Markus et al., 1989, New England Journal of Medicine 320, 1709-1713)...
  18. ncbi request reprint Correlates of depression, including overall and gastrointestinal functional status, among patients with systemic sclerosis
    Paul J Nietert
    Department of Biostatistics, Bioinformatics, and Epidemiology, Center for Health Care Research, Medical University of South Carolina, Charleston, South Carolina, USA
    J Rheumatol 32:51-7. 2005
    ..Patients with systemic sclerosis (SSc) may develop psychological problems in addition to physiologic symptoms. We investigated whether demographic and clinical factors are associated with comorbid depression...
  19. pmc Adjusting O'Brien's test to control type I error for the generalized nonparametric Behrens-Fisher problem
    Peng Huang
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biometrics 61:532-9. 2005
    ..Simulations are performed to compare the adjusted tests to O'Brien's test. The difference is also illustrated using data from a Parkinson's disease clinical trial...
  20. ncbi request reprint A responsive outcome for Parkinson's disease neuroprotection futility studies
    Jordan J Elm
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Ann Neurol 57:197-203. 2005
    ....
  21. pmc Development of a measure to assess patient trust in medical researchers
    Arch G Mainous
    Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Ann Fam Med 4:247-52. 2006
    ..Mistrust of research and researchers may act as a barrier to participation. The purpose of this study was to develop a scale for assessing trust in medical researchers...
  22. doi request reprint Two pharmacy interventions to improve refill persistence for chronic disease medications: a randomized, controlled trial
    Paul J Nietert
    Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Med Care 47:32-40. 2009
    ..Despite the proven effectiveness of many medications for chronic diseases, many patients do not refill their prescriptions in the required timeframe...
  23. pmc A coronary heart disease risk score based on patient-reported information
    Arch G Mainous
    Department of Family Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Cardiol 99:1236-41. 2007
    ..69, p = 0.01). In conclusion, the Personal HEART score identifies 10-year risk for CHD based on self-report data, is similar in predictive ability to the FRS and European SCORE, and has the potential for easy self-assessment...
  24. doi request reprint Repeatable battery for assessment of neuropsychological status in early Parkinson's disease
    Chengwu Yang
    Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
    Mov Disord 24:1453-60. 2009
    ..65 to 0.74 for the two factors in the two datasets. These results suggest that the current RBANS domain and total scores may not provide valid measurement of the neuropsychological status for patients with early PD...
  25. ncbi request reprint An efficient multi-stage, single-arm Phase II futility design for ALS
    Yuko Y Palesch
    Medical University of South Carolina, Charleston, SC, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:55-6. 2004
  26. ncbi request reprint Intention to be screened over time for colorectal cancer in male automotive workers
    Beatty G Watts
    Department of Behavioral Science, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 12:339-49. 2003
    ..A more focused, tailored intervention may be developed using factors that consistently predict intention...
  27. ncbi request reprint Perceptions of diabetes among patients in an urban health care system
    Marvella E Ford
    Henry Ford Health System, Center for Medical Treatment Effectiveness, Programs in Diverse Populations, Detroit, MI, USA
    Ethn Health 7:243-54. 2002
    ....
  28. pmc Caffeine and progression of Parkinson disease
    David K Simon
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Clin Neuropharmacol 31:189-96. 2008
    ..We assessed this relationship using data from 2 recent clinical trials of PD...
  29. ncbi request reprint Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic stroke
    Steven R Levine
    Department of Neurology, Mt Sinai School of Medicine, New York, NY 10029 6574, USA
    JAMA 291:576-84. 2004
    ..The presence of antiphospholipid antibodies (aPL) has been associated with vascular occlusive events. However, the role of aPL in predicting ischemic events, particularly recurrent ischemic stroke, is controversial...
  30. ncbi request reprint The impact of imbalances in baseline stroke severity on outcome in the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study
    Thomas Kwiatkowski
    Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Ann Emerg Med 45:377-84. 2005
    ..Stroke severity was based on the NIH Stroke Scale. We also compare early mortality (2-week and 30-day) in the tPA and placebo groups...
