Alvin Terry

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans
    Roongpetch Keowkase
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    Mol Neurodegener 5:59. 2010
  2. ncbi Lobeline and structurally simplified analogs exhibit differential agonist activity and sensitivity to antagonist blockade when compared to nicotine
    A V Terry
    University of Georgia Clinical Pharmacy Program, Medical College of Georgia, Augusta 30912 2390, USA
    Neuropharmacology 37:93-102. 1998
  3. ncbi Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys
    Alvin V Terry
    Program in Clinical and Experimental Therapeutics, CJ 1020 The Medical College of Georgia, University of Georgia College of Pharmacy Augusta Campus, Augusta, GA 30912, USA
    Psychopharmacology (Berl) 179:725-32. 2005
  4. ncbi Chronic exposure to typical or atypical antipsychotics in rodents: temporal effects on central alpha7 nicotinic acetylcholine receptors
    A V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia, College of Pharmacy Augusta Campus, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroscience 136:519-29. 2005
  5. ncbi Chronic treatment with first or second generation antipsychotics in rodents: effects on high affinity nicotinic and muscarinic acetylcholine receptors in the brain
    A V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912 2300, USA
    Neuroscience 140:1277-87. 2006
  6. ncbi Time-dependent cognitive deficits associated with first and second generation antipsychotics: cholinergic dysregulation as a potential mechanism
    Alvin V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 Fifteenth Street, Augusta, Georgia 30912 2450, USA
    J Pharmacol Exp Ther 320:961-8. 2007
  7. ncbi Oral haloperidol or risperidone treatment in rats: temporal effects on nerve growth factor receptors, cholinergic neurons, and memory performance
    A V Terry
    Department of Pharmacology and Toxicology, CB 3618, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912 2300, USA
    Neuroscience 146:1316-32. 2007
  8. ncbi Time dependent decreases in central alpha7 nicotinic acetylcholine receptors associated with haloperidol and risperidone treatment in rats
    Alvin V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 Fifteenth Street, Augusta, Georgia 30912 2450, USA
    Eur J Pharmacol 571:29-32. 2007
  9. ncbi Protracted effects of chronic oral haloperidol and risperidone on nerve growth factor, cholinergic neurons, and spatial reference learning in rats
    A V Terry
    Department of Pharmacology and Toxicology, CB 3618, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912 2300, USA
    Neuroscience 150:413-24. 2007
  10. ncbi Negative effects of chronic oral chlorpromazine and olanzapine treatment on the performance of tasks designed to assess spatial learning and working memory in rats
    A V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Neuroscience 156:1005-16. 2008

Research Grants

  1. Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders
    Alvin V Terry; Fiscal Year: 2010
  2. Drug Discovery for Cognitive Impairment Associated with Drugs of Abuse
    Alvin V Terry; Fiscal Year: 2010
  3. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2009
  4. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2010
  5. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2009
  6. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2007
  7. Antipsychotics: Temporal Effects on Cognitive Function
    Alvin Terry; Fiscal Year: 2006
  8. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2011

