Research Topics
Genomes and Genes | Jennifer L StrandeSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Publications
SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat heartsJennifer L Strande
Division of Cardiovascular Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
Basic Res Cardiol 102:350-8. 2007....
Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injuryJennifer L Strande
Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
J Inflamm (Lond) 6:34. 2009..We determined the impact of GdCl3 treatment for reperfusion injury on 1) circulating monoctye and neutrophil counts, 2) secretion of inflammatory cytokines, and 3) influx of monocytes and neutrophils into the myocardium...
Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injuryJennifer L Strande
Division of Cardiovascular Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA
Cardiovasc Res 83:325-34. 2009..Although much research has focused on the activated receptor, little is known about the 41-amino acid N-terminal peptide (parstatin). We hypothesized that parstatin would protect the heart against ischaemia-reperfusion injury...
Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitroJennifer L Strande
Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
J Inflamm (Lond) 6:4. 2009..Therefore, the purpose of this study was to examine the expression of thrombin receptors (PAR1 and PAR4) human adipose tissue and whether thrombin stimulates an inflammatory cytokine and growth factor profile in human adipose tissue...
Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signalingJennifer L Strande
Division of Cardiovascular Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
J Pharmacol Exp Ther 324:1045-54. 2008..Thrombin receptor blockade by PAR4 inhibition provides protection against injury from myocardial I/R by unmasking adenosine receptor signaling and supports the hypothesis of a coupling between thrombin receptors and adenosine receptors...
Gadolinium limits myocardial infarction in the rat: dose-response, temporal relations and mechanismsAlfred C Nicolosi
Division of Cardiothoracic Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
J Mol Cell Cardiol 44:345-51. 2008..The mechanism underlying Gd-induced preconditioning appears to be multi-factorial, involving JAK-2, STAT-3 and p44 MAPK pathways, as well as K(ATP) channels...
10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat modelJohn E Baker
Division of Cardiothoracic Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Int J Radiat Biol 85:1089-100. 2009..To determine the impact of 10 Gy total body irradiation (TBI) or local thorax irradiation, a dose relevant to a radiological terrorist threat, on lipid and liver profile, coronary microvasculature and ventricular function...
Parstatin(1-26): the putative signal peptide of protease-activated receptor 1 confers potent protection from myocardial ischemia-reperfusion injuryKasi V Routhu
Division of Cardiovascular Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
J Pharmacol Exp Ther 332:898-905. 2010..This suggests that parstatin(1-26) has a potential therapeutic role in the treatment of ischemia and reperfusion injury...
Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in ratsJohn E Baker
Division of Cardiothoracic Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Cardiovasc Res 77:44-53. 2008..Thrombopoietin (Tpo) is known for its ability to stimulate platelet production. However, it is currently unknown whether Tpo plays a physiological function in the heart...
Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat heartsJennifer L Strande
Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
J Basic Clin Physiol Pharmacol 24:81-4. 2013..However, it is unclear whether NGF protects the heart during infarct. In this study, we sought to address this issue in rat heart exposed to ischemia/reperfusion injury (IRI)...