  31. ncbi request reprint Lessons from adult stroke trials
    Steven G Pavlakis
    Mount Sinai School of Medicine, New York, New York, USA
    Pediatr Neurol 34:446-9. 2006
    ..Because clinical trials, more often than not, fail to give positive (effective treatment) results, it seems reasonable to attempt to learn from others' past experiences before initiating pediatric stroke trials...
  32. ncbi request reprint Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan
    Christopher G Goetz
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 22:41-7. 2007
    ....
  33. ncbi request reprint Recruiting older African American men to a cancer screening trial (the AAMEN Project)
    Marvella E Ford
    Department of Medicine, Baylor College of Medicine, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Gerontologist 43:27-35. 2003
    ..This article describes the demographic characteristics of participants in a randomized trial (the AAMEN Project) designed to recruit older (aged 55+ years) African American men to a cancer screening trial...
  34. ncbi request reprint Recruitment of African Americans with type 2 diabetes to a randomized controlled trial using three sources
    Kimberlydawn Wisdom
    Henry Ford Health System, Center for Medical Treatment Effectiveness Programs in Diverse Populations, One Ford Place, 3E, Detroit, MI 48202, USA
    Ethn Health 7:267-78. 2002
    ..To assess the usefulness of three sources (faith-based organizations (FBOs), health system, and community) for recruitment of African Americans with type 2 diabetes to a randomized controlled trial (RCT)...
  35. ncbi request reprint Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study
    Edward C Jauch
    Department of Emergency Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0769, USA
    Stroke 37:2508-13. 2006
    ..These biochemical markers, myelin basic protein (MBP), neuron-specific enolase (NSE), S100beta, and soluble thrombomodulin, were studied for an association with initial stroke severity, infarct volume, and functional outcome...
  36. ncbi request reprint Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic stroke
    David Tanne
    Stroke Center, Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Stroke 37:1798-804. 2006
    ..We investigated in an exploratory, post hoc analysis the relationship between hemostatic markers and clinical outcomes among patients included in the National Institute of Neurological Disorders and Stroke (NINDS) rtPA Stroke Study...
  37. ncbi request reprint Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials
    Werner Hacke
    Medical University at Heidelberg, Germany
    Lancet 363:768-74. 2004
    ..Quick administration of intravenous recombinant tissue plasminogen activator (rt-PA) after stroke improved outcomes in previous trials. We aimed to analyse combined data for individual patients to confirm the importance of rapid treatment...
  38. ncbi request reprint Improving health outcomes in diverse and vulnerable populations: building on the experience of the Centers for Medical Treatment Effectiveness in Diverse Populations (MEDTEP)
    Barbara C Tilley
    Ethn Health 7:227-30. 2002
  39. ncbi request reprint Correlates and predictors of colorectal cancer screening among male automotive workers
    Amy McQueen
    Center for Health Promotion and Prevention Research, University of Texas School of Public Health, 7000 Fannin, Suite 2568, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:500-9. 2007
    ..We examined both cross-sectional correlates of prior CRCS and predictors of prospective CRCS initiation and maintenance during The Next Step Trial, a 2-year worksite behavioral intervention to promote regular CRCS and dietary change...

Research Grants5

  1. SC Cooperative for Healthy Aging in Minority Populations
    Barbara Tilley; Fiscal Year: 2006
    ....
  2. Southeastern Predoctl Training in Clinical Research(RMI)
    Barbara Tilley; Fiscal Year: 2007
    ..With these approaches we will train the next generation of rigorous, futuristic thinking clinical investigators who will be able to contribute to improving the health of the nation. ..
  3. Parkinson's Disease Clinical Trial: Statistical Center
    Barbara Tilley; Fiscal Year: 2007
    ..Medical University of South Carolina, Charleston, South Carolina Georgia Institute of Technology, Atlanta, Georgia Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL University of Georgia, Augusta, Georgia ..