C L Stucky

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. pmc TRPA1 mediates mechanical sensitization in nociceptors during inflammation
    Richard C Lennertz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e43597. 2012
  2. pmc TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons
    Daniel Vilceanu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 5:e12177. 2010
  3. pmc TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons
    Marie E Barabas
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e47988. 2012
  4. pmc Mechanical sensitization of cutaneous sensory fibers in the spared nerve injury mouse model
    Amanda K Smith
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
    Mol Pain 9:61. 2013
  5. pmc Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception
    Yingqi Weng
    Department of Anesthesiology, Washington University Pain Center, St Louis, MO 63110, USA
    Mol Pain 8:75. 2012
  6. pmc TRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivity
    Marie E Barabas
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Mol Pain 9:9. 2013
  7. pmc Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors
    Sheldon R Garrison
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA
    Mol Pain 8:62. 2012
  8. pmc The dynamic TRPA1 channel: a suitable pharmacological pain target?
    Sheldon R Garrison
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Curr Pharm Biotechnol 12:1689-97. 2011
  9. pmc Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors
    Patrick C Kerstein
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Pain 5:19. 2009
  10. pmc TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons
    Sheldon R Garrison
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurophysiol 107:913-22. 2012

Research Grants

Collaborators

  • Q H Hogan
  • Marie E Barabas
  • X Zhang
  • Sacha A Malin
  • Adrienne E Dubin
  • Patrick C Kerstein
  • David McKemy
  • DEREK MOLLIVER
  • Prisca Honore
  • Gary R Lewin
  • DONALD SIMONE
  • Alvin J Beitz
  • Kathleen Sluka
  • VIRGINIA SEYBOLD
  • J S Mogil
  • Sheldon R Garrison
  • Richard C Lennertz
  • Daniel Vilceanu
  • Amanda K Smith
  • Diana M Bautista
  • Yingqi Weng
  • Elena A Kossyreva
  • Sahera Dirajlal
  • Marcel Rigaud
  • Iryna A Khasabova
  • Carlos Martinez-Salgado
  • Nicole M Breese
  • Allan I Basbaum
  • David Julius
  • Laura E Pauers
  • Karla P Zeitz
  • Crystal L O'Hara
  • Audra A Kramer
  • Audra M Foshage
  • Alexander Dietrich
  • Matthew J Schwab
  • Nashaat Z Gerges
  • Eli Q Harris
  • Cheryl A Hillery
  • M I Nogueron
  • Michelle H Wang
  • Thomas B Dinsmore
  • Gina M Story
  • Patricia A Batista-Schepman
  • Victoria M Wang
  • Douglas E Wright
  • James L Bain
  • Karen A Medler
  • Makoto Tsunozaki
  • Donna I Chernoff
  • Geza Gemes
  • Stephen E Abram
  • Nevena Milenkovic
  • Narla Mohandas
  • Laura Eikmeier
  • Catherine Harding-Rose
  • Joshua M Glazer
  • Marilyn G Parra
  • Rui Wang
  • Amy E Hanson
  • Christiane Wetzel
  • Li Yang Chiang
  • Sven Eric Jordt
  • Anne G Benckendorff
  • Lia G Coicou
  • Pamela R Tsuruda
  • Jing Hu
  • Jan Siemens
  • Annette C George
  • William J Martin
  • Linda Sun
  • Annika B Malmberg
  • Douglas W Bonhaus
  • Nicolas Guy
  • B Porgilsson
  • C J Hillard
  • W E Schneider

