Prem S Shekhawat

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi request reprint Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases
    Prem Shekhawat
    Departments of Pediatric, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 284:E1098-105. 2003
  2. ncbi request reprint Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Pediatr Res 56:323-8. 2004
  3. pmc Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: impact of expanded newborn screening on their diagnosis and management
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA
    Pediatr Res 57:78R-86R. 2005
  4. pmc Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Genet Metab 92:315-24. 2007
  5. pmc Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response
    Srinivas Sonne
    Department of Pediatrics, Medical College of Georgia, Georgia Health Science University, Augusta, Georgia, United States of America
    PLoS ONE 7:e47729. 2012
  6. pmc Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+)
    Sonne R Srinivas
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1046-53. 2007
  7. pmc Enzymes involved in L-carnitine biosynthesis are expressed by small intestinal enterocytes in mice: implications for gut health
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, United States
    J Crohns Colitis 7:e197-205. 2013

Research Grants

  1. PLACENTAL CARNITINE: ROLE IN FETAL DEVELOPMENT
    Prem Shekhawat; Fiscal Year: 2007

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases
    Prem Shekhawat
    Departments of Pediatric, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 284:E1098-105. 2003
    ..Thus human placenta derives energy from fatty acid oxidation, providing a potential explanation for the association of fetal fatty acid oxidation disorders with maternal liver diseases in pregnancy...
  2. ncbi request reprint Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 Null (OCTN2(-/-)) Mice
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Pediatr Res 56:323-8. 2004
    ....
  3. pmc Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: impact of expanded newborn screening on their diagnosis and management
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA
    Pediatr Res 57:78R-86R. 2005
    ..To ensure the long-term benefits of such screening programs, pediatricians and other health care providers must be educated about these disorders and their treatment...
  4. pmc Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Genet Metab 92:315-24. 2007
    ..Our studies suggest that carnitine supplementation, as a means of boosting fatty acid oxidation, may be therapeutically beneficial in patients with inflammation of the intestinal tract...
  5. pmc Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response
    Srinivas Sonne
    Department of Pediatrics, Medical College of Georgia, Georgia Health Science University, Augusta, Georgia, United States of America
    PLoS ONE 7:e47729. 2012
    ....
  6. pmc Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+)
    Sonne R Srinivas
    Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1046-53. 2007
    ..5), 0.40 +/- 0.02 microM). We conclude that ATB(0,+) is a low-affinity/high-capacity transporter for BC, whereas OCTN2 is a high-affinity/low-capacity transporter. ATB(0,+) may mediate intestinal absorption of BC when OCTN2 is defective...
  7. pmc Enzymes involved in L-carnitine biosynthesis are expressed by small intestinal enterocytes in mice: implications for gut health
    Prem S Shekhawat
    Department of Pediatrics, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, United States
    J Crohns Colitis 7:e197-205. 2013
    ....

Research Grants2

  1. PLACENTAL CARNITINE: ROLE IN FETAL DEVELOPMENT
    Prem Shekhawat; Fiscal Year: 2007
    ..abstract_text> ..