C Frank Starmer
Affiliation: Medical University of South Carolina
- What happens when cardiac Na channels lose their function? 1--numerical studies of the vulnerable period in tissue expressing mutant channelsC Frank Starmer
Department of Biometry, Medical University of South Carolina, Suite 200 I Administration Library, 171 Ashley Ave, Charleston, SC 29425, USA
Cardiovasc Res 57:82-91. 2003..We hypothesized that during the VP, the Na conductance at the stimulus site is graded and that NaLOF would favor reentry specifically by flattening this gradient, which would destabilize antegrade front formation...
- What happens when cardiac Na channel function is compromised? 2. Numerical studies of the vulnerable period in tissue altered by drugsC Frank Starmer
Department of Biometry Epidemiology, Charleston, SC 29425, USA
Cardiovasc Res 57:1062-71. 2003....
- Ischemic modulation of vulnerable period and the effects of pharmacological treatment of ischemia-induced arrhythmias: a simulation studyAdrian Cimponeriu
University of Patras, School of Medicine, Department of Medical Physics, 26500 Rion Patras, Greece
IEEE Trans Biomed Eng 50:168-77. 2003..An antiarrhythmic drug with high affinity for drug-channel complex formation elicits a higher level of blockade per time unit. Under this light, we hypothesize that even the modern, fast unbinding drugs are not necessarily safe...
- The role of intrinsic and induced vulnerability in electrically induced cardiac arrhythmiasC Frank Starmer
J Cardiovasc Electrophysiol 17:1369-70. 2006
- Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutationAugustus O Grant
Duke University Medical Center, Box 3504, Durham, North Carolina 27710, USA
J Clin Invest 110:1201-9. 2002..The late component of Na(+) current was increased in the DeltaK1500 mutant channel. These changes can account for the complex phenotype in this kindred and point to an important role of the III/IV linker in channel activation...