G A Silvestri

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Using endobronchial ultrasound features to predict lymph node metastasis in patients with lung cancer
    Jessica S Wang Memoli
    Section of Pulmonary, Critical Care, and Respiratory Services, Washington Hospital Center, Washington, DC, USA
    Chest 140:1550-6. 2011
  2. doi request reprint Screening for lung cancer: it works, but does it really work?
    Gerard A Silvestri
    Medical University of South Carolina, Charleston, 29425, USA
    Ann Intern Med 155:537-9. 2011
  3. ncbi request reprint Endoscopic ultrasound-guided fine needle aspiration for staging patients with carcinoma of the lung
    M B Wallace
    Division of Gastroenterology and Hepatology Digestive Disease Center, Medical University of South Carolina, Charleston 29425, USA
    Ann Thorac Surg 72:1861-7. 2001
  4. ncbi request reprint Cost-efficacy of endoscopic ultrasonography with fine-needle aspiration vs. mediastinotomy in patients with lung cancer and suspected mediastinal adenopathy
    L Aabakken
    Digestive Disease Center, Department of Pulmonary Medicine, Medical University of South Carolina, Charleston, USA
    Endoscopy 31:707-11. 1999
  5. ncbi request reprint Targeted therapy for the treatment of advanced non-small cell lung cancer: a review of the epidermal growth factor receptor antagonists
    Gerard A Silvestri
    Medical University of South Carolina, Room 812 CSB, 171 Ashley Ave, Charleston, SC 29425, USA
    Chest 128:3975-84. 2005
  6. pmc Attitudes towards screening for lung cancer among smokers and their non-smoking counterparts
    Gerard A Silvestri
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas St, PO Box 250630, Charleston, SC, USA
    Thorax 62:126-30. 2007
  7. doi request reprint A phase 3, randomized, double-blind study to assess the efficacy and safety of fospropofol disodium injection for moderate sedation in patients undergoing flexible bronchoscopy
    Gerard A Silvestri
    Department of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC 29425 2220, USA
    Chest 135:41-7. 2009
  8. ncbi request reprint Noninvasive staging of non-small cell lung cancer: ACCP evidenced-based clinical practice guidelines (2nd edition)
    Gerard A Silvestri
    Medical University of South Carolina, Department of Pulmonary and Critical Care Medicine, 171 Ashley Ave, Room 812 CSB, Charleston, SC 29425 2220, USA
    Chest 132:178S-201S. 2007
  9. doi request reprint Screening for lung cancer
    James G Ravenel
    Department of Radiology, Medical University of South Carolina, 169 Ashley Ave, Rm 297, PO Box 250322, Charleston, SC 29425, USA
    AJR Am J Roentgenol 190:755-61. 2008
  10. doi request reprint Pulmonary nodule volume: effects of reconstruction parameters on automated measurements--a phantom study
    James G Ravenel
    Department of Radiology, Medical University of South Carolina, 169 Ashley Ave, PO Box 250322, Charleston, SC 29425, USA
    Radiology 247:400-8. 2008

Research Grants

Detail Information

Publications51

  1. pmc Using endobronchial ultrasound features to predict lymph node metastasis in patients with lung cancer
    Jessica S Wang Memoli
    Section of Pulmonary, Critical Care, and Respiratory Services, Washington Hospital Center, Washington, DC, USA
    Chest 140:1550-6. 2011
    ..Our aim was to evaluate predictors of mediastinal lymph node metastasis in patients undergoing endobronchial ultrasound (EBUS)...
  2. doi request reprint Screening for lung cancer: it works, but does it really work?
    Gerard A Silvestri
    Medical University of South Carolina, Charleston, 29425, USA
    Ann Intern Med 155:537-9. 2011
    ..Although the NLST results are perhaps encouraging, they do not tell us enough that we can be sure that patients who undergo LDCT in an attempt to find early-stage lung cancer will have more benefit than harm...
  3. ncbi request reprint Endoscopic ultrasound-guided fine needle aspiration for staging patients with carcinoma of the lung
    M B Wallace
    Division of Gastroenterology and Hepatology Digestive Disease Center, Medical University of South Carolina, Charleston 29425, USA
    Ann Thorac Surg 72:1861-7. 2001
    ..We studied the accuracy of EUS in a large population of lung cancer patients with and without enlarged mediastinal lymph nodes on computed tomographic (CT) scan...
