Research Topics
| Barbara C TilleySummaryAffiliation: Medical University of South Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Optimizing the ongoing search for new treatments for Parkinson disease: using futility designsB C Tilley
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, P O Box 250835, Charleston, SC 29425, USA
Neurology 66:628-33. 2006..Futility studies may decrease the time to identify treatments unworthy of further pursuit and reduce subjects' exposure to futile treatments...- Screening potential therapies: lessons learned from new paradigms used in Parkinson diseaseBarbara C Tilley
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425
Stroke 38:800-3. 2007..The CINAPS process, and lessons learned from NET-PD futility studies, particularly with respect to calibration controls and assessment of outcome measures, could enhance the choice and testing of new agents for stroke treatment... - Non-linearity of Parkinson's disease progression: implications for sample size calculations in clinical trialsPaulo Guimaraes
Dept of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon St Suite 303, Charleston, SC 29425, USA
Clin Trials 2:509-18. 2005..Models can help better understand behavior of the UPDRS after initiation of symptomatic therapy when scores will improve and eventually start deteriorating again... - Applying a phase II futility study design to therapeutic stroke trialsYuko Y Palesch
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, P O Box 250835, Charleston, SC 29425, USA
Stroke 36:2410-4. 2005..We determined whether some phase III studies could have been avoided if preceded by smaller single-arm phase II studies to evaluate the futility of proceeding to phase III... 
Subject-investigator reproducibility of the Unified Parkinson's Disease Rating ScaleSydney E Seidel
Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
Parkinsonism Relat Disord 18:230-3. 2012..To evaluate the subject-investigator agreement on the Unified Parkinson's Disease Rating Scale (UPDRS) subsections I and II...- Self-reported adherence versus pill count in Parkinson's disease: the NET-PD experienceJordan J Elm
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
Mov Disord 22:822-7. 2007..The most common approach to assessment is to do a pill count at each visit. The simple, 4-question Morisky medication adherence questionnaire may provide an alternative approach to monitoring treatment adherence in PD... - Factors influencing physician referrals of patients to clinical trialsArch G Mainous
Departments of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
J Natl Med Assoc 100:1298-303. 2008..Our purpose was to assess physicians' attitudes and beliefs about patient recruitment, particularly minorities, into clinical trials... - Demographic and clinical factors associated with in-hospital death among patients with systemic sclerosisPaul J Nietert
Department of Biostatistics, Bioinformatics, and Epidemiology, Division of Rheumatology, Medical University of South Carolina, Charleston, SC 29425, USA
J Rheumatol 32:1888-92. 2005..To examine demographic and clinical predictors of in-hospital death of patients with systemic sclerosis (SSc) and determine to what extent apparent racial differences may be attributed to socioeconomic factors... - Nonprescribed antimicrobial drugs in Latino community, South CarolinaArch G Mainous
Medical University of South Carolina, Charleston, South Carolina 29425, USA
Emerg Infect Dis 11:883-8. 2005..Many persons within the Latino community self-medicate with antimicrobial drugs obtained without a prescription both inside and outside the United States, which adds to the reservoir of antimicrobial drugs in the United States... - Racial variation in clinical and immunological manifestations of systemic sclerosisPaul J Nietert
Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, 29425, USA
J Rheumatol 33:263-8. 2006..To clarify which racial differences in disease manifestations can be attributed to differences in other factors such as gender, education, disease classification, and disease duration... - Correlates of depression, including overall and gastrointestinal functional status, among patients with systemic sclerosisPaul J Nietert
Department of Biostatistics, Bioinformatics, and Epidemiology, Center for Health Care Research, Medical University of South Carolina, Charleston, South Carolina, USA
J Rheumatol 32:51-7. 2005..Patients with systemic sclerosis (SSc) may develop psychological problems in addition to physiologic symptoms. We investigated whether demographic and clinical factors are associated with comorbid depression... - Quasi-likelihood estimation for relative risk regression modelsRickey E Carter
Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
Biostatistics 6:39-44. 2005..We apply these methods to a double-blinded randomized trial in primary biliary cirrhosis of the liver (Markus et al., 1989, New England Journal of Medicine 320, 1709-1713)... - English language skills and diabetes and hypertension among foreign-born South Asian adults in EnglandArch G Mainous
