Research Topics
| Joseph RomagnuoloSummaryAffiliation: Medical University of South Carolina Country: USA Publications
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Publications
Designing clinical trials for NOTESJoseph Romagnuolo
Digestive Disease Center, Department of Medicine, Division of Gastroenterology and Hepatology, Medical University of South Carolina, 25 Courteney Drive, ART 7100A, MSC 290, Charleston, SC 29425, USA
Gastrointest Endosc Clin N Am 18:371-85; xi. 2008..The pros and cons of subjective quality of life outcomes are debated, and the role of the patient/consumer in driving the direction and interpretation of clinical trials is discussed...
Simple clinical variables predict liver histology in hepatitis C: prospective validation of a clinical prediction modelJoseph Romagnuolo
Digestive Disease Center, University of South Carolina, 96 Jonathon Lucas Street, PO Box 250 327, Charleston, SC 29425, USA
Scand J Gastroenterol 40:1365-71. 2005..Absence of predictors also predicted a lack of inflammation and fibrosis. Our aim was prospectively to validate this clinical prediction model using an independent multicenter sample...
Allopurinol to prevent pancreatitis after endoscopic retrograde cholangiopancreatography: a randomized placebo-controlled trialJoseph Romagnuolo
Digestive Disease Center, Department of Medicine, Medical University of South Carolina, South Carolina 29425, USA
Clin Gastroenterol Hepatol 6:465-71; quiz 371. 2008..The aim of this study was to determine if allopurinol decreases the rate of PEP...
Endoscopic "antireflux" procedures: not yet ready for prime timeJoseph Romagnuolo
Division of Gastroenterology, Department of Community Health Sciences, University of Calgary Medical Clinic, Calgary, Alberta, Canada
Can J Gastroenterol 18:573-7. 2004..Although they are promising, it is clear that these procedures are still in a preliminary study phase and not ready for "prime time" clinical use...
Post-endoscopy checklist reduces length of stay for non-variceal upper gastrointestinal bleedingJoseph Romagnuolo
Department of Medicine Divisions of Department of Medicine Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, SC, USA
Int J Qual Health Care 17:249-54. 2005..Hypothesis: a detailed checklist addressing factors relevant to discharge planning would shorten hospital stay, when added to the procedure report...
Simple clinical predictors may obviate urgent endoscopy in selected patients with nonvariceal upper gastrointestinal tract bleedingJoseph Romagnuolo
Departments of Medicine and Biometry, Bioinformatics and Epidemiology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
Arch Intern Med 167:265-70. 2007..The aims of this study were to predict whether the modified BRS (mBRS) can predict (1) endoscopic high-risk stigmata (HRS) and (2) rebleeding and mortality...
Utility of endoscopic ultrasound, cytology and fluid carcinoembryonic antigen and CA 19-9 levels in pancreatic cystic lesionsAbdulrahman M Aljebreen
Director of Clinical Research, Medical University of South Carolina MUSC, Digestive Disease Center, 96 Jonathon Lucas St, CSB 210, PO Box 250 327 Charleston, SC 29425 USA
World J Gastroenterol 13:3962-6. 2007..To assess the diagnostic accuracy of endoscopic ultrasound (EUS), fluid tumor markers and cytology in distinguishing benign from (pre)malignant pancreatic cystic lesions...
Accuracy of contrast-enhanced harmonic EUS with a second-generation perflutren lipid microsphere contrast agent (with video)Joseph Romagnuolo
Department of Medicine, Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Gastrointest Endosc 73:52-63. 2011..EUS-FNA has limitations in cancer diagnosis/staging. New contrast agents, transducers, and processors have improved the potential of contrast-enhanced harmonic (CEH)-EUS...
Long-term clinical outcomes after endoscopic minor papilla therapy in symptomatic patients with pancreas divisumGregory D Borak
Division of Gastroenterology and Hepatology, Digestive Disease Center, Medical University of South Carolina, Charleston, SC 29425, USA
Pancreas 38:903-6. 2009..To assess the long-term outcomes of endoscopic minor papilla therapy in a spectrum of symptomatic patients with pancreas divisum...