  4. ncbi request reprint Cost-efficacy of endoscopic ultrasonography with fine-needle aspiration vs. mediastinotomy in patients with lung cancer and suspected mediastinal adenopathy
    L Aabakken
    Digestive Disease Center, Department of Pulmonary Medicine, Medical University of South Carolina, Charleston, USA
    Endoscopy 31:707-11. 1999
    ..The aim of this study was to apply a decision-analysis model to compare the cost-effectiveness of EUS and MED in the preoperative staging of patients with non-small-cell lung cancer...
  5. ncbi request reprint Targeted therapy for the treatment of advanced non-small cell lung cancer: a review of the epidermal growth factor receptor antagonists
    Gerard A Silvestri
    Medical University of South Carolina, Room 812 CSB, 171 Ashley Ave, Charleston, SC 29425, USA
    Chest 128:3975-84. 2005
    ..It is important for pulmonologists to be aware of this class of compounds, as they can provide benefit to patients with NSCLC who may not have been previously considered for antitumor therapy...
  6. pmc Attitudes towards screening for lung cancer among smokers and their non-smoking counterparts
    Gerard A Silvestri
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas St, PO Box 250630, Charleston, SC, USA
    Thorax 62:126-30. 2007
    ..There has been resurgence of interest in lung cancer screening using low-dose computed tomography. The implications of directing a screening programme at smokers has been little explored...
  7. doi request reprint A phase 3, randomized, double-blind study to assess the efficacy and safety of fospropofol disodium injection for moderate sedation in patients undergoing flexible bronchoscopy
    Gerard A Silvestri
    Department of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC 29425 2220, USA
    Chest 135:41-7. 2009
    ..This randomized, double-blind, multicenter study evaluated the use of fospropofol in patients undergoing flexible bronchoscopy...
  8. ncbi request reprint Noninvasive staging of non-small cell lung cancer: ACCP evidenced-based clinical practice guidelines (2nd edition)
    Gerard A Silvestri
    Medical University of South Carolina, Department of Pulmonary and Critical Care Medicine, 171 Ashley Ave, Room 812 CSB, Charleston, SC 29425 2220, USA
    Chest 132:178S-201S. 2007
    ..Several noninvasive imaging studies including chest CT scanning and positron emission tomography (PET) scanning are available. Understanding the test characteristics of these noninvasive staging studies is critical to decision making...
  9. doi request reprint Screening for lung cancer
    James G Ravenel
    Department of Radiology, Medical University of South Carolina, 169 Ashley Ave, Rm 297, PO Box 250322, Charleston, SC 29425, USA
    AJR Am J Roentgenol 190:755-61. 2008
    ..Currently no data exist to suggest that lung cancer screening with CT will result in a decrease in lung cancer mortality...
  10. doi request reprint Pulmonary nodule volume: effects of reconstruction parameters on automated measurements--a phantom study
    James G Ravenel
    Department of Radiology, Medical University of South Carolina, 169 Ashley Ave, PO Box 250322, Charleston, SC 29425, USA
    Radiology 247:400-8. 2008
    ..To prospectively evaluate in a phantom the effects of reconstruction kernel, field of view (FOV), and section thickness on automated measurements of pulmonary nodule volume...
  11. doi request reprint Bronchoscopy for the diagnosis and staging of lung cancer
    Ezzat El-Bayoumi
    Division of Pulmonary and Critical Care Medicine, Allergy, and Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Semin Respir Crit Care Med 29:261-70. 2008
    ..The future holds great promise with further miniaturization of equipment and improvements in computer processing power that may allow for in vivo pathological evaluation of abnormal tissue...
  12. doi request reprint Underuse of surgical resection for localized, non-small cell lung cancer among whites and African Americans in South Carolina
    Nestor F Esnaola
    Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Ann Thorac Surg 86:220-6; discussion 227. 2008
    ..We analyzed the independent effect of race on use of surgical resection in a recent, population-based sample of patients with localized non-small cell lung cancer, controlling for comorbidity and socioeconomic status...
  13. doi request reprint Barriers to hospice enrollment among lung cancer patients: a survey of family members and physicians
    Dee W Ford
    Department of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina29425, USA
    Palliat Support Care 6:357-62. 2008
    ..Despite the advantages of hospice care for lung cancer patients, many are enrolled late in the course of their illness or not at all. We sought to identify reasons for this pattern...