Department of Family Medicine, Medical University of South Carolina, Charleston 29425, USA
Public Health Rep 121:331-6. 2006 - An assessment of racial differences in clinical practices for hypertension at primary care sites for medically underserved patientsDaniel T Lackland
Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
J Clin Hypertens (Greenwich) 6:26-31; quiz 32-3. 2004..Based on the sites examined, ethnic variations in important process and treatment indicators do not explain racial differences in cardiovascular and renal outcomes... - A study of lower extremity amputation rates in older diabetic South CaroliniansWanda C Gonsalves
MUSC, Dept of Family Medicine, 295 Calhoun St, Charleston SC 29425, USA
J S C Med Assoc 103:4-7. 2007..Fortunately, the decrease in LEA rates over time as shown in our study is a step in the right direction. However, the decrease is not consistent across all counties in South Carolina... - Retention of under-represented minorities in drug abuse treatment studiesKathryn M Magruder
Mental Health Service, Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, USA
Clin Trials 6:252-60. 2009..This is especially important in drug abuse treatment studies, as minorities are over-represented in substance abuse clinical treatment programs... - Acculturation and diabetes among Hispanics: evidence from the 1999-2002 National Health and Nutrition Examination SurveyArch G Mainous
Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
Public Health Rep 121:60-6. 2006..The purpose of our research was to examine acculturation among Hispanic Americans with respect to prevalence and control of diabetes... - Unequal burden of disease, unequal participation in clinical trials: solutions from African American and Latino community membersMarvella E Ford
College of Medicine, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
Health Soc Work 38:29-38. 2013..The results suggest the importance of developing a tailored, barriers-focused navigation intervention to improve participation among diverse racial and ethnic populations... - Adjusting O'Brien's test to control type I error for the generalized nonparametric Behrens-Fisher problemPeng Huang
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Biometrics 61:532-9. 2005..Simulations are performed to compare the adjusted tests to O'Brien's test. The difference is also illustrated using data from a Parkinson's disease clinical trial... - A responsive outcome for Parkinson's disease neuroprotection futility studiesJordan J Elm
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
Ann Neurol 57:197-203. 2005.... 
Two pharmacy interventions to improve refill persistence for chronic disease medications: a randomized, controlled trialPaul J Nietert
Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
Med Care 47:32-40. 2009..Despite the proven effectiveness of many medications for chronic diseases, many patients do not refill their prescriptions in the required timeframe...- Repeatable battery for assessment of neuropsychological status in early Parkinson's diseaseChengwu Yang
Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA
Mov Disord 24:1453-60. 2009..65 to 0.74 for the two factors in the two datasets. These results suggest that the current RBANS domain and total scores may not provide valid measurement of the neuropsychological status for patients with early PD... - Development of a measure to assess patient trust in medical researchersArch G Mainous
Department of Family Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
Ann Fam Med 4:247-52. 2006..Mistrust of research and researchers may act as a barrier to participation. The purpose of this study was to develop a scale for assessing trust in medical researchers... - A coronary heart disease risk score based on patient-reported informationArch G Mainous
Department of Family Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Am J Cardiol 99:1236-41. 2007..69, p = 0.01). In conclusion, the Personal HEART score identifies 10-year risk for CHD based on self-report data, is similar in predictive ability to the FRS and European SCORE, and has the potential for easy self-assessment... - An efficient multi-stage, single-arm Phase II futility design for ALSYuko Y Palesch
Medical University of South Carolina, Charleston, SC, USA
Amyotroph Lateral Scler Other Motor Neuron Disord 5:55-6. 2004 - Intention to be screened over time for colorectal cancer in male automotive workersBeatty G Watts
Department of Behavioral Science, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Epidemiol Biomarkers Prev 12:339-49. 2003..A more focused, tailored intervention may be developed using factors that consistently predict intention... - Perceptions of diabetes among patients in an urban health care systemMarvella E Ford
Henry Ford Health System, Center for Medical Treatment Effectiveness, Programs in Diverse Populations, Detroit, MI, USA
Ethn Health 7:243-54. 2002.... - Caffeine and progression of Parkinson diseaseDavid K Simon
