RONALD SEE

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Orexin-1 receptor mediation of cocaine seeking in male and female rats
    Luyi Zhou
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 340:801-9. 2012
  2. ncbi request reprint The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats
    R E See
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 194:321-31. 2007
  3. ncbi request reprint The importance of a compound stimulus in conditioned drug-seeking behavior following one week of extinction from self-administered cocaine in rats
    R E See
    Department of Psychology and Program in Neuroscience, Washington State University, Pullman 99164 4820, USA
    Drug Alcohol Depend 57:41-9. 1999
  4. ncbi request reprint Drug addiction, relapse, and the amygdala
    Ronald E See
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 985:294-307. 2003
  5. ncbi request reprint Muscarinic receptor antagonism in the basolateral amygdala blocks acquisition of cocaine-stimulus association in a model of relapse to cocaine-seeking behavior in rats
    R E See
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue BSB 416A, Charleston, SC 29425, USA
    Neuroscience 117:477-83. 2003
  6. ncbi request reprint Convergent evidence from microdialysis and presynaptic immunolabeling for the regulation of gamma-aminobutyric acid release in the globus pallidus following acute clozapine or haloperidol administration in rats
    Ronald E See
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    J Neurochem 82:172-80. 2002
  7. ncbi request reprint Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior
    R E See
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 154:301-10. 2001
  8. ncbi request reprint Neural substrates of conditioned-cued relapse to drug-seeking behavior
    Ronald E See
    Department of Physiology and Neuroscience, 173 Ashley Avenue, BSB 416A, Medical University of South Carolina, Charleston, SC 29425, USA
    Pharmacol Biochem Behav 71:517-29. 2002
  9. pmc Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking
    Carmela M Reichel
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 337:487-93. 2011
  10. ncbi request reprint Neural substrates of cocaine-cue associations that trigger relapse
    Ronald E See
    Department of Neurosciences, 173 Ashley Avenue, BSB 416, Medical University of South Carolina, Charleston, 29425, USA
    Eur J Pharmacol 526:140-6. 2005

