Preeti B Rajesh

Summary

Affiliation: Medical College of Ohio
Country: USA

Publications

  1. ncbi request reprint Immunobiologic implication of RANTES in seminal plasma of fertile, infertile and immunoinfertile men
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Am J Reprod Immunol 44:197-204. 2000
  2. ncbi request reprint Contraceptive vaccines
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43614 5806, USA
    Drugs 65:593-603. 2005
  3. ncbi request reprint Gene knockouts that affect male fertility: novel targets for contraception
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Lab, Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Health Sciences Center, Morgantown, WV 26506 9186, USA
    Front Biosci (Landmark Ed) 14:3994-4007. 2009
  4. ncbi request reprint Sperm surface protein profiles of fertile and infertile men: search for a diagnostic molecular marker
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Arch Androl 43:173-81. 1999
  5. ncbi request reprint Identification of human sperm peptide sequence involved in egg binding for immunocontraception
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Biol Reprod 62:318-24. 2000
  6. ncbi request reprint Expression of alpha and gamma interferon receptors in the sperm cell
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Mol Reprod Dev 56:189-97. 2000
  7. ncbi request reprint Fertilization-related sperm antigens and their immunocontraceptive potentials
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Am J Reprod Immunol 44:41-6. 2000
  8. ncbi request reprint Antibodies to human sperm YLP12 peptide that is involved in egg binding inhibit human sperm capacitation/acrosome reaction
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Arch Androl 45:227-32. 2000
  9. ncbi request reprint Presence of antibodies to sperm YLP(12) synthetic peptide in sera and seminal plasma of immunoinfertile men
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, OH 43614, USA
    Mol Hum Reprod 7:21-6. 2001
  10. ncbi request reprint Inhibition of murine sperm-oolemma binding by antibodies to an oocyte membrane (OM) antigen: implication in contraceptive vaccine development
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Am J Reprod Immunol 45:52-61. 2001

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Immunobiologic implication of RANTES in seminal plasma of fertile, infertile and immunoinfertile men
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Am J Reprod Immunol 44:197-204. 2000
    ....
  2. ncbi request reprint Contraceptive vaccines
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43614 5806, USA
    Drugs 65:593-603. 2005
    ..Both the efficacy and the lack of immunotoxicity have been reasonably well demonstrated for this vaccine. The present studies focus on increasing the immunogenicity and efficacy of this birth control vaccine...
  3. ncbi request reprint Gene knockouts that affect male fertility: novel targets for contraception
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Lab, Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Health Sciences Center, Morgantown, WV 26506 9186, USA
    Front Biosci (Landmark Ed) 14:3994-4007. 2009
    ..The knockouts of only a few genes/proteins induced a specific effect on fertility without a serious side effect. These genes/proteins may provide novel targets for contraception/contraceptive vaccine development...
  4. ncbi request reprint Sperm surface protein profiles of fertile and infertile men: search for a diagnostic molecular marker
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Arch Androl 43:173-81. 1999
    ..The IASP molecule and its antibodies may provide molecular tools to differentiate between the normal and abnormal sperm, and, thus, may be useful markers for the diagnosis of male-factor infertility...
  5. ncbi request reprint Identification of human sperm peptide sequence involved in egg binding for immunocontraception
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Biol Reprod 62:318-24. 2000
    ....
  6. ncbi request reprint Expression of alpha and gamma interferon receptors in the sperm cell
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Mol Reprod Dev 56:189-97. 2000
    ..These findings may have implications in male infertility and antisperm contraceptive vaccine development...
  7. ncbi request reprint Fertilization-related sperm antigens and their immunocontraceptive potentials
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Am J Reprod Immunol 44:41-6. 2000
    ....
  8. ncbi request reprint Antibodies to human sperm YLP12 peptide that is involved in egg binding inhibit human sperm capacitation/acrosome reaction
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Arch Androl 45:227-32. 2000
    ..These data indicate that the YLP12 peptide sequence is involved in sperm capacitation / acrosome reaction, and may find clinical applications in the diagnosis and treatment of male infertility and immunocontraception...
