Research Topics
| RONALD SEESummaryAffiliation: Medical University of South Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Orexin-1 receptor mediation of cocaine seeking in male and female ratsLuyi Zhou
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
J Pharmacol Exp Ther 340:801-9. 2012..These results show that OX1R signaling plays a role in mediating cocaine seeking, but differs between the sexes for cue-induced reinstatement...
The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in ratsR E See
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Psychopharmacology (Berl) 194:321-31. 2007..Recent studies have implicated an important role for the dorsal striatum during craving for cocaine and in cocaine-seeking after abstinence in rats...- The importance of a compound stimulus in conditioned drug-seeking behavior following one week of extinction from self-administered cocaine in ratsR E See
Department of Psychology and Program in Neuroscience, Washington State University, Pullman 99164 4820, USA
Drug Alcohol Depend 57:41-9. 1999..These findings suggest that compound stimuli may be critical to fully activate drug-seeking behavior in conditions of craving and relapse following prolonged extinction... - Drug addiction, relapse, and the amygdalaRonald E See
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann N Y Acad Sci 985:294-307. 2003..Together, these results reveal the importance of the amygdala as part of a corticolimbic circuit mediating both the acquisition and the expression of conditioning that plays a critical role in relapse to drug-seeking behavior... - Muscarinic receptor antagonism in the basolateral amygdala blocks acquisition of cocaine-stimulus association in a model of relapse to cocaine-seeking behavior in ratsR E See
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue BSB 416A, Charleston, SC 29425, USA
Neuroscience 117:477-83. 2003.... - Convergent evidence from microdialysis and presynaptic immunolabeling for the regulation of gamma-aminobutyric acid release in the globus pallidus following acute clozapine or haloperidol administration in ratsRonald E See
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
J Neurochem 82:172-80. 2002..This decrease in released pallidal GABA may play a role in the low motor side-effect liability of atypical APDs... - Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behaviorR E See
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Psychopharmacology (Berl) 154:301-10. 2001..However, the specific neurotransmitters involved in conditioned reinstatement remain to be determined... - Neural substrates of conditioned-cued relapse to drug-seeking behaviorRonald E See
Department of Physiology and Neuroscience, 173 Ashley Avenue, BSB 416A, Medical University of South Carolina, Charleston, SC 29425, USA
Pharmacol Biochem Behav 71:517-29. 2002..Future studies aimed at discerning the functional roles of these pathways will provide critical direction for the development of treatments for the prevention of relapse... - Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seekingCarmela M Reichel
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
J Pharmacol Exp Ther 337:487-93. 2011..These results support recent preclinical and clinical findings that NAC may serve as an effective treatment for inhibiting relapse in cocaine addicts... - Neural substrates of cocaine-cue associations that trigger relapseRonald E See
Department of Neurosciences, 173 Ashley Avenue, BSB 416, Medical University of South Carolina, Charleston, 29425, USA
Eur J Pharmacol 526:140-6. 2005..Taken together, these results reveal the importance of the amygdala in the acquisition, consolidation, and expression of drug-stimulus learning that drives relapse to drug-seeking behavior... - Aripiprazole blocks reinstatement of cocaine seeking in an animal model of relapseMatthew W Feltenstein
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Biol Psychiatry 61:582-90. 2007..Based on pharmacologic properties that include a stabilization of mesocorticolimbic DA activity, a pathway implicated in addiction, aripiprazole was tested for its ability to prevent relapse to cocaine seeking in rats... - Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatumMarek Schwendt
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Neuroreport 18:1261-5. 2007..Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking... - A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in ratsWilliam J Berglind
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Eur J Neurosci 26:757-66. 2007.... - Potentiated reinstatement of cocaine-seeking behavior following D-amphetamine infusion into the basolateral amygdalaChristopher C Ledford
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
Neuropsychopharmacology 28:1721-9. 2003..These findings suggest that enhanced monoamine tone in the BLA potentiates the motivational effect and/or salience of cocaine-paired cues during reinstatement... - Footshock stress potentiates cue-induced cocaine-seeking in an animal model of relapseDeanne M Buffalari
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Physiol Behav 98:614-7. 2009..Dual targeting of stress and cues is thus a critical consideration for treatment intervention in abstinent drug users... - Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamenRita A Fuchs
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 26:3584-8. 2006.... - Selective inactivation of the ventral hippocampus attenuates cue-induced and cocaine-primed reinstatement of drug-seeking in ratsJason L Rogers
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Neurobiol Learn Mem 87:688-92. 2007..These data indicate that the ventral hippocampus plays an important role in the relapse to cocaine-seeking behavior and may interact with key limbic structures previously implicated in cocaine addiction... - Yohimbine stress potentiates conditioned cue-induced reinstatement of heroin-seeking in ratsKelly M Banna
Department of Neurosciences, Medical University of South Carolina, BSB416B, 173 Ashley Avenue, Charleston, SC 29425, USA
Behav Brain Res 208:144-8. 2010..These results demonstrate that exposure to heroin-paired cues during yohimbine-induced stress greatly potentiates heroin-seeking, and support the simultaneous targeting of both stress and cue activation during relapse intervention... 
Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbensDevadoss J Samuvel
Division of Neuroscience Research, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
J Pharmacol Exp Ther 325:293-301. 2008....- A comparison of the effects of different operant training experiences and dietary restriction on the reinstatement of cocaine-seeking in ratsMichele Bongiovanni
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Pharmacol Biochem Behav 89:227-33. 2008..The results arguably support the approach of not using prior lever training with a non-drug reinforcer and to limit the use of dietary restriction only to the acquisition phase of drug self-administration... - Potentiation of cue-induced reinstatement of cocaine-seeking in rats by the anxiogenic drug yohimbineMatthew W Feltenstein
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Behav Brain Res 174:1-8. 2006..These results demonstrate that exposure to drug-paired cues during a stressful state can greatly potentiate cocaine-seeking and suggest that future treatment interventions should target multiple modalities... - Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in ratsJoselyn McLaughlin
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Psychopharmacology (Berl) 168:57-65. 2003.... - Attenuation of cocaine-seeking by progesterone treatment in female ratsMatthew W Feltenstein
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Psychoneuroendocrinology 34:343-52. 2009..Taken together, these results suggest that progesterone may be a useful therapeutic for preventing relapse in abstinent female cocaine users, especially when the likelihood of relapse is greatest... - Conditioned stimulus-induced reinstatement of extinguished cocaine seeking in C57BL/6 mice: a mouse model of drug relapseRita A Fuchs
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Ave, Suite 403, Charleston, SC 29425, USA
Brain Res 973:99-106. 2003.... - Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletionMarek Schwendt
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Pharmacol Exp Ther 331:555-62. 2009..Greater understanding of the neuroadaptations underlying persistent methamphetamine seeking and cognitive deficits could yield targets suitable for future therapeutic interventions... - Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seekingRachel J Smith
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425 5100, USA
Eur J Neurosci 30:493-503. 2009.... - Repeated aripiprazole administration attenuates cocaine seeking in a rat model of relapseMatthew W Feltenstein
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Psychopharmacology (Berl) 207:401-11. 2009.... - Potentiation of cocaine-primed reinstatement of drug seeking in female rats during estrusTod E Kippin
Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
Psychopharmacology (Berl) 182:245-52. 2005..CONCLUSIONS: Estrus females display heightened sensitivity to the motivational and/or stimulant effects of cocaine, suggesting that hormonal state modulates drug craving and propensity for drug relapse in cocaine addicts... - NMDA receptor blockade in the basolateral amygdala disrupts consolidation of stimulus-reward memory and extinction learning during reinstatement of cocaine-seeking in an animal model of relapseMatthew W Feltenstein
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Neurobiol Learn Mem 88:435-44. 2007..These results suggest that NMDA receptor-mediated mechanisms within the BLA play a crucial role in the consolidation of drug-CS associations into long-term memories that, in turn, drive cocaine-seeking during relapse... - Basolateral amygdala inactivation abolishes conditioned stimulus- and heroin-induced reinstatement of extinguished heroin-seeking behavior in ratsRita A Fuchs
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Psychopharmacology (Berl) 160:425-33. 2002..Furthermore, different neural substrates may mediate drug-primed relapse to cocaine versus heroin-seeking behavior... - Influence of sex and estrous cyclicity on conditioned cue-induced reinstatement of cocaine-seeking behavior in ratsRita A Fuchs
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Psychopharmacology (Berl) 179:662-72. 2005..Furthermore, the role of estrous cyclicity in conditioned-cued relapse has not been investigated... - The role of the dorsomedial prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in ratsRita A Fuchs
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
Neuropsychopharmacology 30:296-309. 2005..Thus, distinct but partially overlapping neural substrates mediate context-induced, explicit CS-induced, and cocaine-primed reinstatement of extinguished cocaine-seeking behavior... - Amygdala mechanisms of Pavlovian psychostimulant conditioning and relapseDeanne M Buffalari
Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA
Curr Top Behav Neurosci 3:73-99. 2010.... - Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in ratsRita A Fuchs
Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci 24:6600-10. 2004.... - Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in ratsSammanda Ramamoorthy
Department of Neurosciences, Division of Neuroscience Research, Medical University of South Carolina, Charleston, SC 29425, USA
Biochem Biophys Res Commun 391:1517-21. 2010..Such changes may be related to habitual patterns of cocaine-seeking observed during relapse... - Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in ratsRita A Fuchs
Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Psychopharmacology (Berl) 176:459-65. 2004..Thus, determination of the involvement of NAC subregions in conditioned cue-induced reinstatement of cocaine seeking is warranted... - Contributions of prolonged contingent and noncontingent cocaine exposure to enhanced reinstatement of cocaine seeking in ratsTod E Kippin
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Psychopharmacology (Berl) 187:60-7. 2006..Specifically, conditioned-cued reinstatement is enhanced by increased cocaine intake and cocaine-primed reinstatement is enhanced by increased cocaine taking... - Anti-relapse medications: preclinical models for drug addiction treatmentNoushin Yahyavi-Firouz-Abadi
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
Pharmacol Ther 124:235-47. 2009..Finally, based on recent advances in our understanding of the neurobiology of relapse and published preclinical data, we highlight the most promising areas for future anti-relapse medication development... - Plasma progesterone levels and cocaine-seeking in freely cycling female rats across the estrous cycleMatthew W Feltenstein
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Drug Alcohol Depend 89:183-9. 2007..Overall, these results suggest that progesterone administration may be a useful intervention for reducing the incidence of relapse... - Dopamine D1 receptor antagonism in the prelimbic cortex blocks the reinstatement of heroin-seeking in an animal model of relapseRonald E See
Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA
Int J Neuropsychopharmacol 12:431-6. 2009..These results suggest that DA D1 receptors regulate prefrontal cortex pathways necessary for the reinstatement of heroin-seeking... - In vivo behavioral effects of stable, receptor-selective neurotensin[8-13] analogues that cross the blood-brain barrierKyle P Kokko
Department of Pharmaceutical Sciences, The Medical University of South Carolina, 280 Calhoun Street, P.O. Box 250140, Charleston, SC 29425, USA
Neuropharmacology 48:417-25. 2005..KK13 is thus the first NT[8-13] analogue described to date that demonstrates inhibition of amphetamine-induced hyperlocomotion without inducing catalepsy while maintaining day-to-day hypothermic potency... - Prenatal stress enhances responsiveness to cocaineTod E Kippin
Department of Psychology, The Neuroscience Research Institute, University of California, Santa Barbara, CA 93106 9660, USA
Neuropsychopharmacology 33:769-82. 2008..Thus, early environmental factors contribute to an individual's initial responsiveness to cocaine and propensity to relapse to cocaine-seeking... - The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seekingRita A Fuchs
Department of Psychology, University of North Carolina at Chapel Hill, 27599, USA
Eur J Neurosci 23:2809-13. 2006.... - Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in ratsM Scott Bowers
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, Emeryville, CA 94608, USA
Psychopharmacology (Berl) 195:397-406. 2007..Acamprosate (calcium acetylhomotaurinate) is a glutamatergic neuromodulator used for the treatment of alcoholism, but its potential efficacy in the treatment of psychostimulant addiction has not been explored...
Research Grants
- Interdisciplinary Medication Development for Multiple Risk Factors in RelapseRONALD SEE; Fiscal Year: 2007....
- Translational Research in Addiction CenterRONALD SEE; Fiscal Year: 2007..abstract_text> ..
- Striatal mechanisms of relapse to cocaine seekingRonald E See; Fiscal Year: 2010..Information gained from this project will provide direction for development of anti-relapse medications for the treatment of cocaine dependence, as well as other drugs of abuse. ..
- Basolateral amygdala-a substrate for relapseRONALD SEE; Fiscal Year: 2006..Information gained from this project will provide direction for development of treatments for craving and for preventing relapse. ..
- BASOLATERAL AMYGDALA--A SUBSTRATE FOR RELAPSERONALD SEE; Fiscal Year: 2001..the questions addressed in this proposal can only be answered by utilizing an animal model such as that proposed here. ..
- PALLIDAL GABA AND ATYPICALITY OF ANTIPSYCHOTIC DRUGSRONALD SEE; Fiscal Year: 2002..The information obtained will facilitate the development of optimal pharmacotherapy for mental disorders, particularly schizophrenia. ..
- Interdisciplinary Medication Development for Multiple Risk Factors in RelapseRonald E See; Fiscal Year: 2010....