Collaborators

Detail Information

Publications44

  1. pmc Orexin-1 receptor mediation of cocaine seeking in male and female rats
    Luyi Zhou
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 340:801-9. 2012
    ..These results show that OX1R signaling plays a role in mediating cocaine seeking, but differs between the sexes for cue-induced reinstatement...
  2. ncbi request reprint The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats
    R E See
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 194:321-31. 2007
    ..Recent studies have implicated an important role for the dorsal striatum during craving for cocaine and in cocaine-seeking after abstinence in rats...
  3. ncbi request reprint The importance of a compound stimulus in conditioned drug-seeking behavior following one week of extinction from self-administered cocaine in rats
    R E See
    Department of Psychology and Program in Neuroscience, Washington State University, Pullman 99164 4820, USA
    Drug Alcohol Depend 57:41-9. 1999
    ..These findings suggest that compound stimuli may be critical to fully activate drug-seeking behavior in conditions of craving and relapse following prolonged extinction...
  4. ncbi request reprint Drug addiction, relapse, and the amygdala
    Ronald E See
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 985:294-307. 2003
    ..Together, these results reveal the importance of the amygdala as part of a corticolimbic circuit mediating both the acquisition and the expression of conditioning that plays a critical role in relapse to drug-seeking behavior...
  5. ncbi request reprint Muscarinic receptor antagonism in the basolateral amygdala blocks acquisition of cocaine-stimulus association in a model of relapse to cocaine-seeking behavior in rats
    R E See
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue BSB 416A, Charleston, SC 29425, USA
    Neuroscience 117:477-83. 2003
    ....
  6. ncbi request reprint Convergent evidence from microdialysis and presynaptic immunolabeling for the regulation of gamma-aminobutyric acid release in the globus pallidus following acute clozapine or haloperidol administration in rats
    Ronald E See
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    J Neurochem 82:172-80. 2002
    ..This decrease in released pallidal GABA may play a role in the low motor side-effect liability of atypical APDs...
  7. ncbi request reprint Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior
    R E See
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 154:301-10. 2001
    ..However, the specific neurotransmitters involved in conditioned reinstatement remain to be determined...
  8. ncbi request reprint Neural substrates of conditioned-cued relapse to drug-seeking behavior
    Ronald E See
    Department of Physiology and Neuroscience, 173 Ashley Avenue, BSB 416A, Medical University of South Carolina, Charleston, SC 29425, USA
    Pharmacol Biochem Behav 71:517-29. 2002
    ..Future studies aimed at discerning the functional roles of these pathways will provide critical direction for the development of treatments for the prevention of relapse...
  9. pmc Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking
    Carmela M Reichel
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 337:487-93. 2011
    ..These results support recent preclinical and clinical findings that NAC may serve as an effective treatment for inhibiting relapse in cocaine addicts...
  10. ncbi request reprint Neural substrates of cocaine-cue associations that trigger relapse
    Ronald E See
    Department of Neurosciences, 173 Ashley Avenue, BSB 416, Medical University of South Carolina, Charleston, 29425, USA
    Eur J Pharmacol 526:140-6. 2005
    ..Taken together, these results reveal the importance of the amygdala in the acquisition, consolidation, and expression of drug-stimulus learning that drives relapse to drug-seeking behavior...
  11. ncbi request reprint Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapse
    Matthew W Feltenstein
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Biol Psychiatry 61:582-90. 2007
    ..Based on pharmacologic properties that include a stabilization of mesocorticolimbic DA activity, a pathway implicated in addiction, aripiprazole was tested for its ability to prevent relapse to cocaine seeking in rats...
  12. ncbi request reprint Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum
    Marek Schwendt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Neuroreport 18:1261-5. 2007
    ..Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking...
  13. ncbi request reprint A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats
    William J Berglind
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Eur J Neurosci 26:757-66. 2007
    ....
  14. ncbi request reprint Potentiated reinstatement of cocaine-seeking behavior following D-amphetamine infusion into the basolateral amygdala
    Christopher C Ledford
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 28:1721-9. 2003
    ..These findings suggest that enhanced monoamine tone in the BLA potentiates the motivational effect and/or salience of cocaine-paired cues during reinstatement...
  15. pmc Footshock stress potentiates cue-induced cocaine-seeking in an animal model of relapse
    Deanne M Buffalari
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Physiol Behav 98:614-7. 2009
    ..Dual targeting of stress and cues is thus a critical consideration for treatment intervention in abstinent drug users...
  16. pmc Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen
    Rita A Fuchs
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 26:3584-8. 2006
    ....
  17. pmc Selective inactivation of the ventral hippocampus attenuates cue-induced and cocaine-primed reinstatement of drug-seeking in rats
    Jason L Rogers
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neurobiol Learn Mem 87:688-92. 2007
    ..These data indicate that the ventral hippocampus plays an important role in the relapse to cocaine-seeking behavior and may interact with key limbic structures previously implicated in cocaine addiction...
  18. pmc Yohimbine stress potentiates conditioned cue-induced reinstatement of heroin-seeking in rats
    Kelly M Banna
    Department of Neurosciences, Medical University of South Carolina, BSB416B, 173 Ashley Avenue, Charleston, SC 29425, USA
    Behav Brain Res 208:144-8. 2010
    ..These results demonstrate that exposure to heroin-paired cues during yohimbine-induced stress greatly potentiates heroin-seeking, and support the simultaneous targeting of both stress and cue activation during relapse intervention...
  19. doi request reprint Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens
    Devadoss J Samuvel
    Division of Neuroscience Research, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 325:293-301. 2008
    ....
  20. pmc A comparison of the effects of different operant training experiences and dietary restriction on the reinstatement of cocaine-seeking in rats
    Michele Bongiovanni
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Pharmacol Biochem Behav 89:227-33. 2008
    ..The results arguably support the approach of not using prior lever training with a non-drug reinforcer and to limit the use of dietary restriction only to the acquisition phase of drug self-administration...
  21. ncbi request reprint Potentiation of cue-induced reinstatement of cocaine-seeking in rats by the anxiogenic drug yohimbine
    Matthew W Feltenstein
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Behav Brain Res 174:1-8. 2006
    ..These results demonstrate that exposure to drug-paired cues during a stressful state can greatly potentiate cocaine-seeking and suggest that future treatment interventions should target multiple modalities...
  22. ncbi request reprint Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in rats