  9. ncbi request reprint Presence of antibodies to sperm YLP(12) synthetic peptide in sera and seminal plasma of immunoinfertile men
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, OH 43614, USA
    Mol Hum Reprod 7:21-6. 2001
    ..The YLP(12) peptide may have applications in the specific diagnosis and treatment of male infertility and in contraceptive vaccine development...
  10. ncbi request reprint Inhibition of murine sperm-oolemma binding by antibodies to an oocyte membrane (OM) antigen: implication in contraceptive vaccine development
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Am J Reprod Immunol 45:52-61. 2001
    ..The present study was conducted to investigate the oocyte membrane protein(s) that is involved in sperm binding in the mouse, and whether or not it can be used for the development of a contraceptive vaccine...
  11. ncbi request reprint Molecular cloning and sequencing of cDNA encoding for human FA-1 antigen
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Mol Reprod Dev 63:256-68. 2002
    ..The sperm-specific human FA-1 recombinant antigen may find applications in immunocontraception, and diagnosis and treatment of immunoinfertility in humans...
  12. ncbi request reprint Passive immunization for immunocontraception: lessons learned from infectious diseases
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Health Education Building, Rm 211, Medical College of Ohio, 3055 Arlington Ave, Toledo, OH 43614 5806, USA
    Front Biosci 9:2457-65. 2004
    ..The overall objective is to examine the feasibility and practicability of the passive immunization approach for immunocontraception...
  13. ncbi request reprint Cloning and sequencing of cDNA encoding for a novel human testis-specific contraceptive vaccinogen: role in immunocontraception
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43614 5806, USA
    Mol Reprod Dev 60:116-27. 2001
    ....
  14. ncbi request reprint Monoclonal antibody against human sperm-specific YLP12 peptide sequence involved in oocyte binding
    R K Naz
    Division of Research, Department of Obstetrics Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Arch Androl 48:169-75. 2002
    ..There was no apparent effect of antibodies on sperm motility. Thus, the monoclonal antibody, if humanized by genetic engineering technology, may provide a useful immunocontraceptive agent...
  15. ncbi request reprint Novel human prostate-specific cDNA: molecular cloning, expression, and immunobiology of the recombinant protein
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Health Education Building, Rm 211, Medical College of Ohio, 3055 Arlington Avenue, Toledo, OH 43614 5806, USA
    Biochem Biophys Res Commun 297:1075-84. 2002
    ..Thus, the novel hNPSA, which has prostate-specific expression and seems to be involved in carcinogenesis, may have applications in the specific diagnosis and treatment of prostate cancer...
  16. ncbi request reprint Vaccine for contraception targeting sperm
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Immunol Rev 171:193-202. 1999
    ..The advances made during the last 5 years suggest that it may be a realistic proposition...
  17. ncbi request reprint Identification of insulin-like growth factor (IGF)-1 receptor in human sperm cell
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Arch Androl 43:153-9. 1999
    ....
  18. ncbi request reprint Cloning and sequencing of a cDNA encoding for a protein specifically expressed in human testis, ovary and placenta
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Health Education Building, Rm 211, Medical College of Ohio, 3055 Arlington Avenue, Toledo, OH 43614 5806, USA
    Front Biosci 9:2020-8. 2004
    ..It may also find clinical applications in the development of a contraceptive vaccine, and specific diagnosis and treatment of infertility in humans...
  19. ncbi request reprint Molecular cloning and sequencing of a novel cDNA encoding for a protein involved in human sperm function
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, 3055 Arlington Avenue, Toledo, Ohio, 43614 5806, USA
    Biochem Biophys Res Commun 284:911-7. 2001
    ..001) inhibited human sperm capacitation and/or acrosome reaction. The novel recombinant NZ-3 antigen may find applications in immunocontraception and in specific diagnosis of human infertility...
