Research Topics
Species | Elliot A SteinSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
| Collaborators
|
Detail Information
Publications
Nicotine-induced limbic cortical activation in the human brain: a functional MRI studyE A Stein
Department of Psychiatry, Biophysics Research Institute, Medical College of Wisconsin, Milwaukee 53226, USA
Am J Psychiatry 155:1009-15. 1998..Such knowledge might help in the development of new behavioral and pharmacological therapies to aid in treating nicotine dependence and to improve smoking cessation success rates...
fMRI: a new tool for the in vivo localization of drug actions in the brainE A Stein
Department of Psychiatry, Medical College of Wisconsin, Milwaukee 53226, USA
J Anal Toxicol 25:419-24. 2001..Examples are given using nicotine and cocaine as a prototypical agents...
Nicotine enhances but does not normalize visual sustained attention and the associated brain network in schizophreniaL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
Schizophr Bull 37:416-25. 2011..These findings provide guidance for developing new treatment strategies for the sustained attention deficit in schizophrenia...
A genetically modulated, intrinsic cingulate circuit supports human nicotine addictionL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Proc Natl Acad Sci U S A 107:13509-14. 2010..Identifying where and how brain circuits link genes to smoking provides practical neural circuitry targets for new treatment development...
Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophreniaJames A Waltz
Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
Neuropsychopharmacology 35:2427-39. 2010....
Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuitsL Elliot Hong
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Arch Gen Psychiatry 66:431-41. 2009..Imaging studies showed that nicotine challenges almost always involve the cingulate cortex, suggesting that this locus may be a key region associated with nicotine addiction and its treatment...
Multiple neuronal networks mediate sustained attentionNatalia S Lawrence
Medical College of Wisconsin, USA
J Cogn Neurosci 15:1028-38. 2003....
Neural correlates of high and craving during cocaine self-administration using BOLD fMRIRobert C Risinger
Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Neuroimage 26:1097-108. 2005..This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system...
Cognitive mechanisms of nicotine on visual attentionNatalia S Lawrence
Department of Psychiatry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Neuron 36:539-48. 2002..These data suggest that nicotine improves attention in smokers by enhancing activation in areas traditionally associated with visual attention, arousal, and motor activation...
Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcersJames A Waltz
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Neuropsychopharmacology 34:1567-77. 2009..These results provide evidence that SZ patients show abnormal brain responses associated with the processing of a primary reinforcer, which may be a source of motivational deficits...
Cingulate hypoactivity in cocaine users during a GO-NOGO task as revealed by event-related functional magnetic resonance imagingJacqueline N Kaufman
Medical College of Wisconsin, Department of Psychiatry, Milwaukee, Wisconsin 53226, USA
J Neurosci 23:7839-43. 2003..The results suggest that addiction may be accompanied by a disruption of brain structures critical for the higher-order, cognitive control of behavior...
Insular and anterior cingulate circuits in smokers with schizophreniaLauren V Moran
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Schizophr Res 142:223-9. 2012..Decreased insula-dACC rsFC may index overlapping circuitry associated with smoking and SZ...
Simultaneous MRI acquisition of blood volume, blood flow, and blood oxygenation information during brain activationYihong Yang
Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21042, USA
Magn Reson Med 52:1407-17. 2004....
Nonlinear responses of cerebral blood volume, blood flow and blood oxygenation signals during visual stimulationHong Gu
Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Magn Reson Imaging 23:921-8. 2005..These data suggest that caution should be taken in the interpretation of hemodynamic-based signals in fMRI...
Hemodynamic and metabolic changes induced by cocaine in anesthetized rat observed with multimodal functional MRIKarl F Schmidt
Center for Comparative NeuroImaging, University of Massachusetts, Worcester, MA, USA
Psychopharmacology (Berl) 185:479-86. 2006....
Focal cerebral ischemia in rats produced by intracarotid embolization with viscous siliconeKathryn K Lauer
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
Neurol Res 24:181-90. 2002..The smaller embolus produces cortical infarction with high rate of survival and neurological recovery...
Functional cerebral hyperemia is unaffected by isovolemic hemodilutionHui Shen
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, 53226, USA
Anesthesiology 96:142-7. 2002..CONCLUSIONS: The results suggest that an increase in baseline flow during hemodilution maintains cortical oxygen supply and consequently preserves the normal functional hyperemic response...
Ca(2+)-activated potassium (K(Ca)) channel inhibition decreases neuronal activity-blood flow couplingRonald J Gerrits
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Brain Res 948:108-16. 2002..These data suggest that the process of cerebral metabolism/blood flow coupling in the rodent WBC involves K(Ca) channels...
Pharmacological applications of magnetic resonance imagingBetty Jo Salmeron
Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, USA
Psychopharmacol Bull 36:102-29. 2002..Included are studies of acute direct effects of drugs, effects of drugs on task-related activation, chronic effects of drugs, effects of drugs on cerebral metabolism, and variable effects of drugs in different populations...
Quantifying the blood oxygenation level dependent effect in cerebral blood volume-weighted functional MRI at 9.4THanbing Lu
Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
Magn Reson Med 58:616-21. 2007..4T. These data suggest that correcting BOLD effect may be necessary for accurately quantifying activation-induced CBV changes at high field...
Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI)Hanbing Lu
Neuroimaging Research Branch, National Institute on Drug Abuse NIDA, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 104:2489-94. 2007..These data suggest that MEMRI may serve as a tool for investigating the effects of pharmacological agents and opens an application of MRI to study CNS drug effects at a systems level...
Neuroanatomical dissociation between bottom-up and top-down processes of visuospatial selective attentionBritta Hahn
NIH National Institute on Drug Abuse, Intramural Research Program, Neuroimaging Research Branch, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuroimage 32:842-53. 2006..The results suggest two largely dissociated neural networks mediating top-down and bottom-up control of visuospatial selective attention...
Noninvasive quantification of cerebral blood volume in humans during functional activationHong Gu
Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr, Building C, Room 383, Baltimore, MD 21042, USA
Neuroimage 30:377-87. 2006..This technique, with its ability to measure quantitative CBV values noninvasively, provides a valuable tool for quantifying hemodynamic signals associated with brain activation...
Blockade of ionotropic glutamatergic transmission in the ventral tegmental area reduces heroin reinforcement in ratZheng-Xiong Xi
Department of Cell Biology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Psychopharmacology (Berl) 164:144-50. 2002..CONCLUSION: These data suggest that ionotropic glutamate receptors in the VTA, presumably by modulating MCL DA efferents and/or tegmental interneurons, modulate opiate reinforcement...
Opiate tolerance by heroin self-administration: an fMRI study in ratZheng-Xiong Xi
Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland, USA
Magn Reson Med 52:108-14. 2004..Together, these data suggest that repeated heroin-SA produces tolerance or desensitization of opiate actions in the rat brain, which may in turn potentiate drug SA behavior and drug intake...
Opiate self-administrationZheng-Xiong Xi
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC, USA
Methods Mol Med 84:251-64. 2003