Detail Information

Publications28

  1. pmc TRPA1 mediates mechanical sensitization in nociceptors during inflammation
    Richard C Lennertz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e43597. 2012
    ....
  2. pmc TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons
    Daniel Vilceanu
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 5:e12177. 2010
    ..The TRPA1 protein may also contribute to a complex that mediates Transient mechanically-activated currents in small IB4 positive C fiber type neurons...
  3. pmc TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons
    Marie E Barabas
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e47988. 2012
    ..Thus, IB4 binding is a better indicator than neuropeptides for TRPA1 expression...
  4. pmc Mechanical sensitization of cutaneous sensory fibers in the spared nerve injury mouse model
    Amanda K Smith
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
    Mol Pain 9:61. 2013
    ..Here we investigated the role of cutaneous sensory fibers in the maintenance of mechanical hyperalgesia in mice post-SNI...
  5. pmc Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception
    Yingqi Weng
    Department of Anesthesiology, Washington University Pain Center, St Louis, MO 63110, USA
    Mol Pain 8:75. 2012
    ..To investigate this, we utilized a battery of behavioral assays and intracellular Ca2+ imaging in DRG neurons to test if pre-treatment with 15d-PGJ2 inhibited TRPA1 to subsequent stimulation...
  6. pmc TRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivity
    Marie E Barabas
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Mol Pain 9:9. 2013
    ..These channels are also expressed extensively in cutaneous nerve fibers. Therefore, we investigated whether TRPA1 and TRPV1 contribute to mechanical and heat hypersensitivity following skin-only surgical incision...
  7. pmc Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors
    Sheldon R Garrison
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA
    Mol Pain 8:62. 2012
    ..Yet, the hypersensitivity in these neural populations alone may not fully explain the mechanical allodynia phenotype in mouse and humans...
  8. pmc The dynamic TRPA1 channel: a suitable pharmacological pain target?
    Sheldon R Garrison
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Curr Pharm Biotechnol 12:1689-97. 2011
    ....
  9. pmc Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors
    Patrick C Kerstein
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Pain 5:19. 2009
    ..In this study we use the ex-vivo skin-nerve preparation to directly determine the contribution of TRPA1 to mechanical- and chemical-evoked responses at the level of the primary afferent terminal...
  10. pmc TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons
    Sheldon R Garrison
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurophysiol 107:913-22. 2012
    ..In contrast, TRPC1-deficient mice exhibited normal paw withdrawal response to more intense mechanical stimuli that are typically considered measures of nociceptive behavior...
  11. pmc Roles of transient receptor potential channels in pain
    Cheryl L Stucky
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res Rev 60:2-23. 2009
    ....
  12. pmc Mechanisms of pain
    C L Stucky
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 98:11845-6. 2001
    ..Understanding these underlying mechanisms has given significant promise for the development of more effective, more specific pain therapies in the near future...
  13. ncbi request reprint The P2Y agonist UTP activates cutaneous afferent fibers
    Cheryl L Stucky
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Pain 109:36-44. 2004
    ..Furthermore, P2Y signaling may contribute to mechanotransduction in low threshold Abeta fibers under normal or pathological conditions...
  14. pmc Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool
    Richard C Lennertz
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci 30:4353-61. 2010
    ..The identification of sanshool-sensitive fibers represents an essential first step in identifying the cellular and molecular mechanisms underlying tingling paresthesia that accompanies peripheral neuropathy and injury...
  15. ncbi request reprint Differential response properties of IB(4)-positive and -negative unmyelinated sensory neurons to protons and capsaicin
    Sahera Dirajlal
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee 53226 0509, USA
    J Neurophysiol 89:513-24. 2003
    ....
  16. pmc Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors
    Daniel Vilceanu
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    J Pain 11:588-99. 2010
    ..Also, SNL had no effect on heat responses in medium-large-diameter neurons from either the injured or adjacent ganglia...
  17. ncbi request reprint Peripheral inflammation selectively increases TRPV1 function in IB4-positive sensory neurons from adult mouse