Influence of race and sex on prevalence and recurrence of colon polypsEli Penn
Digestive Disease Center, Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425 2900, USA
Arch Intern Med 170:1127-32. 2010..We sought to validate these observations and assess whether the increase in CRC in AAs is owing to polyp prevalence or incidence differences vs other factors...
Endoscopic pancreatic sphincterotomy for pancreas divisum by using a needle-knife or standard pull-type technique: safety and reintervention ratesAugustin Attwell
Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, 1501 The Vanderbilt Clinic, Nashville, TN 37232, USA
Gastrointest Endosc 64:705-11. 2006..41) (both P < .01). CONCLUSIONS: NKS is used more than PTS for minor papilla sphincterotomy at our institution, but the 2 techniques appear equally safe and effective. Younger age may be associated with higher reintervention rates...
Chronic calcific pancreatitis: combination ERCP and extracorporeal shock wave lithotripsy for pancreatic duct stonesChristopher Lawrence
Division of Gastroenterology, Medical University of South Carolina, College of Medicine, Charleston, SC 29425 2900, USA
South Med J 103:505-8. 2010..Our aim was to examine the outcomes of the first 30 patients with symptomatic pancreatic stones treated with a combination of ESWL and endoscopic therapies...
Noninvasive vs. selective invasive biliary imaging for acute biliary pancreatitis: an economic evaluation by using decision tree analysisJoseph Romagnuolo
Medical University of South Carolina, Charleston, SC 29425, USA
Gastrointest Endosc 61:86-97. 2005..In nonsevere ABP, it is slightly more costly but is associated with fewer ERCPs and ERCP-related complications. A randomized trial would help to quantify the benefits of avoiding ERCP in these patients...
International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleedingAlan N Barkun
Division of Gastroenterology, Montreal General Hospital Site, McGill University Health Centre, Montreal, Quebec, Canada
Ann Intern Med 152:101-13. 2010..A multidisciplinary group of 34 experts from 15 countries developed this update and expansion of the recommendations on the management of acute nonvariceal upper gastrointestinal bleeding (UGIB) from 2003...
EUS in patients with surgically altered upper GI anatomyJason A Wilson
Digestive Disease Center, Department of Medicine, Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina, USA
Gastrointest Endosc 72:947-53. 2010..Information regarding the safety and feasibility of EUS-guided FNA (EUS/FNA) in surgically altered anatomy is limited...
Is routine second-look endoscopy effective after endoscopic hemostasis in acute peptic ulcer bleeding? A meta-analysisSara El Ouali
Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada
Gastrointest Endosc 76:283-92. 2012..Routine second-look endoscopy in modern-era peptic ulcer bleeding (PUB) remains controversial...
A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitisB Joseph Elmunzer
Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
N Engl J Med 366:1414-22. 2012..Preliminary research suggests that rectally administered nonsteroidal antiinflammatory drugs may reduce the incidence of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP)...
Post-ERCP pancreatitis rates do not differ between needle-knife and pull-type pancreatic sphincterotomy techniques: a multiendoscopist 13-year experienceChristopher Lawrence
Medical University of South Carolina, Charleston, South Carolina 29425, USA
Gastrointest Endosc 69:1271-5. 2009..The needle-knife pancreatic sphincterotomy technique (NKS) is purported to result in less-frequent post-ERCP pancreatitis compared with a standard pull-type sphincterotomy (PTS)...
Miss rate of pancreas divisum by magnetic resonance cholangiopancreatography in clinical practiceMatthew L Carnes
Division of Gastroenterology Hepatology, Digestive Disease Center, Medical University of South Carolina, Charleston, SC 29425 2900, USA
Pancreas 37:151-3. 2008..Magnetic resonance cholangiopancreatography has emerged as a noninvasive method of examining the pancreatic ductal anatomy. We aim to assess the sensitivity of MRCP for pancreas divisum...
