S Suster

..The purpose of this review is to address these problem areas, in particular as it relates to terminology, histopathologic criteria for diagnosis, and the prognostic significance for the various categories of the WHO schema...

..To present eight cases of a distinctive morphological subtype of lipomatous tumour of soft tissue...

....

..The light microscopic, immunohistochemical, and ultrastructural features of these tumors are reviewed along with the advances in our understanding of these lesions and current trends in nomenclature and terminology...

..A personal approach to the morphological diagnosis of thymoma is described, with a brief explanation for the rationale for simplifying the existing diagnostic categories...

..We conclude that the RT in situ PCR methodology will allow the routine determination of monoclonal vs multiclonal expression patterns of the TCR beta using archival paraffin-embedded tissues.(J Histochem Cytochem 49:139-145, 2001)..

..Overgrowth or clonal expansion of this dendritic cell subpopulation may account for the development of spindle cell lipomas and for the spindle cell component in some cases of "dedifferentiated" liposarcoma...

....

..To present eight cases of primary diffuse peritoneal malignant mesothelioma in children <15 years old, with a discussion of the pitfalls of this diagnosis in the paediatric age group...

..Overall, the general trend for these LS subsets is progressive disease, metastatic disease for ML and PL with a much shorter interval for PL, and metastatic disease and local recurrence for DDL...

..Evidence-based pathology promotes the use of systematic reviews and analysis of data with meta-analysis rather than subjective reviews of the literature...

..The present cases highlight an important histopathologic feature of thymomas, which can pose problems in diagnosis, namely when dealing with small mediastinoscopic biopsy specimens...

..The authors' experience was reviewed at a large academic medical center over a 30-year period (1971-2000) with metastases to soft tissue...

..Recognition of this growth pattern is important for prognosis and avoiding misdiagnosis with papillary renal cell carcinoma and other tumors...

..This review will focus on current criteria for diagnosis of these tumors, with a review of the various histopathologic appearances that they can adopt...

..A large number of histologic variants have been described. In general, these tumors remain a diagnosis of exclusion and, as a group, represent high-grade neoplasms with a very aggressive clinical behavior and an often-ominous prognosis...

..We review the current status of thymoma classification and comment on problem areas and future trends that may offer a more pragmatic approach to these tumors...

..This panel may additionally be of assistance in the diagnosis of myofibroblastic sarcoma...

..Pulmonary artery sarcoma is an uncommon entity with a poor prognosis. The role of early diagnosis, histologic classification, surgical treatment, and adjuvant therapy in patient outcome is discussed...

..The present cases highlight the ubiquitous distribution of soft tissue giant cell tumors and the importance of considering these tumors in the differential diagnosis of posterior mediastinal neoplasms...

..We conclude that myxoinflammatory fibroblastic sarcoma is a distinct soft tissue tumor of low-grade malignancy and, until now, described only in extremities, although not confined to acral sites...

..Recognition of this unusual morphologic appearance is of importance to avoid mistaking these lesions for other types of malignant neoplasm...

..There may be mild to marked follicular dendritic cell dysplasia. The HVCD predominates in this location. These lesions are usually unassociated with POEMS, Epstein-Barr virus, human herpesvirus-8, or monoclonal rearrangements of IgH...

..The possible relationship of the rhabdomyomatous component of this tumor with the myoid cells of the thymus is discussed...

..The base of the lesion showed features of adenomyomatous hyperplasia. The possible relationships of this lesion with adenomyomatous hyperplasia and other stromal lesions of the gallbladder are reviewed...

..Synovial sarcoma should be considered in the differential diagnosis of biphasic and monophasic spindle cell neoplasms of the mediastinum...

..Both cases highlight the ubiquitous distribution of ALHE/EH and underscore the importance of keeping these lesions in the differential diagnosis of vascular and lymphoid lesions of the lung...

..However, CDX2 is not a sensitive marker for poorly differentiated colorectal carcinoma...

..Sclerosing paraganglioma should be included in the differential diagnosis of sclerosing lesions of the head and neck region and mediastinum. Appropriate immunohistochemical stains may be of aid for establishing the correct diagnosis...

..Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features...

..Evidence-based pathology promotes the use of systematic reviews of literature and meta-analysis of data to synthesize the results of multiple publications...