Research Topics
Genomes and Genes | Rashmi SoodSummaryAffiliation: Medical College of Wisconsin Country: USA Publications
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Publications
Thrombophilia and fetal loss: Lessons from gene targeting in miceRashmi Sood
Medical College of Wisconsin, Milwaukee, WI, USA
Thromb Res 123:S79-84. 2009..Genetically engineered mice have led to the development of new insights into the etiology and pathogenesis of thrombophilia-associated fetal loss. These insights are the focus of this review...
Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulinRashmi Sood
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226, USA
Blood 112:585-91. 2008..Our findings demonstrate that fetal prothrombotic mutations can cause localized activation of maternal platelets at the feto-maternal interface in a mother with normal hemostatic function...
Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothersRashmi Sood
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
J Exp Med 204:1049-56. 2007..e., thrombosis or pregnancy loss), depending on the vascular bed in which this interaction occurs...
Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein CEdward J Kerschen
Blood Research Institute, Milwaukee, WI 53226, USA
J Exp Med 204:2439-48. 2007....
Fetomaternal cross talk in the placental vascular bed: control of coagulation by trophoblast cellsRashmi Sood
Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
Blood 107:3173-80. 2006....
Caveolin-1-dependent apoptosis induced by fibrin degradation productsYi He Guo
Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226 3548, USA
Blood 113:4431-9. 2009....
Cause-effect relation between hyperfibrinogenemia and vascular diseaseBryce Kerlin
Blood Research Institute, Blood Center of SE Wisconsin, Milwaukee 53226, USA
Blood 103:1728-34. 2004....
The thrombomodulin-protein C system is essential for the maintenance of pregnancyBerend Isermann
Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA
Nat Med 9:331-7. 2003..These findings show a new function for the thrombomodulin-protein C system in controlling the growth and survival of trophoblast cells in the placenta. This function is essential for the maintenance of pregnancy...
Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemiaBryce A Kerlin
Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee, WI 53226, USA
Blood 102:3085-92. 2003..76). The findings suggest that FV Leiden constitutes a rare example of a balanced gene polymorphism that maintains the FV Leiden mutation in the general gene pool due to a survival advantage of VL+/- in severe sepsis...
Embryogenesis and gene targeting of coagulation factors in miceRashmi Sood
Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
Best Pract Res Clin Haematol 16:169-81. 2003..Abnormal signalling by placental trophoblasts at the feto-maternal interface is suggested as a hitherto unrecognized mechanism that may underlie adverse pregnancy outcome associated with haemostatic disorders...