Endoscopic ultrasound: a meta-analysis of test performance in suspected biliary obstructionDonald Garrow
Division of General Internal Medicine, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Clin Gastroenterol Hepatol 5:616-23. 2007..It appears comparable to MRCP (magnetic resonance cholangiopancreatography), although its use is less widely disseminated. We aimed to summarize EUS test performance in suspected biliary disease with meta-analysis...
Low symptomatic premature stent occlusion of multiple plastic stents for benign biliary strictures: comparing standard and prolonged stent change intervalsChristopher Lawrence
Medical University of South Carolina, Charleston, South Carolina 29425, USA
Gastrointest Endosc 72:558-63. 2010..Stents are often changed every 3 to 4 months based on the known median patency of a single biliary stent, but patency data for multiple biliary stents are lacking...
Patterns of use of endoscopic retrograde cholangiopancreatography in a Canadian provinceRobert J Hilsden
Department of Medicine, University of Calgary, Calgary, Alberta, Canada
Can J Gastroenterol 18:619-24. 2004..Data on current endoscopic retrograde cholangiopancreatography (ERCP) practice patterns drawn from large population-based samples are limited...
Measuring episodic abdominal pain and disability in suspected sphincter of Oddi dysfunctionValerie Durkalski
Division of Biostatistics and Epidemiology, Medical University of South Carolina, Charleston, 135 Cannon Street, Ste 303, Charleston, SC 29425, United States
World J Gastroenterol 16:4416-21. 2010..To evaluate the reliability of an instrument that measures disability arising from episodic abdominal pain in patients with suspected sphincter of Oddi dysfunction (SOD)...
Poor patient knowledge regarding family history of colon polyps: implications for the feasibility of stratified screening recommendationsPooja Sukhwani Elias
Medical University of South Carolina, Digestive Disease Center, Charleston, South Carolina 29425, USA
Gastrointest Endosc 75:598-603. 2012..This information is then used to guide screening recommendations for these patients...
Effect of simply recording colonoscopy withdrawal time on polyp and adenoma detection ratesAndrew Taber
Digestive Diseases Center, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Gastrointest Endosc 71:782-6. 2010..Attempts have been made to increase the WT; however, simply knowing that a quality measure, such as the WT, is being monitored, by itself, may improve the quality of an examination...
Natural orifice transluminal endoscopic surgery versus laparoscopic surgery for inadvertent colon injury repair: feasibility, risk of abdominal adhesions, and peritoneal contamination in a porcine survival modelJoseph Romagnuolo
Division of Gastroenterology and Hepatology, Department of Medicine, Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Gastrointest Endosc 71:817-23. 2010..Adhesions are common after conventional surgery; natural orifice transluminal endoscopic surgery (NOTES) avoids peritoneal disruption and may reduce adhesions...
Canadian credentialing guidelines for esophagogastroduodenoscopyTerry Ponich
Division of Gastroenterology, University of Western Ontario, London, Canada
Can J Gastroenterol 22:349-54. 2008
Challenges in planning and initiating a randomized clinical study of sphincter of Oddi dysfunctionPeter B Cotton
Division of Gastroenterology and Hepatology, Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Gastrointest Endosc 72:986-91. 2010..The value of ERCP manometry with sphincterotomy is unproven and carries significant risks...
Conventional versus Rosemont endoscopic ultrasound criteria for chronic pancreatitis: comparing interobserver reliability and intertest agreementBruce Kalmin
Digestive Disease Center, Divission of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, South Dakota 29425, USA
Can J Gastroenterol 25:261-4. 2011..The Rosemont criteria (RC) were recently proposed by expert consensus to standardize endoscopic ultrasound (EUS) features and thresholds for diagnosing chronic pancreatitis (CP); however, they are cumbersome and are not validated...
Intraobserver agreement among endosonographers for endoscopic ultrasound features of chronic pancreatitis: a blinded multicenter studyJohn G Lieb
Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA
Pancreas 40:177-80. 2011..Assess intraobserver agreement among endosonographers for endoscopic ultrasound (EUS) features of chronic pancreatitis (CP)...
