Joseph J Senn

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. ncbi request reprint Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    Joseph J Senn
    Department of Pediatrics, Charles P Darby Children s Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:26865-75. 2006
  2. pmc Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States
    Mol Immunol 44:3092-9. 2007
  3. ncbi request reprint Interleukin-6 induces cellular insulin resistance in hepatocytes
    Joseph J Senn
    Graduate Program in Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 51:3391-9. 2002
  4. ncbi request reprint Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    Joseph J Senn
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13740-6. 2003
  5. ncbi request reprint Non-CpG-containing antisense 2'-methoxyethyl oligonucleotides activate a proinflammatory response independent of Toll-like receptor 9 or myeloid differentiation factor 88
    Joseph J Senn
    Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    J Pharmacol Exp Ther 314:972-9. 2005

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    Joseph J Senn
    Department of Pediatrics, Charles P Darby Children s Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:26865-75. 2006
    ..This study provides strong evidence that TLR2 mediates the initial events of fatty acid-induced insulin resistance in muscle...
  2. pmc Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression
    Hongkuan Fan
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States
    Mol Immunol 44:3092-9. 2007
    ..Understanding the role of beta-arrestins in regulation of TLR signaling pathways may provide novel insights into control mechanisms for inflammatory gene expression...
  3. ncbi request reprint Interleukin-6 induces cellular insulin resistance in hepatocytes
    Joseph J Senn
    Graduate Program in Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Diabetes 51:3391-9. 2002
    ..These data suggest that IL-6 plays a direct role in insulin resistance at the cellular level in both primary hepatocytes and HepG2 cell lines and may contribute to insulin resistance and type 2 diabetes...
  4. ncbi request reprint Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    Joseph J Senn
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13740-6. 2003
    ..These data suggest that induction of SOCS-3 in liver may be an important mechanism of IL-6-mediated insulin resistance...
  5. ncbi request reprint Non-CpG-containing antisense 2'-methoxyethyl oligonucleotides activate a proinflammatory response independent of Toll-like receptor 9 or myeloid differentiation factor 88
    Joseph J Senn
    Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    J Pharmacol Exp Ther 314:972-9. 2005
    ..These data implicate a TLR-independent mechanism of activation for non-CpG 2'-MOE oligonucleotides...