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Clin Neuropharmacol 31:189-96. 2008..We assessed this relationship using data from 2 recent clinical trials of PD... - Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with ischemic strokeSteven R Levine
Department of Neurology, Mt Sinai School of Medicine, New York, NY 10029 6574, USA
JAMA 291:576-84. 2004..The presence of antiphospholipid antibodies (aPL) has been associated with vascular occlusive events. However, the role of aPL in predicting ischemic events, particularly recurrent ischemic stroke, is controversial... - Recruiting older African American men to a cancer screening trial (the AAMEN Project)Marvella E Ford
Department of Medicine, Baylor College of Medicine, Veterans Affairs Medical Center, Houston, TX 77030, USA
Gerontologist 43:27-35. 2003..This article describes the demographic characteristics of participants in a randomized trial (the AAMEN Project) designed to recruit older (aged 55+ years) African American men to a cancer screening trial... - The impact of imbalances in baseline stroke severity on outcome in the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke StudyThomas Kwiatkowski
Department of Emergency Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
Ann Emerg Med 45:377-84. 2005..Stroke severity was based on the NIH Stroke Scale. We also compare early mortality (2-week and 30-day) in the tPA and placebo groups... - Lessons from adult stroke trialsSteven G Pavlakis
Mount Sinai School of Medicine, New York, New York, USA
Pediatr Neurol 34:446-9. 2006..Because clinical trials, more often than not, fail to give positive (effective treatment) results, it seems reasonable to attempt to learn from others' past experiences before initiating pediatric stroke trials... - Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing planChristopher G Goetz
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
Mov Disord 22:41-7. 2007.... - Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke StudyEdward C Jauch
Department of Emergency Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0769, USA
Stroke 37:2508-13. 2006..These biochemical markers, myelin basic protein (MBP), neuron-specific enolase (NSE), S100beta, and soluble thrombomodulin, were studied for an association with initial stroke severity, infarct volume, and functional outcome... - Recruitment of African Americans with type 2 diabetes to a randomized controlled trial using three sourcesKimberlydawn Wisdom
Henry Ford Health System, Center for Medical Treatment Effectiveness Programs in Diverse Populations, One Ford Place, 3E, Detroit, MI 48202, USA
Ethn Health 7:267-78. 2002..To assess the usefulness of three sources (faith-based organizations (FBOs), health system, and community) for recruitment of African Americans with type 2 diabetes to a randomized controlled trial (RCT)... - Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic strokeDavid Tanne
Stroke Center, Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
Stroke 37:1798-804. 2006..We investigated in an exploratory, post hoc analysis the relationship between hemostatic markers and clinical outcomes among patients included in the National Institute of Neurological Disorders and Stroke (NINDS) rtPA Stroke Study... - Improving health outcomes in diverse and vulnerable populations: building on the experience of the Centers for Medical Treatment Effectiveness in Diverse Populations (MEDTEP)Barbara C Tilley
Ethn Health 7:227-30. 2002 - Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trialsWerner Hacke
Medical University at Heidelberg, Germany
Lancet 363:768-74. 2004..0002). INTERPRETATION: The sooner that rt-PA is given to stroke patients, the greater the benefit, especially if started within 90 min. Our results suggest a potential benefit beyond 3 h, but this potential might come with some risks... - Correlates and predictors of colorectal cancer screening among male automotive workersAmy McQueen
Center for Health Promotion and Prevention Research, University of Texas School of Public Health, 7000 Fannin, Suite 2568, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 16:500-9. 2007..We examined both cross-sectional correlates of prior CRCS and predictors of prospective CRCS initiation and maintenance during The Next Step Trial, a 2-year worksite behavioral intervention to promote regular CRCS and dietary change...
Research Grants
- SC Cooperative for Healthy Aging in Minority PopulationsBarbara Tilley; Fiscal Year: 2006....
- Southeastern Predoctl Training in Clinical Research(RMI)Barbara Tilley; Fiscal Year: 2007..With these approaches we will train the next generation of rigorous, futuristic thinking clinical investigators who will be able to contribute to improving the health of the nation. ..
- Parkinson's Disease Clinical Trial: Statistical CenterBarbara Tilley; Fiscal Year: 2007..Medical University of South Carolina, Charleston, South Carolina Georgia Institute of Technology, Atlanta, Georgia Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL University of Georgia, Augusta, Georgia ..