M J Sadofsky

Summary

Affiliation: Medical College of Georgia
Country: USA

Publications

  1. ncbi The RAG proteins in V(D)J recombination: more than just a nuclease
    M J Sadofsky
    Medical College of Georgia, Institute of Molecular Medicine and Genetics, CB 2803, Augusta, GA 30912, USA
    Nucleic Acids Res 29:1399-409. 2001
  2. ncbi A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1
    X Mo
    Medical College of Georgia, Institute of Molecular Medicine and Genetics, CB 2803, Augusta, GA 30912, USA
    Nucleic Acids Res 28:1228-36. 2000
  3. ncbi Definition of a core region of RAG-2 that is functional in V(D)J recombination
    M J Sadofsky
    Laboratory of Molecular Biology, NIDDK, Bethesda, MD 20892
    Nucleic Acids Res 22:1805-9. 1994
  4. ncbi Expression and V(D)J recombination activity of mutated RAG-1 proteins
    M J Sadofsky
    Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892
    Nucleic Acids Res 21:5644-50. 1993
  5. ncbi Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2
    C J McMahan
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 158:2202-10. 1997
  6. ncbi A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination
    X Mo
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Mol Cell Biol 21:2038-47. 2001

Collaborators

Detail Information

Publications6

  1. ncbi The RAG proteins in V(D)J recombination: more than just a nuclease
    M J Sadofsky
    Medical College of Georgia, Institute of Molecular Medicine and Genetics, CB 2803, Augusta, GA 30912, USA
    Nucleic Acids Res 29:1399-409. 2001
    ..Two proteins, RAG1 and RAG2, together form the nuclease that cleaves the DNA at the border of the signal sequences. Additional roles of these proteins in organizing the reaction complex for subsequent steps are explored...
  2. ncbi A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1
    X Mo
    Medical College of Georgia, Institute of Molecular Medicine and Genetics, CB 2803, Augusta, GA 30912, USA
    Nucleic Acids Res 28:1228-36. 2000
    ..We suggest that bends introduced into these DNA substrates at specific locations by the RAG proteins and HMG1 may help distinguish the 12RSS from the 23RSS and may therefore play an important role in the coordinated reaction...
  3. ncbi Definition of a core region of RAG-2 that is functional in V(D)J recombination
    M J Sadofsky
    Laboratory of Molecular Biology, NIDDK, Bethesda, MD 20892
    Nucleic Acids Res 22:1805-9. 1994
    ..Similar results were obtained with substrates that retain either a signal joint or a coding joint, or perform an inversion. Thus all basic features of V(D)J joining are retained in a RAG-2 protein with only the first 75% of the sequence...
  4. ncbi Expression and V(D)J recombination activity of mutated RAG-1 proteins
    M J Sadofsky
    Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD 20892
    Nucleic Acids Res 21:5644-50. 1993
    ..Transport of RAG-1 protein to the nucleus was found even with the most extensive deletions studied. The functionality of the deleted proteins is discussed with relation to an alignment of RAG-1 sequences from five animal species...
  5. ncbi Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2
    C J McMahan
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 158:2202-10. 1997
    ..A variety of other small deletion mutations within the amino acid region 504-1008 also decrease coimmunoprecipitation of RAG2 with RAG1, indicating that much or all of this region is important for complex formation...
  6. ncbi A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination
    X Mo
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    Mol Cell Biol 21:2038-47. 2001
    ..A trypsin cleavage pattern of the native protein supports this conclusion. A two-domain model for RAG1 is evaluated with respect to the larger recombination complex...