  14. doi request reprint Imprecision in automated volume measurements of pulmonary nodules and its effect on the level of uncertainty in volume doubling time estimation
    Paul J Nietert
    Medical University of South Carolina, Biostatistics and Bioinformatics, 135 Cannon St, Suite 303, Charleston, SC 29425, USA
    Chest 135:1580-7. 2009
    ..This study examined the effects of the volume estimation error associated with four CT scan slice thicknesses (0.625, 1.25, 2.50, and 5.00 mm) on estimates of volume doubling time (VDT) for solid nodules of various sizes...
  15. pmc Influence of nodule detection software on radiologists' confidence in identifying pulmonary nodules with computed tomography
    Paul J Nietert
    Department of Medicine, Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Thorac Imaging 26:48-53. 2011
    ..We designed a study to examine the extent to which computed tomography (CT) NDS influences the confidence of radiologists in identifying small pulmonary nodules...
  16. ncbi request reprint Unusual presentations of pulmonary sarcoidosis: cases from the medical university of South Carolina
    Marc A Judson
    Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Semin Respir Crit Care Med 28:75-82. 2007
    ..Atypical presentations may result in a delay in diagnosis as well as unnecessary treatment or diagnostic testing. We discuss four patients with an unusual presentation of thoracic sarcoidosis seen at our Sarcoidosis Clinic...
  17. ncbi request reprint Caring for the dying patient with lung cancer
    Gerard A Silvestri
    Divisions of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston 29425, USA
    Chest 122:1028-36. 2002
  18. ncbi request reprint The noninvasive staging of non-small cell lung cancer: the guidelines
    Gerard A Silvestri
    Medical University of South Carolina, Charleston, SC, USA
    Chest 123:147S-156S. 2003
    ....
  19. ncbi request reprint Glutathione S-transferase M1 polymorphism and the risk of lung cancer
    Lawrence C Mohr
    Department of Medicine, Department of Biometry and Epidemiology, Environmental Biosciences Program, Medical University of South Carolina, 135 Cannon Street, Suite 405, P O Box 250838, Charleston, South Carolina 29425, USA
    Anticancer Res 23:2111-24. 2003
    ..This could lead to new clinical strategies for counseling, risk reduction and the detection of lung at an early and potentially curable stage...
  20. ncbi request reprint Results of the American College of Surgeons Oncology Group Z0050 trial: the utility of positron emission tomography in staging potentially operable non-small cell lung cancer
    Carolyn E Reed
    Hollings Cancer Center, Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston 29425, USA
    J Thorac Cardiovasc Surg 126:1943-51. 2003
    ....
  21. ncbi request reprint Importance of faith on medical decisions regarding cancer care
    Gerard A Silvestri
    Department of Medicine and Center for Health Care Research, Medical University of South Carolina, Charleston 29425, USA
    J Clin Oncol 21:1379-82. 2003
    ..One poorly understood factor is the influence of a patient's faith on how they make medical decisions. We compared the importance of faith on treatment decisions among doctors, patients, and patient caregivers...
  22. doi request reprint High-dose fractionated radiotherapy to 80 Gy for stage I-II medically inoperable non-small-cell lung cancer
    J M Watkins
    Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Med Imaging Radiat Oncol 54:554-61. 2010
    ..The present investigation describes disease control and survival outcomes for a large series of patients prescribed high-dose radiotherapy for early-stage NSCLC...
  23. ncbi request reprint Mediastinal staging of non-small-cell lung cancer
    C Lloyd
    Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, 29425, USA
    Cancer Control 8:311-7. 2001
    ..With further research on the proper roles of these new imaging modalities, they will become more widely used and will improve the accuracy of pretreatment staging of NSCLC...
  24. pmc Carcinoma of the bronchus 60 years later
    G A Silvestri
    Medical University of South Carolina, Charleston, SC 29425, USA
    Thorax 61:1023-8. 2006
  25. ncbi request reprint Predicted impact of attaining smoking reduction goals on mortality
    M D Silverstein
    Center for Health Care Research, Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston 29425-8060, USA
    South Med J 94:176-83. 2001
    ..Maximum reduction in mortality could be achieved by reducing initiation and increasing cessation at all ages, but a reduction in mortality would not occur for several decades...
