Vera L Tarakanova


Affiliation: Medical College of Wisconsin
Country: USA


  1. Darrah E, Jondle C, Johnson K, Xin G, Lange P, Cui W, et al. Conserved Gammaherpesvirus Protein Kinase Selectively Promotes Irrelevant B Cell Responses. J Virol. 2019;93: pubmed publisher
  2. Lange P, Lagunoff M, Tarakanova V. Chewing the Fat: The Conserved Ability of DNA Viruses to Hijack Cellular Lipid Metabolism. Viruses. 2019;11: pubmed publisher
  3. Lange P, Jondle C, Darrah E, Johnson K, Tarakanova V. LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells. J Virol. 2019;93: pubmed publisher
    ..As gammaherpesviruses are ubiquitous oncogenic agents, LXRs may represent a targetable host factor for the treatment of poorly controlled gammaherpesvirus infection and associated lymphomagenesis. ..
  4. Stoltz K, Jondle C, Pulakanti K, Sylvester P, Urrutia R, Rao S, et al. Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus. Virology. 2019;526:52-60 pubmed publisher
    ..Given the emerging appreciation of the physiological relevance of ERV expression in cancer, IRF-1-mediated suppression of specific ERVs may contribute to the overall tumor suppressor activity of this host factor. ..
  5. Kulinski J, Darrah E, Broniowska K, Mboko W, Mounce B, Malherbe L, et al. ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection. Virology. 2015;483:264-74 pubmed publisher
  6. Lange P, Schorl C, Sahoo D, Tarakanova V. Liver X Receptors Suppress Activity of Cholesterol and Fatty Acid Synthesis Pathways To Oppose Gammaherpesvirus Replication. MBio. 2018;9: pubmed publisher
  7. Mboko W, Olteanu H, Ray A, Xin G, Darrah E, Kumar S, et al. Tumor Suppressor Interferon-Regulatory Factor 1 Counteracts the Germinal Center Reaction Driven by a Cancer-Associated Gammaherpesvirus. J Virol. 2015;90:2818-29 pubmed publisher
    ..Further, we found decreased IRF-1 expression in human gammaherpesvirus-induced B cell malignancies. ..
  8. Lange P, Darrah E, Vonderhaar E, Mboko W, Rekow M, Patel S, et al. Type I Interferon Counteracts Antiviral Effects of Statins in the Context of Gammaherpesvirus Infection. J Virol. 2016;90:3342-54 pubmed publisher
  9. Rekow M, Darrah E, Mboko W, Lange P, Tarakanova V. Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency. Virology. 2016;492:140-4 pubmed publisher
    ..This study demonstrates that B-1 B cells harbor the highest frequency of latently infected cells in the peritoneum throughout chronic infection, highlighting a previously unappreciated feature of gammaherpesvirus biology. ..

More Information


  1. Mboko W, Rekow M, Ledwith M, Lange P, Schmitz K, Anderson S, et al. Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection. J Virol. 2017;91: pubmed publisher
    ..Specifically, both type I IFN receptor and IRF-1 expression potentiated antiviral effects of type II IFN to restrict gammaherpesvirus replication in vivo, in the lungs, and in vitro, in primary macrophage cultures. ..
  2. Tarakanova V, Molleston J, Goodwin M, Virgin H. MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner. Virology. 2010;396:323-8 pubmed publisher
    ..This study shows a novel, complement independent cell-type-specific function of a gammaherpesvirus RCA protein...
  3. Darrah E, Kulinski J, Mboko W, Xin G, Malherbe L, Gauld S, et al. B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection. J Virol. 2017;91: pubmed publisher
    ..Thus, our study defines a proviral role of B cell-specific ATM expression during chronic gammaherpesvirus infection. ..
  4. Darrah E, Stoltz K, Ledwith M, Tarakanova V. ATM supports gammaherpesvirus replication by attenuating type I interferon pathway. Virology. 2017;510:137-146 pubmed publisher
    ..This study identifies attenuation of type I IFN responses as the primary mechanism underlying proviral function of ATM during gammaherpesvirus infection. ..