  20. ncbi request reprint Modalities for treatment of antisperm antibody mediated infertility: novel perspectives
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, OH 43614 5806, USA
    Am J Reprod Immunol 51:390-7. 2004
    ....
  21. ncbi request reprint Human synthetic peptide vaccine for contraception targeting sperm
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43614 5806, USA
    Arch Androl 50:113-9. 2004
    ..Thus, the novel synthetic YLP(12) peptide is an attractive candidate for contraceptive vaccine development, and diagnosis and treatment of immunoinfertility in humans...
  22. pmc Role of tyrosine phosphorylation in sperm capacitation / acrosome reaction
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio, USA
    Reprod Biol Endocrinol 2:75. 2004
    ..In this article, we have reviewed the data from our and other laboratories, and have constructed a heuristic model for the mechanisms and molecules involved in capacitation/acrosome reaction...
  23. ncbi request reprint Involvement of protein serine and threonine phosphorylation in human sperm capacitation
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Biol Reprod 60:1402-9. 1999
    ..These findings indicate that protein serine/threonine phosphorylation is involved and may have a physiological role in sperm capacitation...
  24. ncbi request reprint Molecular and immunological characteristics of sperm antigens involved in egg binding
    Rajesh K Naz
    Room 211, Division of Research, Department of Obstetrics and Gynecology, Health Education Building, Medical College of Ohio, 3055 Arlington Avenue, Toledo, OH 43614 5806, USA
    J Reprod Immunol 53:13-23. 2002
    ..Thus, FA-1 and YLP(12) are promising target antigens for the development of contraceptive vaccines as well as for specific diagnosis and treatment of male infertility...
  25. ncbi request reprint Novel human testis-specific cDNA: molecular cloning, expression and immunobiological effects of the recombinant protein
    R Santhanam
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43614-5806, USA
    Mol Reprod Dev 60:1-12. 2001
    ....
  26. pmc Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects
    X Zhu
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, OH 43699, USA
    Proc Natl Acad Sci U S A 94:4704-9. 1997
    ..These findings suggest that the sperm-specific recombinant FA-1 antigen is an attractive candidate for the development of a contraceptive vaccine...
  27. ncbi request reprint Recent advances in contraceptive vaccine development: a mini-review
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Laboratories, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Morgantown, West Virginia 26505, USA
    Hum Reprod 20:3271-83. 2005
    ..The present article will focus on the current status of the anti-sperm, anti-ZP, anti-LHRH/GnRH and anti-HCG vaccines...
  28. ncbi request reprint Cloning and sequencing of cDNA encoding for a human sperm antigen involved in fertilization
    X Zhu
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614, USA
    Mol Reprod Dev 51:176-83. 1998
    ..The recombinant human sperm NZ-2 antigen may find applications in the development of a contraceptive vaccine, and diagnosis and treatment of infertility in humans...
  29. ncbi request reprint Testis-specific proteins and their role in contraceptive vaccine development
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Richard D Ruppert Health Center, 3120 Glendale Avenue, Toledo, OH 43614 5809, USA
    Front Biosci 3:e39-48. 1998
    ..The potential role of these proteins in the development an antisperm contraceptive vaccine(s) is discussed...
  30. ncbi request reprint Testis-specific antigen (TSA-1) is expressed in murine sperm and its antibodies inhibit fertilization
    Ram N Trivedi
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5806, USA
    Am J Reprod Immunol 47:38-45. 2002
    ..The present study was conducted to examine its expression and function in murine sperm, in order to find out whether or not the mouse can provide a suitable model for examining its immunocontraceptive effects...
  31. ncbi request reprint A novel human prostate-specific gene-1 (HPG-1): molecular cloning, sequencing, and its potential involvement in prostate carcinogenesis
    Elizabeth A Herness
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43614, USA
    Cancer Res 63:329-36. 2003
    ..Thus, the novel androgen-responsive HPG-1, which has prostate-specific expression and seems to be involved in carcinogenesis, may have applications in the specific diagnosis and treatment of prostate cancer...