  26. pmc Variation in experts' beliefs about lung cancer growth, progression, and prognosis
    Ellen M Schultz
    Center for Primary Care and Outcomes Research PCOR, 117 Encina Commons, Stanford, CA 94305, USA
    J Thorac Oncol 3:422-6. 2008
    ..Little is known about the natural history of malignant solitary pulmonary nodules (SPN). Experts' beliefs may help fill these knowledge gaps and explain variation in clinical practices...
  27. ncbi request reprint One from column A: choosing between CT, positron emission tomography, endoscopic ultrasound with fine-needle aspiration, transbronchial needle aspiration, thoracoscopy, mediastinoscopy, and mediastinotomy for staging lung cancer
    Gerard A Silvestri
    Chest 123:333-5. 2003
  28. ncbi request reprint Lung cancer. Invasive staging: the guidelines
    Frank C Detterbeck
    Multidisciplinary Thoracic Oncology Program, Division of Cardiothoracic Surgery, University of North Carolina, CB 7065, 108 Burnett Womack Building, Chapel Hill, NC 27599 7065, USA
    Chest 123:167S-175S. 2003
    ..Selection of the optimal approach is best achieved through a multidisciplinary discussion so that all aspects can be weighed appropriately...
  29. doi request reprint Lung cancer: evolving concepts
    Gerard A Silvestri
    Semin Respir Crit Care Med 29:221-2. 2008
  30. ncbi request reprint Multidisciplinary management of lung cancer
    Michael K Gould
    N Engl J Med 350:2008-10; author reply 2008-10. 2004
  31. ncbi request reprint One hundred years of lung cancer
    Stephen G Spiro
    Department of Thoracic Medicine, Middlesex Hospital, Mortimer Street, London WIT 3AA, UK
    Am J Respir Crit Care Med 172:523-9. 2005
    ..The most important and cost-effective management for lung cancer is smoking cessation, but for those with the disease, novel agents and treatment approaches are urgently needed...
  32. ncbi request reprint What happens to patients undergoing lung cancer surgery? Outcomes and quality of life before and after surgery
    John R Handy
    Division of Cardiothoracic Surgery, The Oregon Clinic, Portland, OR 97213, USA
    Chest 122:21-30. 2002
    ..To compare baseline preoperative and 6-month postoperative functional health status and quality of life in patients undergoing lung cancer resection...
  33. ncbi request reprint Lung cancer staging
    John M Barker
    Medical University of South Carolina, Division of Pulmonary and Critical Care Medicine, Charleston, South Carolina 29425, USA
    Curr Opin Pulm Med 8:287-93. 2002
    ....
  34. doi request reprint Lung cancer screening
    Mario Gomez
    Department of Internal Medicine, Division of Pulmonary and Critical Care, Allergy, and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Med Sci 335:46-50. 2008
    ..The objective of this review is to examine the current evidence for lung cancer screening and the clinical effectiveness of screening for lung cancer by using computed tomography...
  35. ncbi request reprint Real-time endobronchial ultrasound-guided transbronchial lymph node aspiration
    Brad D Vincent
    Department of Pulmonary, Critical Care and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Thorac Surg 85:224-30. 2008
    ..Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has recently been introduced. Here we report the use of EBUS-TBNA as a diagnostic modality for mediastinal adenopathy and staging modality for lung cancer...
  36. ncbi request reprint Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    Frank C Detterbeck
    Division of Thoracic Surgery, Department of Surgery, Yale University, 330 Cedar St, FMB 128, New Haven, CT 06520 8062, USA
    Chest 132:202S-220S. 2007
    ..Although imaging studies can provide some guidance, in many situations invasive staging is necessary. Many different complementary techniques are available...
  37. ncbi request reprint CT screening for lung cancer
    Gerard A Silvestri
    N Engl J Med 356:745; author reply 746-7. 2007
  38. ncbi request reprint Intensive care decision making in the seriously ill and elderly
    Christian B Lloyd
    Division of Pulmonary and Critical Care Medicine at the Medical University of South Carolina, Charleston, SC, USA
    Crit Care Med 32:649-54. 2004
    ..To determine the influence of self-reported preadmission quality of life, hypothetical quality of life and mortality prognosis, and length and intensity of intensive care on decision making in the seriously ill and elderly...
