Alexis M Stranahan

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi Chronobiological approaches to Alzheimer's disease
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
    Curr Alzheimer Res 9:93-8. 2012
  2. pmc Physiological variability in brain-derived neurotrophic factor expression predicts dendritic spine density in the mouse dentate gyrus
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, 1120 15th St, rm CA3145, Augusta, GA 30912, United States
    Neurosci Lett 495:60-2. 2011
  3. pmc Bidirectional metabolic regulation of neurocognitive function
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Learn Mem 96:507-16. 2011
  4. doi Reelin signaling in development, maintenance, and plasticity of neural networks
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
    Ageing Res Rev 12:815-22. 2013
  5. pmc Interference with reelin signaling in the lateral entorhinal cortex impairs spatial memory
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Learn Mem 96:150-5. 2011
  6. pmc Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 6825, United States
    Neurobiol Aging 31:1937-49. 2010
  7. pmc Cortical gene transcription response patterns to water maze training in aged mice
    Sung Soo Park
    Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
    BMC Neurosci 12:63. 2011
  8. pmc Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA
    J Neurochem 118:611-5. 2011
  9. pmc Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortex
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Comp Neurol 520:1318-26. 2012
  10. pmc Recruiting adaptive cellular stress responses for successful brain ageing
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Nat Rev Neurosci 13:209-16. 2012