Collaborators

Detail Information

Publications52

  1. ncbi Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans
    Roongpetch Keowkase
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, USA
    Mol Neurodegener 5:59. 2010
    ..The purpose of these experiments was to more specifically investigate the neuroprotective capabilities of these lead compounds both in vitro and in vivo...
  2. ncbi Lobeline and structurally simplified analogs exhibit differential agonist activity and sensitivity to antagonist blockade when compared to nicotine
    A V Terry
    University of Georgia Clinical Pharmacy Program, Medical College of Georgia, Augusta 30912 2390, USA
    Neuropharmacology 37:93-102. 1998
    ....
  3. ncbi Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys
    Alvin V Terry
    Program in Clinical and Experimental Therapeutics, CJ 1020 The Medical College of Georgia, University of Georgia College of Pharmacy Augusta Campus, Augusta, GA 30912, USA
    Psychopharmacology (Berl) 179:725-32. 2005
    ....
  4. ncbi Chronic exposure to typical or atypical antipsychotics in rodents: temporal effects on central alpha7 nicotinic acetylcholine receptors
    A V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia, College of Pharmacy Augusta Campus, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroscience 136:519-29. 2005
    ..e. the alpha7 nicotinic receptor), but that the magnitude of the deficits was not sufficient to impair auditory gating...
  5. ncbi Chronic treatment with first or second generation antipsychotics in rodents: effects on high affinity nicotinic and muscarinic acetylcholine receptors in the brain
    A V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912 2300, USA
    Neuroscience 140:1277-87. 2006
    ....
  6. ncbi Time-dependent cognitive deficits associated with first and second generation antipsychotics: cholinergic dysregulation as a potential mechanism
    Alvin V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 Fifteenth Street, Augusta, Georgia 30912 2450, USA
    J Pharmacol Exp Ther 320:961-8. 2007
    ..Novel strategies to optimize the therapeutics of schizophrenia and maintain cognitive function via adjunctive cholinergic compounds and antipsychotic crossover approaches are also discussed...
  7. ncbi Oral haloperidol or risperidone treatment in rats: temporal effects on nerve growth factor receptors, cholinergic neurons, and memory performance
    A V Terry
    Department of Pharmacology and Toxicology, CB 3618, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912 2300, USA
    Neuroscience 146:1316-32. 2007
    ....
  8. ncbi Time dependent decreases in central alpha7 nicotinic acetylcholine receptors associated with haloperidol and risperidone treatment in rats
    Alvin V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 Fifteenth Street, Augusta, Georgia 30912 2450, USA
    Eur J Pharmacol 571:29-32. 2007
    ..These data suggest that haloperidol and risperidone may be associated with time dependent decreases in an important neurobiological substrate of memory...
  9. ncbi Protracted effects of chronic oral haloperidol and risperidone on nerve growth factor, cholinergic neurons, and spatial reference learning in rats
    A V Terry
    Department of Pharmacology and Toxicology, CB 3618, Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912 2300, USA
    Neuroscience 150:413-24. 2007
    ....
  10. ncbi Negative effects of chronic oral chlorpromazine and olanzapine treatment on the performance of tasks designed to assess spatial learning and working memory in rats
    A V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Neuroscience 156:1005-16. 2008
    ..These animal data indicate that chronic oral treatment with chlorpromazine or olanzapine can impair the performance of tasks designed to assess specific components of cognition that are affected in schizophrenia...
  11. ncbi Repeated exposures to subthreshold doses of chlorpyrifos in rats: hippocampal damage, impaired axonal transport, and deficits in spatial learning
    A V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy Augusta Campus, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Pharmacol Exp Ther 305:375-84. 2003
    ..Some of these symptoms may be attributed to effects of the OP on axonal transport...
  12. ncbi Chronic antipsychotic treatment: protracted decreases in phospho-TrkA levels in the rat hippocampus
    Alvin V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Int J Neuropsychopharmacol 13:799-805. 2010
    ..These data indicate that chronic antipsychotic treatment may result in deleterious effects on neurotrophin signalling in an important brain region for information processing and cognition...
  13. ncbi The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development
    A V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia, Augusta, GA 30912 2450, USA
    J Pharmacol Exp Ther 306:821-7. 2003
    ..Therefore, cholinergic-based strategies will likely remain valid as one approach to rational drug development for the treatment of AD other forms of dementia...
  14. ncbi Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats
    Alvin V Terry
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912, United States
    Physiol Behav 102:149-57. 2011
    ..These results may also help to identify specific components of the NGF-signaling pathway that could serve as targets for novel drug discovery and development for age-related disorders of cognition (e.g., Alzheimer's disease)...