  39. ncbi request reprint Racial differences pertaining to a belief about lung cancer surgery: results of a multicenter survey
    Mitchell L Margolis
    University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 139:558-63. 2003
    ..Several African-American patients asserted that this belief was common in the African-American community...
  40. ncbi request reprint Conformal high dose external radiation therapy, 80.5 Gy, alone for medically inoperable non-small cell lung cancer: a retrospective analysis
    James J Urbanic
    Department of Radiation Oncology, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    J Thorac Oncol 1:112-9. 2006
    ..Retrospective analysis of patients with medically inoperable non-small cell lung cancer treated with continuous high-dose external beam radiation therapy at the Medical University of South Carolina...
  41. ncbi request reprint The treatment of advanced non-small cell lung cancer
    Stephen G Spiro
    Department of Thoracic Medicine, University College Hospitals NHS Trust, The Middlesex Hospital, London, UK
    Curr Opin Pulm Med 11:287-91. 2005
    ..In particular, it reviews the recommendations for chemotherapy in the elderly and for those with a poor performance status. The role of the newer growth factor-inhibiting agents is also discussed...
  42. ncbi request reprint A 69-year-old with lung mass and mediastinal lymphadenopathy on chest computed tomography
    Shivakumar Vignesh
    Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Clin Gastroenterol Hepatol 5:908-11. 2007
  43. ncbi request reprint A seismic shift in staging
    Gerard A Silvestri
    J Thorac Oncol 2:682-3. 2007
  44. ncbi request reprint Screening for lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    Peter B Bach
    Memorial Sloan Kettering Cancer Center, 307 East 63rd St, Third Floor, New York, NY 10021, USA
    Chest 132:69S-77S. 2007
    ..Because early-stage disease can be successfully treated, a screening technique that can detect lung cancer before it has spread might be useful in decreasing lung cancer mortality...
  45. ncbi request reprint Accuracy of EUS criteria and primary tumor site for identification of mediastinal lymph node metastasis from non-small-cell lung cancer
    Nathan Schmulewitz
    Medical University of South Carolina, Charleston, South Carolina, USA
    Gastrointest Endosc 59:205-12. 2004
    ..The aims of this study were to identify clinical factors, especially primary tumor location, and EUS lymph nodal characteristics predictive of aortopulmonary window and subcarinal lymph node metastases of non-small-cell lung cancer...
  46. ncbi request reprint Variation in training for interventional pulmonary procedures among US pulmonary/critical care fellowships: a survey of fellowship directors
    Nicholas J Pastis
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Chest 127:1614-21. 2005
    ..Our aim was to assess what procedures are offered to fellows in US pulmonary/critical care fellowships and to determine whether the recommended competency numbers are being met...
  47. ncbi request reprint Combined endoscopic and open approach to the removal of expandable metallic tracheal stents
    Andrew M Rampey
    Department of Otolaryngology Head and Neck Surgery and Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, USA
    Arch Otolaryngol Head Neck Surg 133:37-41. 2007
    ..To review complications of indwelling tracheal stents and to describe a technique of stent removal using a combined open and endoscopic approach...
  48. doi request reprint The evolution of bronchoscopy training
    Gerard A Silvestri
    Respiration 76:19-20. 2008
  49. ncbi request reprint A pilot study of narrow-band imaging compared to white light bronchoscopy for evaluation of normal airways and premalignant and malignant airways disease
    Brad D Vincent
    Department of Internal Medicine, Division of Pulmonary and Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, SC, USA
    Chest 131:1794-9. 2007
    ....
  50. ncbi request reprint Boys (and girls) and their toys: a look at new technologies in the bronchoscopy suite
    Gerard A Silvestri
    Am J Respir Crit Care Med 176:1-2. 2007
  51. doi request reprint Deaths among patients with screen-detected lung cancer
    Gerard A Silvestri
    Clin Cancer Res 14:2511; author reply 2511-2. 2008

Research Grants2

  1. K24 Mid-Career Investigator Award in Patient-Oriented Research
    Gerard Silvestri; Fiscal Year: 2007
    ..This study proposes to accomplish that goal which will lead to less unnecessary tests and surgeries for non-cancerous lesions and thus improve the efficacy of the lung cancer screening test. ..