  32. ncbi request reprint Effect of antibodies to sperm-specific recombinant contraceptive vaccinogen (rCV) on murine fertilization: search for an animal model to examine its contraceptive potential
    S C Chauhan
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, OH 43614-5806, USA
    Mol Reprod Dev 60:425-32. 2001
    ..In vitro inhibition of capacitation/acrosome reaction and sperm-zona binding suggest that the mouse can provide a suitable model to examine the immunocontraceptive effects of CV antigen in actively-immunized animals...
  33. ncbi request reprint Involvement of protein tyrosine phosphorylation of human sperm in capacitation/acrosome reaction and zona pellucida binding
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43699 0008, USA
    Front Biosci 1:d206-13. 1996
    ..Since tyrosine phosphorylation is a primary/even exclusive indication of signal transduction, it appears that a signal transduction pathway is involved in fertilizability of human sperm...
  34. ncbi request reprint Fertilization antigen-1 removes antisperm autoantibodies from spermatozoa of infertile men and results in increased rates of acrosome reaction
    A C Menge
    Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor 48109 0272, USA
    Fertil Steril 71:256-60. 1999
    ..To determine if fertilization antigen (FA)-1 will remove autoantibodies from the surface of sperm cells of immunoinfertile men by immune adsorption and permit an increased acrosome reaction (AR)...
  35. ncbi request reprint Effect of actinomycin D and cycloheximide on human sperm function
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614 5809, USA
    Arch Androl 41:135-42. 1998
    ..There seem to be some transcriptional and translational activities in the head and midpiece regions of human sperm during capacitation/acrosome reaction...
  36. pmc Isolation of human single chain variable fragment antibodies against specific sperm antigens for immunocontraceptive development
    A S Samuel
    Reproductive Immunology and Molecular Biology Laboratories, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Morgantown, WV 26506 9186, USA
    Hum Reprod 23:1324-37. 2008
    ..We describe here the development of sperm-reactive human single chain variable fragment (scFv) antibodies of defined sperm specificity for immunocontraception...
  37. ncbi request reprint c-Abl proto-oncoprotein is expressed and tyrosine phosphorylated in human sperm cell
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614, USA
    Mol Reprod Dev 51:210-7. 1998
    ..These findings suggest that the c-Abl or c-Abl-like proteins are present in mature sperm cells that are tyrosine autophosphorylated and may have a role in human sperm cell function...
  38. doi request reprint Presence of antisperm antibodies reactive with peptide epitopes of FA-1 and YLP12 in sera of immunoinfertile women
    Jessica Williams
    Reproductive Immunology and Molecular Biology Laboratory, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Morgantown, WV 26506 9186, USA
    Am J Reprod Immunol 59:518-24. 2008
    ..The present study was conducted to examine the occurrence of isoantibodies to various peptide epitopes of human and murine FA-1 antigen and YLP12 peptide in sera of immunoinfertile and fertile women...
  39. ncbi request reprint Decreased levels of interleukin-12 are not correlated with leukocyte concentration and superoxide dismutase activity in semen of infertile men
    R K Naz
    Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43699 0008, USA
    Arch Androl 41:91-6. 1998
    ..The positive correlation with sperm concentration suggests that IL-12 may have a direct or indirect role in male fertility/infertility and that its levels are not modulated by the presence of leukocytes in the semen...
  40. ncbi request reprint Application of sperm antigens in immunocontraception
    R K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio 43699, USA
    Front Biosci 1:e87-95. 1996
    ..These antigens have been proposed as potential candidates for the development of contraceptive vaccine(s). Their current status, application, relative merits, and immunogenicity in immunocontraception are discussed in this review...
