Research Topics
| G A SilvestriSummaryAffiliation: Medical University of South Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Using endobronchial ultrasound features to predict lymph node metastasis in patients with lung cancerJessica S Wang Memoli
Section of Pulmonary, Critical Care, and Respiratory Services, Washington Hospital Center, Washington, DC, USA
Chest 140:1550-6. 2011..Our aim was to evaluate predictors of mediastinal lymph node metastasis in patients undergoing endobronchial ultrasound (EBUS)...
Screening for lung cancer: it works, but does it really work?Gerard A Silvestri
Medical University of South Carolina, Charleston, 29425, USA
Ann Intern Med 155:537-9. 2011..Although the NLST results are perhaps encouraging, they do not tell us enough that we can be sure that patients who undergo LDCT in an attempt to find early-stage lung cancer will have more benefit than harm...
Endoscopic ultrasound-guided fine needle aspiration for staging patients with carcinoma of the lungM B Wallace
Division of Gastroenterology and Hepatology Digestive Disease Center, Medical University of South Carolina, Charleston 29425, USA
Ann Thorac Surg 72:1861-7. 2001..We studied the accuracy of EUS in a large population of lung cancer patients with and without enlarged mediastinal lymph nodes on computed tomographic (CT) scan...- Cost-efficacy of endoscopic ultrasonography with fine-needle aspiration vs. mediastinotomy in patients with lung cancer and suspected mediastinal adenopathyL Aabakken
Digestive Disease Center, Department of Pulmonary Medicine, Medical University of South Carolina, Charleston, USA
Endoscopy 31:707-11. 1999..The aim of this study was to apply a decision-analysis model to compare the cost-effectiveness of EUS and MED in the preoperative staging of patients with non-small-cell lung cancer... - Targeted therapy for the treatment of advanced non-small cell lung cancer: a review of the epidermal growth factor receptor antagonistsGerard A Silvestri
Medical University of South Carolina, Room 812 CSB, 171 Ashley Ave, Charleston, SC 29425, USA
Chest 128:3975-84. 2005..It is important for pulmonologists to be aware of this class of compounds, as they can provide benefit to patients with NSCLC who may not have been previously considered for antitumor therapy... - Attitudes towards screening for lung cancer among smokers and their non-smoking counterpartsGerard A Silvestri
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas St, PO Box 250630, Charleston, SC, USA
Thorax 62:126-30. 2007..There has been resurgence of interest in lung cancer screening using low-dose computed tomography. The implications of directing a screening programme at smokers has been little explored... - A phase 3, randomized, double-blind study to assess the efficacy and safety of fospropofol disodium injection for moderate sedation in patients undergoing flexible bronchoscopyGerard A Silvestri
Department of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC 29425 2220, USA
Chest 135:41-7. 2009..This randomized, double-blind, multicenter study evaluated the use of fospropofol in patients undergoing flexible bronchoscopy... - Noninvasive staging of non-small cell lung cancer: ACCP evidenced-based clinical practice guidelines (2nd edition)Gerard A Silvestri
Medical University of South Carolina, Department of Pulmonary and Critical Care Medicine, 171 Ashley Ave, Room 812 CSB, Charleston, SC 29425 2220, USA
Chest 132:178S-201S. 2007..Several noninvasive imaging studies including chest CT scanning and positron emission tomography (PET) scanning are available. Understanding the test characteristics of these noninvasive staging studies is critical to decision making... - Screening for lung cancerJames G Ravenel
Department of Radiology, Medical University of South Carolina, 169 Ashley Ave, Rm 297, PO Box 250322, Charleston, SC 29425, USA
AJR Am J Roentgenol 190:755-61. 2008..Currently no data exist to suggest that lung cancer screening with CT will result in a decrease in lung cancer mortality... - Pulmonary nodule volume: effects of reconstruction parameters on automated measurements--a phantom studyJames G Ravenel
Department of Radiology, Medical University of South Carolina, 169 Ashley Ave, PO Box 250322, Charleston, SC 29425, USA
Radiology 247:400-8. 2008..To prospectively evaluate in a phantom the effects of reconstruction kernel, field of view (FOV), and section thickness on automated measurements of pulmonary nodule volume... - Bronchoscopy for the diagnosis and staging of lung cancerEzzat El-Bayoumi