Detail Information

Publications24

  1. ncbi Chronobiological approaches to Alzheimer's disease
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
    Curr Alzheimer Res 9:93-8. 2012
    ....
  2. pmc Physiological variability in brain-derived neurotrophic factor expression predicts dendritic spine density in the mouse dentate gyrus
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, 1120 15th St, rm CA3145, Augusta, GA 30912, United States
    Neurosci Lett 495:60-2. 2011
    ..This observation suggests that there may be a subregionally specific relationship between hippocampal BDNF expression and the density of spines...
  3. pmc Bidirectional metabolic regulation of neurocognitive function
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Learn Mem 96:507-16. 2011
    ..Understanding the mechanisms for this continuum may yield novel therapeutic targets for the prevention and treatment of cognitive decline following aging, disease, or injury...
  4. doi Reelin signaling in development, maintenance, and plasticity of neural networks
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
    Ageing Res Rev 12:815-22. 2013
    ....
  5. pmc Interference with reelin signaling in the lateral entorhinal cortex impairs spatial memory
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Learn Mem 96:150-5. 2011
    ..These observations support a role for entorhinal reelin signaling in spatial learning, and suggest that an intact reelin signaling pathway is essential for synaptic integrity in the adult entorhinal cortex...
  6. pmc Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 6825, United States
    Neurobiol Aging 31:1937-49. 2010
    ..These results suggest that the enhancement of cognitive function by lifelong exercise is associated with an altered transcriptional profile following learning...
  7. pmc Cortical gene transcription response patterns to water maze training in aged mice
    Sung Soo Park
    Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
    BMC Neurosci 12:63. 2011
    ..We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training...
  8. pmc Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA
    J Neurochem 118:611-5. 2011
    ..Taken together, these observations support the existence of a potentially pathogenic relationship between dietary fat intake, peripheral cholesterol and triglyceride levels, brain cell sphingolipid metabolism, and oxidative stress...
  9. pmc Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortex
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Comp Neurol 520:1318-26. 2012
    ..These observations indicate that the dorsal PFC is susceptible to neuron loss with aging in rodent brain and suggest some common basis for vulnerability in cortical circuits across species...
  10. pmc Recruiting adaptive cellular stress responses for successful brain ageing
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Nat Rev Neurosci 13:209-16. 2012
    ..We also describe the mechanisms underlying the neuroprotective actions of exercise and nutritional interventions, with the goal of recruiting these molecular targets for the treatment and prevention of neurodegenerative disease...
  11. ncbi Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA
    Curr Alzheimer Res 9:86-92. 2012
    ..In this respect, physical activity may promote neuronal resilience by reducing inflammation...
  12. pmc Lowering corticosterone levels reinstates hippocampal brain-derived neurotropic factor and Trkb expression without influencing deficits in hypothalamic brain-derived neurotropic factor expression in leptin receptor-deficient mice
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroendocrinology 93:58-64. 2011
    ....
  13. doi Opposing effects of positive and negative stress on hippocampal plasticity over the lifespan
    Marlena Wosiski-Kuhn
    Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USA
    Ageing Res Rev 11:399-403. 2012
    ..These data suggest that exercise-induced neuroprotection and neuronal endangerment following adversity may both be transferable across generations, in a manner that has the potential to impact neuroplasticity over the lifespan...
  14. doi Metabolic reserve as a determinant of cognitive aging
    Alexis M Stranahan
    Physiology Department, Georgia Health Sciences University, Augusta, Georgia, GA 30912, USA
    J Alzheimers Dis 30:S5-13. 2012
    ..Identification of biomarkers for metabolic reserve could assist in generating a predictive model for the likelihood of cognitive decline with aging...
  15. pmc Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    Alexis M Stranahan
    Cellular and Molecular Neurosciences Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Hippocampus 18:1085-8. 2008
    ..We conclude that a high-calorie diet reduces hippocampal synaptic plasticity and impairs cognitive function, possibly through BDNF-mediated effects on dendritic spines...
  16. pmc Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer's disease
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Ames Hall, 3400 N Charles St, Baltimore, MD 21218, USA
    Neural Plast 2010:108190. 2010
    ..Taken together, the existing data point to a regional cascade in which entorhinal cortical alterations directly contribute to downstream changes in its primary afferent region, the hippocampus...
  17. doi Transient increases in dendritic spine density contribute to dentate gyrus long-term potentiation
    Marlena Wosiski-Kuhn
    Physiology Department, Georgia Health Sciences University, Augusta, Georgia, USA
    Synapse 66:661-4. 2012
    ..These results indicate that spine formation is a transient event that is required for dentate gyrus LTP...
  18. pmc Contributions of impaired hippocampal plasticity and neurodegeneration to age-related deficits in hormonal pulsatility
    Alexis M Stranahan
    Laboratory of Neurosciences, Cellular and Molecular Neurosciences Section, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Ageing Res Rev 7:164-76. 2008
    ..We also discuss the results of studies exploring the relationship between circadian phase and hippocampal plasticity in young animals, with the goal of understanding how these mechanisms might be restored in the aging brain...
  19. pmc Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Neurobiol Learn Mem 90:479-83. 2008
    ..The pattern of errors made by adrenally intact diabetic rats was similar to the pattern of errors made by aged rats, suggesting that the cognitive profiles of diabetic and aged rats share common features...
  20. pmc Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes
    Aditi Dey
    Department of Physiology, Georgia Regents University, Augusta, GA, 30912, USA
    J Neuroimmunol 269:20-7. 2014
    ....
  21. doi Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice
    Marlena Wosiski-Kuhn
    Department of Physiology, Medical College of Georgia, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA
    Psychoneuroendocrinology 42:165-77. 2014
    ....
  22. pmc Similarities and differences in spatial learning and object recognition between young male C57Bl/6J mice and Sprague-Dawley rats
    Alexis M Stranahan
    Georgia Health Sciences University, Augusta, GA 30912, USA
    Behav Neurosci 125:791-5. 2011
    ..These observations suggest that while species differences in spatial memory retention are present, they do not correlate with differences in object recognition memory...
  23. pmc Putting age-associated changes in neurogenesis in their place
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neurobiol Aging 31:2179-80. 2010
    ....
  24. pmc Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Cereb Cortex 21:392-400. 2011
    ..Taken together, these findings suggest that reduced reelin expression, emanating from layer II entorhinal neurons, may contribute to network dysfunction that occurs during memory loss in aging...