  15. ncbi Memory-related task performance by aged rhesus monkeys administered the muscarinic M(1)-preferring agonist, talsaclidine
    Alvin V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, GA 30910, USA
    Psychopharmacology (Berl) 162:292-300. 2002
    ..Muscarinic-acetylcholine receptor agonists are yet to be used clinically for the treatment of Alzheimer's disease (AD) even though laboratory evidence continues to support the potential for such an approach...
  16. ncbi Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys
    A V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, Georgia 309 12, USA
    J Pharmacol Exp Ther 301:284-92. 2002
    ..Collectively, the present data suggest that in specific conditions SIB-1553A may improve certain aspects of attentional function in young adult rats and nonhuman primates without adverse side effects...
  17. ncbi Deficits in spatial learning and nicotinic-acetylcholine receptors in older, spontaneously hypertensive rats
    A V Terry
    University of Georgia College of Pharmacy, Medical College of Georgia, Augusta, GA 30912, USA
    Neuroscience 101:357-68. 2000
    ....
  18. ncbi Time-dependent effects of haloperidol and ziprasidone on nerve growth factor, cholinergic neurons, and spatial learning in rats
    Alvin V Terry
    Department of Pharmacology and Toxicology, CB 3618, Medical College of Georgia, 1120 Fifteenth St, Augusta, GA 30912 2450, USA
    J Pharmacol Exp Ther 318:709-24. 2006
    ..e., important neurobiological substrates of memory), and cognitive function...
  19. ncbi Cysteamine treatment ameliorates alterations in GAD67 expression and spatial memory in heterozygous reeler mice
    Ammar Kutiyanawalla
    Department of Psychiatry and Health Behavior, Georgia Health Sciences University, Augusta, GA, USA
    Int J Neuropsychopharmacol 15:1073-86. 2012
    ..Finally, mice deficient in TrkB, showed a reduced response to cysteamine in GAD67 expression suggesting that TrkB signalling plays an important role in GAD67 regulation by cysteamine...
  20. ncbi Differential effects of typical and atypical antipsychotics on nerve growth factor and choline acetyltransferase expression in the cortex and nucleus basalis of rats
    Vinay Parikh
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia, USA
    J Psychiatr Res 38:521-9. 2004
    ..The crossover data further suggest that certain atypical antipsychotic drugs (e.g., clozapine) may have the potential to prevent or reverse the deleterious effects of HAL on important neurochemical substrates of cognitive function...
  21. ncbi Neurotrophins and schizophrenia
    Peter F Buckley
    Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Avenue, Augusta, Georgia 30912, United States
    Schizophr Res 94:1-11. 2007
    ..This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered...
  22. ncbi Effect of repeated nicotine exposure on high-affinity nicotinic acetylcholine receptor density in spontaneously hypertensive rats
    Elizabeth J Hohnadel
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus, Medical College of Georgia, Augusta, GA 30912, USA
    Neurosci Lett 382:158-63. 2005
    ..These results indicate that subjects deficient in nAChRs may be less sensitive to nAChR upregulation with nicotine than normal subjects and require higher doses or longer periods of exposure...
  23. ncbi Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing
    Alvin V Terry
    Department of Pharmacology and Toxicology, University of Georgia College of Pharmacy, Augusta, Georgia 30912 2300, USA
    J Pharmacol Exp Ther 322:1117-28. 2007
    ..Such neurochemical changes may lead to deficits in information processing and cognitive function...
  24. ncbi Spontaneously hypertensive rats: further evaluation of age-related memory performance and cholinergic marker expression
    Caterina M Hernandez
    Program in Clinical and Experimental Therapeutics, University of Georgia, College of Pharmacy, Augusta, GA 30912-2450, USA
    J Psychiatry Neurosci 28:197-209. 2003
    ..CONCLUSION: The SHR may be useful to model some aspects (particularly hypertension-related) of memory disorders, especially those in which cholinergic function is altered...
  25. ncbi The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys
    Ajay Sood
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Neuropharmacology 53:588-600. 2007
    ..Its cytoprotective action might also work to slow the progression of Alzheimer's disease...
  26. ncbi Profile of nicotinic acetylcholine receptor agonists ABT-594 and A-582941, with differential subtype selectivity, on delayed matching accuracy by young monkeys
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Biochem Pharmacol 74:1202-11. 2007
    ....
  27. ncbi Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue
    Guodong Zhang
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 2352, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 858:276-81. 2007
    ..This method was then successfully used to quantify the rat brain tissue concentration of the analytes after chronic treatment with these antipsychotic drugs...
  28. ncbi Erythropoietin prevents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF
    Anilkumar Pillai
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA 30904, USA
    Neuropsychopharmacology 33:1942-51. 2008
