Research Topics
Species | C L StuckySummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Detail Information
Publications
TRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivityMarie E Barabas
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
Mol Pain 9:9. 2013..These channels are also expressed extensively in cutaneous nerve fibers. Therefore, we investigated whether TRPA1 and TRPV1 contribute to mechanical and heat hypersensitivity following skin-only surgical incision...- Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptorsSheldon R Garrison
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA
Mol Pain 8:62. 2012..Yet, the hypersensitivity in these neural populations alone may not fully explain the mechanical allodynia phenotype in mouse and humans... 
The dynamic TRPA1 channel: a suitable pharmacological pain target?Sheldon R Garrison
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Curr Pharm Biotechnol 12:1689-97. 2011....- Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptorsPatrick C Kerstein
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Mol Pain 5:19. 2009..In this study we use the ex-vivo skin-nerve preparation to directly determine the contribution of TRPA1 to mechanical- and chemical-evoked responses at the level of the primary afferent terminal... - TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neuronsSheldon R Garrison
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Neurophysiol 107:913-22. 2012..In contrast, TRPC1-deficient mice exhibited normal paw withdrawal response to more intense mechanical stimuli that are typically considered measures of nociceptive behavior... - Roles of transient receptor potential channels in painCheryl L Stucky
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Brain Res Rev 60:2-23. 2009.... - Mechanisms of painC L Stucky
Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Proc Natl Acad Sci U S A 98:11845-6. 2001..Understanding these underlying mechanisms has given significant promise for the development of more effective, more specific pain therapies in the near future... - The P2Y agonist UTP activates cutaneous afferent fibersCheryl L Stucky
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
Pain 109:36-44. 2004..Furthermore, P2Y signaling may contribute to mechanotransduction in low threshold Abeta fibers under normal or pathological conditions... - Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshoolRichard C Lennertz
Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Neurosci 30:4353-61. 2010..The identification of sanshool-sensitive fibers represents an essential first step in identifying the cellular and molecular mechanisms underlying tingling paresthesia that accompanies peripheral neuropathy and injury... - Differential response properties of IB(4)-positive and -negative unmyelinated sensory neurons to protons and capsaicinSahera Dirajlal
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee 53226-0509, USA
J Neurophysiol 89:513-24. 2003.... - Cannabinoid receptor agonists inhibit depolarization-induced calcium influx in cerebellar granule neuronsM I Nogueron
Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Neurochem 79:371-81. 2001..These data demonstrate that the CB(1) receptor is highly expressed by CGN and agonists serve as potent and efficacious inhibitory modulators of Ca(2+) influx through N-type VSCC... - Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouseNicole M Breese
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Pain 115:37-49. 2005..Together, these data indicate that TRPV1 function and expression are selectively increased in IB4-positive neurons during inflammation in mouse and suggest a novel role for IB4-positive C-fibers during inflammation... - Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptorsDaniel Vilceanu
Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
J Pain 11:588-99. 2010..Because IB4-positive neurons may contribute to the emotional perception of pain, TRPV1 antagonists, targeting both sensory and affective pain components, could have broad analgesic effects... - Species and strain differences in rodent sciatic nerve anatomy: implications for studies of neuropathic painMarcel Rigaud
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, United States
Pain 136:188-201. 2008..Strain-dependent variability in segmental contributions to the sciatic nerve may account in part for genetic differences in pain behavior after spinal nerve ligation... - Impaired sensory nerve function and axon morphology in mice with diabetic neuropathyRichard C Lennertz
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
J Neurophysiol 106:905-14. 2011..These findings suggest that diabetes damages sensory nerves, leading to functional deficits in sensory signaling that underlie the loss of tactile acuity and pain sensation associated with insensate diabetic neuropathy... - The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptorsKarla P Zeitz
Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 22:1010-9. 2002..We conclude that activation of both peripheral and central 5-HT(3) receptors is pronociceptive and that the contribution of peripheral 5-HT(3) receptors involves a novel complement of primary afferent nociceptors... - Neurotrophin-4: a survival factor for adult sensory neuronsCheryl L Stucky
Growth Factor and Regeneration Group, Max Delbrück Institute for Molecular Medicine, D 13122, Berlin Buch, Germany
Curr Biol 12:1401-4. 2002..This is the first evidence that sensory neurons have a physiological requirement for a single neurotrophin for their continued survival in the adult... - GFR alpha2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neuronsCheryl L Stucky
Growth Factors and Regeneration Group, Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, Berlin D 13092, Germany
J Physiol 545:43-50. 2002..Our data are the first to indicate a transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons... - Stomatin and sensory neuron mechanotransductionCarlos Martinez-Salgado
Department of Neuroscience, Max Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Robert Rössle Str, Berlin Buch, Germany
J Neurophysiol 98:3802-8. 2007..We conclude that stomatin is required for normal mechanotransduction in a subpopulation of vertebrate sensory neurons... - Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1Kathleen A Sluka
Physical Therapy and Rehabilitation Science Graduate Program, 1 242 Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
Pain 106:229-39. 2003..Therefore, interfering with ASIC3 might be of benefit in treatment or prevention of chronic hyperalgesia... - The menthol receptor TRPM8 is the principal detector of environmental coldDiana M Bautista
Department of Physiology, University of California, San Francisco, California 94143, USA
Nature 448:204-8. 2007.... - Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuliJeffrey S Mogil
Department of Psychology, Centre for Research on Pain, McGill University, Montreal, Quebec, H3A 1B1, Canada
J Neurosci 25:9893-901. 2005..These data reinforce the hypothesis that ASICs are involved in both mechanical and inflammatory pain, although the increased sensitivity of transgenic mice renders it unlikely that they are direct transducers of nociceptive stimuli... - Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer painIryna A Khasabova
Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 27:10289-98. 2007..More broadly, this study provides a novel in vitro model to resolve the cellular and molecular mechanisms by which tumor cells drive functional changes in nociceptors...
Research Grants
- FUNCTIONAL ANALYSIS OF DISTINCT NOCICEPTOR POPULATIONSCheryl Stucky; Fiscal Year: 2007..Understanding the role of TRPV1 in nerve injury-induced pain behavior sensitization of primary sensory neurons will contribute to the development and use of novel TRPV1 antagonists in patients with neuropathic pain. ..