Feasibility, safety, and effectiveness of transcranial direct current stimulation for decreasing post-ERCP pain: a randomized, sham-controlled, pilot studyJeffrey J Borckardt
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Gastrointest Endosc 73:1158-64. 2011..No studies have examined the analgesic effects of tDCS immediately after surgical/endoscopic procedures. Endoscopy investigating abdominal pain, especially ERCP, can cause significant postprocedural pain...
Routine second look endoscopy: ineffective, costly and potentially misleadingJoseph Romagnuolo
Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
Can J Gastroenterol 18:401-4. 2004..Finally, the Forrest classification may provide dangerously misleading estimates of prognosis because it is being used out of context. This review critically analyzes routine second look endoscopy...
Cost-effectiveness of computerized tomographic colonography versus colonoscopy for colorectal cancer screeningSteven J Heitman
Department of Medicine, University of Calgary, Calgary, Alta
CMAJ 173:877-81. 2005..INTERPRETATION: At present, CT colonography cannot be recommended as a primary means of population-based colorectal cancer screening in Canada...
Infection after ERCP, and antibiotic prophylaxis: a sequential quality-improvement approach over 11 yearsPeter B Cotton
Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Gastrointest Endosc 67:471-5. 2008..Infection is a known complication of ERCP procedures, and the role of antibiotic prophylaxis is uncertain...
Risk factors for complications after ERCP: a multivariate analysis of 11,497 procedures over 12 yearsPeter B Cotton
Department of Medicine, Division of Gastroenterology and Hepatology, Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina 29425 2900, USA
Gastrointest Endosc 70:80-8. 2009..Complications of ERCP are an important concern. We sought to determine predictors of post-ERCP complications at our institution...
Admission hematocrit: a simple, useful and early predictor of severe pancreatitisS Ian Gan
Department of Medicine, Advanced Therapeutic Endoscopy Centre Group, University of Calgary, Calgary, Alberta, Canada
Dig Dis Sci 49:1946-52. 2004..Initial hematocrit appears to be an early, simple, and useful predictor of severe pancreatitis. A normal 24-hr hematocrit does not appear to alter the prediction made by the initial hematocrit...
Transduodenal sphincteroplasty in the management of sphincter of Oddi dysfunction and pancreas divisum in the modern eraKatherine A Morgan
Department of Surgery, Digestive Diseases Center, Medical University of South Carolina, Charleston, SC 29425, USA
J Am Coll Surg 206:908-14; discussion 914-7. 2008..A retrospective review of sphincter of Oddi dysfunction and pancreas divisum patients who underwent TS for refractory pain in a recent time period was undertaken...
Grading the complexity of endoscopic procedures: results of an ASGE working partyPeter B Cotton
Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina 29425 2900, USA
Gastrointest Endosc 73:868-74. 2011..The complexity of procedures also affects outcomes...
Verrucous carcinoma of the esophagus eluding multiple sets of endoscopic biopsies and endoscopic ultrasound: a case report and review of the literatureShane Devlin
Division of Gastroenterology, University of Calary, Calgary, Alberta, Canada
Can J Gastroenterol 18:459-62. 2004..Of the 20 cases that have been reported, this is the second to provide an endosonographic description and the first to describe a change in endoscopic appearance with acid suppression...
Inappropriate use of intravenous pantoprazole: extent of the problem and successful solutionsGilaad G Kaplan
Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
Clin Gastroenterol Hepatol 3:1207-14. 2005..However, a greater improvement in underspending than overspending meant that overall costs were unchanged. CONCLUSIONS: IV PPI was frequently prescribed inappropriately and incorrectly; simple maneuvers resulted in reductions in errors...
Medical or surgical therapy for erosive reflux esophagitis: cost-utility analysis using a Markov modelJoseph Romagnuolo
Division of Gastroenterology, Foothills Hospital, University of Calgary, Calgary, Alberta, Canada
Ann Surg 236:191-202. 2002..CONCLUSIONS: For patients with severe esophagitis, LNF is a cost-effective alternative to long-term maintenance therapy with proton pump inhibitors...
Magnetic resonance cholangiopancreatography: a meta-analysis of test performance in suspected biliary diseaseJoseph Romagnuolo
University of Calgary, Calgary, Alberta, Canada
Ann Intern Med 139:547-57. 2003..Magnetic resonance cholangiopancreatography (MRCP) is one of many newer noninvasive tests that can image the biliary tree...