  41. ncbi request reprint Molecular cloning and sequencing of cDNA encoding for a novel testis-specific antigen
    R K Naz
    Department of Obstetrics and Gynecology Medical College of Ohio, Toledo 43699 0008, USA
    Mol Reprod Dev 48:449-57. 1997
    ..These findings suggest that the sperm-specific recombinant NZ-1 may find applications in the development of a contraceptive vaccine, and in studying the normal and abnormal sperm function and the signal transduction mechanism...
  42. ncbi request reprint Effect of sperm DNA vaccine on fertility of female mice
    Rajesh K Naz
    Department of Obstetrics and Gynecology, Reproductive Immunology and Molecular Biology Laboratories, The West Virginia University, School of Medicine, Morgantown, West Virginia 26505 9186, USA
    Mol Reprod Dev 73:918-28. 2006
    ..These novel findings indicate that the intradermal immunization with a sperm-specific DNA vaccine causes a long-term circulating and local immune response resulting in immunocontraceptive effects in female mice...
  43. pmc Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system
    Rajesh K Naz
    Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Morgantown, WV 26505 9186, USA
    J Reprod Immunol 84:24-31. 2010
    ..Novel proteins identified using this system may find applications in elucidating the fertilization cascade, development of a new generation of non-steroidal contraceptives, and specific diagnosis and treatment of human infertility...
  44. ncbi request reprint Immunocontraceptive effect of Izumo and enhancement by combination vaccination
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Laboratories, Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Morgantown, WV 26505 9186, USA
    Mol Reprod Dev 75:336-44. 2008
    ..The data further indicate that the proteins involved in sperm-egg fusion can also be used for contraceptive vaccine development. The contraceptive effects are enhanced by immunizing with the multipeptide vaccines...
  45. pmc Status of contraceptive vaccines
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Laboratories, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Morgantown, WV 26506 9186, USA
    Am J Reprod Immunol 61:11-8. 2009
    ..This is a review of anti-sperm contraceptive vaccines (CV), and synthesis of human scFv antibodies that can be used as immunocontraceptives...
  46. ncbi request reprint Antisperm immunity for contraception
    Rajesh K Naz
    Robert C Byrd Health Sciences Center North, Reproductive Immunology and Molecular Biology Laboratories, Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Morgantown, West Virginia 26505 9186, USA
    J Androl 27:153-9. 2006
  47. ncbi request reprint Human sperm-specific peptide vaccine that causes long-term reversible contraception
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, 3055 Arlington Avenue, Toledo, OH 43614, USA
    Biol Reprod 67:674-80. 2002
    ..The peptide sequence is an epitope of a 50 +/- 5-kDa membrane protein localized on the acrosome and tail of spermatozoa. Thus, the sperm-specific YLP(12) is an attractive candidate for contraceptive vaccine...
  48. ncbi request reprint Expression of a novel isoform of cyclin I in human testis
    X Zhu
    Department of Obstetrics and Gynecology, Medical College of Ohio, Richard D Ruppert Health Center, Toledo 43614, USA
    Biochem Biophys Res Commun 249:56-60. 1998
    ..This new isoform may have a physiological role in spermatogenesis and/or human sperm cell function--especially in capacitation and/or acrosome reaction...
  49. ncbi request reprint Antisperm vaccine for contraception
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Laboratories, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Morgantown, 26505, USA
    Am J Reprod Immunol 54:378-83. 2005
    ..This study is a review of antisperm contraceptive vaccine (CV) development with the main focus on research going on in our laboratory...
  50. ncbi request reprint Effect of fertilization antigen (FA-1) DNA vaccine on fertility of female mice
    Rajesh K Naz
    Department of Obstetrics and Gynecology, Reproductive Immunology and Molecular Biology Laboratories, The West Virginia University, School of Medicine, Morgantown, West Virginia 26505, USA
    Mol Reprod Dev 73:1473-9. 2006
    ..The anti-fertility effects were enhanced when FA-1 DNA vaccine was combined with YLP(12) DNA vaccine and injected with ODN...
