Mohamed Labib Salem

Summary

Affiliation: Medical University of South Carolina
Country: USA

Publications

  1. pmc Poly-N-acetyl glucosamine gel matrix as a non-viral delivery vector for DNA-based vaccination
    Mohamed L Salem
    Zoology Department, Faculty of Science, Tanta University, Egypt
    Anticancer Res 30:3889-94. 2010
  2. pmc Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivo
    Mohamed L Salem
    Surgery Department and Hollings Cancer Center, Medical University of South Carolina, Charleston, 29425, USA
    Cell Immunol 261:134-43. 2010
  3. pmc Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination
    Mohamed Labib Salem
    Surgery Department, Medical University of South Carolina, Charleston, 29425, USA
    Cancer Immunol Immunother 59:341-53. 2010
  4. pmc Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C)
    Mohamed L Salem
    Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Immunol 182:2030-40. 2009
  5. pmc Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells
    Mohamed L Salem
    Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Immunol 184:1737-47. 2010
  6. ncbi request reprint Defining the ability of cyclophosphamide preconditioning to enhance the antigen-specific CD8+ T-cell response to peptide vaccination: creation of a beneficial host microenvironment involving type I IFNs and myeloid cells
    Mohamed L Salem
    Department of Surgery, Section of Surgical Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, USA
    J Immunother 30:40-53. 2007
  7. ncbi request reprint Review: novel nonviral delivery approaches for interleukin-12 protein and gene systems: curbing toxicity and enhancing adjuvant activity
    Mohamed Labib Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Interferon Cytokine Res 26:593-608. 2006
  8. ncbi request reprint The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu
    Mohamed L Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    Vaccine 24:5119-32. 2006
  9. ncbi request reprint Immunomodulatory and therapeutic properties of the Nigella sativa L. seed
    Mohamed Labib Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    Int Immunopharmacol 5:1749-70. 2005
  10. ncbi request reprint Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity
    Mohamed L Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Immunother 28:220-8. 2005