    ..01). These findings may have significant implications for the development of neuroprotective strategies to improve clinical outcomes when antipsychotic drugs are used chronically...
  29. ncbi Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential
    John N Bain
    Alzheimer's Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912-2300, USA
    Psychopharmacology (Berl) 169:150-60. 2003
    ....
  30. ncbi ELISA methods to measure cholinergic markers and nerve growth factor receptors in cortex, hippocampus, prefrontal cortex, and basal forebrain from rat brain
    Debra A Gearhart
    Department of Clinical and Administrative Pharmacy, Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, Augusta, GA 30912 2450, USA
    J Neurosci Methods 150:159-73. 2006
    ..g., VAChT and HACT/CHT in hippocampus). Thus, these ELISA methods should be particularly useful for comparing the effects of age, disease, drugs, and toxicants on brain levels of key cholinergic and growth factor-related proteins...
  31. ncbi The potential role of cotinine in the cognitive and neuroprotective actions of nicotine
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Life Sci 72:2931-42. 2003
    ....
  32. ncbi Differential effects of haloperidol, risperidone, and clozapine exposure on cholinergic markers and spatial learning performance in rats
    Alvin V Terry
    Program in Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia, USA
    Neuropsychopharmacology 28:300-9. 2003
    ..The results suggest that antipsychotic drugs exert differential and temporally dependent effects on central cholinergic neurons and learning performance...
  33. ncbi A computer-assisted cognitive test battery for aged monkeys
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta 30912, USA
    J Mol Neurosci 19:179-85. 2002
    ..08). If the titrating version of the DMTS is sensitive to mnemonic drugs, the task may prove useful for drug comparisons with aging...
  34. ncbi Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo
    Ramamohana R Jonnala
    Alzheimer's Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912, USA
    Life Sci 70:1543-54. 2002
    ....
  35. ncbi Determination of the lipophilic antipsychotic drug ziprasidone in rat plasma and brain tissue using liquid chromatography-tandem mass spectrometry
    Guodong Zhang
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 2352, USA
    Biomed Chromatogr 22:770-8. 2008
    ..0% and matrix effects were lower than 5.2%. This validated method has been successfully used to quantify the rat plasma and brain tissue concentration of ziprasidone after chronic treatment...
  36. ncbi Relative levels of cytoprotection produced by analogs of choline and the role of alpha7-nicotinic acetylcholine receptors
    Ramamohana R Jonnala
    Alzheimer's Research Center, Medical College of Georgia, Augusta, Georgia 30912-2300l, USA
    Synapse 47:262-9. 2003
    ....
  37. ncbi Novel analogs of choline as potential neuroprotective agents
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Alzheimers Dis 6:S85-92. 2004
    ....
  38. ncbi Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition
    Alvin V Terry
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy (Augusta Campus, Medical College of Georgia, Augusta, GA 30912-2300, USA
    CNS Drug Rev 11:229-52. 2005
    ..Based on its relative safety in man, cotinine should prove useful in the treatment of diseases of impaired cognition and behavior without exhibiting the toxicity usually attributed to nicotine...
  39. ncbi Differential effects of long-term treatment with typical and atypical antipsychotics on NGF and BDNF levels in rat striatum and hippocampus
    Anilkumar Pillai
    Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA, USA
    Schizophr Res 82:95-106. 2006
    ..These data may have significant clinical implications for long-term antipsychotic selection as well as the common practice of antipsychotic switchover...
  40. ncbi Long-term antipsychotic treatments and crossover studies in rats: differential effects of typical and atypical agents on the expression of antioxidant enzymes and membrane lipid peroxidation in rat brain
    Anilkumar Pillai
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA, United States
    J Psychiatr Res 41:372-86. 2007
    ..These data may be very helpful in planning long-term use as well as switch over of these antipsychotics for the management of schizophrenia...
  41. ncbi Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Mol Neurosci 24:85-91. 2004
    ..Yet at doses that were effective in all subjects, there was no relationship between age and the improvement in task accuracy. Likewise, there was no association between baseline task proficiency and improvement in task accuracy...
  42. ncbi The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys
    Jerry J Buccafusco
    Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912, USA
    Neuropharmacology 46:10-22. 2004
    ..They also indicate that the drug is associated with long-term effects that could limit dosing regimens to one dose every two or three days. The nature of the protracted mnemonic effects produced by the compound remains to be elucidated...
  43. ncbi Determination of chlorpyrifos and its metabolites in rat brain tissue using coupled-column liquid chromatography/electrospray ionization tandem mass spectrometry
    Leah N Williamson