    Nicole M Breese
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pain 115:37-49. 2005
    ..Together, these data indicate that TRPV1 function and expression are selectively increased in IB4-positive neurons during inflammation in mouse and suggest a novel role for IB4-positive C-fibers during inflammation...
  18. ncbi request reprint Cannabinoid receptor agonists inhibit depolarization-induced calcium influx in cerebellar granule neurons
    M I Nogueron
    Department of Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurochem 79:371-81. 2001
    ..These data demonstrate that the CB(1) receptor is highly expressed by CGN and agonists serve as potent and efficacious inhibitory modulators of Ca(2+) influx through N-type VSCC...
  19. pmc Species and strain differences in rodent sciatic nerve anatomy: implications for studies of neuropathic pain
    Marcel Rigaud
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Pain 136:188-201. 2008
    ..Strain-dependent variability in segmental contributions to the sciatic nerve may account in part for genetic differences in pain behavior after spinal nerve ligation...
  20. pmc Impaired sensory nerve function and axon morphology in mice with diabetic neuropathy
    Richard C Lennertz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
    J Neurophysiol 106:905-14. 2011
    ..These findings suggest that diabetes damages sensory nerves, leading to functional deficits in sensory signaling that underlie the loss of tactile acuity and pain sensation associated with insensate diabetic neuropathy...
  21. ncbi request reprint Stomatin and sensory neuron mechanotransduction
    Carlos Martinez-Salgado
    Department of Neuroscience, Max Delbrück Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Robert Rössle Str, Berlin Buch, Germany
    J Neurophysiol 98:3802-8. 2007
    ..We conclude that stomatin is required for normal mechanotransduction in a subpopulation of vertebrate sensory neurons...
  22. ncbi request reprint Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1
    Kathleen A Sluka
    Physical Therapy and Rehabilitation Science Graduate Program, 1 242 Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
    Pain 106:229-39. 2003
    ..Therefore, interfering with ASIC3 might be of benefit in treatment or prevention of chronic hyperalgesia...
  23. ncbi request reprint Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli
    Jeffrey S Mogil
    Department of Psychology, Centre for Research on Pain, McGill University, Montreal, Quebec, H3A 1B1, Canada
    J Neurosci 25:9893-901. 2005
    ..These data reinforce the hypothesis that ASICs are involved in both mechanical and inflammatory pain, although the increased sensitivity of transgenic mice renders it unlikely that they are direct transducers of nociceptive stimuli...
  24. pmc GFR alpha2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons
    Cheryl L Stucky
    Growth Factors and Regeneration Group, Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, Berlin D 13092, Germany
    J Physiol 545:43-50. 2002
    ..Our data are the first to indicate a transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons...
  25. ncbi request reprint Neurotrophin-4: a survival factor for adult sensory neurons
    Cheryl L Stucky
    Growth Factor and Regeneration Group, Max Delbrück Institute for Molecular Medicine, D 13122, Berlin Buch, Germany
    Curr Biol 12:1401-4. 2002
    ..This is the first evidence that sensory neurons have a physiological requirement for a single neurotrophin for their continued survival in the adult...
  26. ncbi request reprint The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors
    Karla P Zeitz
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 22:1010-9. 2002
    ..We conclude that activation of both peripheral and central 5-HT(3) receptors is pronociceptive and that the contribution of peripheral 5-HT(3) receptors involves a novel complement of primary afferent nociceptors...
  27. ncbi request reprint The menthol receptor TRPM8 is the principal detector of environmental cold
    Diana M Bautista
    Department of Physiology, University of California, San Francisco, California 94143, USA
    Nature 448:204-8. 2007
    ....
  28. ncbi request reprint Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain
    Iryna A Khasabova
    Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:10289-98. 2007
    ..More broadly, this study provides a novel in vitro model to resolve the cellular and molecular mechanisms by which tumor cells drive functional changes in nociceptors...

Research Grants2

  1. FUNCTIONAL ANALYSIS OF DISTINCT NOCICEPTOR POPULATIONS
    Cheryl Stucky; Fiscal Year: 2007
    ..Understanding the role of TRPV1 in nerve injury-induced pain behavior sensitization of primary sensory neurons will contribute to the development and use of novel TRPV1 antagonists in patients with neuropathic pain. ..