Division of Pulmonary and Critical Care Medicine, Allergy, and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
Semin Respir Crit Care Med 29:261-70. 2008..The future holds great promise with further miniaturization of equipment and improvements in computer processing power that may allow for in vivo pathological evaluation of abnormal tissue... - Underuse of surgical resection for localized, non-small cell lung cancer among whites and African Americans in South CarolinaNestor F Esnaola
Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
Ann Thorac Surg 86:220-6; discussion 227. 2008..We analyzed the independent effect of race on use of surgical resection in a recent, population-based sample of patients with localized non-small cell lung cancer, controlling for comorbidity and socioeconomic status... - Barriers to hospice enrollment among lung cancer patients: a survey of family members and physiciansDee W Ford
Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina29425, USA
Palliat Support Care 6:357-62. 2008..Despite the advantages of hospice care for lung cancer patients, many are enrolled late in the course of their illness or not at all. We sought to identify reasons for this pattern... - Imprecision in automated volume measurements of pulmonary nodules and its effect on the level of uncertainty in volume doubling time estimationPaul J Nietert
Medical University of South Carolina, Biostatistics and Bioinformatics, 135 Cannon St, Suite 303, Charleston, SC 29425, USA
Chest 135:1580-7. 2009..This study examined the effects of the volume estimation error associated with four CT scan slice thicknesses (0.625, 1.25, 2.50, and 5.00 mm) on estimates of volume doubling time (VDT) for solid nodules of various sizes... - Influence of nodule detection software on radiologists' confidence in identifying pulmonary nodules with computed tomographyPaul J Nietert
Department of Medicine, Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
J Thorac Imaging 26:48-53. 2011..We designed a study to examine the extent to which computed tomography (CT) NDS influences the confidence of radiologists in identifying small pulmonary nodules... - Unusual presentations of pulmonary sarcoidosis: cases from the medical university of South CarolinaMarc A Judson
Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Semin Respir Crit Care Med 28:75-82. 2007..Atypical presentations may result in a delay in diagnosis as well as unnecessary treatment or diagnostic testing. We discuss four patients with an unusual presentation of thoracic sarcoidosis seen at our Sarcoidosis Clinic... - Caring for the dying patient with lung cancerGerard A Silvestri
Divisions of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston 29425, USA
Chest 122:1028-36. 2002 - The noninvasive staging of non-small cell lung cancer: the guidelinesGerard A Silvestri
Medical University of South Carolina, Charleston, SC, USA
Chest 123:147S-156S. 2003.... - Glutathione S-transferase M1 polymorphism and the risk of lung cancerLawrence C Mohr
Department of Medicine, Department of Biometry and Epidemiology, Environmental Biosciences Program, Medical University of South Carolina, 135 Cannon Street, Suite 405, P O Box 250838, Charleston, South Carolina 29425, USA
Anticancer Res 23:2111-24. 2003..This could lead to new clinical strategies for counseling, risk reduction and the detection of lung at an early and potentially curable stage... - Results of the American College of Surgeons Oncology Group Z0050 trial: the utility of positron emission tomography in staging potentially operable non-small cell lung cancerCarolyn E Reed
Hollings Cancer Center, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston 29425, USA
J Thorac Cardiovasc Surg 126:1943-51. 2003.... - Importance of faith on medical decisions regarding cancer careGerard A Silvestri
Department of Medicine and Center for Health Care Research, Medical University of South Carolina, Charleston 29425, USA
J Clin Oncol 21:1379-82. 2003..One poorly understood factor is the influence of a patient's faith on how they make medical decisions. We compared the importance of faith on treatment decisions among doctors, patients, and patient caregivers... - High-dose fractionated radiotherapy to 80 Gy for stage I-II medically inoperable non-small-cell lung cancerJ M Watkins
Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Med Imaging Radiat Oncol 54:554-61. 2010..The present investigation describes disease control and survival outcomes for a large series of patients prescribed high-dose radiotherapy for early-stage NSCLC... - Mediastinal staging of non-small-cell lung cancerC Lloyd
Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, 29425, USA
Cancer Control 8:311-7. 2001..With further research on the proper roles of these new imaging modalities, they will become more widely used and will improve the accuracy of pretreatment staging of NSCLC... - Carcinoma of the bronchus 60 years laterG A Silvestri
Medical University of South Carolina, Charleston, SC 29425, USA
Thorax 61:1023-8. 2006 - Predicted impact of attaining smoking reduction goals on mortalityM D Silverstein
Center for Health Care Research, Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston 29425-8060, USA
South Med J 94:176-83. 2001..Maximum reduction in mortality could be achieved by reducing initiation and increasing cessation at all ages, but a reduction in mortality would not occur for several decades... - Variation in experts' beliefs about lung cancer growth, progression, and prognosisEllen M Schultz
Center for Primary Care and Outcomes Research PCOR, 117 Encina Commons, Stanford, CA 94305, USA
J Thorac Oncol 3:422-6. 2008..Little is known about the natural history of malignant solitary pulmonary nodules (SPN). Experts' beliefs may help fill these knowledge gaps and explain variation in clinical practices... - One from column A: choosing between CT, positron emission tomography, endoscopic ultrasound with fine-needle aspiration, transbronchial needle aspiration, thoracoscopy, mediastinoscopy, and mediastinotomy for staging lung cancerGerard A Silvestri
Chest 123:333-5. 2003 - Lung cancer. Invasive staging: the guidelinesFrank C Detterbeck
Multidisciplinary Thoracic Oncology Program, Division of Cardiothoracic Surgery, University of North Carolina, CB 7065, 108 Burnett Womack Building, Chapel Hill, NC 27599 7065, USA
Chest 123:167S-175S. 2003..Selection of the optimal approach is best achieved through a multidisciplinary discussion so that all aspects can be weighed appropriately... - Lung cancer: evolving conceptsGerard A Silvestri
Semin Respir Crit Care Med 29:221-2. 2008 - Multidisciplinary management of lung cancerMichael K Gould
N Engl J Med 350:2008-10; author reply 2008-10. 2004 - One hundred years of lung cancerStephen G Spiro
Department of Thoracic Medicine, Middlesex Hospital, Mortimer Street, London WIT 3AA, UK
Am J Respir Crit Care Med 172:523-9. 2005..The most important and cost-effective management for lung cancer is smoking cessation, but for those with the disease, novel agents and treatment approaches are urgently needed... - What happens to patients undergoing lung cancer surgery? Outcomes and quality of life before and after surgeryJohn R Handy
Division of Cardiothoracic Surgery, The Oregon Clinic, Portland, OR 97213, USA
Chest 122:21-30. 2002..To compare baseline preoperative and 6-month postoperative functional health status and quality of life in patients undergoing lung cancer resection... - Lung cancer stagingJohn M Barker
Medical University of South Carolina, Division of Pulmonary and Critical Care Medicine, Charleston, South Carolina 29425, USA
Curr Opin Pulm Med 8:287-93. 2002.... - Lung cancer screeningMario Gomez
Department of Internal Medicine, Division of Pulmonary and Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Med Sci 335:46-50. 2008..The objective of this review is to examine the current evidence for lung cancer screening and the clinical effectiveness of screening for lung cancer by using computed tomography... - Real-time endobronchial ultrasound-guided transbronchial lymph node aspirationBrad D Vincent
Department of Pulmonary, Critical Care and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann Thorac Surg 85:224-30. 2008..Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has recently been introduced. Here we report the use of EBUS-TBNA as a diagnostic modality for mediastinal adenopathy and staging modality for lung cancer... - Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)Frank C Detterbeck
Division of Thoracic Surgery, Department of Surgery, Yale University, 330 Cedar St, FMB 128, New Haven, CT 06520 8062, USA
Chest 132:202S-220S. 2007..Although imaging studies can provide some guidance, in many situations invasive staging is necessary. Many different complementary techniques are available... - CT screening for lung cancerGerard A Silvestri
