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Genomes and Genes | Haowei ShenSummaryAffiliation: Medical University of South Carolina Country: USA Publications
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Publications
Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptorsHaowei Shen
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Proc Natl Acad Sci U S A 108:19407-12. 2011..Moreover, the data reveal NR2B-containing NMDA receptors as a previously unexplored therapeutic target for treating heroin addiction...
Automated quantification of dendritic spine density and spine head diameter in medium spiny neurons of the nucleus accumbensHaowei Shen
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29425, USA
Brain Struct Funct 213:149-57. 2008..The capacity to rapidly assess spine density and spine head diameter will facilitate quantifying spine plasticity induced by pharmacological and environmental manipulations...
Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiationCassandra D Gipson
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Neuron 77:867-72. 2013..The marked cue-induced synaptic changes in the accumbens were correlated with the intensity of cocaine, but not sucrose seeking, and may explain the difficulty addicts experience in managing relapse to cocaine use...
Reversing cocaine-induced synaptic potentiation provides enduring protection from relapseKhaled Moussawi
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Proc Natl Acad Sci U S A 108:385-90. 2011....
Inhibition of actin polymerization prevents cocaine-induced changes in spine morphology in the nucleus accumbensShigenobu Toda
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB410, Charleston, SC 29425, USA
Neurotox Res 18:410-5. 2010....
Role of mGluR5 neurotransmission in reinstated cocaine-seekingXiusong Wang
Department of Neurosciences, Medical University of South Carolina, Charleston, USA
Addict Biol 18:40-9. 2013..Taken together, these data show that mGluR5 inhibition and stimulation in the NAcore can regulate cocaine-seeking, and demonstrate that one mechanism for this effect is via interactions with Homer proteins...
NAC1 regulates the recruitment of the proteasome complex into dendritic spinesHaowei Shen
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 27:8903-13. 2007..These experiments show that NAC1 modulates the translocation of the UPS from the nucleus into dendritic spines, thereby suggesting a potential missing link in the recruitment of necessary proteolysis machinery for synaptic remodeling...
Glutamate transmission in addictionPeter W Kalivas
Department of Neurosciences, 173 Ashley Ave, BSB410, Medical University of South Carolina, Charleston, SC 29464, USA
Neuropharmacology 56:169-73. 2009..This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction...
