Research Topics
| Alexis M StranahanSummaryAffiliation: Medical College of Georgia Country: USA Publications
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Detail Information
Publications
Chronobiological approaches to Alzheimer's diseaseAlexis M Stranahan
Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
Curr Alzheimer Res 9:93-8. 2012....
Physiological variability in brain-derived neurotrophic factor expression predicts dendritic spine density in the mouse dentate gyrusAlexis M Stranahan
Physiology Department, Georgia Health Sciences University, 1120 15th St, rm CA3145, Augusta, GA 30912, United States
Neurosci Lett 495:60-2. 2011..This observation suggests that there may be a subregionally specific relationship between hippocampal BDNF expression and the density of spines...- Bidirectional metabolic regulation of neurocognitive functionAlexis M Stranahan
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Neurobiol Learn Mem 96:507-16. 2011..Understanding the mechanisms for this continuum may yield novel therapeutic targets for the prevention and treatment of cognitive decline following aging, disease, or injury... - Interference with reelin signaling in the lateral entorhinal cortex impairs spatial memoryAlexis M Stranahan
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Neurobiol Learn Mem 96:150-5. 2011..These observations support a role for entorhinal reelin signaling in spatial learning, and suggest that an intact reelin signaling pathway is essential for synaptic integrity in the adult entorhinal cortex... - Hippocampal gene expression patterns underlying the enhancement of memory by running in aged miceAlexis M Stranahan
Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 6825, United States
Neurobiol Aging 31:1937-49. 2010..These results suggest that the enhancement of cognitive function by lifelong exercise is associated with an altered transcriptional profile following learning... - Cortical gene transcription response patterns to water maze training in aged miceSung Soo Park
Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
BMC Neurosci 12:63. 2011..We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training... - Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stressAlexis M Stranahan
Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA
J Neurochem 118:611-5. 2011..Taken together, these observations support the existence of a potentially pathogenic relationship between dietary fat intake, peripheral cholesterol and triglyceride levels, brain cell sphingolipid metabolism, and oxidative stress... 
Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortexAlexis M Stranahan
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Comp Neurol 520:1318-26. 2012..These observations indicate that the dorsal PFC is susceptible to neuron loss with aging in rodent brain and suggest some common basis for vulnerability in cortical circuits across species...- Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's diseaseAlexis M Stranahan
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA
Curr Alzheimer Res 9:86-92. 2012..In this respect, physical activity may promote neuronal resilience by reducing inflammation... - Lowering corticosterone levels reinstates hippocampal brain-derived neurotropic factor and Trkb expression without influencing deficits in hypothalamic brain-derived neurotropic factor expression in leptin receptor-deficient miceAlexis M Stranahan
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Neuroendocrinology 93:58-64. 2011.... - Recruiting adaptive cellular stress responses for successful brain ageingAlexis M Stranahan
Physiology Department, Georgia Health Sciences University, Augusta, Georgia 30912, USA
Nat Rev Neurosci 13:209-16. 2012..We also describe the mechanisms underlying the neuroprotective actions of exercise and nutritional interventions, with the goal of recruiting these molecular targets for the treatment and prevention of neurodegenerative disease... - Opposing effects of positive and negative stress on hippocampal plasticity over the lifespanMarlena Wosiski-Kuhn
Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
Ageing Res Rev 11:399-403. 2012..These data suggest that exercise-induced neuroprotection and neuronal endangerment following adversity may both be transferable across generations, in a manner that has the potential to impact neuroplasticity over the lifespan... - Metabolic reserve as a determinant of cognitive agingAlexis M Stranahan
Physiology Department, Georgia Health Sciences University, Augusta, Georgia, GA 30912, USA
J Alzheimers Dis 30:S5-13. 2012..Identification of biomarkers for metabolic reserve could assist in generating a predictive model for the likelihood of cognitive decline with aging... - Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged ratsAlexis M Stranahan
Cellular and Molecular Neurosciences Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
Hippocampus 18:1085-8. 2008..We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines... - Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer's diseaseAlexis M Stranahan
Department of Psychological and Brain Sciences, Johns Hopkins University, Ames Hall, 3400 N Charles St, Baltimore, MD 21218, USA
Neural Plast 2010:108190. 2010..Taken together, the existing data point to a regional cascade in which entorhinal cortical alterations directly contribute to downstream changes in its primary afferent region, the hippocampus... - Transient increases in dendritic spine density contribute to dentate gyrus long-term potentiationMarlena Wosiski-Kuhn
Physiology Department, Georgia Health Sciences University, Augusta, Georgia, USA
Synapse 66:661-4. 2012..These results indicate that spine formation is a transient event that is required for dentate gyrus LTP... - Contributions of impaired hippocampal plasticity and neurodegeneration to age-related deficits in hormonal pulsatilityAlexis M Stranahan
Laboratory of Neurosciences, Cellular and Molecular Neurosciences Section, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
Ageing Res Rev 7:164-76. 2008..We also discuss the results of studies exploring the relationship between circadian phase and hippocampal plasticity in young animals, with the goal of understanding how these mechanisms might be restored in the aging brain... - Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levelsAlexis M Stranahan
Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
Neurobiol Learn Mem 90:479-83. 2008..The pattern of errors made by adrenally intact diabetic rats was similar to the pattern of errors made by aged rats, suggesting that the cognitive profiles of diabetic and aged rats share common features... - Similarities and differences in spatial learning and object recognition between young male C57Bl/6J mice and Sprague-Dawley ratsAlexis M Stranahan
Georgia Health Sciences University, Augusta, GA 30912, USA
Behav Neurosci 125:791-5. 2011..These observations suggest that while species differences in spatial memory retention are present, they do not correlate with differences in object recognition memory... - Putting age-associated changes in neurogenesis in their placeAlexis M Stranahan
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Neurobiol Aging 31:2179-80. 2010.... - Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged ratsAlexis M Stranahan
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Cereb Cortex 21:392-400. 2011..Taken together, these findings suggest that reduced reelin expression, emanating from layer II entorhinal neurons, may contribute to network dysfunction that occurs during memory loss in aging...