    Joselyn McLaughlin
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 168:57-65. 2003
    ..Previous evidence has implicated the amygdala and the prefrontal cortex (PFC) as possible substrates for conditioned-cued relapse...
  23. pmc Attenuation of cocaine-seeking by progesterone treatment in female rats
    Matthew W Feltenstein
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychoneuroendocrinology 34:343-52. 2009
    ..Taken together, these results suggest that progesterone may be a useful therapeutic for preventing relapse in abstinent female cocaine users, especially when the likelihood of relapse is greatest...
  24. ncbi request reprint Conditioned stimulus-induced reinstatement of extinguished cocaine seeking in C57BL/6 mice: a mouse model of drug relapse
    Rita A Fuchs
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, Suite 403, Charleston, SC 29425, USA
    Brain Res 973:99-106. 2003
    ....
  25. pmc Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion
    Marek Schwendt
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Pharmacol Exp Ther 331:555-62. 2009
    ..Greater understanding of the neuroadaptations underlying persistent methamphetamine seeking and cognitive deficits could yield targets suitable for future therapeutic interventions...
  26. pmc Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking
    Rachel J Smith
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425 5100, USA
    Eur J Neurosci 30:493-503. 2009
    ....
  27. pmc Repeated aripiprazole administration attenuates cocaine seeking in a rat model of relapse
    Matthew W Feltenstein
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 207:401-11. 2009
    ....
  28. ncbi request reprint Potentiation of cocaine-primed reinstatement of drug seeking in female rats during estrus
    Tod E Kippin
    Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 182:245-52. 2005
    ..However, the influence of the estrous cycle on cocaine-primed reinstatement has not been examined...
  29. pmc NMDA receptor blockade in the basolateral amygdala disrupts consolidation of stimulus-reward memory and extinction learning during reinstatement of cocaine-seeking in an animal model of relapse
    Matthew W Feltenstein
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Neurobiol Learn Mem 88:435-44. 2007
    ..These results suggest that NMDA receptor-mediated mechanisms within the BLA play a crucial role in the consolidation of drug-CS associations into long-term memories that, in turn, drive cocaine-seeking during relapse...
  30. ncbi request reprint Basolateral amygdala inactivation abolishes conditioned stimulus- and heroin-induced reinstatement of extinguished heroin-seeking behavior in rats
    Rita A Fuchs
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 160:425-33. 2002
    ..It is unclear, however, whether the BLA plays a similar role in reinstatement of heroin-seeking behavior...
  31. ncbi request reprint Influence of sex and estrous cyclicity on conditioned cue-induced reinstatement of cocaine-seeking behavior in rats
    Rita A Fuchs
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 179:662-72. 2005
    ..Furthermore, the role of estrous cyclicity in conditioned-cued relapse has not been investigated...
  32. ncbi request reprint The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats
    Rita A Fuchs
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 30:296-309. 2005
    ..Thus, distinct but partially overlapping neural substrates mediate context-induced, explicit CS-induced, and cocaine-primed reinstatement of extinguished cocaine-seeking behavior...
  33. doi request reprint Amygdala mechanisms of Pavlovian psychostimulant conditioning and relapse
    Deanne M Buffalari
    Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
    Curr Top Behav Neurosci 3:73-99. 2010
    ....
  34. ncbi request reprint Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats
    Rita A Fuchs
    Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 24:6600-10. 2004
    ....
  35. pmc Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats
    Sammanda Ramamoorthy
    Department of Neurosciences, Division of Neuroscience Research, Medical University of South Carolina, Charleston, SC 29425, USA
    Biochem Biophys Res Commun 391:1517-21. 2010
    ..Such changes may be related to habitual patterns of cocaine-seeking observed during relapse...
  36. ncbi request reprint Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats
    Rita A Fuchs
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 176:459-65. 2004
    ..Thus, determination of the involvement of NAC subregions in conditioned cue-induced reinstatement of cocaine seeking is warranted...
  37. ncbi request reprint Contributions of prolonged contingent and noncontingent cocaine exposure to enhanced reinstatement of cocaine seeking in rats
    Tod E Kippin
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Psychopharmacology (Berl) 187:60-7. 2006
    ..However, the contributions of prolonged access to cocaine taking vs the pharmacologic effects of the consequent increased cocaine exposure on escalation of drug-seeking behaviors have not been investigated...
  38. pmc Anti-relapse medications: preclinical models for drug addiction treatment
    Noushin Yahyavi-Firouz-Abadi
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Pharmacol Ther 124:235-47. 2009
    ..Finally, based on recent advances in our understanding of the neurobiology of relapse and published preclinical data, we highlight the most promising areas for future anti-relapse medication development...
  39. pmc Plasma progesterone levels and cocaine-seeking in freely cycling female rats across the estrous cycle
    Matthew W Feltenstein
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Drug Alcohol Depend 89:183-9. 2007
    ..Overall, these results suggest that progesterone administration may be a useful intervention for reducing the incidence of relapse...
  40. pmc Dopamine D1 receptor antagonism in the prelimbic cortex blocks the reinstatement of heroin-seeking in an animal model of relapse
    Ronald E See
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
    Int J Neuropsychopharmacol 12:431-6. 2009
    ..These results suggest that DA D1 receptors regulate prefrontal cortex pathways necessary for the reinstatement of heroin-seeking...
  41. ncbi request reprint In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrier
    Kyle P Kokko
    Department of Pharmaceutical Sciences, The Medical University of South Carolina, 280 Calhoun Street, P O Box 250140, Charleston, SC 29425, USA
    Neuropharmacology 48:417-25. 2005
    ..KK13 is thus the first NT[8-13] analogue described to date that demonstrates inhibition of amphetamine-induced hyperlocomotion without inducing catalepsy while maintaining day-to-day hypothermic potency...
  42. pmc Prenatal stress enhances responsiveness to cocaine
    Tod E Kippin
    Department of Psychology, The Neuroscience Research Institute, University of California, Santa Barbara, CA 93106 9660, USA
    Neuropsychopharmacology 33:769-82. 2008
    ..Thus, early environmental factors contribute to an individual's initial responsiveness to cocaine and propensity to relapse to cocaine-seeking...
  43. ncbi request reprint The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seeking
    Rita A Fuchs
    Department of Psychology, University of North Carolina at Chapel Hill, 27599, USA
    Eur J Neurosci 23:2809-13. 2006
    ....
  44. ncbi request reprint Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats
    M Scott Bowers
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
    Psychopharmacology (Berl) 195:397-406. 2007
    ..Acamprosate (calcium acetylhomotaurinate) is a glutamatergic neuromodulator used for the treatment of alcoholism, but its potential efficacy in the treatment of psychostimulant addiction has not been explored...

