Saigusa T, Dang Y, Mullick A, Yeh S, Zile M, Baicu C, et al. Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model. FASEB J. 2016;30:370-9 pubmed publisher
..These data suggest that Agt-ASO effectively attenuates intrarenal RAS and therefore can be a novel and effective agent for treating ADPKD. ..
Coaxum S, Blanton M, Joyner A, Akter T, Bell P, Luttrell L, et al. Epidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger. Am J Physiol Cell Physiol. 2014;307:C554-60 pubmed publisher
..These results suggest that EGF exerts mitogenic effects in the orpk cilia (-) cells via activation of growth-associated amiloride-sensitive NHEs and ERK. ..