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602-2352, USA
    Rapid Commun Mass Spectrom 20:2689-95. 2006
    ..All precision relative standard deviations (RSDs) were less than 16% for the LOQ and less than 11% for the other QC samples. This method was successfully applied to six rats that were injected subcutaneously with chlorpyrifos...
  44. ncbi Modulation of nerve growth factor and choline acetyltransferase expression in rat hippocampus after chronic exposure to haloperidol, risperidone, and olanzapine
    Vinay Parikh
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, GA, USA
    Psychopharmacology (Berl) 172:365-74. 2004
    ....
  45. ncbi Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats
    Elizabeth Hohnadel
    College of Pharmacy, University of Georgia, Augusta, GA 30912, USA
    Neuropharmacology 52:542-51. 2007
    ..These results indicate that some AChEIs may have the potential to improve cognition in schizophrenia by improving auditory sensory gating...
  46. ncbi Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility
    Debra A Gearhart
    Department of Pharmacology and Toxicology, 1120 Fifteenth Street, Medical College of Georgia, Augusta, GA 30912 2300, USA
    Toxicol Appl Pharmacol 218:20-9. 2007
    ..We postulate that disruption of kinesin-dependent intracellular transport could account for some of the long-term effects of organophosphates on the peripheral and central nervous system...
  47. ncbi Disconnection between activation and desensitization of autonomic nicotinic receptors by nicotine and cotinine
    Jerry J Buccafusco
    Department of Pharmacology and Toxicology, Alzheimer s Research Center, Medical College of Georgia, Augusta, GA 30912 2300, United States
    Neurosci Lett 413:68-71. 2007
    ....
  48. ncbi MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition
    Jerry J Buccafusco
    Alzheimer s Research Center, Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Neurochem Res 32:1224-37. 2007
    ..The results of this study are consistent with the potential use of MHP-133 in the treatment of neurodegenerative disorders such as Alzheimer's disease...
  49. ncbi Determination of diisopropylfluorophosphate in rat plasma and brain tissue by headspace solid-phase microextraction gas chromatography/mass spectrometry
    Meng Xu
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 2352, USA
    Rapid Commun Mass Spectrom 22:3069-75. 2008
    ..Stability tests including autosampler and freeze and thaw were also investigated. This validated method was successfully applied to study the neurobehavioral effects of low-level organophosphate exposures...
  50. ncbi Simultaneous determination of five antipsychotic drugs in rat plasma by high performance liquid chromatography with ultraviolet detection
    Guodong Zhang
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 2352, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 856:20-8. 2007
    ..This validated method has been successfully used to quantify the plasma concentration of the analytes for pharmacological and toxicological studies following chronic treatment with antipsychotic drugs in the rat...
  51. ncbi Liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat plasma
    Guodong Zhang
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 2352, USA
    Rapid Commun Mass Spectrom 21:920-8. 2007
    ..This validated method has been successfully used to quantify the plasma concentration of the analytes after chronic treatment with antipsychotic drugs...
  52. ncbi Sensitive liquid chromatography/tandem mass spectrometry method for the determination of the lipophilic antipsychotic drug chlorpromazine in rat plasma and brain tissue
    Guodong Zhang
    Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 2352, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 854:68-76. 2007
    ..9% and matrix effects were lower than 5.6%. This validated method has been successfully used to quantify the rat plasma and brain tissue concentration of chlorpromazine after chronic treatment...

Research Grants17

  1. Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders
    Alvin V Terry; Fiscal Year: 2010
    ..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
  2. Drug Discovery for Cognitive Impairment Associated with Drugs of Abuse
    Alvin V Terry; Fiscal Year: 2010
    ..In addition to cognitive improvement, choline analogs could also prevent the neural toxicity associated with the chronic abuse of several addictive substances. ..
  3. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2009
    ..e., attention and cognitive flexibility). ..
  4. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2010
    ..e., attention and cognitive flexibility). ..
  5. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2009
    ..e., attention and cognitive flexibility). ..
  6. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin Terry; Fiscal Year: 2007
    ..These studies are significant because they will contribute to a better understanding of the toxicity associated with a class of agents that continues to pose a significant environmental risk to millions of people worldwide. ..
  7. Antipsychotics: Temporal Effects on Cognitive Function
    Alvin Terry; Fiscal Year: 2006
    ....
  8. Cholinesterase Inhibitors, Axonal transport, and Memory
    Alvin V Terry; Fiscal Year: 2011
    ..e., attention and cognitive flexibility). ..