Helical CT versus EUS with fine needle aspiration for celiac nodal assessment in patients with esophageal cancerJoseph Romagnuolo
Division of Gastroenterology, University of Calgary, Alberta, Canada
Gastrointest Endosc 55:648-54. 2002..CONCLUSIONS: Despite technological advances, helical CT still appears unreliable, mainly because of insensitivity, for the identification of inoperable T4 or metastatic involvement of celiac lymph node disease in esophageal cancer...
Predicting residual rectal adenocarcinoma in the surgical specimen after preoperative brachytherapy with endoscopic ultrasoundJoseph Romagnuolo
Division of Gastroenterology and Department of Community Health Science, University of Calgary, Calgary, Alberta, Canada
Can J Gastroenterol 18:435-40. 2004..However, external beam radiotherapy appears to decrease the accuracy of EUS from 85% to 40%. The aim of the present study was to prospectively evaluate the accuracy of EUS in assessing the response of rectal cancer to BT...
Preoperative hemoglobin A1c and postoperative glucose control in outcomes after gastric bypass for obesityMark Perna
Department of Surgery, Medical University of South Carolina, Charleston, South Carolina Electronic address
Surg Obes Relat Dis 8:685-90. 2012..Our objectives were to understand the predictive capacity of the preoperative HbA1c level in gastric bypass patients at a single university-based Bariatric Center of Excellence...
Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis: a prospective cohort studyDaniel K Mullady
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Gut 60:77-84. 2011..To compare patients with chronic pancreatitis (CP) with constant pain patterns to patients with CP with intermittent pain patterns...
Predictors of endoscopic findings after Roux-en-Y gastric bypassJason A Wilson
Department of Internal Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Gastroenterol 101:2194-9. 2006..Because a significant majority of marginal ulcers present within 12 months of surgery, it may be reasonable to consider prophylactic PPI therapy during this time period, especially for high risk patients...
Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretationJoseph Romagnuolo
Division of Gastroenterology, University of Calgary, Canada
Am J Gastroenterol 97:1113-26. 2002..Breath tests are valuable tools that are, in general, underutilized in evaluating dyspepsia and functional bloating and diarrhea, as well as suspected malabsorption, including lactose intolerance...
Gender-related changes in the pancreas detected by EUSAndré Kheng Ho Chong
Gastrointest Endosc 62:475. 2005
Postprocedural interpretation of endoscopic retrograde cholangiopancreatography by radiologyNitin Khanna
Department of Medicine Division of Gastroenterology, University of Western Ontario, London, Canada
Can J Gastroenterol 22:55-60. 2008..With the increase in the use of endoscopic retrograde cholangiopancreatography (ERCP) (necessitating real-time interpretation), it is unknown whether post-ERCP radiologist reporting is still necessary or helpful...
Cost-effectiveness of colorectal cancer screening with computed tomography colonography: the impact of not reporting diminutive lesionsJoseph Romagnuolo
Cancer 112:222. 2008
Interobserver agreement for EUS findings in familial pancreatic-cancer kindredsMark Topazian
Mayo Clinic, Rochester, Minnesota 55905, and University of Washington, Seattle, Washington, USA
Gastrointest Endosc 66:62-7. 2007..EUS is a promising modality for pancreatic-cancer screening in high-risk persons, including familial pancreatic-cancer (FPC) kindreds...
Canadian credentialing guidelines for endoscopic retrograde cholangiopancreatographyJohnathon Springer
St Joseph's Health Centre, Toronto, Canada
Can J Gastroenterol 22:547-51. 2008
Diagnostic performance of EUS for chronic pancreatitis: a comparison with histopathologyAndré Kheng Ho Chong
Gastroenterology Department, Fremantle Hospital, University of Western Australia, Fremantle, Western Australia, Australia
Gastrointest Endosc 65:808-14. 2007..EUS has been proposed as a minimally invasive and accurate test to detect chronic pancreatitis (CP)...