N Engl J Med 356:745; author reply 746-7. 2007 - Intensive care decision making in the seriously ill and elderlyChristian B Lloyd
Division of Pulmonary and Critical Care Medicine at the Medical University of South Carolina, Charleston, SC, USA
Crit Care Med 32:649-54. 2004..Length and intensity of intensive care should be incorporated into discussions regarding intensive care... - Racial differences pertaining to a belief about lung cancer surgery: results of a multicenter surveyMitchell L Margolis
University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
Ann Intern Med 139:558-63. 2003.... - Conformal high dose external radiation therapy, 80.5 Gy, alone for medically inoperable non-small cell lung cancer: a retrospective analysisJames J Urbanic
Department of Radiation Oncology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina 27157, USA
J Thorac Oncol 1:112-9. 2006..Most mortality was lung cancer-related. The dose of 80.5 Gy in 7 weeks is supported for patients with single lesions and no prior lobectomy. Local failure dominates and higher effective doses should be explored... - The treatment of advanced non-small cell lung cancerStephen G Spiro
Department of Thoracic Medicine, University College Hospitals NHS Trust, The Middlesex Hospital, London, UK
Curr Opin Pulm Med 11:287-91. 2005..In particular, it reviews the recommendations for chemotherapy in the elderly and for those with a poor performance status. The role of the newer growth factor-inhibiting agents is also discussed... - A 69-year-old with lung mass and mediastinal lymphadenopathy on chest computed tomographyShivakumar Vignesh
Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Clin Gastroenterol Hepatol 5:908-11. 2007 - A seismic shift in stagingGerard A Silvestri
J Thorac Oncol 2:682-3. 2007 - Screening for lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)Peter B Bach
Memorial Sloan Kettering Cancer Center, 307 East 63rd St, Third Floor, New York, NY 10021, USA
Chest 132:69S-77S. 2007..Because early-stage disease can be successfully treated, a screening technique that can detect lung cancer before it has spread might be useful in decreasing lung cancer mortality... - Accuracy of EUS criteria and primary tumor site for identification of mediastinal lymph node metastasis from non-small-cell lung cancerNathan Schmulewitz
Medical University of South Carolina, Charleston, South Carolina, USA
Gastrointest Endosc 59:205-12. 2004..EUS with FNA should be performed for all lymph nodes when an abnormal finding will alter management... - Variation in training for interventional pulmonary procedures among US pulmonary/critical care fellowships: a survey of fellowship directorsNicholas J Pastis
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
Chest 127:1614-21. 2005..Finally, to provide justification for the current competency recommendations, clinical outcomes should be correlated with physicians' procedural volume, as has been done in other subspecialties... - Combined endoscopic and open approach to the removal of expandable metallic tracheal stentsAndrew M Rampey
Department of Otolaryngology Head and Neck Surgery and Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, USA
Arch Otolaryngol Head Neck Surg 133:37-41. 2007..To review complications of indwelling tracheal stents and to describe a technique of stent removal using a combined open and endoscopic approach... - The evolution of bronchoscopy trainingGerard A Silvestri
Respiration 76:19-20. 2008 - A pilot study of narrow-band imaging compared to white light bronchoscopy for evaluation of normal airways and premalignant and malignant airways diseaseBrad D Vincent
Department of Internal Medicine, Division of Pulmonary and Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC, USA
Chest 131:1794-9. 2007.... - Boys (and girls) and their toys: a look at new technologies in the bronchoscopy suiteGerard A Silvestri
Am J Respir Crit Care Med 176:1-2. 2007 - Deaths among patients with screen-detected lung cancerGerard A Silvestri
Clin Cancer Res 14:2511; author reply 2511-2. 2008
Research Grants
- K24 Mid-Career Investigator Award in Patient-Oriented ResearchGerard Silvestri; Fiscal Year: 2007..This study proposes to accomplish that goal which will lead to less unnecessary tests and surgeries for non-cancerous lesions and thus improve the efficacy of the lung cancer screening test. ..