  51. ncbi request reprint Molecular identities of human sperm proteins reactive with antibodies in sera of immunoinfertile women
    Satish Bhande
    Department of Obstetrics and Gynecology, Reproductive Immunology and Molecular Biology Laboratories, School of Medicine, The West Virginia University, Morgantown, West Virginia 26505 9186, USA
    Mol Reprod Dev 74:332-40. 2007
    ..Some of these antigens may find applications in specific diagonsis and treatment of infertility/immunoinfertility, and in the development of new generation of contraceptive modalities including contraceptive vaccines...
  52. ncbi request reprint Search for peptide sequences involved in human antisperm antibody-mediated male immunoinfertility by using phage display technology
    Rajesh K Naz
    Division of Research, Department of Obstetrics and Gynecology, Health Education Building, Medical College of Ohio, Toledo, Ohio, USA
    Mol Reprod Dev 72:25-30. 2005
    ..The phage display technique provides an exciting and novel technology to delineate sperm epitopes involved in immunoinfertility...
  53. ncbi request reprint Prostate-specific genes: present status and future direction
    R K Naz
    Division of Research, HEB Room 211, Medical College of Ohio, 3055 Arlington Avenue, Toledo, OH 43614-5806, USA
    Front Biosci 6:D1083-8. 2001
    ..The long-term objective is to define the lacunae that exist in the literature in our search for an ideal antigen...
  54. ncbi request reprint Novel testis/sperm-specific contraceptive targets identified using gene knockout studies
    Rajesh K Naz
    Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Health Science Center, Morgantown, WV 28506 9186, USA
    Front Biosci 10:2430-46. 2005
    ..The knockouts of only a few genes/proteins induced a specific effect on fertility without a serious side effect. The potential role of these novel genes/proteins in contraception/contraceptive vaccine development is discussed...
  55. ncbi request reprint Gene knockouts that affect female fertility: novel targets for contraception
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Lab, Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Health Sciences Center, Morgantown, WV 26505 9186, USA
    Front Biosci (Schol Ed) 2:1092-112. 2010
    ..Some of these genes may provide novel targets for developing better methods for contraception and specific diagnosis and treatment of female infertility...
  56. pmc Development of genetically engineered human sperm immunocontraceptives
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Laboratories, Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Morgantown, WV 26506 9186, USA
    J Reprod Immunol 83:145-50. 2009
    ..The multi-epitope contraceptive vaccines and preformed engineered antibodies of defined specificity may eliminate concern related to inter-individual variability of the immune response...
  57. ncbi request reprint Novel biomarkers and therapeutic targets for prostate cancer
    Ryan M Williams
    Department of Obstetrics and Gynecology, West Virginia University School of Medicine, Health Sciences Center North, Room 2085, Morgantown, WV 26506 9186, USA
    Front Biosci (Schol Ed) 2:677-84. 2010
    ..Novel markers for the diagnosis and development of new treatment modalities are urgently needed...
  58. ncbi request reprint Peptide vaccines against cancer, infectious diseases, and conception
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Laboratory, Department of Obstetrics and Gynecology, The West Virginia University, School of Medicine, Morgantown, West Virginia 26505 9186, USA
    Front Biosci 12:1833-44. 2007
    ..The current status of many peptide vaccines which are being developed against cancer, infectious diseases, and conception is discussed in this review...
  59. ncbi request reprint Receptors in spermatozoa: are they real?
    Rajesh K Naz
    Reproductive Immunology and Molecular Biology Laboratories, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Morgantown, WV 26505 9186, USA
    J Androl 27:627-36. 2006
  60. ncbi request reprint Male-biased genes of Drosophila melanogaster that are conserved in mammalian testis
    Eli B Rodgers-Melnick
    Reproductive Immunology and Molecular Biology Lab, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Health Sciences Center, Morgantown, WV 26506 9186, USA
    Front Biosci (Elite Ed) 2:841-8. 2010
    ..Several also showed association with human male-factor infertility. These genes/proteins may find applications in the diagnosis and treatment of male infertility and the development of novel contraceptives...