Nita Salzman

Summary

Affiliation: Medical College of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Dysbiosis--a consequence of Paneth cell dysfunction
    Nita H Salzman
    Division of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States Electronic address
    Semin Immunol 25:334-41. 2013
  2. pmc Paneth cell defensins and the regulation of the microbiome: détente at mucosal surfaces
    Nita H Salzman
    Division of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
    Gut Microbes 1:401-6. 2010
  3. pmc Microbiota-immune system interaction: an uneasy alliance
    Nita H Salzman
    Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Curr Opin Microbiol 14:99-105. 2011
  4. pmc Enteric defensins are essential regulators of intestinal microbial ecology
    Nita H Salzman
    Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Nat Immunol 11:76-83. 2010
  5. ncbi request reprint Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria
    Nita H Salzman
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Microbiology 148:3651-60. 2002
  6. pmc Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression
    Nita H Salzman
    Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Infect Immun 71:1109-15. 2003
  7. pmc Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract
    Melissa Barman
    Division of Gastroenterology, Department of Pediatrics, The Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Infect Immun 76:907-15. 2008
  8. ncbi request reprint Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
    Nita H Salzman
    Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nature 422:522-6. 2003
  9. pmc Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection
    Amy Croswell
    Department of Pediatrics, Division of Gastroenterology, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Infect Immun 77:2741-53. 2009
  10. doi request reprint Negative interactions with the microbiota: IBD
    Nita H Salzman
    Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI, USA
    Adv Exp Med Biol 635:67-78. 2008

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Dysbiosis--a consequence of Paneth cell dysfunction
    Nita H Salzman
    Division of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States Electronic address
    Semin Immunol 25:334-41. 2013
    ..These findings suggest that Paneth cell dysfunction should be considered a common cause of dysbiosis. ..
  2. pmc Paneth cell defensins and the regulation of the microbiome: détente at mucosal surfaces
    Nita H Salzman
    Division of Gastroenterology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
    Gut Microbes 1:401-6. 2010
    ....
  3. pmc Microbiota-immune system interaction: an uneasy alliance
    Nita H Salzman
    Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Curr Opin Microbiol 14:99-105. 2011
    ....
  4. pmc Enteric defensins are essential regulators of intestinal microbial ecology
    Nita H Salzman
    Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Nat Immunol 11:76-83. 2010
    ..Our data ascribe a new homeostatic role to alpha-defensins in regulating the makeup of the commensal microbiota...
  5. ncbi request reprint Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria
    Nita H Salzman
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Microbiology 148:3651-60. 2002
    ....
  6. pmc Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression
    Nita H Salzman
    Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Infect Immun 71:1109-15. 2003
    ..Salmonella may gain a specific survival advantage in the intestinal lumen by decreasing the expression of microbicidal peptides in Paneth cells through direct interactions between Salmonella and the small intestinal epithelium...
  7. pmc Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract
    Melissa Barman
    Division of Gastroenterology, Department of Pediatrics, The Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Infect Immun 76:907-15. 2008
    ..These data suggest that several Salmonella virulence factors, particularly those involved in the local mucosal host response, are required for disruption of the intestinal ecosystem...
  8. ncbi request reprint Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
    Nita H Salzman
    Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nature 422:522-6. 2003
    ..HD-5 transgenic mice were markedly resistant to oral challenge with virulent Salmonella typhimurium. These findings provide support for a critical in vivo role of epithelial-derived defensins in mammalian host defence...
  9. pmc Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection
    Amy Croswell
    Department of Pediatrics, Division of Gastroenterology, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Infect Immun 77:2741-53. 2009
    ....
  10. doi request reprint Negative interactions with the microbiota: IBD
    Nita H Salzman
    Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI, USA
    Adv Exp Med Biol 635:67-78. 2008
    ....
  11. pmc A central role for induced regulatory T cells in tolerance induction in experimental colitis
    Dipica Haribhai
    Department of Pediatrics, Section of Rheumatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 182:3461-8. 2009
    ..These results identified a functional role for iT(reg) cells in vivo and demonstrated that both iT(reg) and nT(reg) cells can act in concert to maintain tolerance...
  12. ncbi request reprint Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa
    Nita H Salzman
    Department of Pediatrics, Division of Gastroenterology, The Medical College of Wisconsin, 8701 Watertown Plank Rd Milwaukee, WI 53226, USA
    Semin Immunol 19:70-83. 2007
    ....
  13. pmc A randomized placebo-controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short-chain fatty acids
    Mark A Underwood
    Department of Pediatrics, University of California, Davis, 95616, USA
    J Pediatr Gastroenterol Nutr 48:216-25. 2009
    ..To compare the effect of 2 prebiotic/probiotic products on weight gain, stool microbiota, and stool short-chain fatty acid (SCFA) content of premature infants...
  14. pmc Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    Jan Wehkamp
    Department of Microbiology and Immunology, School of Medicine, University of California, Davis, 95616, USA
    Proc Natl Acad Sci U S A 102:18129-34. 2005
    ..Thus, the specific deficiency of PC defensins that characterizes ileal CD may compromise innate immune defenses of the ileal mucosa and initiate and/or perpetuate this disease...
  15. pmc Prolonged colonization of mice by Vibrio cholerae El Tor O1 depends on accessory toxins
    Verena Olivier
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Infect Immun 75:5043-51. 2007
    ....

Research Grants5