Research Grants20

  1. Interdisciplinary Medication Development for Multiple Risk Factors in Relapse
    RONALD SEE; Fiscal Year: 2007
    ....
  2. Translational Research in Addiction Center
    RONALD SEE; Fiscal Year: 2007
    ..abstract_text> ..
  3. Striatal mechanisms of relapse to cocaine seeking
    Ronald E See; Fiscal Year: 2010
    ..Information gained from this project will provide direction for development of anti-relapse medications for the treatment of cocaine dependence, as well as other drugs of abuse. ..
  4. Basolateral amygdala-a substrate for relapse
    RONALD SEE; Fiscal Year: 2006
    ..Information gained from this project will provide direction for development of treatments for craving and for preventing relapse. ..
  5. BASOLATERAL AMYGDALA--A SUBSTRATE FOR RELAPSE
    RONALD SEE; Fiscal Year: 2001
    ..the questions addressed in this proposal can only be answered by utilizing an animal model such as that proposed here. ..
  6. PALLIDAL GABA AND ATYPICALITY OF ANTIPSYCHOTIC DRUGS
    RONALD SEE; Fiscal Year: 2002
    ..The information obtained will facilitate the development of optimal pharmacotherapy for mental disorders, particularly schizophrenia. ..
  7. Interdisciplinary Medication Development for Multiple Risk Factors in Relapse
    Ronald E See; Fiscal Year: 2010
    ....