Collaborators

Detail Information

Publications24

  1. pmc Poly-N-acetyl glucosamine gel matrix as a non-viral delivery vector for DNA-based vaccination
    Mohamed L Salem
    Zoology Department, Faculty of Science, Tanta University, Egypt
    Anticancer Res 30:3889-94. 2010
    ..This vector is fully biocompatible, biodegradable, and nontoxic. The advantage of the application of this delivery system relative to other approaches is discussed...
  2. pmc Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivo
    Mohamed L Salem
    Surgery Department and Hollings Cancer Center, Medical University of South Carolina, Charleston, 29425, USA
    Cell Immunol 261:134-43. 2010
    ..Taken together, post CTX BM harbors higher numbers of DC precursors capable of differentiating into functional DCs, which be targeted to create host microenvironment riches in activated DCs upon treatment with TLR agonists...
  3. pmc Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination
    Mohamed Labib Salem
    Surgery Department, Medical University of South Carolina, Charleston, 29425, USA
    Cancer Immunol Immunother 59:341-53. 2010
    ....
  4. pmc Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C)
    Mohamed L Salem
    Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Immunol 182:2030-40. 2009
    ..In conclusion, our data show that CTX treatment induces, during the restoration phase, expansion of immature DCs, which are functional and can be exploited in vivo to foster more effective antitumor adoptive immunotherapy strategies...
  5. pmc Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells
    Mohamed L Salem
    Department of Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Immunol 184:1737-47. 2010
    ..Targeting DCs at these phases would significantly improve their contribution to the clinical application of lymphodepletion to adoptive immunotherapy...
  6. ncbi request reprint Defining the ability of cyclophosphamide preconditioning to enhance the antigen-specific CD8+ T-cell response to peptide vaccination: creation of a beneficial host microenvironment involving type I IFNs and myeloid cells
    Mohamed L Salem
    Department of Surgery, Section of Surgical Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, USA
    J Immunother 30:40-53. 2007
    ..Specific targeting of these components may enhance the effectiveness of CTX preconditioning for adoptive immunotherapy...
  7. ncbi request reprint Review: novel nonviral delivery approaches for interleukin-12 protein and gene systems: curbing toxicity and enhancing adjuvant activity
    Mohamed Labib Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Interferon Cytokine Res 26:593-608. 2006
    ..This article discusses the potential capabilities of these nonvirus-based IL-12 delivery systems in different disease settings, including allergy, infection, and cancer...
  8. ncbi request reprint The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu
    Mohamed L Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    Vaccine 24:5119-32. 2006
    ..We conclude that the adjuvant effects of poly (I:C) on antigen-specific CD8(+) T cells appeared to be exquisitely dependent on the rapid induction of certain beneficial cytokines produced in part by NK cells...
  9. ncbi request reprint Immunomodulatory and therapeutic properties of the Nigella sativa L. seed
    Mohamed Labib Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    Int Immunopharmacol 5:1749-70. 2005
    ..Ultimately, results emerging from such studies will substantially improve the immunotherapeutic application of TQ in clinical settings...
  10. ncbi request reprint Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity
    Mohamed L Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Immunother 28:220-8. 2005
    ..Collectively, these results confirm the potential of poly(I:C) as a vaccine adjuvant and suggest that targeting of TLR3 is likely to be a valuable addition to peptide-based vaccination strategies...
  11. ncbi request reprint Systemic treatment with n-6 polyunsaturated fatty acids attenuates EL4 thymoma growth and metastasis through enhancing specific and non-specific anti-tumor cytolytic activities and production of TH1 cytokines
    Mohamed Labib Salem
    Department of Surgery, Section of Surgical Oncology, Holling Cancer Center R313, Medical University of South Carolina, Charleston, SC 29425, USA
    Int Immunopharmacol 5:947-60. 2005
    ..These findings might be of great importance for a proper design of systemic nourishment with PUFAs emulsions for cancer patients...
  12. ncbi request reprint Estrogen, a double-edged sword: modulation of TH1- and TH2-mediated inflammations by differential regulation of TH1/TH2 cytokine production
    Mohamed Labib Salem
    Section of Surgical Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Curr Drug Targets Inflamm Allergy 3:97-104. 2004
    ..Such a concept is valuable when considering the application of combination therapies that include estrogen...
  13. ncbi request reprint Paracrine release of IL-12 stimulates IFN-gamma production and dramatically enhances the antigen-specific T cell response after vaccination with a novel peptide-based cancer vaccine
    Mohamed L Salem
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Immunol 172:5159-67. 2004
    ..Collectively, the results support the potential of F2 gel matrix as a vaccine delivery system and suggest that sustained paracrine release of IL-12 has potential clinical application...
  14. ncbi request reprint Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells
    Mark P Rubinstein
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston 29425, USA
    J Immunol 169:4928-35. 2002
    ..These studies show for the first time that IL-15 is capable of augmenting the primary CD8(+) T cell response to vaccination and contribute to the basis for future experiments exploring the clinical role of IL-15...
  15. pmc The TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naïve recipient mice
    Mohamed L Salem
    Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt
    Vaccine 27:549-57. 2009
    ..These results suggest that CD8+ T cells can be activated by triggering their TLR3. Furthermore, the data support the notion of direct involvement of TLRs in adaptive immune responses...
  16. ncbi request reprint Using poly-N-acetyl glucosamine gel matrix to deliver IL-12 with anti-schistosomasis vaccination
    Mohamed Labib Salem
    Medical University of South Carolina, Charleston, SC, USA
    J Infect Dev Ctries 4:318-28. 2010
    ..The main aim of this study was to use a mouse model to test whether IL-12 released from F2 gel can induce adjuvant effects in the schistosomiasis setting as compared to those obtained after systemic delivery of IL-12...
  17. ncbi request reprint Mechanisms of enhanced antigen-specific T cell response following vaccination with a novel peptide-based cancer vaccine and systemic interleukin-2 (IL-2)
    Christophe L Nguyen
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Room 420P, 96 Jonathan Lucas Street, PO Box 250613, Charleston, SC 29425, USA
    Vaccine 21:2318-28. 2003
    ....
  18. pmc Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    C Marcela Diaz-Montero
    Department of Surgery, Medical University of South Carolina, Hollings Cancer Center, Charleston, SC, USA
    Cancer Immunol Immunother 58:49-59. 2009
    ..This information must be incorporated into the design of future trials exploring immune-based therapeutic strategies. Pharmacologic modulation of MDSC should also be tested in future clinical trials...
  19. pmc Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model
    C Marcela Diaz-Montero
    Department of Surgery, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA
    Cancer Immunol Immunother 57:563-72. 2008
    ..Together, our results suggest that in vitro conditioning of naïve CD8+ T cells with IL-12 prior to ACT could significantly enhance their anti-tumor activity...
  20. ncbi request reprint Transfer of TCR genes into mature T cells is accompanied by the maintenance of parental T cell avidity
    Mark P Rubinstein
    Department of Surgery, Section of Surgical Oncology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Immunol 170:1209-17. 2003
    ..These results suggest that the inherent qualities of the TCR, as dictated by the coding sequence, are the most critical parameters in the generation of high-avidity T cells...
  21. doi request reprint Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses
    Mohamed Labib Salem
    Immunology and Biotechnology Unit, Department of Zoology, Tanta University, Egypt
    Immunol Lett 137:9-14. 2011
    ..This review article focuses on the potential role of TLR expression in T cells in their responses to vaccination regimen containing TLR agonists and how it can be modulated to optimize anti-tumor immunity...
  22. doi request reprint The potential use of Toll-like receptor agonists to restore the dysfunctional immunity induced by hepatitis C virus
    Mohamed L Salem
    Surgery Department and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA
    Cell Immunol 262:96-104. 2010
    ..In this review article, we will discuss potential approaches, focusing on the use of Toll-like receptor agonists, to block the suppressive effects of the regulatory cells and restore the stimulatory effects of DCs and NK cells...
  23. doi request reprint Correlation of viral load with bone marrow and hematological changes in pale patients with chronic hepatitis C virus
    Abdel Raouf Abou El Azm
    Department of Tropical Medicine and Infectious Diseases, Tanta University, Tanta, Egypt
    Arch Virol 157:1579-86. 2012
    ....
  24. ncbi request reprint A role for the peripheral blood fibrocyte in leishmaniasis?
    Dennis J Grab
    Trends Parasitol 20:12. 2004